Neuroradiology
December 2024
Department of Neuroradiology, Istituto Giannina Gaslini, Genoa, Italy.
Various space occupying lesions can arise in the orbit, ranging from developmental anomalies to malignancies, and many of the diseases occurring in children are different from the pathologies in the adult population. As the clinical presentation is frequently nonspecific, radiologic evaluation is essential for lesion detection and characterization as well as patient management. While orbital masses may in some cases involve multiple compartments, a simple compartmental approach is the key for the diagnosis on imaging studies, and MRI is the modality of choice.
View Article and Find Full Text PDFWorld J Urol
December 2024
Department of Urology, Health Sciences University, Adana City Training and Research Hospital, Adana, Turkey.
Purpose: To evaluate stone free rate (SFR) predictivity of three different scoring systems in patients with kidney stones larger than 20 millimeters undergoing retrograde intrarenal surgery(RİRS).
Methods: Digital records of a total of 166 patients were reviewed retrospectively. Epidemiological characteristics (age, gender, medical history) of the patients, stone and affected kidney characteristics (size, volume, location, density, opaque, presence of urinary system anomaly, presence of stones in different calyx, number of stones, lower pole stone, renal infundibulopelvic angle (IPA), renal infundibulopelvic length (RIL), hydronephrosis), and operative characteristics (preoperative ureteral stent, operation duration, postoperative residual fragments, hospitalization time and complications were recorded.
Appl Microbiol Biotechnol
December 2024
Facultad de Ciencias Agrarias, Universidad Nacional de Mar del Plata (UNMdP), Ruta Provincial 226 Km 73.5, B7620, Balcarce, Buenos Aires, Argentina.
Azospirillum argentinense Az19 is an osmotolerant plant growth-promoting bacterium that protects maize plants from drought. In this work, we explored the role of trehalose in the superior performance of Az19 under stress. The trehalase-coding gene treF was constitutively expressed in Az19 through a miniTn7 system.
View Article and Find Full Text PDFJ Craniofac Surg
December 2024
Department of Medical Cosmetology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
Background: Among several skin fillers developed in recent decades, hyaluronic acid (HA) is a widely used filler for face contouring and is generally believed to be safe, long-lasting, not immunogenic, and cost-effective. However, early and delayed complications can also occur following HA filler injection. Unfortunately, there have been reports of HA-related bone erosion in the chin area without clear scientific data regarding its existence and incidence.
View Article and Find Full Text PDFAnn Nucl Med
December 2024
Department of Endocrinology and Metabolism, Rare Bone Disease Center, Amsterdam University Medical Centers (UMC), Vrije Universiteit, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Purpose: [F]NaF PET has become an increasingly important tool in clinical practice toward understanding and evaluating diseases and conditions in which bone metabolism is disrupted. Full kinetic analysis using nonlinear regression (NLR) with a two-tissue compartment model to determine the net rate of influx (K) of [F]NaF is considered the gold standard for quantification of [F]NaF uptake. However, dynamic scanning often is impractical in a clinical setting, leading to the development of simplified semi-quantitative parameters.
View Article and Find Full Text PDFEJNMMI Res
December 2024
Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Background: To intraindividually compare the diagnostic performance of positron emission computed tomography (F-18-FDG-PET/CT) and diffusion-weighted magnetic resonance imaging (DW-MRI) in a non-inferiority design for the discrimination of peripheral nerve sheath tumours as benign (BPNST), atypical (ANF), or malignant (MPNST) in patients with neurofibromatosis type 1 (NF1).
Results: In this prospective single-centre study, thirty-four NF1 patients (18 male; 30 ± 11 years) underwent F-18-FDG-PET/CT and multi-b-value DW-MRI (11 b-values 0 - 800 s/mm²) at 3T. Sixty-six lesions corresponding to 39 BPNST, 11 ANF, and 16 MPNST were evaluated.
EJNMMI Res
December 2024
μNEURO Research Centre of Excellence, Universiteitsplein 1, University of Antwerp, Antwerp, Belgium.
Background: Huntington's disease (HD) is a rare neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant huntingtin protein (mHTT) that is associated with HD-related neuropathophysiology. Noninvasive visualization of mHTT aggregates in the brain, with positron emission tomography (PET), will allow to reliably evaluate the efficacy of therapeutic interventions in HD. This study aimed to assess the radiation burden of [F]CHDI-650, a novel fluorinated mHTT radioligand, in humans based on both in vivo and ex vivo biodistribution in mice and subsequent determination of dosimetry for dosing in humans.
