255 results match your criteria: "CNRS-Universite de Bordeaux[Affiliation]"
Chempluschem
March 2017
Centre de Recherche Paul Pascal, CNRS & Université de Bordeaux, 115, av. Schweitzer, 33600, Pessac, France.
The photocyclization of tetraethyl 1,4-phenylenebis(phenylmaleate) in the presence of iodine and oxygen predominantly yields tetraethyl [5]helicene-5,6,9,10-tetracarboxylate, together with small amounts of tetraethyl dibenz[a,h]anthracene-5,6,12,13-tetracarboxylate and tetraethyl benzo[ghi]perylene-3,4,11,12-tetracarboxylate. The helicene tetraester is planarized to the benzoperylene tetraester by Scholl reaction with AlCl followed by reesterification of the partially hydrolyzed crude product. Subsequent treatment with a branched alkylamine yields a columnar liquid-crystalline benzoperylene diimide whose mesophase is stable at room temperature despite its limited and non-centrosymmetric alkyl periphery.
View Article and Find Full Text PDFBrain Struct Funct
August 2017
Univ. Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France.
In a large sample of 428 healthy adults balanced for gender and manual preference (MP), we investigated planum temporale (PT) surface area variability in relation with Heschl's gyrus (HG) duplication pattern, MP, and familial sinistrality (FS), considering different PT definitions. In a sub-sample of 362 participants, we also investigated whether variability of PT asymmetry was associated with differences in verbal abilities. On each participant brain hemisphere MRI, we delineated a posterior PT area (PT), excluding the second Heschl gyrus in case of either complete posterior duplication (CPD) or common stem partial duplication (CSD).
View Article and Find Full Text PDFAngew Chem Int Ed Engl
March 2017
Department of Applied Chemistry and Biochemistry, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto, 860-8555, Japan.
A new strategy is described for generating strong circularly polarized luminescence with highly tunable emission bands through chiral induction in nonchiral, totally organic, low-molecular-weight fluorescent dyes by chiral nanotemplate systems. Our approach allows the first systematic investigation to clarify the correlation between the circular dichroism and circularly polarized luminescence intensities. As a result, a dilute solution system with the highest circularly polarized luminescence intensity achieved to date and a dissymmetry factor of over 0.
View Article and Find Full Text PDFSci Rep
January 2017
Arizona Center on Aging, University of Arizona, Tucson, AZ, USA.
Major advances in resting-state functional magnetic resonance imaging (fMRI) techniques in the last two decades have provided a tool to better understand the functional organization of the brain both in health and illness. Despite such developments, characterizing regulation and cerebral representation of mind wandering, which occurs unavoidably during resting-state fMRI scans and may induce variability of the acquired data, remains a work in progress. Here, we demonstrate that a decrease or decoupling in functional connectivity involving the caudate nucleus, insula, medial prefrontal cortex and other domain-specific regions was associated with more sustained mind wandering in particular thought domains during resting-state fMRI.
View Article and Find Full Text PDFSci Rep
December 2016
Centre de Résonance Magnétique des Systèmes Biologiques, UMR5536, CNRS/Université de Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France.
Although MEMRI (Manganese Enhanced MRI) informations were obtained on primary tumors in small animals, MEMRI data on metastases are lacking. Thus, our goal was to determine if 3D Look-Locker T1 mapping was an efficient method to evaluate Mn ions transport in brain metastases in vivo. The high spatial resolution in 3D (156 × 156 × 218 μm) of the sequence enabled to detect metastases of 0.
View Article and Find Full Text PDFJ Cell Sci
January 2017
Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
The fluorescence ubiquitination-based cell cycle indicator (FUCCI) is a powerful tool for use in live cells but current FUCCI-based assays have limited throughput in terms of image processing and quantification. Here, we developed a lentiviral system that rapidly introduced FUCCI transgenes into cells by using an all-in-one expression cassette, FastFUCCI. The approach alleviated the need for sequential transduction and characterisation, improving labelling efficiency.
View Article and Find Full Text PDFChemosphere
February 2017
EPHE, PSL Research University, UMR 7619 METIS (UPMC Univ. Paris 06/CNRS/EPHE), F-75005, Paris, France.
The transfer of 23 antibiotics from domestic and hospital sources was investigated in two elementary river watersheds receiving wastewater treatment plant (WWTP) discharges, in relation with the hydrological cycle and seasonal conditions. Antibiotic concentrations in the effluent of a WWTP treating wastewaters from both hospital and domestic sources (18-12 850 ng L) were far higher than those from domestic sources exclusively (3-550 ng L). In rivers, upstream of the WWTP discharges, fluoroquinolones only were found at low concentrations (≤10 ng L).
View Article and Find Full Text PDFChemistry
December 2016
Centre de Recherche Paul Pascal, CNRS & Université de Bordeaux, 115 Avenue Schweitzer, 33600, Pessac, France.
