714 results match your criteria: "CUF Porto Hospital & Institute[Affiliation]"

Avulsive Achilles Tendon Rupture in a Patient With Alkaptonuria: A Case Report.

Cureus

June 2024

Orthopedics and Traumatology, Unidade Local de Saúde de Barcelos/Esposende, Barcelos, PRT.

Article Synopsis
  • Alkaptonuria is a genetic disorder that leads to the accumulation of homogentisic acid, causing black pigmentation in joints and connective tissues, which can lead to severe damage.
  • A 71-year-old man with alkaptonuria experienced an Achilles tendon rupture after a minor fall, which was confirmed by MRI and required surgical intervention.
  • The surgery involved reinserting the tendon with a specialized technique to ensure better load distribution, and the patient successfully regained functionality within a year, showing positive outcomes despite the rare and fragile condition.
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We present a case of a 59-year-old patient with chronic low back pain, caused by a retroperitoneal intraneural tumour. Laparoscopic excision was performed and histology revealed a spinal nerve root neurofibroma. Post-operatively, the patient developed partial motor and sensitive deficits due to tumoral nerve entrapment, with progressive recovery with rehabilitation.

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Many women seek treatment to improve menopausal vasomotor symptoms (VMS). The selection of women most likely to benefit from menopause hormone therapy (MHT) is crucial in clinical practice. There is general agreement that women younger than 60 years or who initiate MHT within the first 10 years of menopause, with no contraindications, have greater benefits considering symptomatic relief and additional advantages.

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Concepts for the Development of Person-Centered, Digitally Enabled, Artificial Intelligence-Assisted ARIA Care Pathways (ARIA 2024).

J Allergy Clin Immunol Pract

October 2024

University Clinic of Respiratory and Allergic Diseases, Pulmonary & Allergy Department, Golnik, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Article Synopsis
  • - The traditional healthcare approach often overlooks patients' personal experiences and strengths, focusing mainly on disease treatment. Person-centered care aims to align medical decisions with individual values and preferences, particularly for those with chronic conditions.
  • - This paper seeks to enhance care for rhinitis and asthma by developing digital care pathways and incorporating real-world evidence to create a more patient-centered approach.
  • - Key components of the review include advancements in mHealth, the integration of artificial intelligence, a novel classification system for airway diseases, and proposals for the ARIA 2024 guidelines, all targeting a sustainable and applicable healthcare model.
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Article Synopsis
  • The study aimed to analyze how well biologic drugs (IL-23 and IL-17 inhibitors) work for treating psoriasis in patients aged 65 and older compared to younger patients.
  • It found that elderly patients had a higher risk of discontinuing treatment, especially with IL-23 inhibitors, while IL-17 inhibitors didn't show a significant difference.
  • Additionally, factors like previous treatments influenced the likelihood of continuing or stopping the medication in elderly patients.
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Article Synopsis
  • * In Portugal, the incidence of Chlamydia has been rising, highlighting the need for improved awareness and strategies for identifying and treating cases.
  • * Recommendations have been adapted from international guidelines to fit Portugal's healthcare system, aiming to create standardized protocols for both symptomatic and asymptomatic individuals.
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Article Synopsis
  • A multidisciplinary panel from various international medical societies was formed to review literature on imaging techniques for diagnosing pelvic deep endometriosis.
  • They drafted 20 preliminary statements on the topic, which underwent multiple revisions and voting rounds to reach consensus among the panel.
  • Ultimately, the finalized document contains 14 statements with strong agreement, 5 with moderate agreement, and aims to guide clinicians in assessing and treating women suspected of having endometriosis.
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Identifying factors influencing adherence, such as patients' beliefs about medication, is essential for effective asthma management. This study aims to assess and gain insight into the beliefs of patients with asthma regarding inhaled medication. This is a secondary analysis of the INSPIRERS studies.

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Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control.

Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control.

Methods: In this cross-sectional study, we assessed real-world data using the MASK-air app.

