Towards Semantic Photogrammetry: Generating Semantically Rich Point Clouds from Architectural Close-Range Photogrammetry.

Developments in the field of artificial intelligence have made great strides in the field of automatic semantic segmentation, both in the 2D (image) and 3D spaces. Within the context of 3D recording technology it has also seen application in several areas, most notably in creating semantically rich point clouds which is usually performed manually. In this paper, we propose the introduction of deep learning-based semantic image segmentation into the photogrammetric 3D reconstruction and classification workflow.

Temozolomide-Acquired Resistance Is Associated with Modulation of the Integrin Repertoire in Glioblastoma, Impact of α5β1 Integrin.

Despite extensive treatment, glioblastoma inevitably recurs, leading to an overall survival of around 16 months. Understanding why and how tumours resist to radio/chemotherapies is crucial to overcome this unmet oncological challenge. Primary and acquired resistance to Temozolomide (TMZ), the standard-of-care chemotherapeutic drug, have been the subjects of several studies.

Chronic IL-15 Stimulation and Impaired mTOR Signaling and Metabolism in Natural Killer Cells During Acute Myeloid Leukemia.

Natural Killer (NK) cells are potent anti-leukemic immune effectors. However, they display multiple defects in acute myeloid leukemia (AML) patients leading to reduced anti-tumor potential. Our limited understanding of the mechanisms underlying these defects hampers the development of strategies to restore NK cell potential.

The Viral Class II Membrane Fusion Machinery: Divergent Evolution from an Ancestral Heterodimer.

A key step during the entry of enveloped viruses into cells is the merger of viral and cell lipid bilayers. This process is driven by a dedicated membrane fusion protein (MFP) present at the virion surface, which undergoes a membrane-fusogenic conformational change triggered by interactions with the target cell. Viral MFPs have been extensively studied structurally, and are divided into three classes depending on their three-dimensional fold.

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at .

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 at the CERN LHC, corresponding to an integrated luminosity of 137 collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented.

Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies.

Crimean-Congo hemorrhagic fever virus (CCHFV) is the most widespread tick-borne zoonotic virus, with a 30% case fatality rate in humans. Structural information is lacking in regard to the CCHFV membrane fusion glycoprotein Gc—the main target of the host neutralizing antibody response—as well as antibody–mediated neutralization mechanisms. We describe the structure of prefusion Gc bound to the antigen-binding fragments (Fabs) of two neutralizing antibodies that display synergy when combined, as well as the structure of trimeric, postfusion Gc.

Precision luminosity measurement in proton-proton collisions at in 2015 and 2016 at CMS.

The measurement of the luminosity recorded by the CMS detector installed at LHC interaction point 5, using proton-proton collisions at in 2015 and 2016, is reported. The absolute luminosity scale is measured for individual bunch crossings using beam-separation scans (the van der Meer method), with a relative precision of 1.3 and 1.

Search for a heavy vector resonance decaying to a boson and a Higgs boson in proton-proton collisions at .

A search is presented for a heavy vector resonance decaying into a boson and the standard model Higgs boson, where the boson is identified through its leptonic decays to electrons, muons, or neutrinos, and the Higgs boson is identified through its hadronic decays. The search is performed in a Lorentz-boosted regime and is based on data collected from 2016 to 2018 at the CERN LHC, corresponding to an integrated luminosity of 137 . Upper limits are derived on the production of a narrow heavy resonance , and a mass below 3.

Search for charged Higgs bosons produced in vector boson fusion processes and decaying into vector boson pairs in proton-proton collisions at .

A search for charged Higgs bosons produced in vector boson fusion processes and decaying into vector bosons, using proton-proton collisions at at the LHC, is reported. The data sample corresponds to an integrated luminosity of 137 collected with the CMS detector. Events are selected by requiring two or three electrons or muons, moderate missing transverse momentum, and two jets with a large rapidity separation and a large dijet mass.

Development and validation of HERWIG 7 tunes from CMS underlying-event measurements.

This paper presents new sets of parameters ("tunes") for the underlying-event model of the event generator. These parameters control the description of multiple-parton interactions (MPI) and colour reconnection in , and are obtained from a fit to minimum-bias data collected by the CMS experiment at , 7, and . The tunes are based on the NNPDF 3.

Measurements of angular distance and momentum ratio distributions in three-jet and + two-jet final states in collisions.

Collinear (small-angle) and large-angle, as well as soft and hard radiations are investigated in three-jet and  + two-jet events collected in proton-proton collisions at the LHC. The normalized production cross sections are measured as a function of the ratio of transverse momenta of two jets and their angular separation. The measurements in the three-jet and  + two-jet events are based on data collected at a center-of-mass energy of 8 , corresponding to an integrated luminosity of 19.

MUSiC: a model-unspecific search for new physics in proton-proton collisions at .

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 , corresponding to an integrated luminosity of 35.9 , are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model.

Measurements of production cross sections of the Higgs boson in the four-lepton final state in proton-proton collisions at .

Production cross sections of the Higgs boson are measured in the ( ) decay channel. A data sample of proton-proton collisions at a center-of-mass energy of 13 , collected by the CMS detector at the LHC and corresponding to an integrated luminosity of 137 is used. The signal strength modifier , defined as the ratio of the Higgs boson production rate in the channel to the standard model (SM) expectation, is measured to be at a fixed value of .

