2,587 results match your criteria: "CSIR─Indian Institute of Integrative Medicine[Affiliation]"
ACS Infect Dis
January 2024
Natural Product & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Canal Road, Jammu 180001, India.
Antimicrobial resistance (AMR) is one of the most challenging problems and is responsible for millions of deaths every year. We therefore urgently require new chemical entities with novel mechanisms of action. Phytocannabinoids have been adequately reported for the antimicrobial effect but not seriously pursued because of either stringent regulatory issues or poor drug-like properties.
View Article and Find Full Text PDFJ Appl Microbiol
December 2023
Fermentation and Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India.
Aims: Citrus limon (lemon) is a widely cultivated citrus fruit. Significant postharvest losses due to fungi plague its production. Environmental and human health hazards have made the application of synthetic fungicides unsuitable.
View Article and Find Full Text PDFChem Commun (Camb)
December 2023
Bioorganic Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Srinagar, Jammu & Kashmir 190005, India.
An efficient strategy towards stereoselective amidation of alkynes is reported. The given method features operational simplicity, excellent functional group tolerance, broad substrate scope and fast kinetics to furnish -enamides. Moreover, the method was successfully applied for the facile synthesis of the natural products lansiumamide A, lansiumamide B and -alatamide.
View Article and Find Full Text PDFChem Biol Interact
January 2024
Laboratory of Neuropathology and Neuropharmacology, Department of Neurology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201500, China; Institute of Neurology, Institutes of Integrative Medicine, Fudan University, Shanghai 201500, China. Electronic address:
Baicalin, a potent anti-oxidative and anti-inflammatory flavonoid compound derived from Scutellaria baicalensis, has emerged as a neuroprotective agent. However, the mechanisms by which baicalin is neuroprotective in Parkinson's disease (PD) remain unclear. In this research, α-syn/MPP and MPTP were used to establish PD models in BV2 cells and C57BL/6 mice, respectively.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
June 2024
Graduate School, Tianjin Medical University, Tianjin, China.
Induction of cancer cell death is an established treatment strategy, but chemotherapy drug-mediated apoptosis can be evaded by many tumors. Pyroptosis is a type of inflammatory programmed cell death (PCD) that is important for organism immunity. Tubeimoside-I (TBMS1) is a plant-derived component that exhibits antitumor activity.
View Article and Find Full Text PDFInt J Biol Macromol
January 2024
Infectious Diseases Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
Leishmaniasis, caused by a protozoan parasite, is among humanity's costliest banes, owing to the high mortality and morbidity ratio in poverty-stricken areas. To date, no vaccine is available for the complete cure of the disease. Current chemotherapy is expensive, has undesirable side effects, and faces drug resistance limitations and toxicity concerns.
View Article and Find Full Text PDFPhytomedicine
January 2024
Shanghai Key Laboratory of Visual Impairment and Restoration, Eye & ENT Hospital, Fudan University, Shanghai 200031, China. Electronic address:
Background: Echinacoside (ECH), a natural active compound, was found to exert neuroprotection in Parkinson's disease (PD). However, the underlying molecular mechanisms remain controversial.
Purpose: This study aimed to explore the roles of ECH in PD and its engaged mechanisms.
Metabolites
October 2023
Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian 116000, China.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. The in-depth study of genes and metabolites related to nucleotide metabolism will provide new ideas for predicting the prognosis of HCC patients. This study integrated the transcriptome data of different cancer types to explore the characteristics and significance of nucleotide metabolism-related genes (NMGRs) in different cancer types.
View Article and Find Full Text PDFInt J Pharm
January 2024
PK-PD Tox & Formulation Section, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
Gemcitabine (GEM) is an important chemotherapeutic agent used alone or in combination with other anticancer agents for the treatment of various solid tumors. In this study, the potential of a dietary supplement, α-tocopherol succinate (TOS) was investigated in combination with GEM by utilizing human serum albumin-based nanoparticles (HSA NPs). The developed nanoparticles were characterized using DLS, SEM and FTIR and evaluated in a panel of cell lines to inspect cytotoxic efficacy.
