Comprehensive Analysis of the NHX Gene Family and Its Regulation Under Salt and Drought Stress in Quinoa ( Willd.).

: Abiotic stresses such as salinity and drought significantly constrain crop cultivation and affect productivity. Quinoa ( Willd.), a facultative halophyte, exhibits remarkable tolerance to drought and salinity stresses, making it a valued model for understanding stress adaptation mechanisms.

Comparative Analysis of Complete Chloroplast Genomes and Phylogenetic Relationships of 21 Sect. ( L.) Plants.

: Section is the most diverse group in the genus L., and this group of plants has a long history of cultivation in China as popular ornamental flowers and oil plants. Sect.

Mutations Causing X-Linked Recessive Oligodontia with Variable Expression.

Background/objectives: The ectodysplasin A () gene, a member of the tumor necrosis factor ligand superfamily, is involved in the early epithelial-mesenchymal interaction that regulates ectoderm-derived appendage formation. Numerous studies have shown that mutations in the gene can cause X-linked ectodermal dysplasia (ED) and non-syndromic oligodontia (NSO). Accordingly, this study aimed to identify the causative genetic mutations of the gene.

Discovery and Characterization of Two Selective Inhibitors for a Mu-Class Glutathione S-Transferase of 25 kDa from Using Computational and Bioinformatics Tools.

Glutathione S-transferases (GSTs) are promising pharmacological targets for developing antiparasitic agents against helminths, as they play a key role in detoxifying cytotoxic xenobiotics and managing oxidative stress. Inhibiting GST activity can compromise parasite viability. This study reports the successful identification of two selective inhibitors for the mu-class glutathione S-transferase of 25 kDa (Ts25GST) from , named and , using a computationally guided approach.

Tracking the Prevalence of Antibiotic Resistance in Within the Spanish Poultry Industry: Insights from a One Health Approach.

/: Antimicrobial resistance (AMR) in species from poultry production represents a significant public health threat due to the potential transmission of AMR through the food chain. This study aimed to examine the relative prevalence, resistance patterns, and mannitol fermentation capacity of isolates from various poultry production systems in Spain over a seven-year period (2017-2023). : A total of 215 isolates were analyzed.

Evaluation of the Synergistic Antimicrobial Activity of Essential Oils and Cecropin A Natural Peptide on Gram-Negative Bacteria.

In an era dominated by the phenomenon of antibiotic resistance, it is increasingly important to look for alternatives to synthetic antibiotics. In light of these considerations, the synergistic use of essential oils and Antimicrobial Peptides (AMPs) seems a viable strategy. In this study, we assessed the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Fractional Inhibitory Concentration (FIC) of three Essential Oils (EOs): winter savory (), bergamot () and cinnamon () and of the insect antimicrobial peptide Cecropin A (CecA), alone and in combination with EOs, against two Gram-negative ATCC bacterial strains: and serovar Typhimurium.

Impact of Low Inclusion Rate of Olive Cake in Dairy Cow Rations on Uterine Health and Fertility Indices During Early Lactation.

Olive cake was incorporated at a low inclusion rate (3.7%) into the rations of dairy cows through partial substitution of maize, and its effects on milk production, general health, and fertility traits were investigated. Multiparous purebred Holstein dairy cows (n = 148) were divided into two groups: a treated group (n = 86) and a control group (n = 62).

Increasing Cattle Herd Size or Density in C Grass-Legume Meadows Reduces Dietary Quality.

Animal density is a grazing management decision implemented by managers that may reduce animal diet quality. Over three years, we collected herd-level cattle samples with varying animal numbers and densities across C grass-legume meadows near Powell, WY, USA. Paddocks ranged in size from 3 to 72 ha, cattle groups ranged from 80 to 370 animals, animal units (AUs; defined as heifers = 0.

Integrated Assessment of Productive, Environmental, and Social Performances of Adopting Low-Protein Diets Technology for Laying Hens.

China, the world's largest egg producer, faces challenges of protein feed shortages and nitrogen pollution from manure. Low-protein diets (LPDs) offer potential solutions, but their adoption by small-scale farmers is uncertain. This study used surveys, meta-analysis, life-cycle assessment, and life-cost analysis to address these gaps.

