Therapeutic Potential of Rare Sesterterpenoids from Aspergillus Variecolor Strain SDG and Docking Studies.

Ethyl acetate extract of the cultures of the soil-derived filamentous fungus, Aspergillus variecolor SDG strain from Nallamala forest resulted in the isolation of extremely rare sesterterpenoids, stellatic acid (1) and andilesin C (2). We report a thorough chemical characterization of these compounds using various spectroscopic techniques and evaluation of their in vitro preclinical therapeutic potential. Stellatic acid exhibits potent antioxidant activity with an IC of 38 μg/mL and significant anticancer activity against HeLa, HepG2, MCF7, and A549 cancer cell lines with an IC of 7-12 μM.

Organic BODIPY based gels: Optical, electrochemical and self-assembly properties.

Two novel BODIPY dyes, BOC3 and BC12, were synthesized with variable alkyl chains at terminal amide functional units. BC12, featuring a longer alkyl chain (-C12H25), formed a gel compared to BOC3, which has a shorter alkyl chain (-CH2OCH3), due to supra molecular self-assembly in film. Both dyes exhibited absorption peaks around 530 nm in the visible region, with a red shift of about 30 nm in the film state, essential for organic electronic applications.

Gold(I) complexes of the type [AuL{κC-2-CHP(S)Ph}] [L = PTA, PPh, PPh(CH-3-SONa) and PPh(2-py)]: Synthesis, characterisation, crystal structures, and In Vitro and In Vivo anticancer properties.

Four new mononuclear gold (I) compounds of the type [AuL{κC-2-CHP(S)Ph}] {L = PTA (1), PPh (2), PPh(CH-3-SONa) (3), and PPh(2-py) (4)} were prepared by scission of the dinuclear compound [Au{μ-2-CHP(S)Ph}] by L or via a transmetalation reaction using the organotin reagent 2-MeSnCHP(S)Ph and a suitable gold halide precursor. The cytotoxic potential of complexes 1-4 was evaluated against four human cancer cell lines of diverse cellular origin: cervical (HeLa), prostate (PC-3), non-small cell lung adenocarcinoma (A549), and fibrosarcoma (HT-1080). The in vitro cytotoxicity results showed that 1 demonstrated exceptional anticancer activity with IC values ranging from 0.

Novel electron donor-acceptor (EDA) complex promoted arylation of 2-oxo-2-chromene-3-carbonitriles under visible light irradiation.

An efficient and operationally simple photochemical method has been demonstrated under transition metal-free, photocatalyst-free, and oxidant-free conditions. In recent times, diaryliodonium salts have become one of the most popular arylating sources under photoinduced conditions. Herein, we developed a visible light induced arylation of heterocycles using an EDA complex that is formed from 2,6-lutidine and diaryliodonium triflate.

Biochanin-A co-crystal formulation improves bioavailability and ameliorates cerulein-induced pancreatitis by attenuating the inflammation.

Co-crystallization of a therapeutic ingredient with an appropriate co-former is a powerful technique to augment the physicochemical and pharmacokinetic properties and the effectiveness of Active Pharmaceutical Ingredients (APIs). Biochanin A (BCA), a flavonoid with medicinal potential, is limited by poor solubility and low oral bioavailability. This study aimed to design and develop a novel BCA-nicotinamide cocrystal as BCC to enhance BCA's oral bioavailability and explore its therapeutic potential for ameliorating cerulein-induced acute pancreatitis (CIAP) by elucidating the target identification utilizing tissue/serum metabolite profiles.

MCM-41 from rice husk silica as a support for Ni catalyst in the emission-free production of H by CH cracking.

Selecting a sustainable source of silica from biomass waste was the research challenge that was put forth in this investigation. Herein, the MCM-41 support has been synthesized using a renewable rice husk and explored as a support for Ni-Cu catalyst in the production of zero-emission H through CH pyrolysis. The role of Cu promoter was investigated by doping different amounts of Cu loading to 30wt%Ni/R-MCM-41catalyst, which improved the catalytic performance in terms of CH conversion and stability.