View Article and Find Full Text PDFNeurosurg Rev
December 2024
Neurological Surgery, Thomas Jefferson University, Philadelphia, PA, US.
Objective: In recent years, the application of robotic assistance in diagnostic and therapeutic endovascular neurointerventional procedures has gained notable attention. In this systematic review and meta-analysis, we aim to evaluate the feasibility, safety, and current indications of robotic-assisted neurointerventions and to assess the degree of robotic assistance and reasons for unplanned manual conversion from robotic assistance.
Methods: We searched Medline, Scopus, Web of Science, and Cochrane Library databases following PRISMA guidelines and included studies with ≥ 4 patients reporting on robotic-assisted neurointerventions.
Eur Radiol
December 2024
Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Objectives: To establish a spectral CT-based nomogram for predicting the response to neoadjuvant chemotherapy (NAC) in patients with locally advanced esophageal squamous cell carcinoma (ESCC).
Methods: This retrospective study included 172 patients with ESCC who underwent spectral CT scans before NAC followed by resection. Based on postoperative tumor regression grades (TRG), 34% (58) of patients were responsive (TRG1) and 66% (114) were non-responsive (TRG2-3).
Purpose: To evaluate the diagnostic yield and safety profile of percutaneous image-guided biopsy of mesenteric lesions.
Materials, Methods, And Procedures: Image-guided percutaneous biopsies of the mesentery at a single institution from 2000 to 2022 were identified and reviewed. Relevant demographic and procedural data were abstracted from the medical record.
Eur J Nucl Med Mol Imaging
December 2024
Department of Radiation Oncology, Stanford University, Stanford, CA, USA.
Purpose: Nanoparticles are highly efficient vectors for ferrying contrast agents across cell membranes, enabling ultra-sensitive in vivo tracking of single cells with positron emission tomography (PET). However, this approach must be fully characterized and understood before it can be reliably implemented for routine applications.
Methods: We developed a Langmuir adsorption model that accurately describes the process of labeling mesoporous silica nanoparticles (MSNP) with Ga.
Menopause
January 2025
From the Department of Radiology, Mayo Clinic, Rochester, MN.
Objective: To assess the association of systolic and diastolic blood pressure (SBP and DBP) in recently menopausal women with white matter hyperintensity (WMH) volume later in life and determine whether short-term menopausal hormone therapy (mHT) modifies these associations.
Methods: Kronos Early Estrogen Prevention Study (KEEPS) was a multicenter, randomized, double-blinded, placebo-controlled 4-year mHT trial (oral conjugated equine estrogens or transdermal 17β-estradiol). KEEPS continuation was an observational follow-up of the participants 10 years after the end of mHT.
Vet Sci
December 2024
Virscio, Inc. 4 Science Park, New Haven, CT 06511, USA.
Social housing provides a high level of enrichment for captive non-human primates, but providing this in research situations can be challenging. We have developed a multifactorial animal selection and introduction process coordinated by veterinary and animal care behavioral teams. This process sought to successfully establish lasting same-sex pairs and trios for African green monkeys () in studies lasting from three months to over a year.
View Article and Find Full Text PDFVet Sci
December 2024
Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
Cutaneous squamous cell carcinoma (CSCC) in dogs is a locally invasive tumor that typically occurs in areas of poorly pigmented skin due to sun exposure. Identifying new biomarkers, such as syndecan-1 (CD138) and E-cadherin, is fundamental for tumor diagnosis and prognosis. Dysregulation of syndecan-1, expressed in epithelial tissue, fibroblasts, and plasma cells, is associated with poor prognosis in several types of cancer.
View Article and Find Full Text PDFVet Sci
December 2024
Ospedale Veterinario I Portoni Rossi, Anicura Italy Holding, via Roma 51, 40069 Zola Predosa, Italy.
An 11-year-old spayed female Beagle presented with tenesmus and was identified with a rectal wall mass. Diagnostic imaging (abdominal ultrasound and computed tomography) localised the mass in the right rectal wall and documented no evidence of metastatic disease. Subsequently, the dog underwent surgery for tumour excision.
View Article and Find Full Text PDFVet Sci
November 2024
Departamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos, Facultad de Veterinaria, Universidad de Las Palmas de Gran Canaria, Trasmontaña, Arucas, 35413 Las Palmas, Spain.
