Exploring the Optical and Energetic Properties of a Co(II)-Based Mixed Ligand MOF.

Due to their remarkable properties, including remarkable porosity and extensive surface area, metal-organic frameworks (MOFs) are being investigated for various applications. Herein, we report the first Co(II)-based mixed ligand MOF, formulated Co(HTrz)(d-cam)(μ-OH). Its 3D structure framework is composed of helical chains {[Co(μ-HTrz)]} connected by d-camphorate ligand building blocks and featured as an extended structure in an AB-AB fashion.

Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress.

NLRP3 is a pattern recognition receptor with a well-documented role in inducing inflammasome assembly in response to cellular stress. Deregulation of its activity leads to many inflammatory disorders including gouty arthritis, Alzheimer disease, and cancer. Whereas its role in the context of cancer has been mostly explored in the immune compartment, whether NLRP3 exerts functions unrelated to immunity in cancer development remains unexplored.

Impact of synthesis route on structural, magnetic, magnetocaloric and critical behavior of NdSrMnO manganite.

NdSrMnO polycrystalline manganite was synthesized by two different methods: the auto-combustion reaction (NSMO-AC) and the sol-gel method (NSMO-SG). The structural, magnetic, magnetocaloric and critical behavior of the samples were examined. Rietveld refinements of the XRD patterns revealed that both compounds are pure single phase indexed to the orthorhombic system adopting the space group.

Magnetic and spectroscopic properties of Ni-Zn-Al ferrite spinel: from the nanoscale to microscale.

This article presents the annealing effect on the structural, elastic, thermodynamic, optical, magnetic, and electric properties of NiZnFeAlO (NZFAO) nanoparticles (NPs). The samples were successfully synthesized by the sol-gel method followed by annealing of the as-synthesized at 600, 800, 900, 1050, and 1200 °C. This approach yielded the formation of a highly crystalline structure with crystallite size ranging from 17 nm to 40 nm.

Effectiveness of a multicomponent pharmacist intervention at hospital discharge for drug-related problems: A cluster randomised cross-over trial.

Aims: The aim of this study was to assess whether a pharmacist intervention associating medication reconciliation at discharge with a link to the community pharmacist reduces drug-related problems (DRP) in adult patients during the 7 days after hospital discharge in 22 university or general hospitals in France.

Methods: We conducted a cluster randomised cross-over superiority trial with hospital units as the cluster unit. The primary outcome was a composite of any kind of DRP (prescription/dispensation, patient error or gap due to no medication available) during the 7 days after discharge, assessed by phone with the patient and community pharmacist.

Anomalous behavior above the Curie temperature in (Nd Gd )SrMnO ( = 0, 0.1, 0.3 and 0.5).

Magnetic properties were studied just above the ferromagnetic-paramagnetic (FM-PM) phase transition of (Nd Gd )SrMnO with = 0, 0.1, 0.3 and 0.

Pr doping at the A-site of LaBaMnO nanocrystalline material: assessment of the relationship between structural and physical properties and Bean-Rodbell model simulation of disorder effects.

Bulk nanocrystalline samples of (La Pr )BaMnO (0.075 ≤ ≤ 0.30) manganites with a fixed carrier concentration are prepared by the sol-gel based Pechini method.

Phylogeny and Sequence Space: A Combined Approach to Analyze the Evolutionary Trajectories of Homologous Proteins. The Case Study of Aminodeoxychorismate Synthase.

During the course of evolution, variations of a protein sequence is an ongoing phenomenon however limited by the need to maintain its structural and functional integrity. Deciphering the evolutionary path of a protein is thus of fundamental interest. With the development of new methods to visualize high dimension spaces and the improvement of phylogenetic analysis tools, it is possible to study the evolutionary trajectories of proteins in the sequence space.

Large magnetocaloric effect in manganese perovskite La Bi BaMnO near room temperature.

La Bi BaMnO ( = 0 and 0.05) ceramics were prepared the sol-gel method. Structural, magnetic and magnetocaloric effects have been systematically studied.

Achievement of 2009 and 2017 Kidney Disease: Improving Global Outcomes mineral and bone targets and survival in a French cohort of chronic kidney disease Stages 4 and 5 non-dialysis patients.

