Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction.

Metabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke. Effective management often demands new medications due to complexity of the conditions and limitations of current treatments. Natural compounds are increasingly recognized in drug discovery due to their vast chemical diversity, commercial availability, low cost, and minimal side effects.

'Bhim Kol (Musa Balbisiana)' Wine: Chemical Profiling and Antidiabetic Properties with MD Simulation Insights.

Musa balbisiana (Bhim Kol), an exotic fruit that offers numerous benefits can be fermented to obtain a unique indigenous wine. This study explores the fermentation of Musa balbisiana (Bhim Kol) fruit to produce a unique indigenous wine using strain of Saccharomyces cerevisiae and sugar over a 21-day period. Chemical profiling via GC-MS analysis revealed the presence of major volatile compounds such as butan-1-ol, propanoic acid, 2-phenylethanol, oxolane-2,5-dione etc.

Simultaneous Removal of As(iii) and As(v) from Aqueous Solution by Using Iron-Functionalized Polythiophene: A Novel Approach toward Water Treatment.

Arsenic contamination in groundwater poses a significant threat to human health, affecting millions worldwide. This study presents a novel approach for simultaneous remediation of both As(III) and As(V) by using iron-functionalized polythiophene (PTh@Fe) composites. The PTh@Fe composite was synthesized by a reduction process involving FeCl/FeCl byproducts of polymerization, resulting in a highly efficient adsorbent for both As(III) and As(V) species.

In vitro assessment of Ethanolic extracts from specific herbs on controlling aquatic leech (Tyrannobdella rex) and land leech (Philobdella sp.) infestation in Mithun (Bos frontalis).

Leech infestation poses a significant threat to Mithun (Bos frontalis) in the north-eastern region of India, leading to various health issues and potential fatality. To address this pressing concern, we conducted a comprehensive research study aimed at assessing the efficacy of herbal plant extracts against aquatic leeches, particularly Tyrannobdella rex, and land leeches of the Philobdella sp. Our investigation involved the evaluation of six distinct plant extracts, with a focus on their ability to combat leech infestation.

In silico, in vitro, and in vivo acute and sub-acute toxicity profiling of whole plant methanol extract of Equisetum diffusum D. Don from the sub-Himalayan West Bengal, India, having ethnobotanical uses.

Background: Equisetum diffusum D. Don commonly known as 'Himalayan horsetail', has been traditionally used in the treatment of back pain, bone fracture and dislocation, and arthritis by various tribal communities of India. Our previous study confirmed the anti-inflammatory efficacy of the plant through in silico, in vitro, and in vivo model studies.

Biochar carbon nanodots for catalytic acetalization of biodiesel by-product crude glycerol to solketal: process optimization by RSM and life cycle cost analysis.

Carbon-based nanodots have garnered recent interest for their simple synthesis and versatile utility, ranging from biomedical to (opto) electronic applications, evolving into a tunable and biocompatible material. Here, for the first time, a biochar (lotus leaf) derived carbon nanodots was synthesized through hydrothermal carbonization. The synthesized hollow spherical biochar was engineered via functionalization by grafting -SOH active sites.

Access to Isoxazoles via Photo-oxygenation of Furan Tethered α-Azidoketones.

Photocatalyst-free visible light-enabled direct oxygenation of furan-tethered α-azidoketones was studied. The reaction yielded various products depending on the substituents, with isoxazoles forming as the major products. The findings suggest that singlet oxygen was generated during the reaction and reacted with α-azidoketones in a [4 + 2] fashion to yield endoperoxides, which rearranged in multiple ways to generate isoxazoles.

Transition metal-free efficient synthesis of bis(indolyl)propynes (BIPs).

A transition metal-free approach has been devised for the synthesis of a variety of bis(indolyl)propyne (BIP) derivatives. The strategy involves an iodine-catalyzed cascade condensation of α,β-unsaturated acetylenic aldehydes with diversely substituted indoles. The strategy was applicable to gram scale synthesis and a library of 50 molecules, which were afforded in good to excellent yields (up to 96%), was developed.

Anti-inflammatory potential of Piper betleoides C. DC., a promising Piper species of Northeast India: in vitro and in vivo evidence and mechanistic insight.

The present study aims to investigate the anti-inflammatory potential of the leaf hydroalcoholic extract of Piper betleoides C. DC., also known as "Jangli Paan" in Northeast India, using lipopolysaccharide (LPS)-treated both cell culture (RAW264.

Sterility Mosaic Disease of Pigeonpea ( (L.) Huth): Current Status, Disease Management Strategies, and Future Prospects.

Pigeonpea () is one of the important grain legume crops cultivated in the semi-arid tropics, playing a crucial role in the economic well-being of subsistence farmers. India is the major producer of pigeonpea, accounting for over 75% of the world's production. Sterility mosaic disease (SMD), caused by (PPSMV) and transmitted by the eriophyid mite (), is a major constraint to pigeonpea cultivation in the Indian subcontinent, leading to potential yield losses of up to 100%.

Unraveling the interplay of common groundwater ions in arsenic removal by sulfide-modified nanoscale zerovalent iron.

Sulphidation of nZVI (S-nZVI) has shown to significantly improve the arsenic removal capacity of nZVI, concurrently modifying the sequestration mechanism. However, to better apply S-nZVI for groundwater arsenic remediation, the impact of groundwater coexisting ions on the efficacy of arsenic uptake by S-nZVI needs to be investigated. This present study evaluates the potential of S-nZVI to remove arsenic in the presence of typical groundwater coexisting ions such as Cl, HA, HCO, PO and SO through batch adsorption experiments.

