Carcavrol from Thymus leptobotrys Essential Oil: Isolation, Comparative Antibacterial and Antioxidant Activites and Mechanistic Insights via Molecular Docking.

Carvacrol is the main compound of several medicinal and aromatic plant essential oils (EOs), such as Thymus leptobotrys Murb which is a Moroccan endemic plant. Carvacrol is a versatile scaffold that serves as a central model for the design and synthesis of new drug substances with promising biological properties. In this context, this study aimed to isolate carvacrol from T.

Design, Hemisynthesis, Characterization, Molecular Docking, and Dynamics Evaluation of Novel Totarol-1,2,3-Triazole Derivatives as Leishmaniasis and Toxoplasmosis Agents.

Tropical parasitic diseases like leishmaniasis pose significant public health challenges, impacting millions of individuals globally. Current drug treatments for these diseases have notable drawbacks and side effects, underscoring the pressing need for new medications with improved selectivity and reduced toxicity. Through structural modifications of both natural and synthetic compounds using click chemistry, researchers have been able to produce derivatives showing promising activity against these parasites.

Novel D-Ribofuranosyl Tetrazoles: Synthesis, Characterization, In Vitro Antimicrobial Activity, and Computational Studies.

The goal of this study was to synthesize and evaluate new antimicrobial compounds. We specifically focused on the development of 2,5-disubstituted tetrazole derivatives containing the O-methyl-2,3-O-isopropylidene-(D)-ribofuranoside groups through N-alkylation reactions. The synthesized compounds were characterized using H and C nuclear magnetic resonance (NMR) spectroscopy.

Multiscale derivation of deterministic and stochastic cross-diffusion models in a fluid: A review.

This paper presents a survey and critical analysis of the mathematical literature on modeling of dynamic populations living in a fluid medium. The present review paper is divided into two main parts: The first part deals with the multiscale derivation of deterministic and stochastic cross-diffusion systems governed by the incompressible Navier-Stokes equations. The derivation is obtained from the underlying description at the microscopic scale in kinetic theory models according to the micro-macro decomposition method.

Copper oxide nanoparticles-decorated cellulose acetate: Eco-friendly catalysts for reduction of toxic organic dyes in aqueous media.

In this study, we aimed to gain insight into the potential of catalytic reduction using copper oxide nanoparticles decorated cellulose acetate as a biosupport (CuO@CA) for the removal of specific pollutants. The prepared catalyst was submitted to a series of spectroscopy techniques for characterization purposes. The results of the catalytic tests on methylene orange (MO) and methylene blue (MB) solutions suggest that the elimination efficiency may be influenced by several factors, including the catalyst dose and the concentration of the pollutant.

Microbial enzymatic indices for predicting composting quality of recalcitrant lignocellulosic substrates.

Three different enzymes alkaline phosphatase, Urease and Dehydrogenase were measured during this study to monitor the organic matter dynamics during semi-industrial composting of mixture A with 1/3 sludge+2/3 palm waste and mixture B with ½ sludge+1/2 palm waste. The phosphatase activity was higher for Mix-A (398.7 µg PNP g h) than Mix-B (265.

Green synthesis of benzimidazole derivatives using copper(II)-supported on alginate hydrogel beads.

The study addresses the challenge of developing sustainable and efficient catalytic systems for the synthesis of benzimidazole derivatives, which are of significant importance in the field of medicinal chemistry due to their diverse biological activities. The objective is to develop a recyclable and environmentally friendly catalyst utilizing copper(II)-loaded alginate hydrogel beads, which can facilitate the synthesis of these compounds while minimizing environmental impact. The preparation process entails crosslinking sodium alginate with copper(II) ions to form hydrogel beads, which are then washed and characterized through techniques such as scanning electron microscopy (SEM), Energy dispersive X-ray spectroscopy (EDX), Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Inductively coupled plasma (ICP), and Zeta potential to analyses the morphology, composition and porosity of the beads.

Synthesis and characterization of a crosslinked deacetylated chitin modified chicken bone waste-derived hydroxyapatite and TiO biocomposite for defluoridation of drinking water.