Alleviating -Induced Intestinal Lesions in Chickens Using the Xylanase Xyn10C and Its Binary Cocktail with a Protease.

infection can induce necrotic enteritis and lead to significant economic loss to the chicken industry. In this study, a xylanase (Xyn10C), which effectively promotes the growth of probiotics, and a protease, which degrades the biofilm of were analyzed for their ability to alleviate -induced necrotic enteritis in broiler chickens. A total of 300 male AA chickens were divided into five treatment groups (control, no enzyme and no challenge; Cp, no enzyme, challenge; Xyn, Xyn10C plus challenge; Xyn+Am, Xyn10C+Amylase plus challenge; Xyn+Ap, Xyn10C+Alkaline protease plus challenge).

A Survey of Parents' Perspective of Receiving a Developmental Diagnosis for Their Child.

Receiving a diagnosis, such as cerebral palsy (CP), can have lasting impacts on caregivers and families. Previous literature has described that caregivers wish to receive a diagnosis together, without delay, in a private, direct, honest, and sympathetic way. This study aimed to understand the experience of caregivers of children with cerebral palsy (CP) or similar conditions when receiving a diagnosis for their child.

Radiographic and Clinical Results of Combined Bone and Soft-Tissue Tailored Surgeries for Hip Dislocation and Subluxation in Cerebral Palsy.

Background/objectives: The aim of the study is to present middle-term results of tailored bone and soft-tissue surgeries in subluxated and dislocated hips in children affected by cerebral palsy.

Methods: A total of 87 medical records belonging to 73 children affected by CP, treated with combined soft-tissue releases, VDO, and pelvic osteotomy, were reviewed retrospectively. Radiological measurements of AI, RI, and NSA were obtained before surgery, postoperatively, at 12 and 24 months after surgery.

Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function.

Diabetes is a chronic metabolic disorder whose prevalence increases every year, affecting more than 530 million adults worldwide. Type 1 (T1D) and type 2 diabetes (T2D), the most common forms of diabetes, are characterized by the loss of functional pancreatic β-cells, mostly due to apoptosis. B-cell leukemia/lymphoma 2 (Bcl-2) and B-cell lymphoma-extra large (Bcl-xL), two anti-apoptotic proteins belonging to the Bcl-2 family, are crucial for regulating the intrinsic pathway of apoptosis.

Periodontal Indices as Predictors of Cognitive Decline: Insights from the PerioMind Colombia Cohort.

: Poor oral health and periodontitis have been epidemiologically linked to cognitive decline and mild cognitive impairment (MCI) in older adults. However, specific metrics directly linking these clinical signs are exceedingly limited. : To address this gap and develop novel tools to help clinicians identify individuals at risk of cognitive decline, we established the PerioMind Colombia Cohort, comprising elderly Colombian subjects who underwent comprehensive neurocognitive and periodontal evaluations.

The Effects of Synthetic Polymers on the Release Patterns of Bupivacaine Hydrochloride from Sodium Hyaluronate Hydrogels.

Background: Using hydrogels for the controlled release of drugs is beneficial for patients, who then receive the proper dose of the medicinal substance. In addition, the formulation can provide more consistent drug absorption while reducing the frequency of dosing.

Objectives: The aim of this investigation is to propose a novel HA (sodium hyaluronate)-based hydrogel for intra-articular injection doped with synthetic polymers and incorporated with bupivacaine hydrochloride (Bu) as a local anesthetic.

Physical Exercise Interventions Using Virtual Reality in Children and Adolescents with Cerebral Palsy: Systematic Review.

Background/objectives: Cerebral palsy (CP) is a neurological disorder that affects movement and posture. Physical activity (PA) is safe and crucial for healthy development; however, this population faces barriers that hinder its implementation. Virtual reality (VR) is an emerging and promising technology that promotes PA in young people with CP.

A simple new method to determine leaf specific heat capacity.

Background: Quantifying plant transpiration via thermal imaging is desirable for applications in agriculture, plant breeding, and plant science. However, thermal imaging under natural non-steady state conditions is currently limited by the difficulty of quantifying thermal properties of leaves, especially specific heat capacity (C). Existing literature offers only rough estimates of C and lacks simple and accurate methods to determine it.

