Clinical Characteristics and Management of Oral Candidiasis Associated with Calcinosis, Raynaud's Phenomenon, Esophageal Dysmotility, Sclerodactyly, and Telangiectasia Syndrome.

Calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia (CREST) syndrome, a systemic sclerosis subtype, features skin thickening, vascular issues, and organ involvement, causing complications in the gastrointestinal and musculoskeletal systems. Herein, we present a rare case of oral candidiasis, with CREST syndrome. The patient presented with xerostomia, tongue erythema, and burning pain.

Safety and Efficacy of Ferric Carboxymaltose for Iron Deficiency Anemia in Inflammatory Bowel Disease: A Systematic Review.

Ulcerative colitis and Crohn's disease, two types of inflammatory bowel disease (IBD), often cause anemia, primarily due to iron deficiency and chronic inflammation. Anemia negatively affects patients' daily functioning and quality of life, causing symptoms including headaches, exhaustion, and dyspnea. In IBD, iron deficiency arises from reduced intake, chronic blood loss, and impaired absorption.

Disseminated Leiomyomatosis Following a Robotic-Assisted Myomectomy With Power Morcellation: A Case Report.

This case reports a 44-year-old female who presented to the gynecologic oncology clinic status post robotic-assisted laparoscopic myomectomy with intraperitoneal unprotected power morcellation in 2012, with an incidental finding of three conglomerate solid masses in the abdomen above the uterus, with each mass measuring approximately 15.5 cm. The patient underwent an exploratory laparotomy where multiple masses greater than 10 cm were found scattered throughout the abdominal cavity.

Splenic Infarct: A Rare Complication of Infectious Mononucleosis in a Monospot-Negative Patient.

Splenic infarction with infectious mononucleosis (IM) caused by Epstein-Barr Virus (EBV) has been reported as a rare complication of IM. The monospot test, often used to diagnose EBV-related IM, may produce false-negative results, especially in atypical presentations or early stages of infection. This report describes the case of a monospot-negative patient who developed splenic infarction as a complication of IM.

Heterotopic Triplet Pregnancy After Assisted Reproductive Techniques: A Systematic Review.

Heterotopic pregnancy is defined as the simultaneous presence of an intrauterine and an extrauterine pregnancy and is considered a rare condition. As a part of this entity, heterotopic triplet pregnancy, defined as the presence of three embryos, with at least one being ectopic, is exceedingly rare. In recent years, the broad use of assisted reproductive techniques to help infertile couples has contributed to the constant rise of non-spontaneous heterotopic triplets.

A Case Report of Spontaneous Pneumomediastinum (Hamman's Syndrome) During Labor.

Hamman's syndrome is characterized by spontaneous pneumomediastinum triggered by Valsalva maneuvers and is an uncommon complication during labor and the postpartum period. It is typically benign and managed conservatively with oxygen therapy and analgesia. We present the clinical case of a 21-year-old primigravida who developed spontaneous pneumomediastinum during labor, manifesting with subcutaneous emphysema and dyspnea.

Sudden Onset of Unexplained Leg Pain Following Open Reduction and Internal Fixation of a Displaced Tibial Tuberosity Fracture: A Case Report of Deep Venous Thrombosis in an Adolescent Athlete.

This case report presents a 16-year-old basketball player, who developed deep venous thrombosis (DVT) following surgical intervention for a displaced tibial tuberosity fracture and forearm fractures. Despite few identifiable thrombotic risk factors, the patient's postoperative course was complicated by unexplained leg pain, fever, and ultimately confirmed DVT. Prompt management with therapeutic anticoagulation and multidisciplinary care led to favourable outcomes.

A Comprehensive Analysis of Surgical Outcomes for Spinal Fractures in Patients With Ankylosing Spondylitis: A 13-Year Prospective Study.

Introduction: Ankylosing spondylitis (AS), a chronic inflammatory spondyloarthropathy affecting the spine, progressively leads to increased spinal stiffness. This condition increases the risk of spine fractures in patients, even from trivial injuries. The process of slow bone formation within the ligaments of the spine and the fusion of the spinal diarthrosis contribute to the most prominent symptom of progressive stiffness of joints, predominantly affecting the spine and sacroiliac joints.

Augmented Reality-Assisted Microsurgery for Severe Thoracic Ossification of the Ligamentum Flavum: A Case Report.

