Machine learning approach for anxiety and sleep disorders analysis during COVID-19 lockdown.

The Severe Acute Respiratory Syndrome (SARS)-CoV-2 virus caused COVID-19 pandemic has led to various kinds of anxiety and stress in different strata and sections of the society. The aim of this study is to analyse the sleeping and anxiety disorder for a wide distribution of people of different ages and from different strata of life. The study also seeks to investigate the different symptoms and grievances that people suffer from in connection with their sleep patterns and predict the possible relationships and factors in association with outcomes related to COVID-19 pandemic induced stress and issues.

Quantum chemical calculations, spectroscopic studies and molecular docking investigations of the anti-cancer drug quercitrin with B-RAF inhibitor.

Quercitrin is an anti-lung cancer agent. It is a naturally occurring flavonoid and its derivatives are mainly present in nuts and beverages. It is mainly available as a glycoside, and the quercitrin glycosides are found to prevent the metastasis of cancer.

Lanthanum oxide nanoparticle-collagen bio matrix induced endothelial cell activation for sustained angiogenic response for biomaterial integration.

Rare earth lanthanum oxide nanoparticle reinforced collagen biomatrix that elicited the endothelial cell activation to promote angiogenesis for biomaterial integration was developed and evaluated in the present study. The structural integrity of collagen was not compromised on crosslinking of lanthanum oxide nanoparticle to collagen biomolecule. As-synthesised collagen biomatrix was shown to have improved mechanical strength, a lesser susceptibility to proteolytic degradation and good swelling properties.

Screening of multi-faceted phosphate-solubilising bacterium from seagrass meadow and their plant growth promotion under saline stress condition.

Soil salinity is one of the major limiting factors of the crop production, it has been constantly increasing in agricultural land due to the impact of climate change and urbanisation. High salinity in the agrolands can lead ionic, oxidative, osmotic and water stress to crops. A potential phosphate solubilising bacterium, Curtobacterium luteum was isolated from marine environment (seagrass meadow) and was evaluated for the enhancement of plant growth promotion of three different agro plants (rice, tomato and chilli) using agro saline soil.

Advanced oxidation processes: Performance, advantages, and scale-up of emerging technologies.

Advanced oxidation processes (AOPs) are promising technologies for partial or complete mineralization of contaminants of emerging concern by highly reactive hydroxyl, hydroperoxyl, superoxide, and sulphate radicals. Detailed investigations and reviews have been reported for conventional AOP systems that have been installed in full-scale wastewater treatment plants. However, recent efforts have focused on the peroxymonosulphate, persulphate, catalytic ozonation, ultrasonication and hydrodynamic cavitation, gamma radiation, electrochemical oxidation, modified Fenton, and plasma-assisted AOPs.

Computer-aided diagnosis of COVID-19 from chest X-ray images using histogram-oriented gradient features and Random Forest classifier.

The decision-making process is very crucial in healthcare, which includes quick diagnostic methods to monitor and prevent the COVID-19 pandemic disease from spreading. Computed tomography (CT) is a diagnostic tool used by radiologists to treat COVID patients. COVID x-ray images have inherent texture variations and similarity to other diseases like pneumonia.

Applications of molybdenum oxide nanoparticles impregnated collagen scaffolds in wound therapeutics.

Introduction: The highly complex pathophysiology of the wound micro-environment demands the development of a multi-faceted system which would enhance the wound healing cascade. Incorporation of nanotechnology in wound therapeutics has opened up new avenues to tourment the diseased condition. Amongst the various types of nanoparticles molybdenum oxide nanoparticles posses various inherent properties that makes it a versatile material to be used in healing.

Applying polypharmacology approach for drug repurposing for SARS-CoV2.

Unlabelled: Exploring the new therapeutic indications of known drugs for treating COVID-19, popularly known as drug repurposing, is emerging as a pragmatic approach especially owing to the mounting pressure to control the pandemic. Targeting multiple targets with a single drug by employing drug repurposing known as the polypharmacology approach may be an optimised strategy for the development of effective therapeutics. In this study, virtual screening has been carried out on seven popular SARS-CoV-2 targets (3CL, PL, RdRp (NSP12), NSP13, NSP14, NSP15, and NSP16).

Effective inhibition of adipogenesis-mediated inflammation by a macular carotenoid, lutein in vitro.