View Article and Find Full Text PDFInt Immunopharmacol
January 2024
Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
Koenimbine (1), a carbazole alkaloid isolated from Murraya koenigii, belongs to the Rutaceae family. Various pharmacological effects such as anti-diabetic, melanogenesis inhibition, anti-diarrheal, anti-cancer, and anti-inflammatory properties of koenimbine have already been reported. In the current study, we investigated the anti-inflammatory role of koenimbine (1) and its novel semi-synthetic derivative 8-methoxy-3,3,5-trimethylpyrano[3,2-a] carbazole-11(3H)-yl) (3-(trifluoromethyl) phenyl) methanone (1G) in both in vitro and in vivo biological systems.
View Article and Find Full Text PDFClin Transl Sci
January 2024
Department of Emergency Internal Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
In a previously published clinical trial, we demonstrated that tirofiban was effective and safe in acute ischemic stroke (AIS) patients who did not undergo early recanalization treatments. We aimed to evaluate neuroimaging characteristics and their clinical significance to guide tirofiban treatment. In this post hoc analysis, location of infarcts (anterior circulation stroke [ACS] vs.
View Article and Find Full Text PDFACS Omega
November 2023
Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
In the present study, a series of benzotriazole-based β-amino alcohols were efficiently synthesized in excellent yields via aminolysis of benzotriazolated epoxides under catalyst- and solvent-free conditions. Further these β-amino alcohols were successfully utilized to synthesize the corresponding benzotriazole-based oxazolidine heterocyclic derivatives. All the synthesized compounds were characterized by various spectroscopic techniques such as H NMR, C NMR, and mass spectroscopy for structure elucidation.
View Article and Find Full Text PDFFitoterapia
January 2024
Tianjin NanKai Hospital, Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Integrative Medicine for Acute Abdominal Diseases, No. 6 Changjiang Road, Nankai District, Tianjin 300100, China. Electronic address:
Cholelithiasis is a common and frequently occurring disease worldwide that belongs to the category of jaundice in traditional Chinese medicine. Yinchenhao decoction (YD) consists of Artemisia capillaris Thunb., Gardenia jasminoides J.
View Article and Find Full Text PDFOrg Lett
November 2023
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.
A mild electron donor-acceptor complex-mediated approach for the synthesis of -acyl--hemiacetals has been reported. The key feature of this protocol is that it allows for direct access to electrophilic -acylimines at room temperature without prefunctionalization of the hydroxyl group. The generated -acylimine can react with different nucleophiles, viz.
View Article and Find Full Text PDFChin Med
November 2023
Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Background: In this study, we aimed to combine transcriptomic and network pharmacology to explore the crucial mRNAs and specific regulatory molecules of Buyang Huanwu Decoction (BYHWD) in intracerebral hemorrhage (ICH) treatment.
Methods: C57BL/6 mice were randomly divided into three groups: sham, ICH, and BYHWD. BYHWD (43.
Environ Monit Assess
November 2023
Department of Chemical Engineering, Ujjain Engineering College, Ujjain, Madhya Pradesh, 456001, India.
The occurrence of pharmaceutical compounds in water is a rising issue in the environment. These drugs in the waste may be toxic to aquatic organisms and humans as they disrupt the endocrine system, cause genotoxicity, etc. Several techniques were used for the treatment of pharmaceutical wastewater, such as physical, chemical, physiochemical, and biological processes like adsorption, chemical coagulation, and activated sludge processes, but these techniques possess several merits and demerits, such as higher installation and operation costs.
View Article and Find Full Text PDFJ Tradit Chin Med
October 2023
Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
This study aims to provide evidence regarding whether Qingufei paidu decoction (, QFPD) treatment in the acute phase shows long-term benefits for coronavirus disease 2019-associated sequelae. The 10 databases will be retrieved. Every reference list of related trials and gray literature will be searched as well.
View Article and Find Full Text PDFComplement Med Res
February 2024
J S Āyurveda Mahāvidyālaya (JSAM), Nadiad, India.