Synthesis and cytotoxicity studies of novel -arylbenzo[]quinazolin-2-amines.

In this paper, we report a short and efficient synthesis of novel -arylbenzo[]quinazoline-2-amines. We have prepared a focused library of nineteen representative examples which have been submitted to cytotoxicity assays against a representative panel of eight cancer cell lines and several molecules gave attractive results in this area.

Observation of excellent photocatalytic and antibacterial activity of Ag doped ZnO nanoparticles.

Nanotechnology is the platform with the greatest promise for scientific advancements. One of the advancement is improvement in photocatalytic and antibacterial performance. This work was undertaken to synthesize un-doped and silver (Ag) doped zinc oxide (ZnO) nanoparticles (NPs) using an inexpensive wet chemical method and to investigate the structural and optical properties, photocatalytic and antibacterial activity.

Liquid chromatography-high-resolution mass spectrometry-based metabolomics revealing the effects of zearalenone and alpha-zearalenol on human endometrial cancer cells.

Human exposure to mycotoxins through food involve a mixture of compounds, which can be harmful to human health. The Fusarium fungal species are known to produce zearalenone (ZEN), a non-steroidal estrogenic mycotoxin, and its metabolite alpha-zearalenol (α-ZEL), both of which possess endocrine-disruptive properties. Given their potential harm to human health through food exposure, investigating the combined effects of ZEN and α-ZEL becomes crucial.

Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice.

Aging is usually accompanied by mitochondrial dysfunction, reduced energy levels, and cell death in the brain and other tissues. Mitochondria play a crucial role in maintaining cellular energy through oxidative phosphorylation (OXPHOS). However, OXPHOS is impaired as the mitochondrial oxygen supply decreases with age.

Role of Trap Optimization in a Heterostructure Carbon Nitride as a Methodology to Enhance Photocatalytic Hydrogen Production.

Carbon-based catalysts hold significant promise for photocatalytic hydrogen evolution. A critical challenge lies in optimizing the balance between electron longevity and its accumulation to avoid bottlenecks in photocatalytic efficiency. In this study, we introduce an innovative and efficient strategy for the rapid extraction (<100 fs) of photoinduced free electrons from a carbon-based catalyst without forming additional metal-based heterojunction hybrids.

RETRACTED: Padghan et al. Pyrene-Phosphonate Conjugate: Aggregation-Induced Enhanced Emission, and Selective Fe Ions Sensing Properties. 2017, , 1417.

The Editorial Office retracts the article "Pyrene-Phosphonate Conjugate: Aggregation-Induced Enhanced Emission, and Selective Fe Ions Sensing Properties" [...

Silver-catalyzed regioselective synthesis of pyrano heterocycles: a versatile route to samoquasine A derivatives.

This study introduces a silver-catalyzed method for the efficient and regioselective synthesis of pyrano heterocycles, utilizing readily available alcohols and water as nucleophiles. The method demonstrates high efficiency, delivering excellent yields and selectivity, and is scalable to gram quantities while maintaining broad functional group tolerance. Notably, the synthesized pyrano[3,4-]quinolines were successfully transformed into diverse samoquasine A derivatives, underscoring the method's applicability in natural product synthesis.

Visible-light-mediated flow protocol for Achmatowicz rearrangement.

The batch processes of APIs/pharmaceutical synthesis are prone to suffer significant limitations, including longer process time, shortage of skilled manpower, laborious post-synthetic work-up, etc. To address the inherent limitations of batch processes, a novel approach was undertaken, resulting in the establishment and development of a visible light-assisted modular photo-flow reactor with a seamlessly integrated post-synthetic work-up procedure enabling the efficient synthesis of dihydropyranones from furfuryl alcohols. The reaction uses sun light as green energy source, and the novel photo-flow reactor platform developed with an integrated system enabling a downstream process in a time and labor-efficient manner which facilitates the Achmatowicz rearrangement, resulting in a fast (10 min) formation of the dihydropyranone products.

