Ni-Doped CsPbBr Perovskite: Synthesis of Highly Stable Nanocubes.

A nanocube of Ni-doped CsPbBrnanocrystals (NCs) has been successfully synthesized and characterized by various spectroscopy techniques such as High-resolution transmission electron microscopy (HR-TEM), field emission scanning electron microscopy (FE-SEM), X-ray photoelectron spectroscopy (XPS), etc. The optoelectronic properties of NCs have been investigated with different solvents. HR-TEM and FE-SEM reveal that the obtained Ni-doped CsPbBrNCs exhibit cubic-rectangular morphologies with different sizes.

Revealing sex-specific molecular changes in hypoxia-ischemia induced neural damage and subsequent recovery using zebrafish model.

Functional recovery from hypoxia-ischemia depends on an individual's response to the ischemic damage and recovery. Many of the neurological disorders, including cerebral stroke have sex-specific characteristics. Deciphering the differential molecular mechanisms of sex-specific recovery from hypoxic-ischemic insult can improve medical practice in the treatment of cerebral stroke.

Impact of A-D-A-Structured Dithienosilole- and Phenoxazine-Based Small Molecular Material for Bulk Heterojunction and Dopant-Free Perovskite Solar Cells.

Herein, the synthesis of the novel acceptor-donor-acceptor (A-D-A)-structured small molecule Si-PO-2CN based on dithienosilole (DTS) as building block flanked by electron-rich phenoxazine (POZ) units, which are terminated with dicyanovinylene, is presented. Si-PO-2CN showed unique electrochemical and photophysical properties and has been successfully employed in perovskite solar cells (PSCs) as well as in bulk heterojunction organic solar cells (OSCs). The PSCs fabricated with dopant-free Si-PO-2CN as hole-transport material (HTM) exhibited a power conversion efficiency (PCE) of 14.

Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice.

Arbutin is a glycoside reported for its anti-oxidant, anti-inflammatory and anti-tumor properties. However, the cardioprotective effect of Arbutin is not well established. The study aims to understand the effect of arbutin on isoproterenol (ISO)-induced cardiac hypertrophy in mice.

D-π-A-π-D Structured Diketopyrrolopyrrole-Based Electron Donors for Solution-Processed Organic Solar Cells.

Solution-processable D-π-A-π-D structured two organic small molecules bearing thienyl diketopyrrolopyrrole (TDPP) and furanyl diketopyrrolopyrrole (FDPP) as central acceptor units and cyano on the π-bridge and phenothiazine as the terminal donor units, coded as and , are designed and synthesized. The C-H arylation and Suzuki coupling protocols have been adopted for synthesizing the molecules. Solution-processed organic solar cells (OSCs) were constructed with these molecules as the donors and phenyl-C-butyric acid methyl ester as the acceptor yielding power conversion efficiencies (PCE) of 4.

Pyrazolo-benzothiazole hybrids: Synthesis, anticancer properties and evaluation of antiangiogenic activity using in vitro VEGFR-2 kinase and in vivo transgenic zebrafish model.

A series of new pyrazolo-benzothiazole hybrids (7-26) were synthesised and screened for their cytotoxic activity towards several cancer cell lines [colon (HT-29), prostate (PC-3), lung (A549), glioblastoma (U87MG)] and normal human embryonic kidney cell line (Hek-293T). Compounds 8, 9, 13, 14, 18, 19, 23, and 24 displayed significant activity, with compound 14 being particularly potent towards all the tested cancer cell lines with IC values in the range 3.17-6.

miR-30 Family miRNAs Mediate the Effect of Chronic Social Defeat Stress on Hippocampal Neurogenesis in Mouse Depression Model.

Depression is a debilitating psychiatric disorder with a high rate of relapse and a low rate of response to antidepressant treatment. There is a dearth of new antidepressants due to an incomplete understanding of the molecular mechanisms involved in its etiopathology. Chronic stress appears to be one of the foremost underlying causes of depression.

Design and synthesis of 4β-Acetamidobenzofuranone-podophyllotoxin hybrids and their anti-cancer evaluation.

A new series of amide derivatives of 4β-Acetamidobenzofuranone-podophyllotoxin hybrids (14a-g) were synthesized and their chemical structures were confirmed by H, C NMR and mass spectral data. Further, all the synthesized Acetamidobenzofuranone-podophyllotoxin hybrids were evaluated for in vitro cytotoxic activity against a panel of four human cancer cell lines i.e.

