4 results match your criteria: "Cairo University Giza 12613 Egypt kmdawood@sci.cu.edu.eg +202 35727556.[Affiliation]"
Recent progress in therapeutic applications of fluorinated five-membered heterocycles and their benzo-fused systems.
RSC Adv
October 2024
Department of Chemistry, Faculty of Science, Cairo University Giza 12613 Egypt (+202) 35727556.
Article Synopsis
- * Over 20% of marketed medications contain fluorine, with nearly 300 approved fluorine-containing drugs, highlighting their significance in pharmaceuticals.
- * This review focuses on the therapeutic potential of five-membered heterocycles and their fused systems, detailing various activities like antiviral, anti-inflammatory, and more, often showing effectiveness comparable to standard reference drugs.
Recent advances on anticancer and antimicrobial activities of directly-fluorinated five-membered heterocycles and their benzo-fused systems.
RSC Adv
June 2024
Department of Chemistry, Faculty of Science, Cairo University Giza 12613 Egypt +202 35727556.
Article Synopsis
- Fluorinated heterocycles are crucial in pharmaceuticals, with about 20% of anticancer and antibiotic drugs containing fluorine atoms, prompting this review of five-membered and benzo-fused systems with fluorine.
- These compounds have demonstrated notable anticancer and antimicrobial activities, with some serving as lead structures for drug development, showing efficacy comparable to or better than existing drugs.
- Studies indicate that the type of substituents on these fluorinated heterocycles (electron-donating or electron-withdrawing) greatly influences their biological activity and safety profiles, showcasing reduced cytotoxicity in non-cancerous cells.
Correction: Microwave-assisted chemoselective synthesis and photophysical properties of 2-arylazo-biphenyl-4-carboxamides from hydrazonals.
RSC Adv
October 2023
Chemistry Department, Faculty of Science, University of Kuwait P.O. Box 5969 Safat 13060 Kuwait +965 24816482.
[This corrects the article DOI: 10.1039/D3RA04558G.].
View Article and Find Full Text PDFMicrowave-assisted chemoselective synthesis and photophysical properties of 2-arylazo-biphenyl-4-carboxamides from hydrazonals.
RSC Adv
August 2023
Chemistry Department, Faculty of Science, University of Kuwait P.O. Box 5969 Safat 13060 Kuwait +965 24816482.
The reaction of 3-oxo-2-arylhydrazonopropanals with acetoacetanilide in an equimolar ratio, under DBU/1,4-dioxane/microwave irradiation reaction conditions, resulted in chemoselective formation of 4-arylazo-5-hydroxy-benzamide derivatives. The structures of the obtained biphenyl-4-carboxamides were characterized by several spectroscopic techniques including IR, H- and C-NMR, MS and HRMS, and X-ray single crystals of three examples. The photophysical properties of the new products were also evaluated, with a particular focus on their absorption and emission spectra, which provided valuable information regarding their optical properties.
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