Lived experience, perceptions, and expectations of close relatives of nursing home residents and strengths-based nursing: a phenomenological approach.

Conflicts between residents' families and professionals are frequently described in nursing homes. This phenomenological study aims to describe and understand the experience, expectations and needs of residents' relatives. Forty-three interviews were conducted in six selected nursing homes.

[Lived experience, perceptions, and expectations of close relatives of nursing home residents and strength-based nursing, a phenomenological approach].

Dissensions between residents' families and professionals are frequently described in nursing homes. This phenomenological study aims to describe and understand experience, expectations and needs of residents' relatives. Forty-three interviews were conducted in the 6 selected nursing homes.

[Quality of life in palliative care].

Palliative care aims to improve the quality of life of patients with a serious or terminal progressive disease, through global and multidisciplinary care. The notion of quality of life is multidimensional and unique to each individual patient, making them key players in their own care. Taking into account the different dimensions of a patient's quality of life is necessary in order to propose a personalised and appropriate care plan.

[Announcing the death of a patient to the family].

Breaking the news of a patient's death is a defining moment in the process of caring for families. Making this announcement requires professionalism, taking into account the suffering of the loved one and the challenges specific to this moment. Beyond the theory and proposed benchmarks, the way this news is broken must be thought through by the departments and caregivers.

Haploidentical Bone Marrow Transplantation with Post-Transplantation Cyclophosphamide Plus Thiotepa Improves Donor Engraftment in Patients with Sickle Cell Anemia: Results of an International Learning Collaborative.

Curative therapy for individuals with severe sickle cell disease (SCD) who lack an HLA-identical sibling donor has been frustratingly elusive. In with the goal of improving engraftment while minimizing transplantation-related morbidity, a multi-institutional learning collaborative was developed in the context of a Phase II clinical trial of nonmyeloablative, related HLA-haploidentical (haplo) bone marrow transplantation (BMT) with post-transplantation cyclophosphamide. All eligible participants had hemoglobin SS, and 89% (16 of 18) had an identifiable donor.

The role of prostate cancer antigen 3 (PCA3) in prostate cancer detection.

The prostate cancer antigen 3 (PCA3) score has been the first urine assay to obtain the Food and Drug Administration approval for guiding decisions regarding additional biopsies. Different aspects of this urinary assay (diagnostic performance, prognostic value, cost/benefit balance, integration with other molecular and imaging modalities) have now been well evaluated. Areas covered: This expert review will summarize current achievements and future perspectives provided by this urine biomarker.

Development of liquid chromatography high resolution mass spectrometry strategies for the screening of complex organic matter: Application to astrophysical simulated materials.

The present work aims at developing two LC-HRMS setups for the screening of organic matter in astrophysical samples. Their analytical development has been demonstrated on a 100-µg residue coming from the photo-thermo chemical processing of a cometary ice analog produced in laboratory. The first 1D-LC-HRMS setup combines a serially coupled columns configuration with HRMS detection.

[Announcement of the death of a loved one to a geriatric inpatient].

A geriatric inpatient may learn of the death of a loved one. The medical team must assess what is the kindest way to announce it to the patient who is already fragile. It will address the patient's relationship with the loved one, the right to information, and the position of the family.

Long-term follow-up study of endarterectomy versus angioplasty in patients with symptomatic severe carotid stenosis trial.

Background And Purpose: We aimed at comparing the long-term benefit-risk balance of carotid stenting versus endarterectomy for symptomatic carotid stenosis.

Methods: Long-term follow-up study of patients included in Endarterectomy Versus Angioplasty in Patients With Symptomatic Severe Carotid Stenosis (EVA-3S), a randomized, controlled trial of carotid stenting versus endarterectomy in 527 patients with recently symptomatic severe carotid stenosis, conducted in 30 centers in France. The main end point was a composite of any ipsilateral stroke after randomization or any procedural stroke or death.

Aggressive epidermotropic cutaneous CD8+ lymphoma: a cutaneous lymphoma with distinct clinical and pathological features. Report of an EORTC Cutaneous Lymphoma Task Force Workshop.

Aims: Aggressive epidermotropic cutaneous CD8(+) lymphoma is currently afforded provisional status in the WHO classification of lymphomas. An EORTC Workshop was convened to describe in detail the features of this putative neoplasm and evaluate its nosological status with respect to other cutaneous CD8(+) lymphomas.

Methods And Results: Sixty-one CD8(+) cases were analysed at the workshop; clinical details, often with photographs, histological sections, immunohistochemical results, treatment and patient outcome were discussed and recorded.

[Clinical pharmacology and aging].

Clinicians must be aware that aging can lead to changes in the pharmacokinetics and pharmacodynamics of many drugs. Drug distribution may be modified with aging secondarily to the decrease of serum albumin and to modifications of body composition (increase in the proportion of fat mass and decrease of lean mass). Hepatic metabolism of several drugs is reduced with age, especially drugs which depend of hepatic blood flow or P450 cytochroms.

[Anticoagulation of older patients: what is new?].

Vitamin-K antagonists (VKA) are the current standard for oral anticoagulation. However, they carry several problems in older patients: frequent bleeding complications, complex management, risk of interactions with multiple drugs. Two new classes of oral anticoagulants (NOA) are now available: direct thrombin inhibitors (dabigatran); and direct factor Xa inhibitors (rivaroxaban, apixaban) and others.

