2 results match your criteria: "CNRS UMR8261 (previously FRE3630) associated with University Paris Diderot[Affiliation]"
Landscape of RNA polyadenylation in E. coli.
Nucleic Acids Res
March 2017
CNRS UMR8261 (previously FRE3630) associated with University Paris Diderot, Sorbonne Paris Cité, Institut de Biologie Physico-Chimique, 13 rue P. et M. Curie, 75005 Paris, France.
Article Synopsis
- Polyadenylation plays a role in bacterial RNA degradation and quality control, but few studies have explored its impact until now.
- In an analysis comparing a wild-type strain with a mutant lacking poly(A)polymerase, 178 transcripts showed significant expression changes, affecting genes related to the FliA regulon and numerous novel transcripts.
- The absence of poly(A)polymerase led to the buildup of various small RNAs, antisense transcripts, and RNA fragments, highlighting the crucial role of polyadenylation in regulating gene expression and degrading structured RNA fragments.
The small RNA SraG participates in PNPase homeostasis.
RNA
October 2016
CNRS UMR8261 (previously FRE3630) associated with University Paris Diderot, Sorbonne Paris Cité, Institut de Biologie Physico-Chimique, 75005 Paris, France.
Article Synopsis
- * The small RNA SraG is positioned between the rpsO and pnp genes and is transcribed oppositely; while its function was previously unknown, it has been shown to affect pnp expression.
- * Overexpressing SraG decreases pnp levels and destabilizes its mRNA, while inhibiting SraG increases pnp expression, suggesting that SraG directly regulates pnp through antisense interactions.