634 results match your criteria: "CT (L.B.); and the University of Oklahoma Health Sciences Center[Affiliation]"
Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.
Brain Commun
January 2025
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate 'pro-aging' or 'pro-youthful' effects on the mouse brain. The clinical relevance and combined effects of these factors for humans is unclear.
View Article and Find Full Text PDFSex Differences in Natural History and Health Outcomes Among Individuals With Tic Disorders.
Neurology
February 2025
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Objectives: To analyze sex differences in outcomes in Tourette syndrome (TS) and Persistent Motor or Vocal tic disorders (PMVT) in the Tourette Association of America International Consortium for Genetics (TAAICG) dataset.
Methods: The relationship between sex and clinical measures was explored in 2,403 participants (N = 2,109 with TS; N = 294 with PMVT) from the TAAICG dataset using generalized estimating equation regression models, and adjusted for age and family relationships.
Results: Female (vs male) participants with TS (25.
A feasibility study of using virtual noncontrast images synthesized from dual-energy computed tomography for radiotherapy treatment planning.
Quant Imaging Med Surg
December 2024
Department of Radiotherapy, Peking Union Medical College Hospital, Beijing, China.
Background: In the traditional computed tomography (CT) simulation process, patients need to undergo CT scans before and after injection of iodine-based contrast agent, resulting in a cumbersome workflow and additional imaging dose. Contrast-enhanced spectral CT can synthesize true contrast-enhanced (TCE) images and virtual noncontrast (VNC) images in a single scan without geometric misalignment. To improve work efficiency and reduce patients' imaging dose, we studied the feasibility of using VNC images for radiotherapy treatment planning, with true noncontrast (TNC) images as references and explored its dosimetric advantages compared to using TCE images.
View Article and Find Full Text PDFDiagnostic Accuracy of Dynamic Stress Myocardial CT Perfusion Compared with Invasive Physiology in Patients with Stents: The Advantage 2 Study.
Radiology
December 2024
From the Centro Cardiologico Monzino, IRCCS, Via C. Belgioioso 173, Milan, Italy (D.A., S.M., D.T., E.C., G.L., S. Galli, G.M., L.G., G.T., S.T., S. Gili, P.M., P.O., V.M., D.M., M.S., C.G., E.M., A.B., M.E.M., A.A., A F., G.P., A.L.B.); Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy (D.A.); IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy (E.C., G.M., L.G., V.M., D.M., M.S., E.G., P.P., E.M., A.L.B.); Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium (J.S., M.B., E.G., P.P., K.S., T.M., C.C.); Department of Medicine, Division of Cardiology, Showa University School of Medicine, Tokyo, Japan (K.S., T.M.); Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy (G.P.); and Department of Radiology, Azienda Ospedaliera di Padova, Padua, Italy (L.Z.).
Background The detection of in-stent restenosis (ISR) with coronary CT angiography (CCTA) is challenging, but CT perfusion (CTP) has demonstrated improved diagnostic accuracy over CCTA in patients with stents. However, there are limited data on the performance of dynamic CTP, which allows noninvasive adjudication of regional myocardial blood flow. Purpose To compare the diagnostic performance of regadenoson-stress dynamic CTP with that of CCTA, using fractional flow reserve (FFR) and the index of microvascular resistance (IMR) as reference standards for epicardial coronary circulation and coronary microcirculation, respectively.
View Article and Find Full Text PDFClinical Trial: Safety and Efficacy of a Novel Oesophageal Delivery System for Topical Corticosteroids Versus Placebo in the Treatment of Eosinophilic Oesophagitis.
Aliment Pharmacol Ther
February 2025
Department of Medicine, Division of Gastroenterology and Hepatology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA.
Background: EsoCap is a thin mucoadhesive film designed to target the oesophageal mucosa. The device loaded with mometasone furoate (ESO-101) is under investigation for the treatment of eosinophilic oesophagitis (EoE).
Aims: To evaluate the efficacy, safety and tolerability of ESO-101 in patients with active EoE.
CT-Defined Pectoralis Muscle Density Predicts 30-Day Mortality in Hospitalized Patients with COVID-19: A Nationwide Multicenter Study.
