An agent-based model facilitating stakeholder engagement in management of estuaries along the Texas Gulf Coast (USA).

We describe an agent-based model purposed for social learning, which was developed by stakeholders, with the technical assistance of professional modelers, to facilitate stakeholder involvement in modeling issues related to the development of an adaptive environmental management plan for the Texas Gulf Coast (USA) estuaries. Stakeholders developed the model during six workshops that spanned a three-year period, and used the model to simulate the population dynamics (recruitment, growth, movement, and mortality) of blue crabs () in the Aransas and Copano Bays in response to various freshwater inflow and harvest scenarios. Results of scenarios representing normal, low, and high harvest levels indicated little effect on blue crab abundances, but harvests increased ≈75 % when harvest level was doubled and decreased ≈50 % harvest level was halved.

Rapid Manufacturing Method of Cardiovascular Models for Experimental Flow Analysis.

Physical anatomical models constructed from medical images are valuable research tools for evaluating patient-specific clinical circumstances. For example, 3D models replicating a patient's internal anatomy in the cardiovascular system can be used to validate Computational Fluid Dynamics (CFD) models, which can then be used to identify potential hemodynamic consequences of surgical decisions by providing insight into how blood and vascular tissue mechanics may contribute to disease progression and post-operative complications. Patient-specific models have been described in the literature; however, rapid prototyping models that achieve anatomical accuracy, optical transparency, and thin-walled compliance in a cost and time-effective approach have proven challenging.

A Case of Long-Term Undiagnosed Cyclodialysis Cleft Following Tanito Microhook Trabeculotomy.

Persistent hypotony following Tanito microhook trabeculotomy (TMH) is rare but may occur due to the development of cyclodialysis clefts. We report a case of a Japanese man in his 40s who developed persistent hypotony and hypotony maculopathy after TMH in the left eye. Fourteen months after the surgery, the patient was referred to our institution due to prolonged hypotony that remained undiagnosed and untreated despite evaluations with gonioscopy and anterior segment optical coherence tomography (AS-OCT) at the referring clinic.

Incidence of Communicating Hydrocephalus Following Intraventricular Hemorrhage Among Adult Patients Treated at a Hospital in Jeddah, Saudi Arabia: A Retrospective Study.

Introduction Intraventricular hemorrhage is a severe condition caused by bleeding within the brain ventricles. It is often due to trauma, tumors, vascular malformation, aneurysm, oxygen deprivation, or idiopathic. A common complication associated with intraventricular hemorrhage is hydrocephalus, which is the accumulation of cerebrospinal fluid in the ventricles.

Favorable response to ketogenic diet therapy in a patient with -related epilepsy.

Dynein Cytoplasmic 1 Heavy chain 1 (-related disorders are a spectrum of conditions including neurodevelopmental disorders, congenital brain malformations, and neuromuscular diseases. These clinical features may co-occur, with four main disease entities including epilepsy with developmental epileptic encephalopathy such as infantile epileptic spasms syndrome (IESS) and Lennox-Gastaut syndrome (LGS), axonal Charcot-Marie-Tooth disease type 2O, spinal muscular atrophy with lower extremity-predominance (SMALED), and congenital cortical malformations. Epilepsy associated with this disorder often becomes drug-resistant and requires multiple medications and, in some cases, non-pharmacological treatments.

Network Pharmacology Combined With Metabolomics Reveals the Mechanism of Yangxuerongjin Pill Against Type 2 Diabetic Peripheral Neuropathy in Rats.

Purpose: This study aims to explore the mechanism of Yangxuerongjin pill (YXRJP) in the treatment of diabetic peripheral neuropathy (DPN) by network pharmacology and metabolomics technology combined with animal experiments, and to provide scientific basis for the treatment of DPN.

Methods: In this study, network pharmacology analysis was applied to identify the active compounds, core targets and signal pathways, which might be responsible for the effect of DPN. The DPN model was established by high-fat diet combined with streptozotocin (STZ) injection, and the rats were given administration for 12 weeks.

Impact of Food Physical Properties on Oral Drug Absorption: A Comprehensive Review.

Food-Drug Interaction (FDI) refers to the phenomenon where food affects the pharmacokinetic or pharmacodynamic characteristics of a drug, significantly altering the drug's absorption rate or absorption extent. These Interactions are considered as a primary determinant in influencing the bioavailability of orally administered drugs within the gastrointestinal tract. The impact of food on drug absorption is complex and multifaceted, potentially involving alterations in gastrointestinal physiology, increases in splanchnic blood flow rates, and shifts in the gut microbiota's composition.

