'What's a D and C between friends?' Space, intimacy and the medicalisation of unmotherhood in modernist literature.

This essay theorises what 'unmotherhood'-or, living outside of motherhood-means within the specific context of 'the modern'. Unmotherhood is an actively constructed state; it is explored through the parameters of agentive choice, social pressure and state control; and at the turn-of-the-20th-century novels articulate this state through specific vocabularies of contemporaneous phenomena of modernity. I look to four novels representative of four forms of unmotherhood: Tess Slesinger's depicts a somewhat voluntary abortion; H.

Correction: Fleary et al. Census Tract Demographics Associated with Libraries' Social, Economic, and Health-Related Programming. 2022, , 6598.

The authors wish to make the following corrections to this paper [...

Response to uncertainty in developmental origins of health and disease research: commentary on Nomura et al. (2022).

We appreciate the comments of Gilman et al. (2023) on our paper and their acknowledgement of its importance in highlighting the significance of this area of research. Further, their acknowledgment that the primary results of our study are in a range that is similar to those from other published studies of children exposed to highly stressful environmental events emphasizes the validity of our findings and the important extension of our results to children experiencing these events in utero.

Association of maternal exposure to Superstorm Sandy and maternal cannabis use with development of psychopathology among offspring: the Stress in Pregnancy Study.

Background: Early-life adverse experiences can elevate the magnitude of the risk of developmental psychopathology, but the potential synergistic effects of multiple factors have not been well studied.

Aims: To determine whether prenatal exposures to maternal stress (Superstorm Sandy) and maternal cannabis use synergistically alter the risk of developmental psychopathology.

Method: The study included 163 children (53.

Zika virus triggers autophagy to exploit host lipid metabolism and drive viral replication.

Background: Zika virus (ZIKV), an arbovirus of global concern, has been associated with neurological complications including microcephaly in newborns and Guillain-Barré syndrome in adults. Like other flaviviruses, ZIKV depends on cholesterol to facilitate its replication; thus, cholesterol has been proposed as a therapeutic target to treat the infection using FDA-approved statins. Cholesterol is stored in intracellular lipid droplets (LD) in the form of cholesterol esters and can be regulated by autophagy.

Prenatal exposure to a natural disaster and early development of psychiatric disorders during the preschool years: stress in pregnancy study.

Background: Growing evidence shows an association between in utero exposure to natural disasters and child behavioral problems, but we still know little about the development of specific psychopathology in preschool-aged children.

Methods: Preschool children (n = 163, mean age = 3.19, 85.

Mapping of antibody epitopes based on docking and homology modeling.

Antibodies are key proteins produced by the immune system to target pathogen proteins termed antigens via specific binding to surface regions called epitopes. Given an antigen and the sequence of an antibody the knowledge of the epitope is critical for the discovery and development of antibody based therapeutics. In this work, we present a computational protocol that uses template-based modeling and docking to predict epitope residues.

Census Tract Demographics Associated with Libraries' Social, Economic, and Health-Related Programming.

: Public libraries can contribute to reducing economic, social, and health inequities through their programming and practices. However, the extent to which libraries regularly provide programming that improve the social determinants of health (SDH) in underserved communities is unclear. : This study explored the relationship between census tract demographic characteristics and library programming implicated in the SDH for underserved groups at risk for health disparities.

Stress in pregnancy: Clinical and adaptive behavior of offspring following Superstorm Sandy.

The current study investigated 304 children from a longitudinal project (the Stress in Pregnancy (SIP) Study) who were exposed and unexposed to Superstorm Sandy ("Sandy") They were prospectively followed from 2 to 6 years of age and their clinical and adaptive behaviors were assessed annually. Using a hierarchical linear model, the study found that Sandy exposure was associated with greater clinical (anxiety, depression, and somatization) and lower adaptive behaviors (social skills and functional communication) at age 2 years. However, the trajectories were notably different between the two groups.

CLUE: Exact maximal reduction of kinetic models by constrained lumping of differential equations.

Motivation: Detailed mechanistic models of biological processes can pose significant challenges for analysis and parameter estimations due to the large number of equations used to track the dynamics of all distinct configurations in which each involved biochemical species can be found. Model reduction can help tame such complexity by providing a lower-dimensional model in which each macro-variable can be directly related to the original variables.

Results: We present CLUE, an algorithm for exact model reduction of systems of polynomial differential equations by constrained linear lumping.

CLUE: exact maximal reduction of kinetic models by constrained lumping of differential equations.

Motivation: Detailed mechanistic models of biological processes can pose significant challenges for analysis and parameter estimations due to the large number of equations used to track the dynamics of all distinct configurations in which each involved biochemical species can be found. Model reduction can help tame such complexity by providing a lower-dimensional model in which each macro-variable can be directly related to the original variables.

Results: We present CLUE, an algorithm for exact model reduction of systems of polynomial differential equations by constrained linear lumping.

Placental Gene Expression and Offspring Temperament Trajectories: Predicting Negative Affect in Early Childhood.