Quality of life in idiopathic pulmonary fibrosis in Latin American countries.

Background: Idiopathic pulmonary fibrosis (IPF) is the most common Interstitial Lung Disease (ILD). It is characterized by dyspnoea and a progressive decline in lung function, which negatively affects life. This study aimed to evaluate Health-Related Quality of Life (HRQoL) in IPF patients in Latin American countries.

Morphological diversity variation of seed traits among 587 germplasm resources of Medicago Genus and 32 germplasm resources of Trigonella Genus.

Germplasm resources within the Medicago genus are highly regarded for their value as forage crops and their critical roles in nitrogen cycling, ecosystem restoration, and soil structure improvement. Therefore, understanding the diversity of seed morphology in this genus is essential for advancing its development and utilization. This study analyzed seed samples from 587 germplasm accessions representing 77 species within Medicago genus, as well as 32 accessions from 21 species within the closely related genus Trigonella.

Acoustic emission characteristics and damage constitutive model of fractured sandstone under uniaxial compression.

To investigate the statistical laws of acoustic emission energy (AEE) avalanche dynamics of sandstone under varying fracture lengths and dip angles, as well as to determine the relationship between acoustic emission (AE) parameters and damage variables, we studied the mechanical properties and AE characteristics of sandstone with a single fracture subjected to uniaxial compression with the aid of the Shimadzu AG-IS test system and the PCI-2 AE system. The AEE characteristics of fractured sandstone under load were analyzed based on the statistical method of avalanche dynamics, with emphasis on AEE distribution, aftershock sequence, and waiting time distribution. The Weibull distribution function that incorporates a correction coefficient β was employed to optimize the Weibull parameters based on the strain equivalent hypothesis theory, which led to the establishment of a statistical damage constitutive model for fractured rock.

Identifying time patterns in Huntington's disease trajectories using dynamic time warping-based clustering on multi-modal data.

One of the principal goals of Precision Medicine is to stratify patients by accounting for individual variability. However, extracting meaningful information from Real-World Data, such as Electronic Health Records, still remains challenging due to methodological and computational issues. A Dynamic Time Warping-based unsupervised-clustering methodology is presented in this paper for the clustering of patient trajectories of multi-modal health data on the basis of shared temporal characteristics.

Morphological evidence of gregarines (Phylum: Apicomplexa) in Triatoma dimidiata, Chagas disease vector in Mexico: Rediscovering Machadoella triatomae and a new intestinal gregarine.

The objective of this study was to morphologically characterize the structures suggestive of gregarines found in the feces of Triatoma dimidiata collected in five municipalities in Yucatan, Mexico. Three hundred ninety-six specimens of T. dimidiata collected during 2022 and 2023 were analyzed, of which 8.

Real-world treatment patterns and clinical characteristics in patients with moderate-to-severe systemic lupus erythematosus: an analysis of the SLE Prospective Observational Cohort Study (SPOCS).

Objectives: Systemic lupus erythematosus (SLE) is a disease with heterogeneous treatment patterns largely based on organ involvement and disease severity. The SLE Prospective Observational Cohort Study (SPOCS) collected data worldwide over 3 years from patients with moderate-to-severe SLE. We report real-world patterns of medication use in patients enrolled in SPOCS.

Risk assessment of chlorophenols (CPs) exposure in vitro:Inhibition of sulfotransferases (SULTs) activity.

Chlorophenols (CPs) are common organic pollutants widely used in many industries. The current study seeks to examine the inhibition of sulfotransferases (SULTs) by CPs. Four SULT isoforms were significantly inhibited by multiply CPs.

Development and temporal-validation of prognostic models for 5-year risk of pneumonia, respiratory failure/collapse, and fracture among adults with cerebral palsy.

Purpose: Pneumonia, respiratory failure, and fracture are common and highly burdensome for adults with cerebral palsy (CP). To date, there are no clinically friendly tools to assess individualized risk of these outcomes for adults with CP. The objective was to develop and validate prognostic models for 5-year risk of pneumonia, respiratory failure/collapse, and fracture for adults with CP.