Ossification of the ligamentum flavum (OLF) can lead to dural ossification, significantly increasing the risk of complications, including intraoperative nerve injury. The application of augmented reality (AR) and advanced digital technologies in spine surgery has the potential to reduce these risks. This case report highlights a perioperative nerve injury-free microsurgery using elastic image fusion technology, which integrates preoperative imaging with intraoperative computed tomography for a patient with severe stenotic OLF and dural ossification.

Preoperative Ultrasonographic Assessment of the Gastric Antrum in Diabetic Patients Before Elective Surgery: A Prospective Observational Comparative Cohort Study.

Background: Diabetic patients may have neuropathy-induced gastroparesis predisposing them to aspiration. Point-of-care gastric ultrasonography (GUSG) is useful in the qualitative assessment of the antrum and quantitative prediction of gastric volume (GV) in diabetic patients. In this study, we compared the GUSG findings between fasting diabetic and non-diabetic patients in the elective preoperative setting.

Evaluation of Risk Factors for Dupilumab-Associated Ocular Sequelae in the Treatment of Atopic Dermatitis.

Dupilumab is a monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling and is used in the treatment of moderate-to-severe atopic dermatitis (AD) in those six months or older who are uncontrolled on or cannot tolerate topical treatments. Ocular surface disease is a recognized adverse effect of dupilumab, yet few studies describe the risk factors for developing ocular adverse effects. There are no standardized recommendations for monitoring patients on this medication.

Occupational Dermatitis in a Paint Mixer: Impact of Symptom Neglect and Strategies for Early Intervention and Prevention.

A 34-year-old paint mixer presented with mild, localized dermatitis on the forearms, traced to low-level exposure to a paint additive. Immediate interventions, including improved personal protective equipment (PPE) and modified job tasks, led to rapid symptom resolution. This report highlights early identification, appropriate workplace controls, and follow-up measures that prevent long-term complications.

Re-optimizing the Time Frame for Classifying Cerebral Venous Sinus Thrombosis: An Unmet Need.

Cerebral venous thrombosis (CVT) is a rare and complex form of stroke, representing a small percentage of all stroke cases. The disease's clinical presentation is highly variable, involving a wide range of medical specialists due to its diverse manifestations. Over the past decade, significant advancements in understanding CVT have been made, particularly in light of the COVID-19 pandemic and subsequent vaccination efforts.

Molecular Assay Versus Serology for Diagnosis of Scrub Typhus Among Patients With Acute Febrile Illness: A Retrospective Study.

Background And Objectives: The epidemiology of scrub typhus caused by has been growing in Odisha, India. The most common symptoms include fever, cough, lymphadenopathy, eschar, and rash. In India, enzyme-linked immunosorbent assays (ELISA) and DNA real-time polymerase chain reaction (DNA RT-PCR) are the most commonly used methods to diagnose scrub typhus.

Head to Toe: A Perioperative Surgical Home Approach to Sepsis and Airway Obstruction in a Geriatric Patient.

The perioperative surgical home (PSH) is a care delivery model designed to improve the perioperative and long-term outcomes of patients undergoing surgery by promoting holistic care and seamless cooperation between different services and subspecialties. An aging population and increased surgical complexity have led to renewed interest in PSH models. An 86-year-old female with diabetes and critical limb ischemia presented with sepsis due to right calcaneal gangrene.

Race Against the Clock: Severe Acute Abdominal Pain With Disastrous Complications.

Although a rare medical condition, gastric ischemia is a medical emergency and requires prompt recognition. Current literature review is scarce, with a primary focus on iatrogenic, surgical, and vascular etiologies. The cases discussed focus on hypoperfusion secondary to refractory shock as the etiology of gastric ischemia and, unfortunately, death.

Posterior Fusion With Pedicle Screw Cement Augmentation and Vertebroplasty Using Calcium Phosphate Cement for Osteoporotic Vertebral Fracture: A Case Report.

Osteoporotic vertebral fractures (OVFs) in elderly patients pose challenges due to bone destruction and surgical risks. This case report describes a minimally invasive approach using calcium phosphate cement (CPC) vertebroplasty and short fusion with cement augmentation of pedicle screws (CAPS) in a 91-year-old woman with severe OVF. The patient underwent CPC vertebroplasty at L1 and CAPS fixation at T12-L2, followed by osteoporosis medication.