Interactions of bexarotene (LGD1069, Targretin) with the coagulation system.

Main Purpose: Bexarotene, (LGD1069, Targretin), is an antitumoral agent used as chemotherapy in the treatment of cutaneous T-cell lymphoma. Therapy with bexarotene is accompanied by adverse events, such as, bleeding, hemorrhage, and coagulopathy

Research Question: In order to design applications for bexarotene, it was very important to gain an understanding of how bexarotene inhibits blood clotting

Methods: We investigated the interaction between bexarotene or vehicle alone, and coagulation factors or blood cells. We used both in vitro and in vivo assays.

Absorption and tissue distribution of a novel carboxymethyldextran after oral administration.

The aim of this study was to investigate the development of an oral dextran derivative OTR4120. Pharmacokinetics (PK) parameters of OTR4120 were determined after treatment with intravenous injection (i.v.

New bacteriological patterns in primary infected aorto-iliac aneurysms: a single-centre experience.

Objectives: To assess causative pathogens and surgical outcomes in patients with primary infected aorto-iliac aneurysms at our institution.

Design: Retrospective study of patients treated at a university hospital between 1992 and 2009.

Results: We identified 26 patients (median age, 63 years) with primary infected aneurysms on the aorta (descending thoracic, n = 2; thoraco-abdominal, n = 3; suprarenal, n = 2; infrarenal, n = 15) or iliac arteries (n = 4).

Pulmonary effects of keratinocyte growth factor in newborn rats exposed to hyperoxia.

Acute lung injury and compromised alveolar development characterize bronchopulmonary dysplasia (BPD) of the premature neonate. High levels of keratinocyte growth factor (KGF), a cell-cell mediator with pleiotrophic lung effects, are associated with low BPD risk. KGF decreases mortality in hyperoxia-exposed newborn rodents, a classic model of injury-induced impaired alveolarization, although the pulmonary mechanisms of this protection are poorly defined.

[Research on "usual" care: new French legislation].

Research on standard or usual care is defined by the law to cover assessments of standard care, except for drug treatments but including medical devices. It involves research about basic health care that uses standard procedures and products. Authorization by the relevant authority (DGS or Afssaps) is not required; the only application is made to a new Comité de protection des personnes.

Effects on coagulation of a synthetic heparan mimetic given intraperitoneally or orally.

OTR4120, which belongs to a family of heparan sulfate-mimetic polymers, promotes tissue repair when injected locally in doses of a few micrograms. As OTR4120 is a sulfated polysaccharide, we investigated its possible role on the coagulation cascade. We used both in vitro and in vivo assays.

[New legislation about clinical research involving "usual care": reminder of recent problems].

Objective: The regulatory framework of clinical research in France was recently modified substantially, in part to transpose into French law directive 2001/20/EC of the European Parliament and Council, which concerns only drug trials. The revision also covered research on "human beings" (Public Health L. 2004-806, 2006-450), on biological samples (revision of bioethics, L.

Limb graft occlusion following EVAR: clinical pattern, outcomes and predictive factors of occurrence.

Introduction: We reviewed our experience with limb occlusion after EVAR in order (1) to assess the clinical pattern and treatment options (2) to assess outcomes and (3) to identify predictive factors of occurrence.

Materials And Method: Between 1995 and 2005, 460 AAA patients were electively treated with a variety of commercially available stent grafts. There were 369 bifurcated and 91 aortouniiliac grafts (829 limbs).

Rapid ventricular pacing induces delayed cardioprotection against myocardial stunning.

Tachycardia with rapid ventricular pacing induces delayed preconditioning against arrhythmias secondary to coronary artery occlusion (CAO) and reperfusion (CAR) but its effects on myocardial stunning remains unknown. Accordingly, we investigated whether delayed preconditioning with ventricular pacing develops against myocardial stunning and whether this phenomenon is triggered by reactive oxygen species. Eight chronically instrumented conscious dogs underwent three experimental sequences in a random order a week apart: (a) 10-min CAO (coronary occluder) followed by CAR, i.

A collision tumor involving Basal cell carcinoma and lentigo maligna melanoma.

Basal cell carcinomas (BCC) are known to co-exist with other cutaneous lesions, but the collision of BCC with malignant melanoma is rare. We report on the case of an 82-year-old woman with a translucent papule set on a beige-brown plaque on the right side of the nose. Histologic examination showed lesions of lentigo maligna melanoma (LMM) in situ and invasive melanoma involving nests of BCC that invaded the dermis.

Elective popliteal aneurysms: does venous availability has an impact on indications?

Aim: The aim of this retrospective study was to evaluate the patency and limb salvage rates after prosthetics or venous bypasses for asymptomatic or mildly symptomatic popliteal aneurysms, in order to determine if small uncomplicated aneurysms (caliber <300%) should be operated or periodically controlled when a venous conduit is not available.

Methods: During a 18 years period, 100 popliteal aneurysms, including 85 asymptomatic and 15 associated with intermittent claudication, were operated on: group I consisted of 80 venous bypasses, and group II consisted of 20 prosthetic bypasses.

Results: Demographics and risks factors were similar in both groups.