2 results match your criteria: "CONICET)-Centro Universitario UNCuyo[Affiliation]"
A modelling study highlights the power of detecting and isolating asymptomatic or very mildly affected individuals for COVID-19 epidemic management.
BMC Public Health
November 2020
Instituto Interdisciplinario de Ciencias Básicas, Universidad Nacional de Cuyo, CONICET, Facultad de Ciencias Exactas y Naturales, Padre J. Contreras 1300, 5500, Mendoza, Argentina.
Background: Mathematical modelling of infectious diseases is a powerful tool for the design of management policies and a fundamental part of the arsenal currently deployed to deal with the COVID-19 pandemic.
Methods: We present a compartmental model for the disease where symptomatic and asymptomatic individuals move separately. We introduced healthcare burden parameters allowing to infer possible containment and suppression strategies.
Mitochondrial stress triggers a pro-survival response through epigenetic modifications of nuclear DNA.
Cell Mol Life Sci
April 2019
Instituto de Histología y Embriología de Mendoza (IHEM, Universidad Nacional de Cuyo, CONICET)-Centro Universitario UNCuyo, 5500, Mendoza, Argentina.
Article Synopsis
- - Mitochondrial dysfunction causes cellular stress, prompting cells to activate survival responses to avoid dying, with changes in nuclear DNA methylation playing a crucial role.
- - Researchers examined how cellular stress responses like apoptosis and autophagy are affected by mitochondrial dysfunction, focusing on DNA methylation’s role in cell survival.
- - Experiments showed that in human muscle cells, severe mitochondrial dysfunction increases DNA methylation and activates pro-survival pathways, a finding supported by studies in tissues from mitochondrial disease patients.