COVID-19-Associated Encephalopathy: A Case Series Demonstrating the Rapid Deterioration of Mental Status and a Review of the Literature.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is known for its severe inflammatory response, often leading to multi-organ dysfunction. Among the less-recognized complications is COVID-19-associated encephalopathy, particularly in the elderly, where it contributes significantly to morbidity and mortality. This report explores the rapid neurocognitive decline observed in six hospitalized patients with COVID-19, with or without pre-existing neurological conditions.

Loss of SMAD1 in acute myeloid leukemia with and fusion genes.

Introduction: -rearrangements define a subclass of acute leukemias characterized by a distinct gene expression signature linked to the dysfunctional oncogenic fusion proteins arising from various chromosomal translocations involving the (also known as ) gene. Research on the disease pathomechanism in -rearranged acute leukemias has mainly focused on the upregulation of the stemness-related genes of the -family and their co-factor .

Results: Here we report the and fusion gene-dependent downregulation of , a TGF-β signaling axis transcription factor.

Outcome of critically ill patients receiving systemic chemotherapy on the intensive care unit.

Objective: Analyze the outcomes of critically ill patients who developed new-onset organ dysfunction and received systemic chemotherapy during their ICU stay.

Design: Retrospective cohort study.

Setting: A tertiary medical center in Germany with an Intensive Care Medicine department consists of 11 intensive care units comprising 140 beds, serving all subspecialties of adult intensive care medicine.

Use of the oxygen reserve index/FiO as a non-invasive index to estimate venous admixture in anesthetized dogs.

The oxygen reserve index (ORi) is a novel, non-invasive parameter that estimates arterial oxygen partial pressure (PaO) during hyperoxia when the fraction of inspired oxygen (FiO) is elevated. This study aimed to assess the utility of the ORi/FiO ratio as an index for quantifying F-shunt, serving as an estimate of venous admixture. Anesthetic records were reviewed from 44 dogs undergoing general anesthesia and requiring arterial catheterization.

Efficacy of a reduced-dosage PRRS MLV vaccine against a NADC34-like strain of porcine reproductive and respiratory syndrome virus.

Introduction: After being discovered for the first time in China in 2017, porcine reproductive and respiratory syndrome virus (PRRSV) NADC34-like strains have become the prevalent strain of PRRSV in certain regions of China. Our previous study showed that reduced Ingelvac PRRS MLV vaccination dosages against NADC30-like PRRSV had a better protection effect than the normal dosage. However, the protective effect of reduced dosages vaccination of Ingelvac PRRS MLV against NADC34-like PRRSV is unclear.

Effects of lipopolysaccharide infusion on feed intake, apparent digestibility, rumen fermentation and microorganisms of young Holstein bulls fed diets with different ratios of lysine and methionine.

The aim of this experiment was to investigate the effects of intravenous infusion of lipopolysaccharide (LPS) and feeding different ratios of lysine (Lys) and methionine (Met) on feed intake, apparent digestibility, rumen fermentation and microorganisms in young Holstein bulls. Five seven-month-old Holstein bulls with similar body weights (279 ± 42 kg) were selected and subjected to a 5 × 5 Latin square experiment. The control group (CON) was fed with basal diet and the ratio of Lys to Met in the diet was adjusted to 3.

An update on oral manifestations of systemic disorders in dogs and cats.

Oral lesions are common in dogs and cats, and determining the underlying etiology of these lesions can be challenging. A wide range of systemic ailments may lead to lesions in the oral cavity, including immune-mediated diseases, adverse drug reactions, viral and bacterial infections, and metabolic and autoimmune diseases. A complete history and thorough physical examination (including a fundic examination) should be obtained in affected patients.

Bees on the run: spp. (Microsporidia) in and related products, Italy.

Introduction: The decline of the European/western honeybee () population is on account of a plethora of microorganisms, such as and , two microsporidian fungi responsible of nosemosis that affects welfare and production of the bee industry. Accordingly, this study aimed to investigate the presence of both pathogens in bees, pollen and honey from apiaries in Southwestern Italy.

Methods: From March to July 2022 and 2023, apiaries ( = 10) were selected and classified as High Impact Areas (HIAs,  = 5) and Low Impact Areas (LIAs,  = 5) according to a 5-point environmental risk index based on factors affecting bee health sand related productions.