A-site composition tuning in methylammonium-based metal halide perovskite colloidal nanocrystals.

Utilizing the soft-lattice nature of metal halide perovskites, we employ post-synthetic cross-ion exchange to synthesize a series of narrow band-gap colloidal nanocrystals of methylammonium-based lead iodide solid solutions of composition FAMAPbI, as well as those of triple-cation composition CsFAMAPbI (TCPbI). The ability to finely tune the compositions not only helps in tailoring the optical properties in the near-infrared region, but also improves the stability of these colloidal nanocrystals towards moisture, which has been demonstrated as compared to their bulk counterparts. The thermal stability of these solid solutions is also comparable to that of the bulk, as evidenced by thermogravimetric studies.

Tuning the properties of soy protein isolate-based adhesive using various sustainable additives.

This work investigates the adhesive property of Soy Protein Isolate(SPI)polymer solution by studying mechanical properties of composites formed using waste wood granules and SPI solutions. To improve the adhesive strength of SPI solution, Carboxymethyl Cellulose Sodium(NaCMC)was mixed (in the weight ratios of 9:1 and 8:2) due to its strong gel formation capabilities. The adhesive performance of these composites was further investigated in the presence and absence of non-toxic additives, including sorbitol (SOR) and stearic acid (SA).

Hierarchical Self-Assembly of SnO Nanoparticles into Porous Microspheres: Exceptionally Selective Ammonia Sensing at Ambient.

Herein, porous SnO microspheres in a three-dimensional (3D) hierarchical architecture were successfully synthesized via a facile hydrothermal route utilizing d-(+)-glucose and cetyltrimethylammonium bromide (CTAB), which act as reducing and structure-directing agents, respectively. Controlled adjustment of the CTAB to glucose mole ratio, reaction temperature, reaction time, and the calcination parameters all provided important clues toward optimizing the final morphologies of SnO with exceptional structural stability and reasonable monodispersity. Electron microscopy analysis revealed that microspheres formed were hierarchical self-assemblies of numerous primary SnO nanoparticles of ∼3-8 nm that coalesce together to form nearly monodispersed and ordered spherical structures of sizes in the range of 230-250 nm and are appreciably porous.

Synthesis and potential anti-inflammatory response of indole and amide derivatives of ursolic acid in LPS-induced RAW 264.7 cells and systemic inflammation mice model: Insights into iNOS, COX2 and NF-κB.

Ursolic acid (3-hydroxy-urs-12-ene-28-oic acid, UA) is a pentacyclic triterpene present in numerous plants, fruits and herbs and exhibits various pharmacological effects. However, UA has limited clinical applicability since it is classified as BCS class IV molecule, characterized by low solubility, low oral bioavailability and low permeability. In the present study, UA was isolated from the biomass marc of Lavandula angustifolia and was structurally modified by an induction of indole ring at the C-3 position and amide group at the C-17 position with the aim to enhance its pharmacological potential.

Synthesis of pyrano[3,2-]chromene-2,5-diones from 4-hydroxycoumarins and aminocrotonates under solvent-free conditions.

A new one-pot approach was developed for the construction of pyrano[3,2-]chromene-2,5-diones by reacting 4-hydroxycoumarins with ethyl 3-oxo-3-phenylpropanoates in the presence of ammonium salts or aminocrotonates under solvent-free conditions. The title compounds were formed by intramolecular cyclization through new C-C and C-O bonds. Structure assignment of compound 3e was confirmed by single crystal X-ray analysis.

Corporate genome screening India (CoGsI) identified genetic variants association with T2D in young Indian professionals.

Rising cases of type 2 diabetes (T2D) in India, especially in metropolitan cities is an increasing concern. The individuals that were most affected are young professionals working in the corporate sector. However, the corporate sector has remained the least explored for T2D risk predisposition.

Autophagy inhibition alleviates tumor desmoplasia and improves the efficacy of locally and systemically administered liposomal doxorubicin.

The abnormal physiology of the tumor microenvironment poses a challenge to the drug delivery in the tumor tissues. The dense tumor stroma hinders the movement of nanomedicine through the interstitium and negatively impacts their efficacy. In this study, hydroxychloroquine (HCQ) was investigated for its impact on alleviating the hindrance offered to the nanomedicine by extracellular matrix (ECM) components such as collagen and hyaluronan.

