FDA-approved polypeptide PTH 1-34 impedes palmitic acid-mediated osteoblasts dysfunction by promoting its differentiation and thereby improving skeletal health.

Excessive consumption of saturated fatty acids creates a debilitating cellular environment that hinders the normal function and survival of osteoblasts, contributing to bone metabolic disorders such as osteoporosis. The FDA-approved polypeptide PTH 1-34 is a well-established therapy for post-menopausal osteoporosis, yet its protective effects in a palmitic acid (PA)-rich hyperlipidemic environment are not well understood. This study investigates the impact of PTH 1-34 on PA-induced cellular responses in osteoblasts.

Assessment of azithromycin-induced toxicity in : Effects on morphology, behavior, and lipid metabolism.

Antibiotics are indispensable in modern healthcare, playing a critical role in mitigating bacterial infections. Azithromycin is used to fight upper respiratory tract infections, however has potential toxic effects that remain inadequately understood. In our present study, azithromycin exposure to led to significant physiological and behavioral change, with pronounced effects observed at the studied concentration.

Broadband Excited YAlO:Cr, Er Phosphors for Enhancing the Spectral Response of GaSb Solar Cell.

We report Er emission in YAlO host, sensitized by Cr. The excitation bands of Cr at 416 and 555 nm are broad and effectively cover the region 400-600 nm. The phosphor can be useful for converting 400-600 nm radiations to infrared (IR) light around 1521 nm.

Probing the synergistic effect of metal-organic framework derived Co-Nx rich interwoven hierarchical porous carbon tube encapsulated dual redox active nanoalloy for high-performance Zn-air battery and supercapacitor applications.

Rechargeable zinc-air batteries (ZABs) with high-performance and stability is desirable for encouraging the transition of the technology from academia to industries. However, achieving this balance remains a formidable challenge, primarily due to the requirement of robust, earth-abundant reversible oxygen electrocatalyst. The present study introduces a simple strategy to synthesize Co-N rich nanoalloy with N-doped porous carbon tubes (NiCo@NPCTs).

Macrobenthic assemblages of anthropogenically active subtidal zones contiguous to a marine protected area: a 9-year revisit.

Traditional taxonomical methods, an appropriate Benthic Biotic Index incorporating the Taxonomical Sufficiency concept and Biological Traits Analyses, were applied concurrently to evaluate the long-term variations in the benthic ecology of subtidal zones of a Marine-Protected Area subjected to prevalent oil and gas industrial activities. Our evaluation spanned two comparable surveys conducted 9 years apart (2010 vs. 2019).

Overexpression of in Potato Enhances Tolerance to Drought Stress.

Calcium-dependent protein kinases (CDPKs), which are activated by transient changes in the Ca concentration in plants, are important for various biological processes, such as growth, development, defense against biotic and abiotic stresses, and others. Mannitol is commonly used as an osmotic regulatory substance in culture medium or nutrient solutions to create water-deficit conditions. Here, we cloned the potato ( L.

Testcross performance and combining ability of intermediate maturing drought tolerant maize inbred lines in Sub-Saharan Africa.

Drought is a major constraint on maize ( L.) production and productivity in Sub-Saharan Africa (SSA). The increase in frequency and severity of drought, driven by climate change, is expected to worsen in the future.

Antibiotic Resistance Dissemination and Mapping in the Environment Through Surveillance of Wastewater.

Antibiotic resistance is one of the major health threat for humans, animals, and the environment, according to the World Health Organization (WHO) and the Global Antibiotic-Resistance Surveillance System (GLASS). In the last several years, wastewater/sewage has been identified as potential hotspots for the dissemination of antibiotic resistance and transfer of resistance genes. However, systematic approaches for mapping the antibiotic resistance situation in sewage are limited and underdeveloped.

Emerging alternative food protein sources: production process, quality parameters, and safety point of view.

The rise in the global population has increased the demand for dietary food protein. Strategies to maximize agricultural and livestock outputs could strain land and freshwater supply and contribute to substantial negative environmental impacts. Consequently, there has been an emphasis on identifying alternative sources of edible proteins that are more sustainable, sustainable, ethical, and healthy.

MYB proteins: Versatile regulators of plant development, stress responses, and secondary metabolite biosynthetic pathways.

MYB proteins are ubiquitous in nature, regulating key aspects of plant growth and development. Although MYB proteins are known for regulating genes involved in secondary metabolite biosynthesis, particularly phenylpropanoids, their roles in terpenoid, glucosinolate, and alkaloid biosynthesis remain less understood. This review explores the structural and functional differences between activator and repressor MYB proteins along with their roles in plant growth, development, stress responses, and secondary metabolite production.

Facile synthesis of size-tunable L-carnosine-capped silver nanoparticles and their role in metal ion sensing and catalytic degradation of -nitrophenol.

