Excited-State Carrier Dynamics in Semiconducting Heterostructures from Self-Sorted NIR Active Dyes.

Heterostructures comprise two or more different semiconducting materials stacked either as co-assemblies or self-sorted based on their dynamics of aggregates. However, self-sorting in heterostructures is rather significant in improving the short exciton diffusion length and charge separation. Despite small organic molecules being known for their self-sorting nature, macrocyclic are hitherto unknown owing to unrestrained assemblies from extended π-conjugated systems.

Tuning the properties of soy protein isolate-based adhesive using various sustainable additives.

This work investigates the adhesive property of Soy Protein Isolate (SPI) polymer solution by studying mechanical properties of composites formed using waste wood granules and SPI solutions. To improve the adhesive strength of SPI solution, Carboxymethyl Cellulose Sodium (NaCMC) was mixed (in the weight ratios of 9:1 and 8:2) due to its strong gel formation capabilities. The adhesive performance of these composites was further investigated in the presence and absence of non-toxic additives, including sorbitol (SOR) and stearic acid (SA).

Transcriptomic Profiling Reveals Sex-Specific Epigenetic Dynamics Involving kdm6b and H3K27 Methylation in Cerebral Ischemia-Induced Neurogenesis and Recovery.

Cerebral ischemic stroke ranks among the leading causes of death and disability worldwide. A significant challenge, beyond the lack of effective therapies, is the frequent oversight of sex as a vital factor in stroke research. This study focuses on elucidating the sex-specific epigenetic mechanisms that contribute to neural damage and recovery in cerebral ischemia.

Effect of PVA-based films incorporated with postbiotics, flax seed mucilage and guar gum to enhance the postharvest quality of fig fruits.

Eco-friendly antimicrobial bio-composite films (BCF) were produced by using guar gum (GG), flax seed mucilage (FM) and polyvinyl alcohol (PVA), supplemented with cell-free supernatant (CFS) of Lactobacillus plantarum (L. p) and Lactobacillus delbrueckii (L. d) by the solvent casting technique.

Yohimbine treatment improves pulmonary fibrosis by attenuating the inflammation and oxidative stress via modulating the MAPK pathway.

Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disorder characterized by the accumulation of extracellular matrix and collagen, resulting in significant parenchymal scarring and respiratory failure that leads to mortality. Yohimbine (YBH) is an α-2 adrenergic receptor antagonist with anti-oxidant and anti-inflammatory properties. In the current study, we aimed to investigate the anti-inflammatory, anti-oxidant and anti-fibrotic activity of YBH against LPS/TGF-β-induced differentiation in BEAS-2B/LL29 cells and bleomycin (BLMN) induced pulmonary fibrosis model in rats.

Ambipolar macrocycle derived from spiro-xanthene and carbazole: synthesis, structure-property relationships, electronic properties and host-guest investigation.

For the first time, we present the detailed synthesis, photophysical, electrochemical, host-guest and charge transport properties of spiro[fluorene-9,9'-xanthene] (SFX) and carbazole macrocycle SPS-NR-02. The electron and hole transport values measured using the space charge limited current (SCLC) method resulted in ambipolar charge transport with an electron to hole mobility ratio of 0.39.

Glucosyltriazole amphiphile treatment attenuates breast cancer by modulating the AMPK signaling.

Breast cancer is the second most frequent cancer among women. Out of various subtypes, triple-negative breast cancers (TNBCs) account for 15% of breast cancers and exhibit more aggressive characteristics as well as a worse prognosis due to their proclivity for metastatic progression and limited therapeutic strategies. It has been demonstrated that AMP-activated protein kinase (AMPK) has context-specific protumorigenic implications in breast cancer cells.

Molecularly Engineered Multifunctional Bridging Layer Derived from Dithiafulavene Capped Spiroxanthene for Stable and Efficient Perovskite Solar Cells.

