Stem cell therapy approaches for non-malignant diseases & non-haematological diseases in India: A systematic review.

Background & objectives Our study aims to provide the diversity of stem cell use for non-malignant, non-haematological diseases in India through the lens of clinical trials. Methods A PRISMA approach was used to evaluate the safety and efficacy of stem cell use for the period 2001-2021 in India. The outcomes were measured using each disease category, types of stem cells, the origin of stem cells, safety, and efficacy.

Unraveling the Autoxidation Mechanisms of Limonene, α-Pinene, and β-Pinene: A Computational Study with Reactivity Prediction Models.

The hydrogen shift reactions of peroxy radicals derived from the ȮH-initiated oxidation of three atmospherically important monoterpenes, limonene, α-pinene, and β-pinene, have been studied. The Bell-Evans-Polanyi relationship (BEPR), Marcus cross relationship (MCR), and Robert-Steel relationship (RSR) are employed to study the factors that contribute to the kinetics of the H-shift reactions. Our results show distinct kinetic behaviors based on the size of the transition-state ring, the functional group present at the H atom abstraction site, and the type of carbon-centered radical formed.

Reaction of unsymmetrical α-bromo-1,3-diketones with -substituted thioureas: regioselective access to 2-(-arylamino)-5-acyl-4-methylthiazoles and/or rearranged 2-(-acylimino)-3--aryl-4-methylthiazoles.

The present study reports some fascinating results of Hantzsch's [3 + 2] cyclic condensation of α-bromo-1,3-diketones, a tri-electrophilic synthon generated by bromination of 1,3-diketones using the mild brominating reagent NBS with trinucleophilic -substituted thioureas. Interestingly, out of a total of 20 combinations, 10 resulted in the exclusive formation of the desired 2-(-arylamino)-5-acyl-4-methylthiazoles regioselectively, seven led to the formation of unexpected 2-(-acylimino)-3--aryl-4-methylthiazoles through an interesting C-N acyl migration, and three furnished a mixture consisting of both products. The regioselectivity pattern of the two products may be attributed to a greater electrophilicity of the carbonyl carbon of the acetyl group than that of the acyl group towards both nitrogens of thiourea.

Insight into the therapeutic potential of pyrazole-thiazole hybrids: A comprehensive review.

Several pyrazole-thiazole hybrids featuring two potentially bioactive pharmacophores with or without linker have been synthesized using the molecular hybridization approach as target structures by medicinal chemists to modulate multiple drug targets simultaneously. The presented review aims to provide an overview of the diversified and wide array of pharmacological activities of these hybrids bestowing anticancer, antifungal, antibacterial, analgesic, anti-inflammatory, antioxidant, antitubercular, antiviral, antiparasitic, and miscellaneous activities. The structure-activity relationships and potential mechanism of action are also reviewed to shed light on the development of more effective and biotargeted candidates.

Design, synthesis and characterization of tetra substituted 2,3-dihydrothiazole derivatives as DNA and BSA targeting agents: advantages of the visible-light-induced multicomponent approach.

This report describes the visible-light-induced one-pot multicomponent regioselective synthesis of a series of 5-aroyl-3-((arylidene)amino)-2-((arylidene)hydrazono)-4-methyl-2,3-dihydrothiazoles as DNA and BSA targeting agents. The multicomponent condensation of thiocarbohydrazide and aldehydes with α-bromo-1,3-diketones, generated by the bromination of unsymmetrical 1,3-diketones with NBS using white LED light as an environmental friendly source in the presence of EtOAc solvent furnished the titled 2,3-dihydrothiazole derivatives in excellent yields. The exact regioisomeric structure was identified unambiguously by employing multinuclear 2D-NMR spectroscopy [H-C] HMBC; [H-C] HMQC and [H-N] HMBC.

HPLC-DAD quantification of mangiferin, antioxidant potential and essential oil composition of the leaves of five varieties of L. of North India.

L. (Mango), native of tropical Asia, has enormous genetic diversity. Comparative phytochemical analysis of leaves of five varieties of .

Strategic Analysis of Collaborative Networks in Spodoptera frugiperda (Lepidoptera: Noctuidae) Research for Improved Pest Management Strategies.