Acad Radiol
December 2024
Institute of Radiology, Neuroradiology and Nuclear Medicine Minden, Ruhr-University-Bochum, Bochum, Germany (J.B., A.S.). Electronic address:
Rationale And Objectives: The prognostic role of computed tomography (CT)-defined skeletal muscle features in COVID-19 is still under investigation. The aim of the present study was to evaluate the prognostic role of CT-defined skeletal muscle area and density in patients with COVID-19 in a multicenter setting.
Materials And Methods: This retrospective study is a part of the German multicenter project RACOON (Radiological Cooperative Network of the COVID-19 pandemic).
Background: In April 2024, our hospital confirmed a rare case of intra-abdominal infection by Kodamaea ohmeri. The patient sought medical attention at our hospital after taking painkillers orally for one month, experiencing recurrent abdominal pain for 17 days and worsening for 7 days. In March 2024, the patient received symptomatic treatment with oral analgesics (diclofenac sodium) for arthritis.
View Article and Find Full Text PDFAn International Consensus Practical Guide on Left Atrial Appendage Closure for the Non-implanting Physician: Executive Summary.
Thromb Haemost
December 2024
St. George's University of London, London, United Kingdom.
Article Synopsis
- Many patients with atrial fibrillation (AF) are not receiving or are stopping oral anticoagulation therapy, despite its importance for stroke prevention.
- While direct oral anticoagulants (DOACs) are available, issues like bleeding risks, poor compliance, and aversion to treatment contribute to this problem.
- A recent expert consensus guide highlights left atrial appendage closure (LAAC) as a safe alternative for stroke prevention in patients who cannot use long-term anticoagulation, detailing the devices, implantation technique, and follow-up requirements for non-implanting physicians.
The QIBA Profile for Dynamic Susceptibility Contrast MRI Quantitative Imaging Biomarkers for Assessing Gliomas.
Radiology
December 2024
From the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).
The dynamic susceptibility contrast (DSC) MRI measures of relative cerebral blood volume (rCBV) play a central role in monitoring therapeutic response and disease progression in patients with gliomas. Previous investigations have demonstrated promise of using rCBV in classifying tumor grade, elucidating tumor viability after therapy, and differentiating pseudoprogression and pseudoresponse. However, the quantification and reproducibility of rCBV measurements across patients, devices, and software remain a critical barrier to routine or clinical trial use of longitudinal DSC MRI in patients with gliomas.
View Article and Find Full Text PDFTwice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons.
N Engl J Med
November 2024
From the Hope Clinic of the Emory University School of Medicine, Decatur (C.F.K.), and Grady Health System (C.F.K.), and the Division of Infectious Diseases, Emory University-Ponce de Leon Center Clinical Research Site, HIV/AIDS Clinical Trials Unit (V.D.C.), Atlanta - all in Georgia; the Divisions of Pediatric and Adult Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore (A.L.A.); Be Well Medical Center, Berkley, MI (P.B.); the Department of Medicine, University of California, San Diego, San Diego (J.B.), the Department of Medicine, University of California, Los Angeles (J.C.), Ruane Clinical Research (P.J.R.), and Drew Center for AIDS Research, Education, and Services, Charles R. Drew University (L.Y.S.), Los Angeles, Optimus Medical Group/StudyOps, San Francisco (S.H.), Mills Clinical Research, West Hollywood (A.M.), Bios Clinical Research, Palm Springs (P.S.), and Gilead Sciences, Foster City (S.C., R.E., P.W., R.S., L.B.B., C.C.C., M.D., J.M.B.) - all in California; Central Texas Clinical Research, Austin (C. Brinson), and Crofoot MD Clinic and Research Center, Houston (G.C.) - both in Texas; the Department of Infectious Diseases, Louisiana State University Health Sciences Center-New Orleans, New Orleans (M.C.); Howard Brown Health (C.C.) and the Division of Infectious Diseases, University of Illinois Health Sciences (R.M.N.) - both in Chicago; the Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami (S.D.