Measurement of the Higgs boson production rate in association with top quarks in final states with electrons, muons, and hadronically decaying tau leptons at .

The rate for Higgs ( ) bosons production in association with either one ( ) or two ( ) top quarks is measured in final states containing multiple electrons, muons, or tau leptons decaying to hadrons and a neutrino, using proton-proton collisions recorded at a center-of-mass energy of by the CMS experiment. The analyzed data correspond to an integrated luminosity of 137 . The analysis is aimed at events that contain , , or decays and each of the top quark(s) decays either to lepton+jets or all-jet channels.

A phase II randomised study of preoperative trastuzumab alone or combined with everolimus in patients with early HER2-positive breast cancer and predictive biomarkers (RADHER trial).

Introduction: Resistance to trastuzumab in breast cancer is an ongoing challenge. Clinical and biological effects of co-targeting HER2 and mammalian target of rapamycin (mTOR) in patients with HER2-positive early operable breast cancer via the addition of everolimus to preoperative trastuzumab were evaluated in a phase II randomised study.

Methods: Patients were randomised 1:1 to receive trastuzumab (4 mg/kg initial dose then 2 mg/kg weekly for 5 weeks) alone or combined with everolimus (10 mg/day for 6 weeks) and then underwent surgery.

Perovskite-Type SrVO as High-Performance Anode Materials for Lithium-Ion Batteries.

Perovskite-type oxides, characterized by excellent multifunctional physical and chemical properties, are widely used in ferroelectric, piezoelectric, energy conversion, and storage applications. It is shown here that the perovskite-type SrVO can achieve excellent electrochemical performance as lithium-ion battery anodes thanks to its high electrically and ionically conductivity. Conducting additive-free SrVO electrodes can deliver a high specific capacity of 324 mAh g at a safe and low average working potential of ≈0.

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling.

Human herpesvirus 8 (HHV-8) is an oncogenic virus that enters cells by fusion of the viral and endosomal cellular membranes in a process mediated by viral surface glycoproteins. One of the cellular receptors hijacked by HHV-8 to gain access to cells is the EphA2 tyrosine kinase receptor, and the mechanistic basis of EphA2-mediated viral entry remains unclear. Using X-ray structure analysis, targeted mutagenesis, and binding studies, we here show that the HHV-8 envelope glycoprotein complex H and L (gH/gL) binds with subnanomolar affinity to EphA2 via molecular mimicry of the receptor's cellular ligands, ephrins (Eph family receptor interacting proteins), revealing a pivotal role for the conserved gH residue E52 and the amino-terminal peptide of gL.

A 2D Front-Tracking Lagrangian Model for the Modeling of Anisotropic Grain Growth.

Grain growth is a well-known and complex phenomenon occurring during annealing of all polycrystalline materials. Its numerical modeling is a complex task when anisotropy sources such as grain orientation and grain boundary inclination have to be taken into account. This article presents the application of a front-tracking methodology to the context of anisotropic grain boundary motion at the mesoscopic scale.

Cerebral mucormycosis: neuroimaging findings and histopathological correlation.

Introduction: Mucormycosis are infections caused by molds of the order Mucorales. These opportunistic infections are rare, difficult to diagnose, and have a poor prognosis. We aimed to describe common radiographic patterns that may help to diagnose cerebral mucormycosis and search for histopathological correlations with imaging data.

Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy?

AIDS first emerged decades ago; however, its cure, i.e., eliminating all virus sources, is still unachievable.

Divorce in the two-component BVMO family: the single oxygenase for enantioselective chemo-enzymatic Baeyer-Villiger oxidations.

Two-component flavoprotein monooxygenases consist of a reductase and an oxygenase enzyme. The proof of functionality of the latter without its counterpart as well as the mechanism of flavin transfer remains unanswered beyond doubt. To tackle this question, we utilized a reductase-free reaction system applying purified 2,5-diketocamphane-monooxygenase I (2,5-DKCMO), a FMN-dependent type II Baeyer-Villiger monooxygenase, and synthetic nicotinamide analogues (NCBs) as dihydropyridine derivatives for FMN reduction.

Measurements of production cross sections and constraints on anomalous triple gauge couplings at .

The production of Z boson pairs in proton-proton ( ) collisions, , where or , is studied at a center-of-mass energy of 13 with the CMS detector at the CERN LHC. The data sample corresponds to an integrated luminosity of 137 , collected during 2016-2018. The production cross section, , measured for events with two pairs of opposite-sign, same-flavor leptons produced in the mass region is consistent with standard model predictions.

Search for dark matter produced in association with a leptonically decaying boson in proton-proton collisions at .

A search for dark matter particles is performed using events with a Z boson candidate and large missing transverse momentum. The analysis is based on proton-proton collision data at a center-of-mass energy of 13 , collected by the CMS experiment at the LHC in 2016-2018, corresponding to an integrated luminosity of 137 . The search uses the decay channels and .

Search for top squark pair production using dilepton final states in collision data collected at .

A search is presented for supersymmetric partners of the top quark (top squarks) in final states with two oppositely charged leptons (electrons or muons), jets identified as originating from quarks, and missing transverse momentum. The search uses data from proton-proton collisions at collected with the CMS detector, corresponding to an integrated luminosity of 137 . Hypothetical signal events are efficiently separated from the dominant top quark pair production background with requirements on the significance of the missing transverse momentum and on transverse mass variables.