This study introduces a novel approach centered around the design and synthesis of an interfacial passivating layer in perovskite solar cells (PSCs). This architectural innovation is realized through the development of a specialized material, termed dithiafulvene end-capped Spiro[fluorene-9,9'-xanthene], denoted by the acronym AF32. In this design architecture, dithiafulvene is thoughtfully attached to the spiroxanthene fluorene core with phenothiazine as the spacer unit, possessing multiple alkyl chains.

Total Synthesis and Revision of Stereochemistry of a Natural Benzo[]isochromene Stereodiad Isolated from .

This study presents a total synthesis and revision of the stereochemical configuration of the conformationally flexible natural product benzo[]isochromene stereodiad alongside its diastereomeric counterparts. The highlights of the synthesis are the TiCl-mediated diastereoselective aldol reaction, Pd-catalyzed lactonization, and Schmidt glycosidation. Our efforts using total synthesis disclosed herein proved that a previously assigned structure required revision.

Enhanced response of WO thin film through Ag loading towards room temperature hydrogen gas sensor.

This study investigates the enhancement of hydrogen gas-sensing performance by introducing silver (Ag) nanoparticles onto tungsten trioxide (WO) thin films. Herein, the WO thin films are deposited onto SiO/Si substrates using a sputtering technique and Ag nanoparticles are loaded onto the WO surface through a spin coating technique. To evaluate the sensing performance of a hydrogen gas, interdigitated titanium (Ti) electrodes are deposited onto the Ag:WO layer.

Uncovering Sex-Specific Epigenetic Regulatory Mechanism Involving H3k9me2 in Neural Inflammation, Damage, and Recovery in the Internal Carotid Artery Occlusion Mouse Model.

Cerebral ischemic stroke is one of the foremost global causes of death and disability. Due to inadequate knowledge in its sequential disease mechanisms, therapeutic efforts to mitigate acute ischemia-induced brain injury are limited. Recent studies have implicated epigenetic mechanisms, mostly histone lysine acetylation/deacetylation, in ischemia-induced neural damage and death.

Silver Nanoparticles Induced Metabolic Perturbations in : Evaluation Using the UPLC-QTof-MS Platform.

Silver nanoparticles (AgNPs) have been widely utilized in various biomedical and antimicrobial technologies, displaying broad-spectrum activities against Gram-negative and Gram-positive bacteria including multidrug-resistant strains. However, the emergence of resistance to AgNPs upon repeated exposure and the survival of bacteria after initial exposure to antimicrobial agents pose a threat, as they may lead to the development of new resistant populations. To combat the early stages of antibacterial resistance, systematic analysis is essential to understand the immediate response of bacteria to antimicrobial agents.

Design, synthesis and biological evaluation of novel cationic liposomes loaded with melphalan for the treatment of cancer.

Therapeutically active lipids in drug delivery systems offer customization for enhanced pharmaceutical and biological effects, improving safety and efficacy. Biologically active N, N-didodecyl-3,4-dimethoxy-N-methylbenzenaminium lipid (Q) was synthesized and employed to create a liposome formulation (FQ) encapsulating melphalan (M) through a thin film hydration method. Synthesized cationic lipids and their liposomal formulation underwent characterization and assessment for additive anti-cancer effects on myeloma and melanoma cancer cell lines.

Optimization of biomethane production from sweet sorghum bagasse using artificial neural networks combined with particle swarm algorithm.

In the face of international movement away from fossil fuels caused pollution menace, many research labs are rushing towards next big breakthrough via effective biorefinery development employing non-edible agro-residues as feedstock. This work aims to evaluate and optimize the methane potential of underutilized full strength sweet sorghum bagasse (SSB) via anaerobic digestion (AD). Biochemical methane potential assays are set up for SSB AD under mesophilic and thermophilic conditions at four substrate-o-inoculum ratios (SIR) 3, 5, 7, and 9 with pH 6.

Conducting 1D nanostructures from light-stimulated copper-metalated porphyrin-dibenzothiophene.