Introduction: The effect of Ayurvedic therapy in type 2 diabetes (T2D) is well documented. For people with type 1 diabetes (T1D), there is little evidence on the applicability of Ayurvedic therapy. This case illustrates the course of Ayurvedic treatment in a person with T1D accompanied by peripheral arterial occlusive disease (PAOD).
View Article and Find Full Text PDFCase Rep Oncol
November 2023
NIIM Research, National Institute of Integrative Medicine, Melbourne, VIC, Australia.
Introduction: Colorectal cancer is the third most common cancer worldwide, with 25% of patients being diagnosed with metastatic disease, mostly in the liver, resulting in poor survival. Standard treatment of stage-IV colorectal cancer consists of primary tumour resection followed by chemotherapy.
Case Presentation: Here, we report on the treatment effectiveness using integrative therapies in a 52-year-old male with metastatic colon cancer and liver lesions to achieve stable partial remission with an overall high level of wellbeing.
Int J Mol Cell Med
January 2023
Department of Biotechnology, Panjab University, Chandigarh, India.
Leukemia is a type of cancer that affects the blood and bone marrow. Acute lymphoid leukaemia, also known as ALL, is regarded as one of the deadliest forms of cancer. Due to the rapid increase in various cancer cases and the development of resistance in cancer cells, it is necessary to identify novel lead molecules with more potent anticancer properties.
View Article and Find Full Text PDFCurr Top Med Chem
May 2024
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
The L. genus is a significant plant family in the Rosaceae group, consisting of around 200 species, primarily shrubs. In India, it has 37 species, most located in the Western Himalayan region of Jammu and Kashmir and Himachal Pradesh.
View Article and Find Full Text PDFNat Prod Res
December 2024
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Three new eudesmane type rare sesquiterpene lactone galactosides, costunosides A-C ( were isolated from the rhizomes of along with ten known compounds (). Costunosides A-C ( are the first example of naturally eudesmane glycosides containing a -galactopyranoside moiety. The structure and relative configurations of these compounds were established by comprehensive analysis of MS and, in particular 1D/2D NMR spectroscopic data.
View Article and Find Full Text PDFHeliyon
November 2023
Department of Biochemistry, College of Science, University of Jeddah, Jeddah, 23218, Saudi Arabia.
Herein, we report a novel, simple, specific, accurate and cost-friendly validated reverse phase-high performance liquid chromatographic (RP-HPLC) method for the quantification of second generation sulphonylurea based antidiabetic drug, glibenclamide (GLB) in rat plasma and its application to calculate pharmacokinetic parameters in wistar rats. The internal standard used was flufenamic acid. The chromatographic separation was conducted on C column (250 mm × 4.
View Article and Find Full Text PDFPeptides
December 2023
Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir 180001, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
The current work demonstrates the synthesis and characterization of piperic acid conjugates with homochiral/heterochiral dipeptides containing phenylalanine as anti-skin cancer agents. The conjugates PA-Phe-Phe-OH, FC-1; PA-Phe-Phe-OH, FC-2; PA-Phe-Phe-OH, FC-3; and PA-Phe-Phe-OH, FC-4 were synthesized, characterized and assessed for cytotoxicity against melanoma cell lines of human and murine origin. Among all, PA-Phe-Phe-OH (FC-3) conjugate was identified as a potential cytotoxic lead against melanoma cells by delineating the anti-proliferative and anti-migratory potential together with its anti-inflammatory potential against pro-inflammatory interleukins (IL-1β, IL-6, and IL-8).
View Article and Find Full Text PDFComplement Ther Med
December 2023
WissHom: Scientific Society for Homeopathy, Wallstraße 48, DE-06366 Koethen, Germany. Electronic address:
Background: Mainly due to the use of different inclusion criteria and quality assessments, systematic reviews (SRs) and meta-analyses (MAs) with homeopathic intervention studies (HOMIS) have shown inconsistent results. We aimed to build recommendations for "Summarizing evidence from Homeopathic Intervention Studies" (Sum-HomIS recommendations) in order to approach standardization.
Methods: Against the background of a framework-project to update the evidence from homeopathic intervention studies, we launched an expert panel on how to assess the quality of HOMIS and how to summarize evidence from HOMIS.