Pleiotropic Function of Cellular Prion Protein: Encompassing Endoplasmic-Reticulum Stress, Cell Proliferation in Vascular Smooth Muscle Cells.

Cellular prion protein (PRNP) has been implicated in various physiological processes in different cell types, for decades. Little has been known how PRNP functions in multiple, yet related processes within a particular system. In our current study, with the aid of high-throughput RNA-sequencing technique, we have presented an overall transcriptome profile of rat vascular smooth muscle cells (VSMCs) with Prnp knockdown.

Corrigendum: Interplay of various evolutionary modes in genome diversification and adaptive evolution of the family .

[This corrects the article DOI: 10.3389/fmicb.2021.

A Comprehensive Review of Arsenic-Induced Neurotoxicity: Exploring the Role of Glial Cell Pathways and Mechanisms.

The review aims to examine the neurotoxic effects of arsenic, particularly exploring the roles of glial cells-astrocytes, microglia, and oligodendrocytes, amid its widespread environmental contamination and impact on cognitive impairments. It highlights the role of altered neurotrophin and growth factor signaling in disrupting neuronal health and cognitive performance. It elucidates the intricate interactions between oxidative stress, DNA damage, neurotransmitter disruption, and cellular signaling alterations, underscoring the vital importance of the glial cells.

An HPLC-based Assay to Study the Activity of Cyclic Diadenosine Monophosphate (C-di-AMP) Synthase DisA from .

Cyclic diadenosine monophosphate (c-di-AMP) is a recently discovered second messenger that modulates several signal transduction pathways in bacterial and host cells. Besides the bacterial system, c-di-AMP signaling is also connected with the host cytoplasmic surveillance pathways (CSP) that induce type-I IFN responses through STING-mediated pathways. Additionally, c-di-AMP demonstrates potent adjuvant properties, particularly when administered alongside the Bacillus Calmette-Guérin (BCG) vaccine through mucosal routes.

Synthesis of novel spiroisoxazolidino hybrids of alantolactone and isoalantolactone via 1,3 dipolar nitrone cycloaddition and its antimicrobial Evaluation.

Alantolactone and isoalantolactone are two isomeric sesquiterpene lactones that were isolated from Innula recemosa. Here, we are used for the semisynthesis of novel isoxazolidine hybrids of alantolactone and isoalantolactone through a two-step process: nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition. The formation of the cycloadduct was well characterized via modern spectroscopic techniques such as HRMS, H NMR, C NMR, DEPT-90, DEPT-135, and 2D NMR.

Breaking the resistance: integrative approaches with novel therapeutics against Klebsiella pneumoniae.

Klebsiella pneumoniae is a leading cause of anti-microbial resistance in healthcare-associated infections that have posed a severe threat to neonatal and wider community. The escalating crises of antibiotic resistance have compelled researchers to explore an innovative arsenal beginning from natural resources to chemical modifications in order to overcome the ever-increasing resistance issues. The present review highlights the drug discovery efforts with a special focus on cutting-edge strategies in the hunt for potential drug candidates against MDR/XDR Klebsiella pneumoniae.

Structural and functional characterization of genes and enzymes involved in withanolide biosynthesis in Physalis alkekengi L.

Physalis alkekengi L. is recognized as a significant source of various secondary metabolites, particularly C steroidal lactones known as withanolides and physalins, renowned for their therapeutic properties with a rich history in traditional medicine. In this study, we characterized the sequences of key downstream genes (PaFPPS, PaSQS, PaSQE, PaCAS, PaHYD1, and PaDWF5-1) involved in the biosynthesis of withanolides, marking the first characterization of these genes in P.

6-aryloxy-2-aminopyrimidine-benzonitrile hybrids as anti-infective agents: Synthesis, bioevaluation, and molecular docking.