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: The study cohort comprised five patients, each presenting with unilateral high axial myopia and classic clinical features of HES, including large angle esotropia, hypotropia, and restricted abduction and supraduction. All patients displayed evident superotemporal globe prolapse on MRI imaging, corresponding to the downward displacement of the LR muscle and medial shift of the SR muscle.Following the surgical procedure, all patients demonstrated significant improvements in both vertical and horizontal deviations, effectively addressing the primary clinical manifestations of HES.

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Effectiveness, Adherence and Safety of Home High Flow Nasal Cannula in Chronic Respiratory Disease and Respiratory Insufficiency: A Systematic Review.

Arch Bronconeumol

August 2024

Microbiology Research Laboratory on Environmental Health, Institute of Environmental Health, Associate Laboratory TERRA, Faculty of Medicine, Universidade de Lisboa, Lisbon, Portugal; Institute of Preventive Medicine and Public Health, Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Egas Moniz Interdisciplinary Research Center, Egas Moniz School of Health & Science, Monte da Caparica, Portugal; Healthcare Department, Nippon Gases Portugal, Vila Franca de Xira, Portugal. Electronic address:

Introduction: The effectiveness of home high flow nasal cannula (HFNC) for the treatment of chronic respiratory failure in patients with chronic respiratory diseases (CRDs) has not been summarized. We aimed to conduct a systematic review of the effectiveness, adherence, and safety of HFNC in the long-term treatment of patients with chronic respiratory diseases and respiratory failure.

Methods: A systematic review was conducted.

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Article Synopsis
  • The most common telemonitoring tools were mobile applications (21) and web-based systems (14), with monitoring duration ranging from 2 weeks to 32 months and data collected on various asthma-related factors, including symptoms and medication adherence.
  • Despite significant research, there is a noted lack of tailored telemonitoring technologies for preschool-aged children, highlighting the need for targeted studies in this area.
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Mechanical insufflation-exsufflation (MI-E) is essential for secretion clearance, especially in neuromuscular disorders. For the best outcomes, initiation of MI-E should be started at the correct time with regular evaluation to the response to treatment. Typically, cough peak flow has been used to evaluate cough effectiveness with and without MI-E.

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Corrigendum: Evaluation of mutations in advanced ER+/HER2-breast cancer in Portugal - U-PIK Project.

Front Mol Biosci

April 2024

IPATIMUP - Instituto de Patologia e Imunologia da Universidade do Porto, Porto, Portugal.

Article Synopsis
  • The text addresses an amendment or correction to a previous article published under the DOI: 10.3389/fmolb.2023.1082915.
  • It highlights the importance of ensuring academic accuracy and transparency in published research.
  • This correction aims to clarify any potential misunderstandings or errors in the original article, reinforcing the integrity of scientific communication.
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Early feeding and nutritional status of Portuguese children in the first 36 months of life: EPACI Portugal 2012-a national representative cross-sectional study.

Porto Biomed J

April 2024

Universidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Porto, Portugal.

Background: Early feeding practices have a critical role in the future not only in health but also in modulating eating habits. This study aimed to assess breastfeeding and complementary feeding practices and the nutritional status of Portuguese toddlers aged 0-36 months.

Methods: EPACI Portugal 2012 is a cross-sectional study of a national representative sample.

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Recommendations for asthma monitoring in children: A PeARL document endorsed by APAPARI, EAACI, INTERASMA, REG, and WAO.

Pediatr Allergy Immunol

April 2024

Department of Pediatrics & Child Health, Director MRC Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.

Monitoring is a major component of asthma management in children. Regular monitoring allows for diagnosis confirmation, treatment optimization, and natural history review. Numerous factors that may affect disease activity and patient well-being need to be monitored: response and adherence to treatment, disease control, disease progression, comorbidities, quality of life, medication side-effects, allergen and irritant exposures, diet and more.

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Endovascular therapy (EVT) is a highly effective stroke treatment, but trials validating this intervention did not include patients with posterior cerebral artery (PCA) occlusion. The aim of this systematic review with meta-analysis was to assess the efficacy and safety of EVT for acute PCA occlusion. PubMed, Scopus, ISI, and CENTRAL were searched for studies assessing EVT in adult patients with PCA occlusion.

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Cardiopulmonary exercise testing in clinical practice: Principles, applications, and basic interpretation.