Control over the dimensionality of stimulated organic semiconductors has aroused significant interest in organic electronics; however, the design of such materials still remains to be decided. Herein, we have developed three dibenzothiophene-appended freebase, zinc-metalated and copper-metalated porphyrin derivatives (PFb-DBT, PZn-DBT and PCu-DBT) in which PCu-DBT leads to an anion-binding complex in chloroform upon the application of light, resulting in self-assembled 1D nanostructures with high electrical conductivity. Nevertheless, light-stimulated freebase and zinc-metalated P-DBT undergo protonation and demetalation.

All-Inorganic Lead-Free Doped-Metal Halides for Bright Solid-State Emission from Primary Colors to White Light.

Metal halides have been explored with the aid of strong photoluminescence for optical and optoelectronic applications. However, the preparation of lead (Pb)-free solid-state emitters with high photoluminescence quantum yields (PLQYs) and tunable emission remains exceptionally challenging. Herein, we report metal ion (Cu(I), Mn(II), and Sn(II))-doped CsZnI single crystals that are primary color (violet, green, and orange/red) emitters with extremely high PLQYs.

Diaryl ether derivative inhibits GPX4 expression levels to induce ferroptosis in thyroid cancer cells.

Papillary thyroid carcinoma contributes to about 80% of the total thyroid cancer cases. BRAF is a frequently occurring mutation in PTCs. Although several BRAF inhibitors are available, many thyroid cancer patients acquire resistance to BRAF inhibitors.

Design and In Vitro Evaluation of Novel Cationic Lipids for siRNA Delivery in Breast Cancer Cell Lines.

Breast cancer is the most common cause of cancer mortality in Western nations, with a terrible prognosis. Many studies show that siRNA plays a role in the development of tumors by acting as a tumor suppressor and apoptosis inhibitor or both. siRNAs may be used as diagnostic and prognostic biomarkers in breast cancer.

Hypoxia Induced Sex-Difference in Zebrafish Brain Proteome Profile Reveals the Crucial Role of H3K9me3 in Recovery From Acute Hypoxia.

Understanding the molecular basis of sex differences in neural response to acute hypoxic insult has profound implications for the effective prevention and treatment of ischemic stroke. Global hypoxic-ischemic induced neural damage has been studied recently under well-controlled, non-invasive, reproducible conditions using a zebrafish model. Our earlier report on sex difference in global acute hypoxia-induced neural damage and recovery in zebrafish prompted us to conduct a comprehensive study on the mechanisms underlying the recovery.

Ionic Liquids Modulating CsPbI Colloidal Quantum Dots Enable Improved Mobility for High-Performance Solar Cells.

Colloidal all-inorganic CsPbI perovskite quantum dots (PQDs) have shown tremendous potential in photovoltaic applications in recent years due to their outstanding optoelectronic properties that general metal halide perovskites offer, along with the added advantages that originates from size reduction and the quantum confinement effect. However, the issue of low carrier mobility in PQD films caused by insulating organic ligands capped on the PQD surface still remains to be addressed while aiming for high-efficiency PQD solar cells. Herein, we propose a novel strategy that takes benefits of ionic liquids, which can offer the high polarity and the electron donating ability to boost the mobility of PQD films in photovoltaic devices.

Co-encapsulated nanoparticles of Erlotinib and Quercetin for targeting lung cancer through nuclear EGFR and PI3K/AKT inhibition.

Erlotinib-based EGFR targeted therapy has proven significant clinical improvement against non-small cell lung cancer (NSCLC). However, the anticancer activity of Erlotinib (Ertb) is limited by the development of Ertb resistance and possess a challenge to clinicians and patients. To explore a better therapeutic strategy, we evaluated Ertb in combinations with different natural products.

1D alignment of Co(II) metalated porphyrin-napthalimide based self-assembled nanowires for photocatalytic hydrogen evolution.

The splitting of water into hydrogen and oxygen under visible light is an emerging phenomenon in green energy technology. Nevertheless, selecting an appropriate photocatalyst is rather significant to enhance hydrogen production on a large scale. In this context, organic photocatalysts have received considerable attention owing to their larger surface area, control in diffusion adsorption, nanostructures and electronic properties.