By taking advantage of an unexpected regioselectivity of intramolecular Scholl reactions on pentaphenylene compounds that favors distorted [5]helicenes over their flat counterparts, a new synthetic approach to twisted graphene nanoribbons has been designed based on side-fused di-tert-butyl-[5]helicene fragments. Syntheses of both small monomers and dimers have been achieved and their structures have been studied. An iterative synthetic strategy has been developed for the formation of longer flexible precursors, which relies on the step-by-step elongation of mono-functionalized oligomeric chains.
View Article and Find Full Text PDFSci Total Environ
January 2017
EPHE, PSL Research University, UMR 7619 METIS (UPMC Univ. Paris 06/CNRS/EPHE), F-75005 Paris, France.
Investigation of domestic and hospital effluents in a sewage system of an elementary watershed showed that antibiotics belonging to eight classes were present with concentrations ranging from
PLoS One
August 2017
Laboratoire Ecologie & Biologie des Interactions, Equipe Microbiologie de l'Eau, Université de Poitiers, UMR CNRS 7267, Poitiers, France.
Antimicrobial peptides can be used as therapeutic agents against cancer cells. Warnericin RK and derivatives (WarnG20D and WarnF14V) were tested on various, solid tumor or leukemia, cancer cells. These peptides appeared to be cytotoxic on all the cell types tested, cancerous as well healthy, but very interestingly displayed no deleterious effect on healthy mononuclear cells.
View Article and Find Full Text PDFSci Rep
July 2016
Laboratoire de Chimie des Polymères Organiques, CNRS - ENSCPB - Université de Bordeaux - UMR 5629, F-33607 Pessac, France.
Unlabelled: Due to the rising need for clean energy, thermoelectricity has raised as a potential alternative to reduce dependence on fossil fuels. Specifically, thermoelectric devices based on polymers could offer an efficient path for near-room temperature energy harvesters. Thus, control over thermoelectric properties of conducting polymers is crucial and, herein, the structural, electrical and thermoelectric properties of poly(3,4-ethylenedioxythiophene) (PEDOT) thin films doped with p-toluenesulfonate (Tos) molecules were investigated with regards to thin film processing.
View Article and Find Full Text PDFNucleic Acids Res
September 2016
Institut Pasteur, Unité de Virologie Moléculaire et Vaccinologie, UMR 3569 IP-CNRS, Paris 75015, France
Cold Spring Harb Perspect Biol
September 2016
Institut de Biochimie et de Génétique Cellulaire UMR 5095, CNRS - Université de Bordeaux, 33077 Bordeaux, France.
The [Het-s] prion of the fungus Podospora anserina is a well-studied model system to elucidate the action of prions and beyond. The [Het-s] prion works as an activation trigger of a cell death execution protein termed HET-S. Amyloid transconformation of the prion-forming region of HET-S induces activation of its pore-forming cell death execution HeLo domain.
View Article and Find Full Text PDFJ Chem Phys
May 2016
Laboratoire de Chimie Physique, UMR 8000 CNRS-Univ. Paris-Sud, Univ. Paris-Saclay, Bât. 350, Centre Universitaire Paris-Sud, F-91405 Orsay Cedex, France.
We report the first experimental observations of X(+) (1)Σ(+)←X (2)Π and a(+) (3)Π←X (2)Π single-photon ionization transitions of the CH radical performed on the DESIRS beamline at the SOLEIL synchrotron facility. The radical was produced by successive hydrogen-atom abstractions on methane by fluorine atoms in a continuous microwave discharge flow tube. Mass-selected ion yields and photoelectron spectra were recorded as a function of photon energy using a double imaging photoelectron/photoion coincidence spectrometer.
View Article and Find Full Text PDFEur J Neurosci
May 2016
Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, University of Bordeaux, Bordeaux, France.
Recent data have provided evidence that microglia, the brain-resident macrophage-like cells, modulate neuronal activity in both physiological and pathophysiological conditions, and microglia are therefore now recognized as synaptic partners. Among different neuromodulators, purines, which are produced and released by microglia, have emerged as promising candidates to mediate interactions between microglia and synapses. The cellular effects of purines are mediated through a large family of receptors for adenosine and for ATP (P2 receptors).
View Article and Find Full Text PDFChemistry
May 2016
Centre de Recherche Paul Pascal, CNRS & Université de Bordeaux, 115, av. Schweitzer, 33600, Pessac, France.
Whereas perylene tetracarboxdiimides derived from amino-n-alkanes if at all only show monotropic (thermodynamically unstable) mesogenic self-assembly, the hexagonal columnar liquid crystalline state can be stabilized over a broad temperature range with doubly branched, doubly racemic alkyl residues. An improved tendency to homeotropic surface orientation is observed, and the orientation of the liquid crystalline domains is maintained upon cycling through the crystalline state at room temperature.
View Article and Find Full Text PDFChemistry
June 2016
Centre de Recherche Paul Pascal, CNRS & Université de Bordeaux, 115, av. Schweitzer, 33600, Pessac, France.