This report explores the potential of novel 6-aryloxy-2-aminopyrimidine-benzonitrile scaffolds as promising anti-infective agents in the face of the increasing threat of infectious diseases. Starting from 2-amino-4,6-dichloropyrimidine, a series of 24 compounds inspired from the antiviral drugs dapivirine, etravirine, and rilpivirine were designed and synthesized via a two-step reaction sequence in good yields. Biological testing of synthetic analogs revealed potent inhibition against both viral and tuberculosis targets.

Exploring the therapeutic potential of triterpenoid saponins from : Mechanistic insights into hepatoprotection, immunomodulation, anticancer activities, molecular docking, and pharmacokinetics.

The study comprehensively investigated the therapeutic potential of triterpenoid saponin extract (GST), encompassing its hepatoprotective, immunomodulatory, and anticancer activities. The study employed a Prednisolone (PRD)-induced immunosuppressed rat model to assess the hepatoprotective and immunomodulatory effects of GST. Using this model, GST was found to modulate haematopoiesis, improving RBC, platelet, and WBC counts, underscoring its potential in hematopoietic homeostasis.

Understanding Neurogenesis and Neuritogenesis via Molecular Insights, Gender Influence, and Therapeutic Implications: Intervention of Nanomaterials.

Neurological disorders impact global health by affecting both central and peripheral nervous systems. Understanding the neurogenic processes, i.e.

A Simplified Protocol for Isolation and Culture of Keratinocyte Stem Cells from Neonatal Mice.

Isolation of primary keratinocyte stem cells (KSCs) from neonatal mouse epidermis is essential for studying skin physiology and related disorders. Traditional methods often struggle to balance keratinocyte proliferation and differentiation, and although recent advancements using low-calcium culture conditions have improved these techniques, protocols remain scattered. This study presents a streamlined approach to expand mouse KSCs in low-calcium medium (<0.

C-H Functionalization of Imidazo[1,5-]pyridines: A Metal-Free Approach for Methylene Insertion to Access C(sp)-C(sp)-H-C(sp) Bond Formation.

Formaldehyde has been used as a solvent and a source of carbon to insert a methylene group for bridging two imidazo[1,5-]pyridine molecules without using any metal catalysis. This strategy has been extended on other alkyl-, aryl-, and heteroaryl aldehydes as well. This C(sp)-C(sp)-H-C(sp) bond forming reaction proceeds via C(sp)H functionalization of imidazo[1,5-]pyridine and was applied on a wide range of substrates offering moderate to good yields of methylene-bridged/inserted bis-imidazo[1,5-]pyridines.

Ellagic Acid Induces DNA Damage and Apoptosis in Cancer Stem-like Cells and Overcomes Cisplatin Resistance.

Cancer stem cells (CSCs) are responsible for chemoresistance and tumor relapse in many solid malignancies, including lung and ovarian cancer. Ellagic acid (EA), a natural polyphenol, exhibits anticancer effects on various human malignancies. However, its impact and mechanism of action on cancer stem-like cells (CSLCs) are only partially understood.

Isolation, Characterization, In Vitro and In Silico Assessment of Undescribed Bioactive Constituents from L. Heartwood.

heartwood is well acknowledged for its medicinal properties and use in the furniture and handicraft industries. Owing to its medicinal properties, the present investigation aims to isolate and characterize the secondary metabolites from the heartwood. The investigation led to the isolation of one undescribed dehydropterocarpan and eleven known compounds.

Biochemical and molecular mechanisms of Rhodococcus rhodochrous IITR131 for polyethylene terephthalate degradation.

Aims: To isolate polyethylene terephthalate (PET)-degrading bacteria and elucidate the underlying mechanisms of PET biodegradation through biochemical and genome analysis.

Methods And Results: Rhodococcus rhodochrous IITR131 was found to degrade PET. Strain IITR131 genome revealed metabolic versatility of the bacterium and had the ability to form biofilm on PET sheet, resulting in the cracks, abrasions, and degradation.

Phyto-metabolomic investigation of biologically active fraction of leaf.

(Wight & Arn.) Benth., leaves are used traditionally in variety of diseases.

A critical review on the symbiotic effect of bacteria and microalgae on treatment of sewage with biofertilizer production.

Wastes like sewage, kitchen and industrial are the major sources of environmental pollution and health hazards. Sewage contains 99.9% water and 0.