This study utilized CT imaging to investigate the rostral part of the head of the crested porcupine's head. By combining CT images with anatomical cross-sections, we have provided a detailed description of the structures in this area. This information could be useful for diagnosing disorders and improving their treatment in the nasal cavity and paranasal sinuses of crested porcupines.
View Article and Find Full Text PDFTomography
December 2024
Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Background/objectives: Calculating the radiation dose from CT in F-PET/CT examinations poses a significant challenge. The objective of this study is to develop a deep learning-based automated program that standardizes the measurement of radiation doses.
Methods: The torso CT was segmented into six distinct regions using TotalSegmentator.
Tomography
December 2024
Clinic for Radiology and Nuclear Medicine, University Hospital, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Background: Medical imagesegmentation is an essential step in both clinical and research applications, and automated segmentation models-such as TotalSegmentator-have become ubiquitous. However, robust methods for validating the accuracy of these models remain limited, and manual inspection is often necessary before the segmentation masks produced by these models can be used.
Methods: To address this gap, we have developed a novel validation framework for segmentation models, leveraging data augmentation to assess model consistency.
Tomography
December 2024
Centre for Research and Development, Uppsala University, Region Gävleborg, SE 801 88 Gävle, Sweden.
Background: This study aimed to assess the interobserver variability of semi-automatic diameter and volumetric measurements versus manual diameter measurements for small lung nodules identified on computed tomography scans.
Methods: The radiological patient database was searched for CT thorax examinations with at least one noncalcified solid nodule (∼3-10 mm). Three radiologists with four to six years of experience evaluated each nodule in accordance with the Fleischner Society guidelines using standard diameter measurements, semi-automatic lesion diameter measurements, and volumetric assessments.
Tomography
December 2024
Department of Diagnostic Radiology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.
Objectives: We evaluated the noise reduction effects of deep learning reconstruction (DLR) and hybrid iterative reconstruction (HIR) in brain computed tomography (CT).
Methods: CT images of a 16 cm dosimetry phantom, a head phantom, and the brains of 11 patients were reconstructed using filtered backprojection (FBP) and various levels of DLR and HIR. The slice thickness was 5, 2.
Tomography
November 2024
Department of Diagnostic Radiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Photon-counting detector computed tomography (PCD-CT) offers energy-resolved CT data with enhanced resolution, reduced electronic noise, and improved tissue contrast. This study aimed to evaluate the visibility of intracranial perforating arteries on ultra-high-resolution (UHR) CT angiography (CTA) on PCD-CT. A retrospective analysis of intracranial UHR PCD-CTA was performed for 30 patients.
View Article and Find Full Text PDFSports (Basel)
December 2024
Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, VA 22030, USA.
External (EL) and internal (IL) load are commonly used methods used to quantify training load in team sports. Playing time and playing position may influence the training loads for specific athletes throughout a season. The purpose of the current study was to evaluate the effect of athlete playing status and individual in-season practices on EL and IL across a collegiate women's basketball season.
View Article and Find Full Text PDFTrop Med Infect Dis
December 2024
Trachoma Control Program, The Carter Center, Atlanta, GA 30307, USA.
Trachoma recrudescence is a serious concern for trachoma control programs. Programs define recrudescence as the return of trachomatous inflammation-follicular (TF) prevalence above elimination threshold (≥5%) on district-level trachoma surveillance surveys (TSSs). This study aimed to determine potential correlates of trachoma recrudescence within a historically highly endemic region.
View Article and Find Full Text PDFTrop Med Infect Dis
December 2024
Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA.
Although every youth in pediatric/adolescent HIV care will need to transition to adult-oriented care, there are no existing evidence-based interventions to optimize health through this process. Healthcare transition poses a persistent challenge to the health of youth living with HIV, which may result in gaps in care engagement, medication adherence, and viral suppression. Our process evaluation of , a multilevel mobile health (mHealth) intervention, included iterative interviews with youth, providers, and Transition Champions.
View Article and Find Full Text PDFToxins (Basel)
December 2024
Molecular Toxinology Lab, Research and Development Department, Ezequiel Dias Foundation-FUNED, Belo Horizonte 30510-010, MG, Brazil.
Spiders of the genus represent a public health problem in Brazil due to the severity of the cutaneous and systemic effects that may result from their bite. In the systemic form of loxoscelism, hemolytic anemia, thrombocytopenia, and disseminated intravascular coagulation can occur. Despite the seriousness of accidents, the venom of some species has not yet been properly characterized considering these hemotoxic effects, such as that of , , and .
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