2 results match your criteria: "CSIC-SODERCAN-University of Cantabria)[Affiliation]"

The limb dorsoventral axis: Lmx1b's role in development, pathology, evolution, and regeneration.

Dev Dyn

September 2024

Department of Cellular and Molecular Signalling, Instituto de Biotecnología y Biomedicina de Cantabria (IBBTEC), CSIC-SODERCAN-University of Cantabria), Santander, Spain.

Article Synopsis
  • - The study highlights the importance of dorsoventral patterning in limb anatomy, which has not been as thoroughly researched as other developmental axes and involves key extensor and flexor muscles.
  • - It discusses how the transcription factor Lmx1b is crucial for determining dorsal limb characteristics and its role in conditions like Nail-Patella syndrome, bringing attention to genetic and molecular implications.
  • - The review also explores the connection between dorsoventral polarity and digit tip regeneration, aiming to encourage further investigation into this vital yet underrated aspect of limb function and evolution.
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Conjugation of DNA through a type IV secretion system (T4SS) drives horizontal gene transfer. Yet little is known on the diversity of these nanomachines. We previously found that T4SS can be divided in eight classes based on the phylogeny of the only ubiquitous protein of T4SS (VirB4).

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