ʟ-Carnosine is a dipeptide with notable antioxidant, antiglycation, metal chelating, and neuroprotective properties. Despite its many biological roles, applying ʟ-carnosine as a capping agent in nanoparticle synthesis has remained underexplored. This study explores the potential of ʟ-carnosine in synthesizing tunable plasmonic silver nanoparticles (ʟ-car-AgNPs).

Dimethylamine Bismuth Iodide: A Lead-Free Perovskite Enabling Ultra-Sensitive UVC Photodetection with Low Operating Voltage and High Detectivity.

Ultraviolet (UV) photodetectors (PDs) are essential for various applications, but traditional materials face challenges in cost, fabrication, and performance. This study introduces dimethylamine bismuth iodide (DMABI) as a promising lead-free perovskite for UV PDs, particularly in the UVC region. DMABI demonstrates exceptional device parameters, including an ultralow dark current of 0.

Covalent Organic Frameworks for Photocatalysis.

The global energy crisis and environmental concerns are driving research into renewable energy and sustainable energy conversion and storage technologies. Solar energy, as an ideal sustainable resource, has significant potential to contribute to the goal of net-zero carbon emissions if effectively harnessed and converted into a reliable and storable form of energy. Photocatalysts have the potential to convert sunlight into chemical energy carriers.

Critical review on on-site sanitation technologies: Typologies, treatment and transition towards circular economy.

Around 4.2 billion people globally depend on on-site sanitation systems, with 43% relying on basic or unsafe facilities with key challenges of containment, emptying, transport, treatment and resource recovery from faecal sludge. This review paper critically examines faecal sludge characteristics and treatment technologies in terms of urine diversion capability, land requirements and capital as well as operational expenditure based on Indian and international practices.

Plant growth-promoting Bacillus amyloliquefaciens orchestrate homeostasis under nutrient deficiency exacerbated drought and salinity stress in Oryza sativa L. seedlings.

Nutrient deficiency intensifies drought and salinity stress on rice growth. Bacillus amyloliquefaciens inoculation provides resilience through modulation in metabolic and gene regulation to enhance growth, nutrient uptake, and stress tolerance. Soil nutrient deficiencies amplify the detrimental effects of abiotic stresses, such as drought and salinity, creating substantial challenges for overall plant health and crop productivity.

Interaction of VO-hydrazonates with lysozyme.

Vanadium compounds (VCs) exhibit a broad range of pharmacological properties, with their most significant medical applications being in the treatment of cancer and diabetes. The therapeutic effects and mode of action of VCs may be associated with their ability to bind proteins and, consequently, understanding the VC-protein interaction is of paramount importance. Among the promising VCs, the VO complex with the aroylhydrazone furan-2-carboxylic acid ((3-ethoxy-2-hydroxybenzylidene)hydrazide, hereafter denoted as VC1), deserves attention, since it exhibits cytotoxicity against various cancer cell lines, including HeLa.

Reduced-Graphene-Oxide-Based Thin Films: An Alternative Coating for Harsh Space Environments.

Polymeric materials are commonly used as the outermost layer in spacecraft passive thermal control. However, in geostationary earth orbit environments, the polymeric layer is susceptible to environmental hazards, particularly electrostatic charges. In this study, we develop a graphene-based coating on a polymeric polyimide (Kapton) and discuss its suitability in simulated harsh space environments for electrostatic dissipation.

Computational Simulation and Biophysical Study on Cerium Chloride-Induced B-to-Z Transition in (CG) DNA.

Rare earth elements have been shown to trigger the B-to-Z DNA transition in diverse self-assembled branched DNA architectures. Herein, we investigated the influence of cerium chloride on the conformational changes of DNA sequences containing repeated cytosine-guanine (CG) or guanine-cytosine (GC) sequences. The CD results show that (CG) repeats were susceptible to the formation of Z-DNA at low concentrations of CeCl.

Application of functional metagenomics in the evaluation of microbial community dynamics in the Arabian Sea: Implications of environmental settings.

Ocean microbial communities form the base of marine food webs, facilitating energy transfer and nutrient cycling, thereby supporting higher trophic levels. We investigated their composition and functional profiles across depths (surface waters 0, 29, and 63 m and bottom waters 100, 150, and 200 m) in the central-eastern Arabian Sea (CEAS) using next-generation sequencing. It was hypothesized that the composition and functional diversity of these communities would be influenced by depth and environmental parameters.

Antimicrobial resistance genes and associated mobile genetic elements in Escherichia coli from human, animal and environment.

The global rise of antimicrobial resistance (AMR) poses a significant threat to human health. The environment plays an essential role in transmission of antimicrobial resistance genes (ARGs) between human and animal. Bacterial communities harbour diverse ARGs, carried by mobile genetic elements (MGEs) like plasmids and insertion sequences (ISs).