This work represents an innovative approach to the synthesis and characterization of a chitosan-based biocomposite for fluoride adsorption. The work involved the development of a biocomposite based on modified chicken bone waste-derived hydroxyapatite and TiO. The composite was characterized using scanning electron microscopy with Energy Dispersive X-ray analysis (SEM-EDX), X-ray diffraction (XRD), Fourier-transform infrared analysis (FTIR), thermal-gravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS).

A Comprehensive Review of Moroccan Medicinal Plants for Diabetes Management.

Moroccan flora, renowned for its diverse medicinal plant species, has long been used in traditional medicine to manage diabetes. This review synthesizes ethnobotanical surveys conducted during the last two decades. Among these plants, 10 prominent Moroccan medicinal plants are evaluated for their phytochemical composition and antidiabetic properties through both and studies.

Novel Bis-1,2,3-triazole-thiazolidinone hybrid as anticancer agents that induce apoptosis and molecular modeling study.

A series of (R)-Carvone-based 1,2,3-triazole-thiazolidinone hybrids were synthesized and characterized by spectroscopic techniques NMR and HRMS. The chemical reactivity and the stability parameters were observed via DFT. The objective was to evaluate the anticancer activity of the synthesized compounds against cancer cell lines.

Growth, Biochemical Traits, Antioxidant Enzymes, and Essential Oils of Four Aromatic and Medicinal Plants Cultivated in Phosphate-Mine Residues.

Revegetation emerges as a promising approach to alleviate the adverse impacts of mining residues. However, it is essential to evaluate the characteristics of these materials and select suitable plant species to ensure successful ecosystem restoration. This study aimed to investigate the effects of phosphate-mine residues (MR) on the growth, biochemical properties, and essential oil concentration of L.

Rhodium/Trialkylamines Catalyzed Reductive Hydroformylation in Ionic Liquid/Heptane Medium: An Unexpected Concept for Catalyst Recycling in Batch and Continuous Flow Processes.

We report here the rhodium catalyzed reductive hydroformylation of methyl 10-undecenoate. Our approach is based on an ionic liquid/heptane biphasic system associated with commercially available trialkylamines. The effects of various reaction parameters such as amine type, amine amount, temperature, syngas pressure and composition were studied in order to minimize the rhodium leaching and increase the production of primary alcohols.

Thiazolidinone-linked-1,2,3-triazoles with (R)-Carvone as new potential anticancer agents.

This study explores the cytotoxic and apoptotic effects of novel thiazolidinone-1,2,3-triazole hybrids on HT-1080, A-549, and MDA-MB-231 cancer cell lines. The synthesized compounds underwent comprehensive characterization (NMR and HRMS) to confirm their structures and purity. Subsequent anticancer activity screening across diverse cancer cell lines revealed promising antitumor potential notably, compounds and .

Phenotype and molecular characterization of Wilson's disease in Morocco.

Background And Study Aims: In Morocco the prevalence of Wilson disease (WD) and the spectrum of mutations are not known. The aim of the present study was to estimate the prevalence of WD in Morocco, to evaluate the phenotype among a large cohort of WD patients, and to characterize ATP7B variants in a subgroup of WD patients.

Patients And Methods: We collected data from 226 patients admitted to five university hospital centers in Morocco between 2008 and 2020.

Easily deposited ZnO nanorods on siloxene nanosheets: investigation of morphological, dielectric, ferroelectric, and energy storage properties.

The integration of metal oxides onto two-dimensional layered siloxene has proven to be an effective strategy for expanding potential applications across diverse fields. Herein, we present the synthesis and detailed characterization of zinc oxide (ZnO) nanorods deposited on siloxene nanosheets using the wet chemical precipitation method without the need of alkali. The presence of ZnO nanorods was confirmed through electron microscopy analyses.

[Williams-Beuren syndrome: a retrospective study of a series of 11 cases at the Mohammed VI University Hospital in Marrakech].