An innovative in situ method of creating hybrid dendrimer nano-assembly: An efficient next generation dendritic platform for drug delivery.

Dendrimers have proven to be effective for drug delivery and their biodisposition varies with change on their surface, generation and core. In an effort to understand the role of critical nanoscale design parameters, we developed a novel hybrid dendrimer approach to harness unique features of individual dendrimers and create a nano-assembly. We report an easy in situ method of creating hybrid dendrimer nano-assembly by mixing G4.

Novel trisaccharide based phospholipids as immunomodulators.

A focused library of novel mannosylated glycophospholipids was synthesized employing imidate coupling and H-phosphate phosphorylation methods. All novel glycophospholipids were evaluated for their receptor interactions by molecular docking studies. Docking studies revealed dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) specific interaction of the glycophospholipid ligand P4 acts, which was further confirmed by in vitro DC-SIGN expression on monocyte-derived dendritic cells (MoDCs).

Effectiveness of Solvent Vapor Annealing over Thermal Annealing on the Photovoltaic Performance of Non-Fullerene Acceptor Based BHJ Solar Cells.

We explore two small molecules containing arms of dicyano-n-hexylrhodanine and diathiafulvalene wings terminated with benzothiadiazole linker, denoted as BAF-4CN and BAF-2HDT, respectively, as small molecule non-fullerene acceptors (SMNFAs) in organic solar cells. The proposed materials are mixed with a low band gap polymer donor PTB7-Th having broad absorption in the range of 400-750 nm to form solution-processed bulk heterojunctions (BHJs). The photoluminescence (PL) measurements show that both donor and acceptor can quench each other's PL effectively, implying that not only electrons are transferred from PTB7-Th → SMNFAs but also holes are transferred from SMNFAs → PTB7-Th for efficient photocurrent generation.

Recent Progress and Emerging Applications of Rare Earth Doped Phosphor Materials for Dye-Sensitized and Perovskite Solar Cells: A Review.

Although the efficiency of Dye-sensitized and Perovskite solar cell is still below the performance level of market dominance silicon solar cells, in last few years they have grabbed significant attention because of their fabrication ease using low-cost materials, and henceforth these cells are considered as a promising alternative to commercial photovoltaic devices. However, third generation solar cells have significant absorption in the visible region of solar spectrum, which confines their power conversion efficiency. Subsequently, the performance of current photovoltaics is significantly hampered by the transmission loss of sub-band-gap photons.

Protective effect of galangin against dextran sulfate sodium (DSS)-induced ulcerative colitis in Balb/c mice.

Objective And Design: Inflammatory bowel disease (IBD) is known to cause chronic inflammation in the digestive tract by the immune malfunction. Herein, we demonstrate the protective effect of galangin (GAL), a phytochemical, on LPS-induced inflammation in cultured mouse macrophages (RAW 264.7) and the treatment of DSS-induced ulcerative colitis in Balb/c mice.

MACoBr: lead-free cobalt-based perovskite for electrochemical conversion of water to oxygen.

We have synthesized a lead-free stable organic-inorganic perovskite (MA2CoBr4) by using non-hazardous solvents such as methanol and ethanol, which are eco-friendly and safe to handle in comparison to DMF, toluene, etc. Single crystals of MA2CoBr4 were grown using a simple solution technique, and their electrochemical oxygen evolution was investigated in a wide pH range.

Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice.

Inflammatory bowel disease is an umbrella-term used to describe a set of chronic inflammatory conditions that affect the gastro-intestinal tract. Since most of the inflammatory medications in current use have several undesirable side-effects, stevioside, a naturally occurring, high-intensity sweetener was assessed in our study for its anti-inflammatory properties by in-vitro and in-vivo experiments. Stevioside was observed to significantly inhibit the levels of LPS induced elevation of cytokines, TNF-α (P < 0.

Synthesis and biological evaluation of new bisindole-imidazopyridine hybrids as apoptosis inducers.

A series of diindolylmethanes (5a-t) were designed, synthesized, and examined for their cytotoxicity against four human cancer cell lines like prostate (DU-145), lung (A549), breast (MCF-7) and cervical cancer (HeLa). These results revealed that among all the hybrids, two (5k and 5r) were identified and exhibited significant cytotoxic effect against A549 cancer cells with IC values of 1.65 ± 0.