-L.), Therafirst Medical Center, Fort Lauderdale (A.L.), Midway Immunology and Research Center, Fort Pierce (M.R.), and CAN Community Health, Sarasota (T.S.) - all in Florida; the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN (A.G.); Washington Health Institute, Washington, DC (T.H.); Fenway Health Medical Clinic, Boston (K.H.M.); Philadelphia FIGHT Community Health Centers-Jonathan Lax Treatment Center, Philadelphia (K.M.); the Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham (O.T.V.G.); the Section of Infectious Diseases, Yale School of Medicine, New Haven, CT (O.O.); Centro Ararat, San Juan, Puerto Rico (M.A.-Q.); the HIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Center and Center of Excellence in Tuberculosis, Faculty of Medicine, Chulalongkorn University (A.A.), and the Institute of HIV Research and Innovation-Pribta Tangerine Clinic (N.P.) - both in Bangkok; Complexo Hospitalar Universitário Professor Edgard Santos, Salvador (C. Brites), Universidade Federal de São Paulo (R.S.D.), Centro de Referência e Treinamento DST/AIDS-SP (J.V.M.), and Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (R.V.), São Paulo, Fundação Oswaldo Cruz-Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro (B.G.), Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus (M.L.), and the Infectious Diseases Service, Hospital Nossa Senhora da Conceição, Porto Alegre (B.S.) - all in Brazil; Fundación Huésped (P.C.) and Hospital General de Agudos José María Ramos Mejía (M.H.L.) - both in Buenos Aires; Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales, Universidad Nacional Mayor de San Marcos (J.A.G.-C., J.S.) and Via Libre (J.G.V.), Lima, and Asociación Civil Selva Amazónica, Iquitos (J.C.H.) - all in Peru; Desmond Tutu Health Foundation, Cape Town (R.K.), Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Johannesburg (N.N.), and the Aurum Institute-Pretoria Clinical Research Site, Pretoria (Z.Z.) - all in South Africa; Centro de Investigacion Farmaceutica Especializada de Occidente, Guadalajara, Mexico (A.P.R.); and Gilead Sciences, Cambridge, United Kingdom (C.D.).
Background: Twice-yearly subcutaneous lenacapavir has been shown to be efficacious for prevention of HIV infection in cisgender women. The efficacy of lenacapavir for preexposure prophylaxis (PrEP) in cisgender men, transgender women, transgender men, and gender-nonbinary persons is unclear.
Methods: In this phase 3, double-blind, randomized, active-controlled trial, we randomly assigned participants in a 2:1 ratio to receive subcutaneous lenacapavir every 26 weeks or daily oral emtricitabine-tenofovir disoproxil fumarate (F/TDF).
Liquid Biopsy versus CT: Comparison of Tumor Burden Quantification in 1065 Patients with Metastases.
Radiology
November 2024
From the Département d'Imagerie, Gustave Roussy, Université Paris Saclay, 114 Rue Edouard Vaillant, 94805 Villejuif, France (L.D., S.A., J.H., S. Morer, C.D., F. Bidault, C.B., S. Muller, N.L.); Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay (BioMAPS), Université Paris-Saclay, Inserm, Centre national de la recherche scientifique, Commissariat à l'Énergie Atomique, Villejuif, France (Y.B., L. Lawrance, O.G., S.A., F.W., F. Bidault, C.B., N.L.); OPtimisation Imagerie et Santé (OPIS), Inria, CentraleSupélec, Université Paris-Saclay, Gif-Sur-Yvette, France (Y.B., H.T.); Departments of Medical Biology and Pathology (D.V., L. Lacroix, E.R.), Cancer Medicine (M.A., M.S., S. Moog, M.F.M., M.T., A.B.T., B.V., N.A., B.B., F.A., F. Barlesi), Hematology (J.B.M.), and Genetics (O.C.), Gustave Roussy, Villejuif, France; Departments of Imaging (M.K.) and Medical Oncology (A.I.), Institut Bergonié, Bordeaux, France; Département d'Innovation Thérapeutique et des Essais Précoce, Gustave Roussy, Villejuif, France (A.B., L.B., C.N., A. Geraud, M.S., F.B.D., C.S., A. Gazzah, A.H., Y.L., S.P., A.I.); Oncostat, Inserm, Paris-Saclay University, labeled Ligue Contre le Cancer, Villejuif, France (A.B.); Mathématiques et Informatique pour la Complexité et les Systèmes (MICS), CentraleSupélec, Université Paris-Saclay, Gif-Sur-Yvette, France (P.H.C.); Université Paris-Saclay, Faculté de médecine, Le Kremlin Bicêtre, Paris, France (A.B., B.B., F.A., J.C.S., F. Barlesi, N.L.); Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark (L.B.); Gustave Roussy, Villejuif, France (J.C.S.); and Guerbet Research, Villepinte, France (L. Lawrance).
