5 results match your criteria: "CNRS and Montpellier University[Affiliation]"
Low Percentage of Perforin-Expressing NK Cells during Severe SARS-CoV-2 Infection: Consumption Rather than Primary Deficiency.
J Immunol
April 2024
Institute of Human Genetics, UMR9002, CNRS and Montpellier University, Montpellier, France.
Article Synopsis
- Genetic defects in perforin delivery have been implicated in hemophagocytic lymphohistiocytosis, leading researchers to investigate its role in severe COVID-19 infections.
- A study of 54 SARS-CoV-2-infected patients revealed significantly lower levels of perforin-expressing NK cells compared to healthy controls, but this decrease was not associated with disease severity or predictive of mortality.
- Findings suggest that the low frequency of perforin-positive NK cells in COVID-19 patients may be due to consumption rather than a primary defect in perforin expression, as levels returned to normal one year post-infection.
T4 apoptosis in the acute phase of SARS-CoV-2 infection predicts long COVID.
Front Immunol
January 2024
Immunology Department, Nîmes University Hospital, Nîmes, France.
Background: As about 10% of patients with COVID-19 present sequelae, it is important to better understand the physiopathology of so-called long COVID.
Method: To this aim, we recruited 29 patients hospitalized for SARS-CoV-2 infection and, by Luminex, quantified 19 soluble factors in their plasma and in the supernatant of their peripheral blood mononuclear cells, including inflammatory and anti-inflammatory cytokines and chemokines, Th1/Th2/Th17 cytokines, and endothelium activation markers. We also measured their T4, T8 and NK differentiation, activation, exhaustion and senescence, T cell apoptosis, and monocyte subpopulations by flow cytometry.
Low perforin expression in CD8+ T lymphocytes during the acute phase of severe SARS-CoV-2 infection predicts long COVID.
Front Immunol
November 2022
Institute of Human Genetics, Unité Mixte de Recherche 9002 (UMR9002), Centre National de Recherche Scientifique (CNRS) and Montpellier University, Montpellier, France.
Article Synopsis
- T cell cytotoxicity is crucial for fighting antiviral infections like SARS-CoV-2, especially in determining the severity of acute disease and the development of long COVID.
- A study measured the levels of perforin in T cells from hospitalized COVID-19 patients and found that perforin-positive T cells were more prevalent compared to healthy controls, but this did not relate to disease severity or mortality.
- Interestingly, high levels of perforin-positive T8 cells during the acute phase could predict long COVID symptoms one year later, suggesting that enhancing T cell activity early on might reduce the chances of prolonged health issues post-infection.
A Transposon Story: From TE Content to TE Dynamic Invasion of Genomes Using the Single-Molecule Sequencing Technology from Oxford Nanopore.
Cells
July 2020
Institute of Human Genetics, UMR9002, CNRS and Montpellier University, 34396 Montpellier, France.
Article Synopsis
- Transposable elements (TEs) are key components of genomes but are challenging to study due to their repetitive sequences and the limitations of short-read sequencing technologies.
- A new pipeline using long-read sequencing from Oxford Nanopore Technology (ONT) effectively identifies TE insertion sites and sequences, revealing that TE landscapes in certain wild-type strains are more similar than previously believed.
- This pipeline also allowed for the recovery of piRNA cluster sequences that short-read sequencing could not, and the analysis of unstable lines did not support the theory that piRNA clusters are hotspots for TE insertions.
Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate.
Cell Rep
March 2017
Unité Mixte de Recherche 5535, Institut de Génétique Moléculaire de Montpellier, CNRS and Montpellier University, 34293 Montpellier, France. Electronic address:
The nuclear cap-binding complex (CBC) stimulates processing reactions of capped RNAs, including their splicing, 3'-end formation, degradation, and transport. CBC effects are particular for individual RNA families, but how such selectivity is achieved remains elusive. Here, we analyze three main CBC partners known to impact different RNA species.
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