The fall armyworm (FAW) poses a significant global threat to food security, and economics. Timely detection is crucial, and this research explores innovative techniques like data analysis, remote sensing, satellite imagery, and AI with machine learning algorithms for predicting and managing outbreaks. Emphasizing the importance of community engagement and international collaboration, social network analysis (SNA) is employed to uncover collaborative networks in FAW management research.

A Sustainable and Regenerative Process for the Treatment of Textile Effluents Using Nonphotocatalytic Water Splitting by Nanoporous Oxygen-Deficient Ferrite.

Water is crucial for life. Being the world's third-largest industry, the textile industry pollutes 93 billion cubic meters of water each year. Only 28% of textile wastewater is treated by lower- to middle-income countries due to the costly treatment methods.

Epigenetic regulation influenced by soil microbiota and nutrients: Paving road to epigenome editing in plants.

Soil is a complex ecosystem that houses microbes and nutrients that are necessary for plant development. Edaphic properties of the soil and environmental conditions influence microbial growth and nutrient accessibility. Various environmental stimuli largely affect the soil microbes and ionic balance, in turn influencing plants.

Response of varying combined nutrients on biomass and biochemical composition of marine diatoms Chaetoceros gracilis and Thalassiosira weissflogii.

Marine diatoms have high adaptability and are known to accumulate lipids under nutrient stress conditions. The present study involves determining the effect of varying macro and micronutrients on growth kinetics and metabolite production of oleaginous marine diatoms, Thalassiosira weissflogii and Chaetoceros gracilis. The results highlighted that C.

Trifluoromethyl-β-dicarbonyls as Versatile Synthons in Synthesis of Heterocycles.

Trifluoromethyl group relishes a privileged position in the realm of medicinal chemistry because its incorporation into organic molecules often enhances the bioactivity by altering pharmacological profile of molecule. Trifluoromethyl-β-dicarbonyls have emerged as pivotal building blocks in synthetic organic chemistry due to their facile accessibility, stability and remarkable versatility. Owing to presence of nucleophilic and electrophilic sites, they offer multifunctional sites for the reaction.

Visible Light-Prompted Regioselective Synthesis of Novel 5-Aroyl/hetaroyl-2',4-dimethyl-2,4'-bithiazoles as DNA- and BSA-Targeting Agents.

Organic transformations mediated by visible light have gained popularity in recent years as they are green, renewable, inexpensive, and clean and yield excellent products. The present study describes cyclo-condensation of 2-methylthiazole-4-carbothioamide with differently substituted α-bromo-1,3-diketones achieved by utilizing a white light-emitting diode (LED) (9W) to accomplish the regioselective synthesis of novel 5-aroyl/hetaroyl-2',4-dimethyl-2,4'-bithiazole derivatives as DNA/bovine serum albumin (BSA)-targeting agents. The structure characterization of the exact regioisomer was achieved unequivocally by heteronuclear two-dimensional nuclear magnetic resonance (2D-NMR) spectroscopy [H-C] HMBC; [H-C] HMQC; and [H-N] HMBC.

Region-wise and state-wise synthesis of vehicular emissions in India and their mitigation due to vehicular emissions standards.

The implementation of different stages of Bharat Stage Emission standards (BSES) in India for reducing the vehicular emissions has been in different parts of the country at various points of time. A quantitative assessment of the emission standards in mitigating vehicular emissions at different Indian states will provide an estimate of achievable emissions standards for future norms. In this regard, the present work reports an assessment of the BS standards - BS-III, BS-IV and BS-VI in reducing the exhaust emissions in each of the Indian states.

Tailoring the mechanistic pathways and kinetics of OH-addition reaction of sulfoxaflor and its ecotoxicity assessment.

Sulfoxaflor is one of the widely used insecticides in agricultural lands to protect crops from insects. Due to its persistent nature, sulfoxaflor is identified as an environmental pollutant. In the present work, the mechanism and kinetics of sulfoxaflor degradation initiated by OH radical addition reaction are studied by using quantum chemical calculations.

A Computational Perspective on the Chemical Reaction of HFO-1234zc with the OH Radical in the Gas Phase and in the Presence of Mineral Dust.