Background Tumor fraction (TF) at liquid biopsy is a potential noninvasive marker for tumor burden, but validation is needed. Purpose To evaluate TF as a potential surrogate for tumor burden, assessed at contrast-enhanced CT across diverse metastatic cancers. Methods This retrospective monocentric study included patients with cancer and metastatic disease, with TF results and contemporaneous contrast-enhanced CT performed between January 2021 and January 2023.
View Article and Find Full Text PDF[18F]-Fluorodeoxyglucose Uptake as a Marker of Residual Anaplastic and Poorly Differentiated Thyroid Carcinoma Following BRAF-Targeted Therapy.
AJNR Am J Neuroradiol
November 2024
From the Department of Neuroradiology / Head and Neck Imaging (S.A.D., K.O.L., R.D., A.M.K.), Department of Head and Neck Surgery (J.R.W., X.Z., A.M., M.E.Z.), Department of Pathology (S.M.H.), and Department of Endocrine Neoplasia and Hormonal Disorders (M.E.C., N.L.B., R.D., P.I.), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Background And Purpose: Neoadjuvant BRAF-directed therapy and immunotherapy followed by surgery improves survival in patients with BRAF-mutant anaplastic thyroid carcinoma (ATC), more so in those who have complete ATC pathologic response. This study assesses the ability of FDG-PET to non-invasively detect residual high-risk pathologies including ATC and poorly differentiated thyroid carcinoma (PDTC) in the preoperative setting.
Materials And Methods: This retrospective, single-center study included consecutive BRAF-mutant ATC patients treated with at least 30 days of neoadjuvant BRAF-directed therapy and who underwent FDG-PET/CT within 30 days prior to surgery.
Large-scale scattering-augmented optical encryption.
Nat Commun
November 2024
State Key Laboratory of CNS/ATM & MIIT Key Laboratory of Complex-field Intelligent Sensing, Beijing Institute of Technology, Beijing, China.
Data proliferation in the digital age necessitates robust encryption techniques to protect information privacy. Optical encryption leverages the multiple degrees of freedom inherent in light waves to encode information with parallel processing and enhanced security features. However, implementations of large-scale, high-security optical encryption have largely remained theoretical or limited to digital simulations due to hardware constraints, signal-to-noise ratio challenges, and precision fabrication of encoding elements.
View Article and Find Full Text PDFAssociation of Changes in Cerebral and Hypothalamic Structure With Sleep Dysfunction in Patients With Genetic Frontotemporal Dementia.
Neurology
December 2024
From the Integrated Program in Neuroscience (P.T.B.), McGill, Montréal, Canada; Department of Neurology (J.C.V.S., H.S., L.C.J.), Erasmus Medical Centre, Rotterdam, Netherlands; Department of Neurology (F.M.), Donostia Universitary Hospital, San Sebastián, Spain; Institut D'Investigacións Biomèdiques August Pi I Sunyer (R.S.-V.), University of Barcelona, Spain; Faculté de Médecine (R.L.), Université Laval, Québec City, Canada; Department of Neurobiology (C.G.), Karolinska Institutet, Solna, Sweden; Sunnybrook Research Institute (M.M.), Toronto, Canada; Tanz Centre for Research in Neurodegenerative Diseases (C.T.), University of Toronto, Canada; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, United Kingdom; Department of Clinical and Experimental Sciences (B.B.), University of Brescia, Italy; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Hertie-Institute for Clinical Brain Research and Center of Neurology (M.S.), University of Tübingen, Germany; Neurology (D.G.), University of Milan, Italy; Department of Neurosciences (R.V.), KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Nuffield Department of Clinical Neurosciences (C.B.), University of Oxford, United Kingdom; Wolfson Molecular Imaging Centre (A.G.), University of Manchester, United Kingdom; Institut du Cerveau-ICM (I.L.B.), Hôpital Pitié-Salpêtrière, Paris, France; 31Fondazione IRCCS (P.T.), Istituto Neurologico Carlo Besta, Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Neurology (F.P.), Université Lille, France; Department of Neurology (J.L.), Ludwig-Maximilians Universität München, Munich, Germany; Department of Neurology (M.O.), University of Ulm, Germany; Department of Neurofarba (S.S.), University of Florence, Italy; Department of Neurodegenerative Disease (A.B., D.M.C., L.L.R., M.B., J.D.R.), University College London, United Kingdom; and Department of Psychiatry (G.A.D., M.C., S.D.), McGill University, Montréal, Canada.