An absolute interlinks between inflammation and obesity with scarce investigations on the role of lutein in inflammation-induced obesity motivated us to explore the protective mechanism of lutein on adipogenesis-mediated inflammation in vitro by culturing RAW264.7 macrophages in adipocyte conditioned medium. The RAW264 macrophage cells were cultured with adipocyte-conditioned media, and the potency of lutein on the expression of adipocyte inflammation-associated protein markers (IL-1β, MCP-1, TNF-α, IL-6, NF-κB, and IKKα/β) were analyzed by western blotting.

A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys.

Data science has been an invaluable part of the COVID-19 pandemic response with multiple applications, ranging from tracking viral evolution to understanding the vaccine effectiveness. Asymptomatic breakthrough infections have been a major problem in assessing vaccine effectiveness in populations globally. Serological discrimination of vaccine response from infection has so far been limited to Spike protein vaccines since whole virion vaccines generate antibodies against all the viral proteins.

A comprehensive overview of vaccines developed for pandemic viral pathogens over the past two decades including those in clinical trials for the current novel SARS-CoV-2.

The unprecedented coronavirus disease 2019 (COVID-19) is triggered by a novel strain of coronavirus namely, Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). Researchers are working around the clock to control this pandemic and consequent waves of viral reproduction, through repurposing existing drugs as well as designing new vaccines. Several countries have hastened vaccine design and clinical trials to quickly address this outbreak.

Research advances in the fabrication of biosafety and functional leather: A way-forward for effective management of COVID-19 outbreak.

With the recent events following the pandemic COVID-19, global awareness about the use of biosafety materials has been in raise. Leather industry being a major commodity-driven sector, its role in addressing the issues concerning the safe use of leather products has become inevitable for the sustainability of the industry. A significant number of researches have been conducted to fabricate bio-safe leather by incorporating different types of antimicrobial agents during leather manufacturing.

Role of heavy metals (copper (Cu), arsenic (As), cadmium (Cd), iron (Fe) and lithium (Li)) induced neurotoxicity.

Parkinson's disease (PD) is a neurodegenerative condition characterized by the dopamine (DA) neuronal loss in the substantia nigra. PD impairs motor controls symptoms such as tremor, rigidity, bradykinesia and postural imbalance gradually along with non-motor problems such as olfactory dysfunction, constipation, sleeping disorder. Though surplus of factors and mechanisms have been recognized, the precise PD etiopathogenesis is not yet implied.

DMSO-allyl bromide: a mild and efficient reagent for atom economic one-pot -allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles.

A mixture DMSO-allyl bromide has been developed as a reagent for an atom economic one-pot -allylation and aryl bromination under basic conditions. Utilizing this reagent, -allylation-bromination of a number of 2°-aryl amines, aryl aminoamides, indoles, and 7-aza indoles has been achieved. The scope of the substrates and limitations, the synthetic utility of the products, and a plausible reaction mechanism have been proposed.

Insights into protein-ionic liquid interaction: A comprehensive overview on theoretical and experimental approaches.

Owing to highly tunable nature, ionic liquids are nesting stance in the scientific community for a wide variety of applications ranging from electrochemistry to product purification, from chemical and biomedical applications to biotechnological interventions and proteomics. Proteins are unstable in its native form and several attempts have been made to stabilize them by addition of various additives. This review focusses on the studies conducted to improve protein stability with ionic liquids along with an emphasis on the mechanism of interaction.

Wound healing in second-degree burns in rats treated with silver sulfadiazine: a systematic review and meta-analysis.

Objective: This study aims to assess the wound healing efficacy in second-degree burns in rats treated with 1% silver sulfadiazine (SSD)-a sulfonamide antibiotic.

Method: This is a systematic literature review and meta-analysis performed according to the PICO (Population, Intervention, Comparison and Outcomes) strategy.

Results: The review found 100 studies in PubMed, Web of Science and other search engines.

Green Chemical Synthesis of N-Cholyl-L-Cysteine Encapsulated Gold Nanoclusters for Fluorometric Detection of Mercury Ions.

Herein we report a simple, single-step, cost-effective, environmentally friendly, and biocompatible approach using sodium salt of N-cholyl-L-cysteine (NaCysC) capped gold nanoclusters (AuNCs) with green emission properties at above the CMC in aqueous medium under UV-light irradiation. The primary and secondary CMC of NaCysC was found to be 4.6 and 10.

Adsorption of chromium by exopolysaccharides extracted from lignolytic phosphate solubilizing bacteria.

