Early developmental trajectories of the impaired hand in infants with unilateral cerebral palsy.

Aim: To identify developmental trajectories of impaired hand function in infants aged 3 to 15 months with unilateral cerebral palsy (CP).

Method: Sixty-three infants (37 male; median gestational age 37 weeks [interquartile range 30-39.1 weeks]) recruited as part of a randomized trial with a confirmed diagnosis of unilateral CP were included.

Prevalence of and risk factors for osteoporosis and fragility fracture in adults with cerebral palsy: A systematic review.

Aim: To systematically review the prevalence and incidence of osteoporosis, osteopenia, low bone mass, and fragility fracture in adults with cerebral palsy (CP), and identify the risk factors for osteoporosis and fracture.

Method: A systematic literature search was performed in the MEDLINE, PubMed, CINAHL, AMED, Cochrane Reviews, EMBASE, and EBM database reviews from inception until May 2024. Search terms covered a combination of keywords for CP, fracture, osteoporosis, incidence and prevalence, and risk factors.

The role of laminins in cancer pathobiology: a comprehensive review.

Laminins (LMs) are a family of heterotrimeric glycoproteins that form the structural foundation of basement membranes (BM). By acting as molecular bridges between cells and the extracellular matrix (ECM) through integrins and other surface receptors, they regulate key cellular signals that influence cell behavior and tissue architecture. Despite their physiological importance, our understanding of the role of LMs in cancer pathobiology remains fragmented.

Effectiveness of a 2-dose varicella vaccination program in Changzhou, China, during the transitional period (2017-2022): a registry-based case-cohort study.

Background: The benefits of improving coverage and timeliness of varicella vaccination need to be quantified in countries where varicella vaccine (VarV) has not yet been included in national immunization programs. This longitudinal study analyzed the vaccine effectiveness (VE) of the varicella vaccination program implemented in Changzhou City during the transitional period (2017-2022).

Methods: Using the Immunization Information System and National Notifiable Infectious Disease Surveillance System registry data, this retrospective case-cohort study assessed the VEs of varicella vaccination for Changzhou children born from 2016 to 2021.

Clinical value of miR-200b in diagnosis and prognosis of childhood pneumonia.

Background: Childhood pneumonia (CP) is a common respiratory infectious disease in children with high morbidity and mortality. However, differential changes in miRNAs may interact with the regulation of CP. The aim of this paper was to discuss the miR-200b expression in CP and its diagnostic and prognostic value.

Changes in microbiome composition during ontogeny and dispersal of the coral boring sponge Thoosa mismalolli.

Dispersal is an important life history trait that plays a key role in the demography and evolution of species. We employed a combined approach of DNA sequencing and transmission electron microscopy to examine the changes in the microbiome during the ontogeny and dispersal of the coral-excavating sponge Thoosa mismalolli. The results show that sponge can acquired their associated bacteria via both vertical (VT) and horizontal transmission (HT).

Prepartum supplementation of Ascophyllum nodosum meal or ethylenediamine dihydroiodide: Effects on colostrum yield and growth and health of dairy calves.

We aimed to evaluate the effects of prepartum supplementation of different I sources (Ascophyllum nodosum [ASCO] meal and ethylenediamine dihydroiodide [EDDI]) on colostrum yield of cows, and blood concentrations of glucose, BHB, and thyroid hormones and growth of dairy calves. Forty multiparous Holstein cows were blocked by lactation number and expected calving date and assigned to 1 of 4 treatments 28 d before parturition: (1) EDDI supplemented (11 mg/d) to a basal diet to meet the NRC (2001) I concentration of 0.5 mg of I/kg of DMI (control = CON [0 g/d of ASCO meal]; actual I concentration = 0.

The FIRE biosensor illuminates iron regulatory protein activity and cellular iron homeostasis.

On Earth, iron is abundant, bioavailable, and crucial for initiating the first catalytic reactions of life from prokaryotes to plants to mammals. Iron-complexed proteins are critical to biological pathways and essential cellular functions. While it is well known that the regulation of iron is necessary for mammalian development, little is known about the timeline of how specific transcripts network and interact in response to cellular iron regulation to shape cell fate, function, and plasticity in the developing embryo and beyond.