Background And Objectives: Sleep dysfunction is common in patients with neurodegenerative disorders; however, its neural underpinnings remain poorly characterized in genetic frontotemporal dementia (FTD). Hypothalamic nuclei important for sleep regulation may be related to this dysfunction. Thus, we examined changes in hypothalamic structure across the lifespan in patients with genetic FTD and whether these changes related to sleep dysfunction.
View Article and Find Full Text PDFAssociation of Initial Side of Brain Atrophy With Clinical Features and Disease Progression in Patients With Frontotemporal Dementia.
Neurology
December 2024
From the Alzheimer's Disease and Other Cognitive Disorders Unit (S.B.-E., J.J.-P., A.P.M., M.B., A.L., R.S.-V.), Neurology Service, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic per a la Recerca Biomèdica, Universitat de Barcelona, Spain; VIB Center for Molecular Neurology (M.V., R.R.); Department of Biomedical Sciences (M.V., R.R.), University of Antwerp, Belgium; Dementia Research Centre (A.B., L.L.R., P.H.F., E.F.-B., J.D.R.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (J.C.V.S., L.C.J., H.S.), Erasmus Medical Centre, Rotterdam, Netherlands; Clinique Interdisciplinaire de Mémoire (R.L.), Département des Sciences Neurologiques, CHU de Québec, and Faculté de Médecine, Université Laval, Canada; Division of Neurogeriatrics, Bioclinicum (C.G.), Department of Neurobiology, Care Sciences and Society; Center for Alzheimer Research, Karolinska Institutet; Unit for Hereditary Dementias (C.G.), Theme Inflammation and Aging, Karolinska University Hospital, Solna, Sweden; Department of Biomedical (D.G.), Surgical and Dental Sciences, University of Milan; Fondazione Ca' Granda (D.G.), IRCCS Ospedale Policlinico, Milan, Italy; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven; Neurology Service (R.V.), University Hospitals Leuven; Leuven Brain Institute (R.V.), KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione IRCCS Istituto Neurologico Carlo Besta (P.T.), Milano, Italy; Neurology Service (I.S.), Faculty of Medicine, University Hospital of Coimbra (HUC), University of Coimbra; Center for Neuroscience and Cell Biology (I.S.), Faculty of Medicine, University of Coimbra, Portugal; Division of Psychology Communication and Human Neuroscience (A.G.), Wolfson Molecular Imaging Centre, University of Manchester, United Kingdom; Department of Nuclear Medicine (A.G.), Center for Translational Neuro- and Behavioral Sciences, University Medicine Essen; Department of Geriatric Medicine (A.G.), Klinikum Hochsauerland, Arnsberg; Department of Neurology (J.L.), Ludwig-Maximilians Universität München; German Center for Neurodegenerative Diseases (DZNE) (J.L.); Munich Cluster of Systems Neurology (SyNergy) (J.L.), Munich, Germany; Department of Neurofarba (S.S.), University of Florence; IRCCS Fondazione Don Carlo Gnocchi (S.S.), Florence, Italy; Department of Neurology (M.O.), University of Ulm, Germany; Univ Lille (F.P.), France; Department of Psychiatry (S.D.), McGill University Health Centre, McConnell Brain Imaging Centre (S.D.), Montreal Neurological Institute, McGill University, Montreal, Québec, Canada; Medical Sciences Division (C.B.), Nuffield Department of Clinical Neurosciences, University of Oxford, Department of Brain Sciences (C.B.), Imperial College London, United Kingdom; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225; Centre de référence des démences rares ou précoces (I.L.B.), IM2A, Département de Neurologie; Département de Neurologie (I.L.B.), AP-HP - Hôpital Pitié-Salpêtrière, Paris, France; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London; Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), Ontario; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute, University of Toronto, Canada; Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust (J.B.R.), University of Cambridge, United Kingdom; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Germany; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia Universitary Hospital, San Sebastian, Spain; Neurology Unit (B.B.), Department of Clinical and Experimental Sciences, University of Brescia, Italy; and Department of Neuroscience (R.R.), Mayo Clinic, Jacksonville, FL.
Background And Objectives: Pathogenic variants in the gene cause frontotemporal dementia (FTD-) with marked brain asymmetry. This study aims to assess whether the disease progression of FTD- depends on the initial side of the atrophy. We also investigated the potential use of brain asymmetry as a biomarker of the disease.