Exposure to prenatal stress increases offspring risk for long-term neurobehavioral impairments and psychopathology, such as Attention Deficit Hyperactivity Disorder (ADHD). Epigenetic regulation of glucocorticoid pathway genes may be a potential underlying mechanism by which maternal conditions 'program' the fetal brain for downstream vulnerabilities. The present study aims to investigate whether mRNA expression of glucocorticoid pathway genes in the placenta predict offspring negative affect during early childhood (between 6 and 24 months).

Triviality of differential Galois cohomology of linear differential algebraic groups.

For a partial differential field , we show that the triviality of the first differential Galois cohomology of every linear differential algebraic group over is equivalent to being algebraically, Picard-Vessiot, and linearly differentially closed. This cohomological triviality condition is also known to be equivalent to the uniqueness up to an isomorphism of a Picard-Vessiot extension of a linear differential equation with parameters.

The children of Superstorm Sandy: Maternal prenatal depression blunts offspring electrodermal activity.

We set out to examine the relations between prenatal exposure to the natural disaster Superstorm Sandy, maternal depression, and offspring electrodermal activity (EDA). EDA was measured via skin conductance response (SCR) magnitude in 198 children (M = 42.54 months, SD = 12.

SIAN: software for structural identifiability analysis of ODE models.

Summary: Biological processes are often modeled by ordinary differential equations with unknown parameters. The unknown parameters are usually estimated from experimental data. In some cases, due to the structure of the model, this estimation problem does not have a unique solution even in the case of continuous noise-free data.

The 2D:4D ratio does not always correlate with economic behavior: A field experiment with African-Americans.

Several studies present evidence of correlations between prenatal testosterone exposure measured with the 2D:4D ratio and behaviors such as pro-social behavior, risk and patient attitudes, and self-employment. Individuals exposed prenatally to higher levels of testosterone have lower levels of risk aversion, higher levels of patience and invest more in others, and in themselves, therefore have higher individual financial wellbeing. We test these hypotheses with a sample of 115 African-Americans who live in a low-income urban area in the U.

Freshwater reservoir offsets and food crusts: Isotope, AMS, and lipid analyses of experimental cooking residues.

Freshwater reservoir offsets (FROs) occur when AMS dates on charred, encrusted food residues on pottery predate a pot's chronological context because of the presence of ancient carbon from aquatic resources such as fish. Research over the past two decades has demonstrated that FROs vary widely within and between water bodies and between fish in those water bodies. Lipid analyses have identified aquatic biomarkers that can be extracted from cooking residues as potential evidence for FROs.

Solvent Retention and Crack Evolution in Dropcast PEDOT:PSS and Dependence on Surface Wetting.

The drying of nanocolloidal polymers is governed by the interplay among surface tension, evaporation, and contact-line pinning, among other phenomena. Here, we describe the sequential evolution of poly-3,4-ethylenedioxythiophene:poly(styrene sulfonate) (PEDOT:PSS) through two distinct regimes evidenced by annular or radial cracking and show that the cracking dynamics and solvent-retention postdrying and postcracking are mediated by wetting to the substrate surface. The corresponding changes in the PEDOT:PSS morphology are also observed to relate to the radial or cracking dynamics.

High-resolution Thermal Micro-imaging Using Europium Chelate Luminescent Coatings.

Micro-electronic devices often undergo significant self-heating when biased to their typical operating conditions. This paper describes a convenient optical micro-imaging technique which can be used to map and quantify such behavior. Europium thenoyltrifluoroacetonate (EuTFC) has a 612 nm luminescence line whose activation efficiency drops strongly with increasing temperature, due to T-dependent interactions between the Eu ion and the organic chelating compound.

Triode for Magnetic Flux Quanta.

In an electronic triode, the electron current emanating from the cathode is regulated by the electric potential on a grid between the cathode and the anode. Here we demonstrate a triode for single quantum magnetic field carriers, where the flow of individual magnetic vortices in a superconducting film is regulated by the magnetic potential of striae of soft magnetic strips deposited on the film surface. By rotating an applied in-plane field, the magnetic strip potential can be varied due to changes in the magnetic charges at the strip edges, allowing accelerated or retarded motion of magnetic vortices inside the superconductor.

Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics.

The panoply of microorganisms and other species present in our environment influence human health and disease, especially in cities, but have not been profiled with metagenomics at a city-wide scale. We sequenced DNA from surfaces across the entire New York City (NYC) subway system, the Gowanus Canal, and public parks. Nearly half of the DNA (48%) does not match any known organism; identified organisms spanned 1,688 bacterial, viral, archaeal, and eukaryotic taxa, which were enriched for harmless genera associated with skin (e.

Bayesian neural adjustment of inhibitory control predicts emergence of problem stimulant use.

Bayesian ideal observer models quantify individuals' context- and experience-dependent beliefs and expectations about their environment, which provides a powerful approach (i) to link basic behavioural mechanisms to neural processing; and (ii) to generate clinical predictors for patient populations. Here, we focus on (ii) and determine whether individual differences in the neural representation of the need to stop in an inhibitory task can predict the development of problem use (i.e.