Spatial variability and context-dependence of fouling communities in recreational marinas: A study in the Western Mediterranean with a focus on non-indigenous species (NIS).

Fouling communities were studied in twenty-six recreational marinas located along the continental and island coasts of Tuscany as well as Corsica (Western Mediterranean), focusing on the occurrence of non-indigenous species (NIS), in order to assess the variability of these assemblages at different spatial scales. Among the 560 taxa identified, 32 were alien or cryptogenic, with six new records for the study area. Results of this survey showed remarkable spatial variability of fouling community structure and NIS assemblage i) between marinas located on the mainland with respect to those on the islands (sectors), ii) among marinas within the same sector, and iii) among areas within the most of marinas.

Factors associated with sarcopenia in a population of non-disabled older patients.

Background And Aim: To evaluate the association between sarcopenia and metabolic syndrome.

Patients And Methods: A case-control study.

Setting: Geriatric Care Clinic of Metepec (México).

Investigating polychlorinated alkanes in technical chlorinated paraffin mixtures and polymer products available in Vietnam.

Chlorinated paraffins (CPs) are chemical additives mostly composed of polychlorinated alkanes (PCAs) which may impact on the environment and human health; however, little is known about their presence in Southeast Asia. To fill this knowledge gap, we assessed 74 PCA homolog groups commonly referred to as short-chain (SCCPs: PCAs-C), medium-chain (MCCPs: PCAs-C), and long-chain CPs (LCCPs: PCAs-C) in technical CP mixtures (n = 4) and polymer samples (n = 49), including recycled plastics, collected in Vietnam in 2023. The contents of measured PCA homolog groups in technical CP mixtures were 86,000-930,000 mg/kg for PCAs-C; 85,000-990,000 mg/kg for PCAs-C; and 23,000-180,000 mg/kg for PCAs-C.

Biological testing unification for hemodialysis membranes evaluation: A step towards standardization.

Current hemodialysis treatments can cause adverse effects, many of which are linked to the membranes used in the process. These issues are being addressed through new materials and technologies, making it urgent to establish minimum guidelines for evaluating such membranes. This review proposes standardizing the biological tests and variables to evaluate the performance of new membranes, aiming to replicate hemodialysis conditions closely.

Improvement of measured and perceived disability in overweight patients with Multiple Sclerosis trough different patterns of Mediterranean hypocaloric diet.

Objectives: overweight and other cardiovascular risk factors are known contributors to disability accrual in Multiple Sclerosis (MS). We aimed to explore the impact of three hypocaloric dietetic patterns, based on the Mediterranean diet, on cardiovascular risk and clinical status in overweight persons with MS (pwMS).

Material And Methods: overweight pwMS (body mass index-BMI ≥25 kg/m) were prospectively enrolled, randomly allocated to three hypocaloric dietetic plans differing in macronutrients composition (carbohydrates/proteins/lipids: diet A 65 %/15 %/20 %; diet B 35 %/25 %/40 %; diet C 50 %/20 %/30 %) and followed-up for 1 year (6 months of dietetic intervention + 6 months of observation).

Prognostic relevance of lymph node metastasis in pancreaticoduodenectomy for distal cholangiocarcinoma: Rational extent and number-based nodal classification for regional lymphadenectomy.

Background: We investigated the rational extent of regional lymphadenectomy and evaluated the prognostic impact of number-based regional nodal classification in patients with distal cholangiocarcinoma.

Methods: This study included 191 patients with distal cholangiocarcinoma who underwent pancreaticoduodenectomy. The nos.

Prediction of microbial crude protein flow from the rumen of dairy cattle by means of dietary characteristics - a meta-analysis.

Protein supply to ruminants relies mainly on the flow of microbial crude protein (MCP) from the rumen, which is commonly assumed to primarily depend on energy supply. This study evaluated this assumption with recent data and tested if ruminally fermented organic matter (FOM) was a better predictor of MCP flow than total-tract digestible organic matter (DOM) and if more variables could improve the prediction of MCP flow. A previously published data set was extended by additional studies resulting in a data set of 139 studies including 407 treatment means, typical to Central European rations.