Rev Port Cardiol

September 2024

Department of Cardiology, Pulmonary Vascular Disease Unit, Centro Hospitalar Universitário de Santo António, Porto, Portugal; CAC ICBAS-CHP - Centro Académico Clínico Instituto de Ciências Biomédicas Abel Salazar - Centro Hospitalar Universitário de Santo António, Porto, Portugal; Department of Immuno-Physiology and Pharmacology, UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, Universidade do Porto, Porto, Portugal; ITR - Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal.

Cardiopulmonary exercise testing (CPET) provides a noninvasive and integrated assessment of the response of the respiratory, cardiovascular, and musculoskeletal systems to exercise. This information improves the diagnosis, risk stratification, and therapeutic management of several clinical conditions. Additionally, CPET is the gold standard test for cardiorespiratory fitness quantification and exercise prescription, both in patients with cardiopulmonary disease undergoing cardiac or pulmonary rehabilitation programs and in healthy individuals, such as high-level athletes.

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Article Synopsis
  • * Various examinations, including nail clipping and onychoscopy, revealed abnormalities such as nail plate thinning, hyperkeratosis, and irregular ridging.
  • * A biopsy confirmed the presence of malignant onychopapilloma through signs like cellular atypia, matrix metaplasia, and increased Ki-67 staining, although it tested negative for HPV.
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Poor Rhinitis and Asthma Control Is Associated With Decreased Health-Related Quality of Life and Utilities: A MASK-air Study.

J Allergy Clin Immunol Pract

June 2024

Department of Community Medicine, Information, and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; Centre for Health Technology and Services Research, Health Research Network (CINTESIS@RISE), Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Allergic rhinitis (AR) and asthma may affect health-related quality of life. However, national estimates on the quality of life of patients with AR or asthma are lacking.

Objective: To provide estimates for utility scores and EuroQoL five-dimension (EQ-5D) visual analog scale (VAS) for patients with AR or asthma.

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Regional, sex, and age inequities in asthma hospital admissions in Spain and Portugal.

Clin Transl Allergy

April 2024

Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Asthma presents a significant health challenge, imposing a considerable burden on healthcare services. Discrepancies in asthma-related hospitalisations may reflect underlying health disparities. We aimed to analyse inequities in asthma hospital admissions in mainland Portugal and Spain, from a regional perspective and considering sex and age.

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Revised European guidelines for the accreditation of sleep medicine centres.

J Sleep Res

December 2024

Department of Neurology, Medical Park Bad Feilnbach, Bad Feilnbach, Germany.

The accreditation of sleep centres aims to ensure high-quality diagnosis and management of sleep centres. European accreditation standards were introduced in 2006, and were aimed at centres offering inpatient polysomnography and vigilance tests (Mean Sleep Latency Test and Maintenance of Wakefulness Test). Since then, the practice of sleep medicine has evolved, with greater use of ambulatory polysomnography and polygraphy.

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Objectives: To collect real-world data about the knowledge and self-perception of young radiologists concerning the use of contrast media (CM) and the management of adverse drug reactions (ADR).

Methods: A survey (29 questions) was distributed to residents and board-certified radiologists younger than 40 years to investigate the current international situation in young radiology community regarding CM and ADRs. Descriptive statistics analysis was performed.

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Study Design: Clinical practice guideline development.

Objectives: Acute spinal cord injury (SCI) can result in devastating motor, sensory, and autonomic impairment; loss of independence; and reduced quality of life. Preclinical evidence suggests that early decompression of the spinal cord may help to limit secondary injury, reduce damage to the neural tissue, and improve functional outcomes.

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Article Synopsis
  • The study aimed to develop clinical guidelines for using intraoperative neuromonitoring (IONM) to detect spinal cord injuries during spine surgery, targeting high-risk patients and establishing management protocols.
  • The research involved a systematic review following PRISMA standards and GRADE protocols, with an international team reaching consensus on recommendations for IONM effectiveness and diagnostic accuracy.
  • Key recommendations included using IONM for high-risk spine surgery patients and promoting proactive identification and interdisciplinary management strategies for those at risk of intraoperative spinal cord injury.
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