Williams-Beuren syndrome is a rare genetic disease (1/20 000) characterized by a microdeletion at 7q11.23 encompassing about 28 genes, including the elastin gene, ELN. It is a sporadic disease in the majority of cases.

A novel chitosan-alginate@Fe/Mn mixed oxide nanocomposite for highly efficient removal of Cr (VI) from wastewater: Experiment and adsorption mechanism.

In this study, the synthesis and experimental theoretical evaluation of a new chitosan/alginate/hydrozyapatite nanocomposite doped with Mn2 and Fe2O3 for Cr removal was reported. The physicochemical properties of the obtained materials were analyzed using the following methods: SEM-EDX, XRD, FTIR, XPS, pH drift measurements, and thermal analysis. The adsorption properties were estimated based on equilibrium and adsorption kinetics measurements.

Cheese wastewater treatment through combined coagulation-flocculation and photo-Fenton-like advanced oxidation processes for reuse in irrigation: effect of operational parameters and phytotoxicity assessment.

The present study aims to investigate the efficiency of a combined cheese wastewater treatment approach involving coagulation with ferric chloride coupled with a photo-Fenton-like oxidation process for potential reuse in irrigation. Laboratory-scale tests were conducted, examining the effect of various operational parameters on the treatment process. Specifically, the effects of initial wastewater pH, coagulant dosage, decantation time for the coagulation process, and initial pH, chemical oxygen demand (COD) concentration, and Fe and HO dosages for photo-Fenton-like oxidation were studied.

Combined Measurement of the Higgs Boson Mass from the H→γγ and H→ZZ^{*}→4ℓ Decay Channels with the ATLAS Detector Using sqrt[s]=7, 8, and 13 TeV pp Collision Data.

A measurement of the mass of the Higgs boson combining the H→ZZ^{*}→4ℓ and H→γγ decay channels is presented. The result is based on 140  fb^{-1} of proton-proton collision data collected by the ATLAS detector during LHC run 2 at a center-of-mass energy of 13 TeV combined with the run 1 ATLAS mass measurement, performed at center-of-mass energies of 7 and 8 TeV, yielding a Higgs boson mass of 125.11±0.

L'expérience de l'accouchement en milieu surveillé dans la province d'Essaouira au Maroc: Quelle réalité?

RésuméUne expérience positive de l'accouchement (EPA) est fondamentale pour des soins maternels de qualité. Toutefois, de nombreuses femmes subissent des comportements non respectueux lors de ce moment crucial. Au Maroc, peu d'études ont mesuré cette expérience, et les éléments l'influençant demeurent insuffisamment documentés.

Copper phosphorylated cellulose nanofibers mediated azide-alkyne cycloaddition click reaction in water.

Heterogenous copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) was performed by using the phosphorylated carbohydrate-based cellulose nanofibers loaded with copper(II) ions. The copper-containing phosphorylated cellulose nanofibers (here after noted Cu(II)-PCNFs) were prepared in two different morphologies, namely the paper and foam ones and characterized by different techniques, including Scanning Electronic Microscopy (SEM), Energy Dispersive X-ray (EDX), Brauner-Emmett-Teller (BET), FT-IR spectroscopy (FTIR), Thermal Gravimetric Analysis (TGA), X-ray Photoelectron spectroscopy (XPS) and Atomic Force Microscopy (AFM). Cu(II)-PCNFs showed high activity in the CuAAC reaction when applied to the ligation of various organic azides and terminal alkynes without any reducing agent, resulting in the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles in water at room temperature.

From himachalenes to trans-himachalol: unveiling bioactivity through hemisynthesis and molecular docking analysis.

In this study, we report the first total hemisynthesis of trans-himachalol sesquiterpene, a stereoisomer of the natural cis-himachalol isolated from Cedrus atlantica essential oils, from himachalenes mixture in five steps. Reactions conditions were optimized and structures of the obtained compounds were confirmed by IR, mass spectra, H, and C NMR. The synthesized compounds were investigated for potential activities on various isolated smooth muscles and against different neurotransmitters using molecular docking.