ERF114/115/109 are essential for jasmonate-repressed non-canonical JAZ8 activity in JA signaling.

Jasmonate (JA), a key plant hormone, regulates various aspects of plant development and stress responses, primarily through the degradation of canonical jasmonate-ZIM domain (JAZ) proteins by the SCF complex. While JAZ8, a non-canonical JAZ protein lacking the degron signal, has been shown to repress JA responses, the mechanism by which JA inhibits JAZ8 activity remains unclear. Here, we demonstrate that Arabidopsis ethylene response factor 114 (ERF114), ERF115, and ERF109 regulate JA signaling through interacting with JAZ8.

Deciphering transcription activity of mammalian early embryos unveils on/off of zygotic genome activation by protein translation/degradation.

Quantification of transcription activities in mammalian preimplantation embryos is challenging due to a huge amount of maternally stored transcripts and paucity of research materials. Here, we investigate genome-wide transcription activities of mouse and human preimplantation embryos by quantifying elongating RNA polymerase II. Two transcriptional waves are identified in early mouse embryos, with summits at the 2-cell and 8-cell stages.

Lack of context modulation in human single neuron responses in the medial temporal lobe.

In subjects implanted with intracranial electrodes, we use two different stories involving the same person (or place) to evaluate whether and to what extent context modulates human single-neuron responses. Nearly all neurons (97% during encoding and 100% during recall) initially responding to a person/place do not modulate their response with context. Likewise, nearly none (<1%) of the initially non-responsive neurons show conjunctive coding, responding to particular persons/places in a particular context during the tasks.

Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection.

Macrophages express pattern recognition and cytokine receptors that mediate proinflammatory signal transduction pathways to combat microbial infection. To retaliate against such responses, pathogenic microorganisms have evolved multiple strategies to impede innate immune signaling. Recent studies demonstrated that YopJ suppression of TAK1 signaling during Yersinia pseudotuberculosis infection promotes the assembly of a RIPK1-dependent death-inducing complex that enables caspase-8 to directly cleave and activate gasdermin D (GSDMD).

Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis.

Here, we used single cell RNA sequencing and single cell spatial transcriptomics to characterize the forebrain neural stem cell (NSC) niche under homeostatic and injury conditions. We defined the dorsal and lateral ventricular-subventricular zones (V-SVZs) as two distinct neighborhoods and showed that, after white matter injury, NSCs are activated to make oligodendrocytes dorsally for remyelination. This activation is coincident with an increase in transcriptionally distinct microglia in the dorsal V-SVZ niche.

A Paper-Based Sensor for the Detection of Gastroesophageal Reflux Disease Utilizing a Cleavable Fluorescent Polymer.

Nowadays, gastroesophageal reflux disease (GERD) has emerged as one of the major hazards to the health of the upper gastrointestinal tract, and there is an urgent need for a low-cost, user-friendly, and non-invasive detection method. Herein, a paper-based sensor (CP sensor) for the non-invasive screening of GERD is proposed. The sensor is structured as a specially shaped cellulose paper strip embedded with fluorescent colloids, which are self-assembled from a cleavable synthetic fluorescent polymer (P4).

Investigation of the effect of perioperative parathyroid autotransplantation in incidental parathyroidectomy cases on the development of postoperative hypocalcemia: a retrospective observational study.

Purpose: One of the most common and significant complications following thyroid surgery is postoperative hypocalcemia due to postoperative hypoparathyroidism. This study aimed to observe the effect of parathyroid gland autotransplantation on postoperative hypocalcemia in cases of incidental parathyroidectomy in total thyroidectomy cases.

Methods: Patients who underwent bilateral total thyroidectomy surgery were retrospectively analyzed.

Efficiency of carbon dioxide capture with metal substitutions in the MIL-88A metal-organic framework.

Carbon dioxide capture is a vital approach for mitigating air pollution and global warming. In this context, metal-organic frameworks are promising candidates. Particularly, MIL-88A (M), where the metal nodes (M) are connected to fumarate linkers in its structure, has demonstrated significant potential for CO capture.