856 results match your criteria: "Calcinosis Cutis"

A Clinicopathological Study of Scrotal Calcinosis and Literature Review.

Int J Surg Pathol

November 2024

Department of Pathology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Article Synopsis
  • The study examined 14 adult men with scrotal calcinosis to understand its clinicopathological features and potential causes, finding that it typically appears as hard nodules on the scrotum.
  • The analysis included comparisons with 81 cases of extrascrotal calcinosis and a large group of patients with epidermoid cysts, suggesting that scrotal calcinosis may arise from epidermoid cysts rather than being idiopathic.
  • The disease is characterized by calcium deposits in the skin and is generally asymptomatic, with surgical excision being an effective treatment.
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Treatment of Calcinosis in Dermatomyositis-Case Report and Review.

J Clin Med

October 2024

Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Collegium Medicum, University of Warmia and Mazury, Al. Wojska Polskiego 30, 10-229 Olsztyn, Poland.

Article Synopsis
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Article Synopsis
  • Idiopathic scrotal calcinosis (ISC) is a rare skin condition with an unclear cause, characterized by yellowish-white nodules on the scrotum that can itch or sting.
  • A 36-year-old patient underwent surgical removal of these nodules, and tests confirmed the diagnosis of ISC, revealing abnormal collagen fiber buildup around the calcified areas.
  • The study suggests a potential link between human papillomavirus (HPV) infection and ISC, proposing a new understanding of its causes and emphasizing the need for further research into the disease’s mechanisms.
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Article Synopsis
  • Sarcoidosis is an unknown multi-system disease characterized by granulomas, primarily seen in the lungs but can also cause lymph node issues and rarely affects the kidneys.
  • A case study of a 59-year-old man reveals that despite normal chest imaging, he was diagnosed with sarcoidosis due to symptoms like renal failure and the presence of noncaseating granulomas in a skin biopsy.
  • The report emphasizes that sarcoidosis can present without lung symptoms, suggesting that doctors should consider it when diagnosing unexplained high calcium levels, even in the absence of typical lung or skin signs.
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Article Synopsis
  • - Dermatomyositis (DM) is an autoimmune disease causing muscle weakness and inflammation, along with unique skin symptoms.
  • - About 8% of DM patients experience calcinosis cutis, where calcium deposits form in soft tissues, leading to severe treatment challenges and potential complications.
  • - A case study highlights a 69-year-old woman with DM who developed a severe version of calcinosis cutis, illustrating the disease's impact.
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Leg Ulceration with Infected Calcinosis Cutis Mimicking Osteomyelitis: A Case Report.

J Am Podiatr Med Assoc

September 2024

‡Ocean County Foot & Ankle Surgical Associates, Toms River, NJ.

Article Synopsis
  • - A patient developed a leg ulcer after a skin biopsy, which did not heal because of an underlying calcified mass, leading to multiple hospital visits for sepsis.
  • - The condition diagnosed was calcinosis cutis, suspected to be the cause of repeated infections associated with the ulcer.
  • - After the calcified mass was surgically removed, the patient healed without further infections, emphasizing the need to investigate calcified masses in nonhealing leg ulcers.
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Article Synopsis
  • Reactive "syringomatoid" eccrine proliferations are similar to syringomas but are less extensive, making it hard to differentiate between the two.
  • There is significant overlap in their histological features, suggesting they might exist on a continuum.
  • This text discusses a rare case of syringomatoid hyperplasia linked with calcinosis cutis in a 54-year-old male, noted as the first of its kind in literature.
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Updated solution for diagnosis and management of calcinosis cutis: A retrospective review.

Medicine (Baltimore)

August 2024

Department of Plastic and Reconstructive Surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Republic of Korea.