View Article and Find Full Text PDFRSNA 2023 Abdominal Trauma AI Challenge: Review and Outcomes.
Radiol Artif Intell
January 2025
From the Department of Medical Imaging, St Michael's Hospital, Unity Health Toronto, 30 Bond St, Toronto, ON, Canada M5B 1W8 (S.H., Z.H., H.M.L., I.Y., E.C.); Edward S. Rogers Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario, Canada (Z.H., E.S.); The Jackson Laboratory, Bar Harbor, Me (R.L.B.); Department of Radiology, The Ohio State University, Columbus, Ohio (L.M.P.); Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada (F.H.B.); Department of Radiology, Scripps Clinic Medical Group and University of California San Diego, San Diego, Calif (J.D.R.); Radiological Society of North America, Oak Brook, Ill (M.V.); Department of Radiology, Thomas Jefferson University, Philadelphia, Pa (A.E.F.); Department of Radiology, Weill Cornell Medicine, New York, NY (G.S.); Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, Calif (J.M.), Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (B.S.M.); Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (M.A.D.); Duke University School of Medicine, Durham, NC (K.M.); North York General Hospital, Toronto, Ontario, Canada (E.S.); and Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada (E.C.).
Purpose To evaluate the performance of the winning machine learning models from the 2023 RSNA Abdominal Trauma Detection AI Challenge. Materials and Methods The competition was hosted on Kaggle and took place between July 26 and October 15, 2023. The multicenter competition dataset consisted of 4274 abdominal trauma CT scans, in which solid organs (liver, spleen, and kidneys) were annotated as healthy, low-grade, or high-grade injury.
View Article and Find Full Text PDFImplementing the Risk Stratification and Clinical Management of Breast Cancer Families Using Polygenic Risk Score Evaluation: A Pilot Study.
J Pers Med
September 2024
Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy.
Article Synopsis
- * It involved a retrospective evaluation of PRS among different risk families, showing that while PVs are critical for carriers’ risk estimation, PRS enhances risk assessment for non-carriers.
- * The findings suggest that integrating PRS with genetic status can provide a clearer picture of individual lifetime risk, aiding personalized management strategies for both carrier and non-carrier women in BC families.
Malformations of Cortical Development: Updated Imaging Review.
Radiographics
November 2024
From the Department of Radiology, Hospital Sírio-Libanês, Adma Jafet 91, Bela Vista, São Paulo, Brazil 01308-050 (J.M.B., T.J.P.L., I.S.A., D.S.D., H.W.L., M.G.M.M., M.F.L.D., S.S.A., P.C.P., V.T.G., J.T.T., C.T.A.); Departments of Radiology (M.G.M.M., P.C.P., L.R.L.B.O., C.C.L.) and Oncology (C.C.L.), University of São Paulo, São Paulo, Brazil; and Department of Medical Imaging, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (P.J.M.).
Malformations of cortical development (MCD) are structural anomalies that disrupt the normal process of cortical development. Patients with these anomalies frequently present with seizures, developmental delay, neurologic deficits, and cognitive impairment, resulting in a wide spectrum of neurologic outcomes. The severity and type of malformation, in addition to the genetic pathways of brain development involved, contribute to the observed variability.
View Article and Find Full Text PDFThe RSNA Abdominal Traumatic Injury CT (RATIC) Dataset.