Design of a wasp-inspired biopsy needle capable of self-propulsion and friction-based tissue transport.

Percutaneous pancreatic core biopsy is conclusive but challenging due to large-diameter needles, while smaller-diameter needles used in aspiration methods suffer from buckling and clogging. Inspired by the ovipositor of parasitic wasps, which resists buckling through self-propulsion and prevents clogging via friction-based transport, research has led to the integration of these functionalities into multi-segment needle designs or tissue transport system designs. This study aimed to combine these wasp-inspired functionalities into a single biopsy needle by changing the interconnection of the needle segments.

The Predictive Factors of Acne Scarring and Post-Inflammatory Hyperpigmentation: A Retrospective Cohort Study.

Introduction: Acne vulgaris, a prevalent dermatological condition, often results in long-term complications such as scarring and hyperpigmentation. While extensive research has focused on treatment modalities, there is a notable gap in understanding the factors contributing to the development of acne scarring and post-inflammatory hyperpigmentation (PIH).

Purpose: This study was conducted to identify the factors contributing to the development of acne scarring and post-inflammatory hyperpigmentation (PIH).

Prediction of Distant Metastasis of Renal Cell Carcinoma Based on Interpretable Machine Learning: A Multicenter Retrospective Study.

Background : The traditional tool for predicting distant metastasis in renal cell carcinoma (RCC) is still insufficient. We aimed to establish an interpretable machine learning model for predicting distant metastasis in RCC patients.

Methods: We involved a population-based cohort of 121433 patients (mean age = 63 years; 63.

Value of routine blood count surveillance in detecting relapse in acute lymphoblastic leukemia.

Background: Children with acute lymphoblastic leukemia (ALL) have excellent outcomes, with >85% survival without relapse following contemporary therapies. Clinical and complete blood count (CBC) assessments are commonly used surveillance methods to detect relapses. We aimed to evaluate the efficacy of routine blood testing for detecting relapse using a systematic method of assessing normal and abnormal results.

Robot-assisted laparoscopic ipsilateral ureteroureterostomy for duplex kidneys in children: preliminary single-center experience.

Objective: This study evaluates the efficacy and safety of robot-assisted laparoscopic ipsilateral ureteroureterostomy (RAL-IUU) in treating children with duplex kidney ureteral malformations by detailing our early single-center experience.

Materials And Methods: We conducted a retrospective analysis of clinical data from 14 children with complete duplex kidney ureteral malformations treated with RAL-IUU at our institution from December 2021 to January 2024. Clinical data included patient demographics, surgical details, and postoperative outcomes.

Self-Care Behavior Based on Knowledge of Patients with Hypertension: A Cross-Sectional Study.

Background: Adequate self-care behavior is an important factor in controlling hypertension to reduce the number of complications. A patient's knowledge about hypertension can influence their self-care behavior in practice.

Purpose: The aim of this study was to identify self-care behaviors among hypertension patients based on their knowledge.

First full intracorporeal robotic cystectomy and neobladder in a renal transplant recipient.

The literature regarding robotic-assisted radical cystectomy in kidney transplant recipients is limited. We present the first reported case of robotic-assisted radical cystectomy with a full intracorporeal orthotopic neobladder in a kidney transplant recipient. A 36-year-old man was diagnosed with muscle-invasive urothelial carcinoma 12 years after kidney transplantation.

Effects of microbial fermentation on the anti-inflammatory activity of Chinese yam polysaccharides.

In this study, Chinese yam polysaccharides (CYPs) were fermented using M616, and changes in the chemical composition, structure, and anti-inflammatory activity of CYPs before and after fermentation were investigated. The carbohydrate content of M616-fermented CYP (CYP-LP) increased from 71.03% ± 2.

Change in mineral composition and cooking quality in legumes grown on semi-arid alfisols due to elevated CO and temperature.

This study aimed to determine the effects of elevated carbon dioxide (eCO) and temperature (eT) on the phytochemical and nutritional parameters of legumes. Field experiments were conducted using black gram ( L.), green gram ( L.

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and gut microbiota composition: what do we know?