Cu-doped LaNiO perovskite catalyst for DRM: revisiting it as a molecular-level nanocomposite.

Dry reforming of methane (DRM) was extensively studied on Cu-doped LaNiO catalysts. The main findings of this work are as follows: (i) thermal switching of the catalyst phase between the parent perovskite and molecular-level nanocomposite of individual components formed during DRM, (ii) reusability of the catalyst with enhanced activity, and (iii) regeneration of the catalyst phase at a lower temperature than that required for the formation of the parent perovskite. The present investigation provides an extensive analysis and understanding of the DRM reaction using Cu-doped LaNiO compared to the result reported by Moradi , (, 2012, , 797-801) and hence provides new insights into its catalytic activity.

Ag-Catalyzed Domino Decarboxylative Alkylation/Dearomative Annulation: Entry to Fused-Pyrido[4,3-]Indolones.

Here we report the development of unprecedented silver-catalyzed intramolecular annulations of -acrolyl-2-(3-indolyl) benzimidazoles with alkyl carboxylic acids to construct complex fused-pentacyclic alkaloid scaffolds. Divergent reactivities are noticed with altered groups at C2-indole of the substrate. The reaction proceeds through decarboxylative alkylation, followed by dearomative annulation in a domino manner with excellent diastereoselectivity.

Advanced AIE Materials for Environmental Monitoring: Selective Sensing of Thorium(IV) in Aquatic Systems.

Thorium (Th) is commonly used in various applications, but its long-term exposure poses health risks, necessitating its detection in aqueous environments. Traditional methods such as inductively coupled plasma mass spectrometry are sensitive but require complex instrumentation. Optical sensors, particularly fluorometry-based methods, are simpler, cost-effective, and selective.

NHC-Catalyzed Umpolung Driven Intramolecular Cyclizations for the Generation of 3,4-Cycloheptanone Annulated Tetracyclic Indole Derivatives.

In this Letter, we disclose the development and exploitation of umpolung reactivity of N-heterocyclic carbene (NHC) organocatalysts in generating tetracyclic indole derivatives with the introduction of a cycloheptane ring forming event. The NHC-catalyzed intramolecular vinylogous Stetter, Stetter, benzoin, and formal cross-dehydrogenative coupling transformations have been executed, enabling the construction of 3,4-cycloheptannulated indole derivatives in good to excellent yields. The developed protocols utilize an inexpensive catalyst and feature operational simplicity, atom economy, gram-scale syntheses, and postsynthetic availability.

Emerging ZnO Semiconductors for Photocatalytic CO Reduction to Methanol.

Carbon recycling is poised to emerge as a prominent trend for mitigating severe climate change and meeting the rising demand for energy. Converting carbon dioxide (CO) into green energy and valuable feedstocks through photocatalytic CO reduction (PCCR) offers a promising solution to global warming and energy needs. Among all semiconductors, zinc oxide (ZnO) has garnered considerable interest due to its ecofriendly nature, biocompatibility, abundance, exceptional semiconducting and optical properties, cost-effectiveness, easy synthesis, and durability.

Rh(III)-Catalyzed Chemoselective [4 + 2] Annulations for the Synthesis of [1,3]Oxazinoindolones: A Combined Experimental and Computational Study.

The interaction of -alkoxy-1-indole-1-carboxamides with transition metals leads to indole-fused heterocyclic scaffolds through directing group leaving/migration, [3 + 2], N-C2 [4 + 1], and [4 + 2] annulations. However, the corresponding O-C2 [4 + 2] annulation reactions have never been reported. Herein, we report the chemoselective annulation of -alkoxy-1-indole-1-carboxamides catalyzed by Rh(III), affording [1,3]oxazinoindolones through a hitherto unknown reaction pathway.