Radiol Artif Intell
November 2024
From the Department of Radiology, Scripps Clinic Medical Group and University of California, San Diego, 200 W Arbor Dr, San Diego, CA 92103-8749 (J.D.R.); Department of Medical Imaging, St Michael's Hospital, Unity Health Toronto, Toronto, Canada (H.M.L., S.H., S.M., E.C.); The Jackson Laboratory, Bar Harbor, Maine (R.L.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.J., S.N.); Department of Radiology, The Ohio State University, Columbus, Ohio (L.M.P.); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (B.S.M.); Department of Radiology, Thomas Jefferson University, Philadelphia, Pa (A.E.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (K.M.); Department of Radiology, Weill Cornell Medicine, New York, NY (G.S.); Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (M.A.D.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, Calif (J.M.); Departments of Radiological Sciences and Computer Science, University of California, Irvine, Irvine, Calif (P.D.C.); Department of Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (F.H.B.); Department of Radiology, Alfred Health, Monash University, Melbourne, Australia (M.L.); Department of Radiology, University of Utah, Salt Lake City, Utah (T.R.); Department of Diagnostic and Interventional Radiology, University Hospital of Würzburg, Würzburg, Germany (J.P.G., A.S.K.); Department of Medical Imaging, Mater Dei Hospital, Msida, Malta (S.G.S.); Department of Diagnostic Radiology, Kingston Health Sciences Center, Queen's University, Kingston, Canada (A.D.C.); Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University Tübingen, Tübingen, Germany (S.A.); Division of Nephrology, Department of Internal Medicine, China Medical University Hospital and College of Medicine, China Medical University, Taichung, Taiwan (C.C.K.); Big Data Center, China Medical University Hospital, Taichung, Taiwan (C.C.K.); AKI-CARE (Clinical Advancement, Research and Education) Center, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (C.C.K.); Department of Medical Imaging, Liverpool Hospital, Sydney, Australia (L.A.); Department of Radiology, Hospital Universitario Ramón y Cajal, Madrid, Spain (A.V.C.); Department of Radiology, Gold Coast University Hospital, Griffith University, Gold Coast, Australia (A.S.); Department of Medical Imaging, Clínica Santa María, Santiago, Chile (F.A.S.T.); Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand (A.J.); Department of Radiology, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio (L.K.B.); Department of Radiology, Tallaght University Hospital, Dublin, Ireland (M. Brassil); Department of Radiology, Arrazi Hospital, CHU Mohamed VI Cadi Ayyad University, Marrakech, Morocco (A.E.H.); Department of Radiology, Koç University School of Medicine, Istanbul, Turkey (H.D.); Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina (M. Becircic); Department of Diagnostic Radiology, Medical College of Wisconsin, Milwaukee, Wis (A.G.B.); Department of Diagnostic Imaging, Universidade Federal de São Paulo, São Paulo, Brazil (E.M.J.d.M.F.); and Department of Medical Imaging, University of Toronto, Toronto, Canada (S.M., S.H., E.C.).
Idiopathic myointimal hyperplasia of the mesenteric veins-a report of two cases.
AME Case Rep
August 2024
AdventHealth Department of Colorectal Surgery, Surgical Health Outcomes Consortium (SHOC), Orlando, FL, USA.
Background: Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is a rare condition that poses a diagnostic challenge to surgeons and pathologists alike. Our aim is to describe two cases of IMHMV requiring operative intervention. The challenge going forward is accurately and systematically identifying factors from both a pathologic and clinical perspective that guide timely diagnosis and avoid unnecessary treatment.
View Article and Find Full Text PDFThe epithelial barrier theory and its associated diseases.
Allergy
December 2024
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, over 350,000 new chemical substances have been introduced to the lives of humans. In recent years, the epithelial barrier theory came to light explaining the growing prevalence and exacerbations of these diseases worldwide.
View Article and Find Full Text PDFThe Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors.
J Diabetes Sci Technol
November 2024
University of California San Francisco, San Francisco, CA, USA.
Article Synopsis
- An error grid is a tool that helps compare glucose levels measured by devices to see if they are correct and to identify any risks.
- Experts created a new error grid called the DTS Error Grid that works for both blood glucose monitors (BGMs) and continuous glucose monitors (CGMs), organizing accuracy into five risk zones.
- The results showed that the DTS Error Grid provides a clearer picture of how accurate these devices are and includes a separate matrix to evaluate how well CGMs track glucose trends over time.
A machine learning approach in a monocentric cohort for predicting primary refractory disease in Diffuse Large B-cell lymphoma patients.
PLoS One
October 2024
Division of Hematology, Hematology and oncology Department, Grand Hôpital de Charleroi, Charleroi, Belgium.
Introduction: Primary refractory disease affects 30-40% of patients diagnosed with DLBCL and is a significant challenge in disease management due to its poor prognosis. Predicting refractory status could greatly inform treatment strategies, enabling early intervention. Various options are now available based on patient and disease characteristics.
View Article and Find Full Text PDFClinical Use of Bedside Portable Ultra-Low-Field Brain Magnetic Resonance Imaging in Patients on Extracorporeal Membrane Oxygenation: Results From the Multicenter SAFE MRI ECMO Study.
Circulation
December 2024
Department of Surgery, Division of Cardiac Surgery (S.-M.C., S.K., C.W., J.K.K., I.D.C., Z.D., M.A., H.R., J.B., S.K., B.S.K., G.J.W.), Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Early detection of acute brain injury (ABI) at the bedside is critical in improving survival for patients with extracorporeal membrane oxygenation (ECMO) support. We aimed to examine the safety of ultra-low-field (ULF; 0.064-T) portable magnetic resonance imaging (pMRI) in patients undergoing ECMO and to investigate the ABI frequency and types with ULF-pMRI.