Post-streptococcal autoimmune neuropsychiatric disorders (PANDAS) are a group of pathological condition characterized by sudden-onset obsessive-compulsive and tic disorders following beta-hemolytic Streptococcus group A (GAS) infection, hypothesized to be caused by autoimmune mechanisms targeting the basal ganglia. Scant literature is available regarding the microbiota composition in children with PANDAS, however few studies support the hypothesis that streptococcal infections may alter gut microbiota composition in these patients, leading to chronic inflammation that may impact the brain function and behavior. Notable changes include reduced microbial diversity and shifts in bacterial populations, which affect metabolic functions crucial for neuroinflammation.

Functional safety-oriented hazard analysis and risk assessment for vehicular fuel cell systems.

Functional safety is an emerging trend for safety design in the automobile industry. This study is an innovative exploration of a hazard analysis and quantitative risk assessment (QRA) methodology based on the functional safety of vehicular fuel cell systems. In this study, the potential hazards that fuel cell vehicles may encounter during operation were identified using the automobile generic hazard list.

Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implications.

The Neural Crest cells are multipotent progenitor cells formed at the neural plate border that differentiate and give rise to a wide range of cell types and organs. Directional migration of NC cells and their correct positioning at target sites are essential during embryonic development, and defects in these processes results in congenital diseases. The NC migration begins with the epithelial-mesenchymal transition and extracellular matrix remodeling.

Impacts of intestinal microbiota metabolite trimethylamine N-oxide on cardiovascular disease: a bibliometric analysis.

Background: Trimethylamine N-oxide (TMAO), a metabolite dependent on intestinal microbiota, is closely related to the emergence, progression, and prognosis of cardiovascular disease (CVD), and has received increasing attention in recent years.

Objective: The current research hotspots and future development trends in TMAO and CVD field are found through bibliometrics analysis, which provides reference for further study.

Methods: The bibliometrics tools VOSviewer and CiteSpace were used to analyze the publications from the Web of Science Core Collection (WOSCC) database.

Recombinant Marek's disease virus expressing VP1 and VP2 proteins provides robust immune protection against chicken infectious anemia virus.

Chicken infectious anemia (CIA) is a highly contagious disease caused by the chicken infectious anemia virus (CIAV), and it poses a serious threat to the poultry industry. However, effective control measures and strategies have not been identified. In this study, a recombinant Marek's disease virus (rMDV) expressing the VP1 and VP2 proteins of CIAV was successfully constructed using CRISPR/Cas9, and a commercial Marek's disease virus (MDV) vaccine strain was used as the vector.

Management of traumatic brain injury and acute respiratory distress syndrome-What evidence exists? A scoping review.

Introduction: Up to 20% of patients with traumatic brain injury (TBI) develop acute respiratory distress syndrome (ARDS), which is associated with increased odds of mortality. Guideline-based treatment for ARDS includes "lung protective" ventilation strategies, some of which are in opposition to "brain protective" strategies used for ventilation with patients with TBI. We conducted a scoping review of ventilation management strategies with clinical outcomes among patients with TBI and ARDS.

DISCOntinuation of disease-modifying therapies in MS: The DISCOMS extension trial.

Background: In the DISCOMS (DISCOntinuation of disease-modifying therapies (DMTs) in multiple sclerosis (MS)) randomized clinical trial, we could not demonstrate that discontinuing MS DMTs in older, stable adults was not inferior to continuing DMTs. Relapses were rare in both groups, and most new disease activity was one to two new brain magnetic resonance imaging (MRI) lesions unassociated with clinical changes.

Objective/aims: Describe results of the DISCOMS extension study.

Novel serum biomarkers for early diagnosis of gestational diabetes mellitus-a review.

Gestational diabetes mellitus (GDM) affects 9-25% of pregnancies. Undiagnosed or poorly managed GDM is associated with both short- and long-term complications in the fetus and mother. The pathogenesis of GDM is complex and has not yet been fully elucidated.

A Needle in a Haystack: Transient Porosity in a Closed Pore Square Lattice Coordination Network.

Guest transport through discrete voids (closed pores) in crystalline solids is poorly understood. Herein, we report the gas sorption properties of a nonporous coordination network, [Co(bib)2Cl2]n·2MeOH (sql-bib-Co-Cl-α), featuring square lattice (sql) topology and the bent linker 1,3-bis(1H-imidazol-1-yl)benzene (bib). The as-synthesized sql-bib-Co-Cl-α has 11.