In the present study, exopolysaccharide (EPS) producing phosphate solubilizing bacterium, Enterobacter soli was screened from rhizospheres soils of mangrove environment. The enhanced production of EPS by Enterobacter soli (EsEPS) was obtained by optimization of cultural conditions, maximum production (3.86 ± 0.

Supramolecular self-assembly mediated aggregation-induced emission of fluorene-derived cyanostilbenes: multifunctional probes for live cell-imaging.

The first discovery of aggregation-induced emission (AIE), whereby luminogen aggregation plays a positive role in enhancing the light-emission efficiency, has piqued the interest of many researchers as it opens up a new avenue for the exploration of practically beneficial luminescent materials. Diverse AIE-active luminogens (or AIEgens) with tunable emission colours and very high quantum yields (up to unity) in the solid state have been extensively utilised in a broad range of fields including optoelectronics, energy and bioscience. In this article, we describe novel fluorene-based fluorogens that exhibit bright emission in the solid-state, mechanical stimuli-responsive optical properties and aggregation-induced emissive ability, and were able to modulate their donor and acceptor properties.

Facile Multicomponent Synthesis, Computational, and Docking Studies of Spiroindoloquinazoline Compounds.

Synthesis of spiroindoloquinazolines via one-pot three-component condensation reactions of tryptanthrin, malononitrile or ethylcyanoacetate, and nucleophiles was carried out in MeOH using triethylamine as the base catalyst under reflux conditions. This method has the advantages of short reaction time, excellent yields, and an easy work-up procedure. The structural properties of the compound {2-amino-6-methyl-spiro-[12]Indolo(2,1-)quinazoline-12-one]12',4-pyrano(2,3-)pyrazole]-3-carbonitrile} and the obtained crystal were analyzed by the DFT theoretical calculation method, using the B3LYP 6-311G(d,p) basis set and were found to be in agreement with the experimental results.

A cyclodextrin-based macrocyclic oligosaccharide cavitand with a dual functionality limits the collagen fibrillogenesis: A possible carbohydrate-based therapeutic molecule for fibrotic diseases.

β-Cyclodextrin (β-CD), a macrocyclic oligosaccharide cavitand, is a well-known candidate for drug delivery and formulation. In this study, we extended the application of β-CD using a β-cyclodextrin sulfate (β-CDS) as a possible therapeutic for fibrotic diseases caused by excess deposition of collagen fibrils. We have strategically chosen β-CDS, which mimics the natural existence of dermatan sulfate in the extracellular matrix, for limiting collagen fibrillation.

Electro-oxidation of tannery wastewater to achieve zero discharge - a step towards sustainability.

Pilot-scale electro-oxidation equipment with a functional capacity of 0.2 m/hr, with titanium electrodes coated with TiO/RuO/IrO as both anodes and cathodes, was designed. It was installed on the premises of a commercial tannery.

Slaughterhouse and poultry wastes: management practices, feedstocks for renewable energy production, and recovery of value added products.

The slaughterhouse and poultry industry is possibly one of the fastest-growing sectors driven by the increasing demand in food availability. Subsequently, the wastes produced from the slaughterhouse and poultry industry are in huge quantities, which could be a promising resource for the recovery of value added products, and bioenergy production to minimize the dependence on fossil fuels. Furthermore, the wastes from slaughterhouses and poultry are a hub of pathogens that is capable of infecting humans and animals.

Cascade aryne insertion/vinylogous aldol reaction of vinyl-substituted β-keto/enol carbonyls.

Cyclic and acyclic vinyl substituted β-keto/enol carbonyl substrates, on reaction with arynes, result in differentially substituted naphthyl carbocycles, hitherto difficult to synthesize with existing protocols. While the substitutions on the arynes have no role, the ring size of the cyclic β-keto/enol esters has a profound influence on the product formation.

Nitrogen Fixation at the Edges of Boron Nitride Nanomaterials: Synergy of Doping.

Synthesis of ammonia at ambient conditions is very demanding yet challenging to achieve due to the production of ammonia fuel, which is considered to be a future fuel for sustainable energy. In this context, computational studies on the catalytic activity of the edge sites of boron nitride nanomaterials for possible nitrogen reduction into ammonia have been investigated. Geometrical and electronic properties of zigzag and armchair B-open edges of BN sheet (B) models have been unraveled to substantiate their catalytic nature.