View Article and Find Full Text PDFGene-Specific Effects on Brain Volume and Cognition of in Frontotemporal Lobar Degeneration.
Neurology
October 2024
From the VIB Center for Molecular Neurology (M.V., R.R., V.B., S.W.); Department of Biomedical Sciences (M.V., M.V.B., S.W., R.R.), University of Antwerp, Belgium; Department of Neurology (E.M.R., M.F.M.), David Geffen School of Medicine, University of California, Los Angeles; Department of Neurology (N.C.-L., V.K.R., T.K., K.K., B.F.B.); Department of Psychiatry and Psychology (N.C.-L., J.A.F., D.S.K., L.K.F.), Mayo Clinic, Rochester, MN; Department of Epidemiology and Biostatistics (J.K.), University of California, San Francisco; Department of Quantitative Health Sciences (C.M., D.E.B.), Mayo Clinic, Rochester, MN; Department of Neurology (A.M.S., A.A.W.), Memory and Aging Center, University of California, San Francisco; Weill Institute for Neurosciences, San Francisco, California; Institute for Precision Health (D.H.G.), Departments of Neurology, Psychiatry and Human Genetics at David Geffen School of Medicine, UCLA; Department of Neuroscience (T.G., L.P., M.B., N.R.G.-R.), Mayo Clinic, Jacksonville, FL; Alzheimer's Disease and Other Cognitive Disorders Unit (S.B.-É.), Neurology Service, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic per a la Recerca Biomèdica, Uni; Department of Neurology (B.A., B.C.D.), Case Western Reserve University, Cleveland, OH; Department of Neurology (S.B.), University of Michigan, Ann Arbor; Department of Neurology (A.C.B.), University of North Carolina, Chapel Hill; Department of Neurology (D.C.), Indiana University, Indianapolis; Department of Neurology (R.R.D.), Vanderbilt University, Nashville, TN; Department of Neurology (K.D.-R.), University of Washington, Seattle, WA; Department of Neurosciences (D.G., G.C.L., I.L.), University of California, San Diego, La Jolla; Departments of Neurology and Psychiatry (N.G.), Washington University School of Medicine, Washington University, St. Louis, MO; Department of Psychiatry and Behavioral Sciences (I.M.G.), Northwestern Feinberg School of Medicine, Chicago, IL; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (L.S.H.), College of Physicians and Surgeons; Department of Neurology (L.S.H.), Columbia University, New York; Division of Neurology (G.-Y.R.H.), University of British Columbia, Vancouver, Canada; Department of Psychiatry and Human Behavior (E.D.H.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology and Penn Frontotemporal Degeneration Center (D.J.I.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; National Institute of Neurological Disorders and Stroke (J.Y.K., A.S.), National Institutes of Health, Bethesda, MD; Department of Neurology (J.C.M., B.P.), Houston Methodist, TX; Department of Psychiatry and Behavioral Sciences (C.U.O.), Johns Hopkins University, Baltimore, MD; Department of Neurology (P.S.P.), University of Colorado, Aurora; Cleveland Clinic Lou Ruvo Center for Brain Health (A.R., D.W.), Las Vegas, NV; Department of Neurology (E.D.R.), University of Alabama at Birmingham; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases (A.C.S.), UT Health San Antonio; Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), Division of Neurology, University of Toronto, Ontario, Canada; Department of Neurology (H.W.H., A.L.B., H.J.R.), Memory and Aging Center, University of California, San Francisco; Weill Institute for Neurosciences, San Francisco, CA; and Department of Neuroscience (R.R.), Mayo Clinic, Jacksonville, FL.
Article Synopsis
- The study investigates the role of the genetic variant rs1990622 as a potential modifier of disease risk in frontotemporal lobar degeneration (FTLD), particularly among those with pathogenic variants.
- Researchers enrolled participants from the ALLFTD study, analyzing the impact of rs1990622 on gray matter volume and cognitive function across various genetic groups related to FTD.
- Results indicate that carriers of the minor allele of rs1990622 show increased gray matter volume and better cognitive performance, especially in the thalamus and among presymptomatic individuals.