Article Synopsis
  • Calcinosis cutis has five types (dystrophic, metastatic, idiopathic, iatrogenic, calciphylaxis) and can be misdiagnosed as cancer, making management difficult.
  • A study of 7 patients, treated between 2013-2022, highlighted successful diagnoses and complete mass excisions without significant complications, leading to full recovery.
  • The use of imaging techniques (X-rays, ultrasound, CT, MRI) was crucial for accurate diagnosis and treatment, promoting safer, less invasive procedures and preventing recurrences.
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Article Synopsis
  • Calcinosis cutis is the buildup of calcium in the skin, mainly due to chronic inflammation linked with collagen issues. !* -
  • Surgical options exist, but evidence for effective treatments is limited; intravenous sodium thiosulfate has shown promise in treating calciphylaxis and may help stabilize dystrophic calcinosis cutis in some cases. !* -
  • Higher skin absorption of sodium thiosulfate may enhance its effectiveness, supported by its success in calciphylaxis treatment according to previous reports. !*
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Article Synopsis
  • A 9-year-old boy was diagnosed with eruptive syringomas and large lesions of calcinosis cutis that look like calcified nodules under the skin.
  • * The study explores the connection between eruptive syringomas and calcinosis cutis, highlighting their various appearances.
  • * The authors categorize five distinct presentations and associations between these conditions, which has not been previously documented in the literature.*
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Article Synopsis
  • - Calcinosis cutis is a skin condition characterized by calcium salt buildup in the skin, often appearing as painless nodules or plaques; it can arise from trauma, cancers, or connective tissue disorders.
  • - Treatment options vary depending on the severity of the condition and may include both medical and surgical approaches, guided by diagnostic tests like fine needle aspiration and imaging.
  • - A specific case involves a 35-year-old man who had a swelling on his left foot for two years, and after surgical intervention, he experienced a positive recovery.
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Genital calcinosis cutis: Microscopic evidence supporting a dystrophic origin.

Pediatr Dermatol

November 2024

Department of Dermatology, Division of Pediatric Dermatology, University of California, San Francisco, USA.

Article Synopsis
  • * A study presented a 9-year-old girl with vulvar CC and a 15-year-old boy with preputial CC, where tissue analysis showed specific conditions linked to the calcification.
  • * The findings suggest that some cases of genital CC, thought to be without known cause (idiopathic), may actually have identifiable origins, highlighting the importance of thorough medical examination and monitoring.
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Article Synopsis
  • Calcinosis cutis is the buildup of calcium salts in the skin that can lead to inflammation and joint issues, mostly seen in autoimmune connective tissue diseases (CTDs), but its prevalence is not well understood.
  • * A retrospective study analyzed 839 CTD patients, finding that 56 had calcinosis, which is about 6.67%, with an average diagnosis age of 41 years and an onset time of almost 6 years.
  • * The study suggests calcinosis, while rare in the general population, is a significant issue for CTD patients; more research is needed on its causes and treatment options.
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Treatment of calcinosis cutis associated with autoimmune connective tissue diseases.

Arch Dermatol Res

June 2024

Department of Dermatology, Massachusetts General Hospital, 50 Staniford Street, Suite 200, Boston, MA, 02114, USA.

Article Synopsis
  • - Calcinosis cutis is a skin condition often linked to autoimmune diseases, marked by calcium salt deposits in the skin that can cause pain and impact quality of life.
  • - Managing calcinosis cutis is challenging due to the lack of standard treatments, with most evidence derived from individual case reports showing varied results.
  • - The article reviews current treatment options and discusses how choices may depend on individual patient factors and the severity of their condition.
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Neonatal Calcinosis Cutis After Treatment of Hypocalcemia with Calcium Gluconate: A Report of 2 Cases.

Am J Case Rep

June 2024

Department of Orthopedic Surgery, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.

Article Synopsis
  • - Calcium gluconate is commonly used to treat neonatal issues like hypocalcemia and can lead to complications if it leaks into soft tissue, causing skin problems such as redness and calcification.
  • - Two neonatal cases of calcinosis cutis are described: a 12-day-old male with a calcified mass in his foot after receiving calcium gluconate for hypocalcemia, and a 1-month-old female with a similar mass following treatment for cystic fibrosis.
  • - Both cases resolved with symptomatic treatment, emphasizing the need for careful monitoring of neonates receiving calcium gluconate to prevent and address potential skin complications.
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Article Synopsis
  • Juvenile systemic sclerosis (JSSc) is a rare autoimmune disease mainly affecting kids and teens, linked to a mix of genetic, environmental, and immune factors.
  • The condition leads to excessive collagen production, causing symptoms like shortness of breath, chest pain, and kidney issues, though calcinosis cutis is uncommon in JSSc.
  • A case study discusses a 14-year-old girl with breathlessness and lesions who underwent surgery for calcinosis cutis, highlighting the importance of early diagnosis and treatment to prevent serious health risks.
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