Background: The aim of the third French Phosphorus and Calcium Observatory (Photo-Graphe 3) was to assess the achievement of international Kidney Disease: Improving Global Outcomes (KDIGO) recommendations on optimal serum phosphate, calcium and parathyroid hormone (PTH) levels and possible associations with mortality in patients with chronic kidney disease (CKD).

Methods: This was a prospective, observational study conducted with nephrologists in France who were selected using a clustering approach. Adult patients with non-dialysis Stage 4 or 5 CKD and no kidney graft history were eligible.

TSPO and amyloid deposits in sub-regions of the hippocampus in the 3xTgAD mouse model of Alzheimer's disease.

The involvement of the 18kDa translocator protein (TSPO), a marker of neuroinflammation, in Alzheimer's disease (AD) remains controversial. In the present report, we used [I]-CLINDE, a SPECT TSPO radiotracer never before used in AD, and we investigated the relationship between TSPO and amyloid plaque density (using [I]-DRM106) in a triple transgenic mouse model of AD (3xTgAD, APP, PS1 and Tau). Our results show that TSPO increases appear before those of amyloid deposits.

Structural, magnetic and magnetocaloric properties of 0.75LaCaMnO/0.25LaSrMnO nanocomposite manganite.

The present study involves an investigation of structural, magnetic and magnetocaloric effect (MCE) properties of 0.75LaCaMnO/0.25LaSrMnO composite material.

Tetrakis(ethyl-4(4-butyryl)oxyphenyl)porphyrinato zinc complexes with 4,4'-bpyridin: synthesis, characterization, and its catalytic degradation of Calmagite.

This work reports on the synthesis and characterization of a new porphyrins complex:[Zn(TEBOP)(4,4'-bpy)](4,4'-bipyridine)(5,10,15,20-(tetraethyl-4(4-butyryl)oxyphenyl)porphyrinato)zinc(ii) (3). Single crystal X-ray diffraction, photophysical and electrochemical characteristics were studied. The prepared complex, penta-coordinated zinc(ii) porphyrin derivatives shows moderate ruffling distortion and the zinc atom is nearly planar with the porphyrin core.

Structure and Properties of Cartilage Proteoglycans.

The most abundant cartilage proteoglycan is aggrecan, a bottlebrush shaped molecule that possesses over 100 glycosaminoglycan (chondroitin sulfate and keratan sulfate) chains. The side-chains are linear sulfated polysaccharides that are negatively charged under physiological conditions. Aggrecan interacts with hyaluronic acid (HA) to form large aggregates.

Magnetocaloric study, critical behavior and spontaneous magnetization estimation in LaCaSrMnO perovskite.

A detailed study of structural, magnetic and magnetocaloric properties of the polycrystalline manganite LaCaSrMnO is presented. The Rietveld refinement of X-ray diffraction pattern reveals that our sample is indexed in the orthorhombic structure with space group. Magnetic measurements display a second order paramagnetic (PM)/ferromagnetic (FM) phase transition at Curie temperature = 304 K.

Copper-doped lanthanum manganite LaCeSrMn Cu O influence on structural, magnetic and magnetocaloric effects.

Bulk nanocrystalline samples of LaCeSrMn Cu O (0 ≤ ≤ 0.15) manganites are prepared by the sol-gel based Pechini method. The effect of the substitution for Mn with Cu upon the structural and magnetic properties has been investigated by means of X-ray diffraction (XRD), Raman spectroscopy and dc magnetization measurements.

Achievement of Kidney Disease: Improving Global Outcomes mineral and bone targets between 2010 and 2014 in incident dialysis patients in France: the Photo-Graphe3 study.

Background: Abnormal serum phosphate, calcium and parathyroid hormone (PTH) levels in patients with chronic kidney disease (CKD) undergoing haemodialysis have been associated with poor survival. The French Phosphorus and Calcium Observatory (Photo-Graphe 3) aimed to estimate the percentage of CKD patients achieving the three Kidney Disease: Improving Global Outcomes (KDIGO) targets about optimal serum phosphate, calcium and PTH over a 3.5-year follow-up period.

Critical phenomena and estimation of the spontaneous magnetization from a mean field analysis of the magnetic entropy change in LaCaPbMnAlSnO.