The twofold glyoxylic Perkin reaction of perylene-3,9-diglyoxylic acid with thiophene-diacetic acid followed by oxidative photocylization and reaction with α-branched primary alkylamines yields columnar liquid-crystalline diimides with two sulfur atoms in the condensed arene system. A broad temperature range of the hexagonal columnar mesophase is induced by racemic doubly branched alkyl chains. The HOMO and LUMO energy levels of these thiophene-derived diimides qualify them as electron donors with respect to perylene diimides.
View Article and Find Full Text PDFJ Struct Biol
November 2016
Laboratoire Biogéosciences UMR 6282, CNRS - Université de Bourgogne Franche-Comté (UBFC) - 6 Boulevard Gabriel, 21000 DIJON, France; Ruder Boskovic Institute, Center for Marine Research Rovinj, Giordano Paliaga 5, 52210 ROVINJ, Croatia. Electronic address:
Calcium carbonate skeletal tissues in metazoans comprise a small quantity of occluded organic macromolecules, mostly proteins and polysaccharides that constitute the skeletal matrix. Because its functions in modulating the biomineralization process are well known, the skeletal matrix has been extensively studied, successively via classical biochemical approaches, via molecular biology and, in recent years, via transcriptomics and proteomics. The optimistic view that the deposition of calcium carbonate minerals requires a limited number of macromolecules has been challenged, in the last decade, by high-throughput approaches.
View Article and Find Full Text PDFMol Autism
April 2016
INSERM UMR 1163, Laboratory of Molecular and pathophysiological bases of cognitive disorders, Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, Necker-Enfants Malades Hospital, 24 boulevard du Montparnasse, 75015 Paris, France.
Background: Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders caused by the interaction between genetic vulnerability and environmental factors. MicroRNAs (miRNAs) are key posttranscriptional regulators involved in multiple aspects of brain development and function. Previous studies have investigated miRNAs expression in ASD using non-neural cells like lymphoblastoid cell lines (LCL) or postmortem tissues.
View Article and Find Full Text PDFContrast Media Mol Imaging
May 2016
University Medical Center Utrecht, Department of Radiology, Imaging Division, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Encapsulation of anticancer drugs in triggerable nanocarriers can beneficially modify pharmacokinetics and biodistribution of chemotherapeutic drugs, and consequently increase tumor drug concentration and efficacy, while reducing side effects. Thermosensitive liposomes release their contents triggered by hyperthermia, which can be, for example, precisely delivered using an MR Imaging-guided focused ultrasound procedure. In such a scenario, it is attractive to demonstrate the accumulation of liposomes before applying hyperthermia, as well as to document the release of liposome content using MRI.
View Article and Find Full Text PDFAnalyst
December 2015
CEA Saclay, DSM, IRAMIS, CEA/CNRS UMR3685-NIMBE, Laboratoire Structure et Dynamiquepar Reśonance Magnetique, F-91191, Gif-sur-Yvette Cedex, France.
A prototype 1 mm High-Resolution micro-Magic Angle Spinning (HRμMAS) probe is described. High quality (1)H NMR spectra were obtained from 490 μg of heterogeneous biospecimens, offering a rich-metabolite profiling. The results demonstrate the potential of HRμMAS as a new NMR analytical tool in metabolomics.
View Article and Find Full Text PDFJ Cell Sci
November 2015
INSERM, U1053, Bordeaux F-33076, France Université de Bordeaux, Bordeaux F-33076, France
Every two years, the French Society for Cell Biology (SBCF) organises an international meeting called 'Imaging the Cell'. This year, the 8th edition was held on 24-26 June 2015 at University of Bordeaux Campus Victoire in the city of Bordeaux, France, a UNESCO World Heritage site. Over the course of three days, the meeting provided a forum for experts in different areas of cell imaging.
View Article and Find Full Text PDFSci Rep
July 2015
Non-self recognition in fungi, Institut de Biochimie et de Génétique Cellulaire, UMR 5095, CNRS - Université de Bordeaux, 1 rue Camille Saint Saens, 33077 Bordeaux cedex, France.
In mammals and fungi, Nod-like receptors (NLR) activate downstream cell death execution proteins by a prion-like mechanism. In Podospora anserina, the NWD2 NLR activates the HET-S Helo-domain pore-forming protein by converting its prion-forming domain into a characteristic β-solenoid amyloid fold. The amyloid forming region of HET-S/s comprises two repetitions of a 21 amino acid motif.
View Article and Find Full Text PDFCurr Opin Hematol
September 2015
aCentre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculté de Médecine de l'Université Laval, Québec, QC, Canada bUMR-5248-CBMN CNRS-Université de Bordeaux-IPB, Institut Universitaire de France, Allée Geoffroy Saint-Hilaire, F-33600 Pessac, France.
Purpose Of Review: Platelet microparticles are small extracellular vesicles abundant in blood. The present review will introduce the mechanisms underlying the generation of microparticles, and will describe the diverse microparticle subtypes identified to date. The most appropriate methodologies used to distinguish microparticle subtypes will be also presented.
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