Recent progress in microbial biosurfactants production strategies: Applications, technological bottlenecks, and future outlook.

Biosurfactants are surface-active compounds produced by numerous microorganisms. They have gained significant attention due to their wide applications in food, pharmaceuticals, cosmetics, agriculture, and environmental remediation. The production efficiency and yield of microbial biosurfactants have improved significantly through the development and optimization of different process parameters.

Molecular characterization of recombinant citrus yellow mosaic badnavirus infecting Coorg mandarin exhibiting yellow mosaic disease symptoms in high humid tropic region of Western Ghats.

Unlabelled: The citrus yellow mosaic badnavirus (CMBV) is one of the most important viruses causing yellowing and declining in different species. The Coorg mandarin, pomelo and grapefruit showing the yellow mosaic disease symptoms were collected from different famers field during the survey. Further viral pathogenicity was confirmed through grafting on Rangpur lime as root stock.

InVO-Decorated TiC MXene for Efficient Photocatalytic Hydrogen Evolution.

The generation of hydrogen through photocatalysis is a fascinating technology for addressing environmental concerns and the energy crisis. Nevertheless, the quest for cost-effective, stable, and efficient photocatalysts in the realm of energy conversion remains a significant challenge. Herein, we designed novel InVO/TiC MXene (IVTC) heterostructures by employing acid etching to produce TiC MXene with an accordion-like morphology, using the hydrothermal technique for the production of orthorhombic InVO nanoparticles (NPs), and integrating them through a self-assembly approach.

Synthesis of fluorinated spiro-1,3-oxazines and thiazines Selectfluor-mediated intramolecular cyclization.

A fluorination-induced intramolecular cyclization for the synthesis of fluoro-substituted spiro-1,3-oxazine and spiro-1,3-thiazine derivatives is described. -(2-(Cyclohex-1-en-1-yl)ethyl)benzamide and benzothioamide are used as the substrates, and the cationic fluorinating agent Selectfluor works as the fluoride source. The reaction yields a single diastereomer.

Ultrasensitive and selective colorimetric and smartphone-based detection of arsenic ions in aqueous solution using alliin-chitosan-AgNPs.

In this study, we developed a highly selective and sensitive colorimetric sensor for arsenic [As(iii)] detection using alliin-chitosan-stabilized silver nanoparticles (AC-AgNPs). The AC-AgNPs were synthesized using a complex prepared by mixing aqueous garlic extract containing alliin and chitosan extracted from shrimp. The synthesis of AC-AgNPs was confirmed by UV-vis spectroscopy, which showed a surface plasmon resonance (SPR) band at 403 nm, and TEM analysis revealing spherical nanoparticles with a mean diameter of 7.

Estimation of environment stability for fruit yield and capsaicin content by using two models in Jacq. (Ghost Pepper) with multi-year evaluation.

Background: Jacq. (Ghost Pepper) is well-known for its high pungency and pleasant aroma. The recent years witnessed a significant decline in popularity of this important crop due to the use of inferior planting material and lack of elite lines.

Heterogeneous Iron-Based Catalysts for Organic Transformation Reactions: A Brief Overview.

Iron (Fe) is considered to be one of the most significant elements due to its wide applications. Recent years have witnessed a burgeoning interest in Fe catalysis as a sustainable and cost-effective alternative to noble metal catalysis in organic synthesis. The abundance and low toxicity of Fe, coupled with its competitive reactivity and selectivity, underscore its appeal for sustainable synthesis.

Externally supplied ascorbic acid moderates detrimental effects of UV-C exposure in cyanobacteria.

The defensive role performed by exogenously supplied ascorbic acid in the cyanobacterium Nostoc muscorum Meg1 against damages produced by UV-C radiation exposure was assessed in this study. Exposure to UV-C (24 mJ/cm) significantly enhanced reactive oxygen species (ROS) (50%) along with peroxidation of lipids (21%) and protein oxidation (22%) in the organism. But, addition of 0.

Magnetic engineering nanoparticles: Versatile tools revolutionizing biomedical applications.

The use of nanoparticles has increased significantly over the past few years in a number of fields, including diagnostics, biomedicine, environmental remediation, and water treatment, generating public interest. Among various types of nanoparticles, magnetic nanoparticles (MNPs) have emerged as an essential tool for biomedical applications due to their distinct physicochemical properties compared to other nanoparticles. This review article focuses on the recent growth of MNPs and comprehensively reviews the advantages, multifunctional approaches, biomedical applications, and latest research on MNPs employed in various biomedical techniques.

Delineating the Acquired Genetic Diversity and Multidrug Resistance in Alcaligenes from Poultry Farms and Nearby Soil.

Alcaligenes faecalis is one of the most important and clinically significant environmental pathogens, increasing in importance due to its isolation from soil and nosocomial environments. The Gram-negative soil bacterium is associated with skin endocarditis, bacteremia, dysentery, meningitis, endophthalmitis, urinary tract infections, and pneumonia in patients. With emerging antibiotic resistance in A.

Eryngial: An α,β-Unsaturated Fatty Aldehyde as the Major Phytotoxin in Spiny Coriander (Eryngium foetidum L.) Essential Oil.

Weed species many times possess allelochemicals as a part of their survival strategy. These metabolites can be potential targets in search of natural phytotoxins. This study aims to evaluate the phytotoxic ability of fatty aldehyde-rich essential oil from spiny coriander (Eryngium foetidum) leaves, also known as fitweed or spiritweed and to further identify the active phytotoxins.