In the present work, we have studied the universal critical behavior in the perovskite-manganite compound LaCaPbMnAlSnO. Experimental results revealed that all samples exhibit a second-order magnetic phase transition. To study the critical behavior of the paramagnetic-ferromagnetic transition, various techniques such as modified Arrott plots, the Kouvel-Fisher method and critical isotherm analysis were used to determine the values of the Curie temperature , as well as the critical exponents (corresponding to the spontaneous magnetization), (corresponding to the initial susceptibility) and (corresponding to the critical magnetization isotherm).

Hypolipidemic and cardioprotective effects of Ulva lactuca ethanolic extract in hypercholesterolemic mice.

Context: Hypercholesterolemia has significant cardiac consequences, since it is among the major risk factors of ischemic heart diseases.

Objective: The aim was searching the cardioprotective effect of chemical constituents from the sea lettuce Ulva lactuca upon hypercholesterolemic regime in mice.

Material And Methods: Mice were randomly divided into three groups: untreated group, hypercholesterolemic group, and mice receiving 1% cholesterol associated with U.

[Management of bone and mineral metabolism disorders before the dialysis stage remains still perfectible. Data from the French Phosphorus and Calcium Survey Photo-Graphe].

Only limited data is available on the management of the chronic kidney disease-associated bone and mineral metabolism disorder (CKD-MBD) in the pre-dialysis stages of CKD in France. A better knowledge of current management habits could lead to an improvement in the implementation of international recommendations (KDIGO). The 3rd version of the French Phosphorus and Calcium Survey Photo-Graphe (Sanofi) included a cohort of CKD stages 4 and 5 patients, whose aim was to examine the prevalence of CKD-MBD and the quality of its management in patients under the care of 62 nephrologists from over 20 geographical regions in France.

Lepidic predominant adenocarcinoma and invasive mucinous adenocarcinoma of the lung exhibit specific mucin expression in relation with oncogenic drivers.

Objectives: To evaluate MUC1, MUC2, MUC5B, MUC5AC, and MUC6 expression in invasive lepidic predominant adenocarcinoma (LPA) and invasive mucinous adenocarcinoma (IMA) of the lung, and the impact of oncogenic drivers.

Materials And Methods: MUC1, MUC2, MUC5B, MUC5AC, MUC6, TTF1 and Hnf4α immunohistochemistry was performed on surgical samples from 52 patients with IMA (n=25) or LPA (n=27). We searched for EGFR, KRAS, BRAF, and HER2 mutations and ALK, ROS1, and NRG1 rearrangements.

Magnetic Anisotropy in Pentacoordinate Ni and Co Complexes: Unraveling Electronic and Geometrical Contributions.

The magnetic properties of the pentacoordinate [M (Me cyclam)N ] (Me cyclam=tetramethylcyclam; N =azido; M=Ni, Co) complexes were investigated. Magnetization and EPR studies indicate that they have an easy plane of magnetization with axial anisotropy parameters D close to 22 and greater than 30 cm for the Ni and Co complexes, respectively. Ab initio calculations reproduced the experimental values of the zero-field splitting parameters and allowed the orientation of the anisotropy tensor axes with respect to the molecular frame to be determined.

Discrete Mesh Approach in Morphogenesis Modelling: the Example of Gastrulation.

Morphogenesis is a general concept in biology including all the processes which generate tissue shapes and cellular organizations in a living organism. Many hybrid formalizations (i.e.

Wound Healing and Scale Modelling in Zebrafish.

We propose to study the wound healing in Zebrafish by using firstly a differential approach for modelling morphogens diffusion and cell chemotactic motion, and secondly a hybrid model of tissue regeneration, where cells are considered as individual objects and molecular concentrations are described by partial differential equations.

NRG1 fusion in a French cohort of invasive mucinous lung adenocarcinoma.

Invasive mucinous lung adenocarcinoma (IMA) is a rare subtype of lung adenocarcinoma with no effective treatment option in advanced disease. KRAS mutations occur in 28-87% of the cases. NRG1 fusions were recently discovered in KRAS-negative IMA cases and otherwise negative for known driver oncogenes and could represent an attractive therapeutic target.