Formulation and evaluation of cyclodextrin complexes for improved anticancer activity of repurposed drug: Niclosamide.

Niclosamide, previously used as an anthelmintic drug is currently being repurposed for its anticancer activity. Niclosamide is a brick like biopharmaceutical classification system (BCS) class II drug with poor aqueous solubility and dissolution consequently leading to low bioavailability. By considering the physicochemical properties and geometry of niclosamide, inclusion complex with cyclodextrin was prepared by freeze drying method and characterized using FT-IR, DSC, PXRD, and HNMR.

Metallated Macrocyclic Derivatives as a Hole - Transporting Materials for Perovskite Solar Cells.

Spiro-OMeTAD is widely used as thehole-transporting material (HTM) in perovskite solar cells (PSC), which extracts positive charges and protects the perovskite materials from metal electrode, setting a new world-record efficiency of more than 20 %. Spiro-OMeTAD layer engross moisture leading to the degradation of perovskite, and therefore, has poor air stability. It is also expensive therefore limiting scale-up, so macrocyclic metal complex derivatives (MMDs) could be a suitable replacement.

Planar Antiaromatic Core-Modified 24π Hexaphyrin(1.0.1.0.1.0) and 32π Octaphyrin(1.0.1.0.1.0.1.0) Bearing Alternate Hybrid Diheterole Units.

The Lewis acid catalyzed self-condensation of hybrid diheterole (furan-pyrrole and thiophene-pyrrole) precursors has afforded novel Hückel antiaromatic 24π hexaphyrin(1.0.1.

Synthesis of Benzo[d]imidazo[2,1-b]thiazole-Propenone Conjugates as Cytotoxic and Apoptotic Inducing Agents.

Background: Cancer can be considered as a disease in which normal cells start behaving badly, multiplying uncontrollably, ignoring signals to stop and accumulating to form a mass that is generally termed as a tumor. Apoptosis or programmed cell death is a physiological process that enables organisms to control their cell numbers in many developmental and physiological settings and to eliminate unwanted cells and it plays essential role in chemotherapy-induced tumor-cell killing. The correct balance between apoptosis and inhibition of apoptosis is important in animal development as well as in tissue homeostasis.

Solvent-Assisted Tuning of the Size and Shape of CsPbBr Nanocrystals via Redispersion Process at Ambient Condition.

All-inorganic CsPbBr perovskite nanocrystals are emerging as a new class of semiconductors with outstanding optoelectronic properties and great potential for various applications, such as, lasing, photon detection, photovoltaics, etc. This article provides the effect of solvents on the reprecipitation of CsPbBr perovskite at room temperature. The results observed for CsPbBr perovskite in various antisolvents showed various cubes (nano- to microsized), self-assembly of nanocubes and nanorods.

Stipulating Low Production Cost Solar Cells All Set to Retail…!

Today's solar cells are exceptionally in demand whilst excess exploitation of natural fossil fuels. In this context, the first and second generation solar cells commercially available in market for more than decades however limitations in production cost and large-scale applications insist to generate inexpensive materials for fabrication. Thereby, organic materials based solar cells explored and emerging as third generation solar cells which possess flexibility, low cost and large-scale applications.

Operational strategy of high rate anaerobic digester with mixed organic wastes: effect of co-digestion on biogas yield at full scale.

The present research work is aimed at providing an economically feasible solution for the farmers to exploit the mixed organic wastes (MOW) as resources for the generation of biogas based electrical power and utilize the same for irrigation purpose to reduce the dependence on electricity board. A full scale biomethanation plant has been installed based on anaerobic gas lift reactor (AGR) technology to analyse, understand the operational parameters of anaerobic digestion and assess the performance of a high rate biomethanation plant by co-digesting the MOW such as poultry litter (PL), cattle manure (CM) and napier grass (NG) at ambient temperature. The biomethanation plant was incorporated with inline pre and post-processing unit assembly.

IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo.

Autophagy is a homeostatic process that recycles damaged organelles and long-lived proteins by delivering them in double-membrane vesicles to lysosomes for degradation. Autophagy has a prominent role in survival, proliferation, and resistance of tumors in metabolic and chemotherapeutic stress conditions. Clinical trials with chloroquine-a known autophagy inhibitor-were unable to achieve complete autophagy inhibition in vivo, warranting the search for more potent autophagy inhibitors.