1 results match your criteria: "CNRS and Toulouse University[Affiliation]"
The telomerase inhibitor Gno1p/PINX1 activates the helicase Prp43p during ribosome biogenesis.
Nucleic Acids Res
June 2014
Equipe labellisée Ligue Contre le Cancer, LBME, CNRS and Toulouse University, Toulouse 31062, France
Article Synopsis
- Prp43p, a key helicase in ribosome synthesis, is activated by yeast Gno1p and its human counterpart PINX1, which interact with Prp43p through their G-patch domain.
- Alterations in the G-patch disrupt these interactions, negatively impacting Prp43p's activity and ribosome biogenesis in yeast.
- Gno1p is shown to associate with early pre-ribosomal particles, and its interaction with PINX1 is essential for the maturation of ribosome precursors.