The gas phase and heterogeneous reaction on mineral dust aerosols of trace gases could significantly affect the tropospheric oxidation capacity and aerosol composition of the atmosphere. In this work, the OH radical-initiated oxidation of a hydrofluoroolefin, HFO-1234zc, and subsequent reaction of favorable intermediates with other reactive species, such as O, HO, and NO ( = 1-2) radicals, were studied, and the role of mineral dust in the form of silicate clusters on the reaction mechanism and rate constant was studied. In the gas phase, OH radical addition to HFO-1234zc is kinetically more favorable than the H-atom abstraction reaction.

Mapping, clustering, and analysis of research in psychiatric genomics.

Introduction: The distribution pattern and knowledge structure of psychiatric genomics were surveyed based on literature dealing with both psychiatry and genomics/genetics. Coword analysis and bibliographic coupling of the records retrieved from Scopus and PubMed for 2016-2020 revealed the subsurface research aspects.

Method: The data were analyzed using coword analysis and clustering methods using Sci2 and VOSviewer.

Two unusual conjugated fatty acids, parinaric acid and α-eleostearic acid, are present in several species, but not in congener .

Unlabelled: Parinaric and α-eleostearic acids are unusual conjugated fatty acids. Unusual fatty acids, in general, are known to have roles in defense response; however, the role of parinaric acid in is not known, nor is it known whether it occurs in different species of or its closest monotypic relative, (L.) Wight & Arn.

Autoxidation of Formaldehyde with Oxygen-A Comparison of Reaction Channels.

The autoxidation of formaldehyde through initiation by triplet oxygen is studied via two initial steps: (1) H-atom abstraction and (2) O addition reaction. The reaction energy profiles show that the reactions are thermodynamically and kinetically demanding. A comparison of the pathways of these initial reactions and the search for a less energy-demanding pathway is presented.

Visible-Light-Prompted Synthesis and Binding Studies of 5,6-Dihydroimidazo[2,1-]thiazoles with BSA and DNA Using Biophysical and Computational Methods.

Fused heterocyclic systems containing a bridgehead nitrogen atom have emerged as imperative pharmacophores in the design and development of new drugs. Among these heterocyclic moieties, the imidazothiazole scaffold has long been used in medicinal chemistry for the treatment of various diseases. In this study, we have established a simplistic and environmentally safe regioselective protocol for the synthesis of 5,6-dihydroimidazo[2,1-]thiazole derivatives from easily available reactants.

Stress-The hidden pandemic for school children and adolescents in India during COVID-19 era.

Unlabelled: The effects of coronavirus are not just physical but also psychological in all age groups and more so common among children. Some children may have had experience of quarantine restrictions during this COVID-19 pandemic. Due to increased digital connections 'emotional contagion' where the distress and fear experienced by one spread to another person may also be common in children.

Vision on Synthetic and Medicinal Facets of 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine Scaffold.

The present review article strives to compile the latest synthetic approaches for the synthesis of triazolothiadiazine and its derivatives, along with their diverse pharmacological activities, viz. anticancer, antimicrobial, analgesic and anti-inflammatory, antioxidant, antiviral, enzyme inhibitors (carbonic anhydrase inhibitors, cholinesterase inhibitors, alkaline phosphatase inhibitors, anti-lipase activity, and aromatase inhibitors) and antitubercular agents. The review focuses particularly on the structure-activity relationship of biologically important 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines, which have profound importance in drug design, discovery and development.

microRNA 166: an evolutionarily conserved stress biomarker in land plants targeting HD-ZIP family.

MicroRNAs (miRNAs) are significant class of noncoding RNAs having analytical investigating and modulatory roles in various signaling mechanisms in plants related to growth, development and environmental stress. Conserved miRNAs are an affirmation of land plants evolution and adaptation. They are a proof of indispensable roles of endogenous gene modulators that mediate plant survival on land.

Root Trait Variation in Lentil ( Medikus) Germplasm under Drought Stress.

Drought is the most critical environmental factor across the continents affecting food security. Roots are the prime organs for water and nutrient uptake. Fine tuning between water uptake, efficient use and loss determines the genotypic response to water limitations.

Mechanism and kinetics for the reaction of methyl peroxy radical with O.

Quantum chemical calculations and dynamics simulations were performed to study the reaction between methyl peroxy radical (CHO) and O. The reaction proceeds through three different pathways (1) H-atom abstraction, (2) O addition and (3) concerted H-atom shift and O addition reactions. The concerted H-atom shift and O addition pathway is the most favourable reaction both kinetically and thermodynamically.