Hepatoblastoma in a patient with neurofibromatosis type 1: A case report.

Background: Neurofibromatosis type 1 (NF1) is one of the most common genodermatoses. It can affect every organ and is associated with an increased risk of benign and malignant tumors. Most common tumoral locations involve nervous system and soft tissues but a large variety of tumors have been described.

Enhanced mechanical properties and in vitro bioactivity of silicon nitride ceramics with SiO, YO, and AlO as sintering aids.

Silicon nitride (Si₃N₄) ceramics exhibit excellent mechanical properties and biocompatibility, making them highly suitable for biomedical applications, particularly in implants. In this study, the mechanical properties and bioactivity of Si₃N₄ ceramics with varying amounts of Y₂O₃-Al₂O₃-SiO₂ sintering aids were investigated. Increasing the sintering additive content from 4 wt% to 8 wt% substantially improved the bulk density of the ceramics, leading to notable enhancements in mechanical properties.

Electrochemical pH modulator coupled with Ni-based electrode for glucose sensing.

The non-enzymatic electrochemical detection of glucose by direct oxidation using electrodes modified with suitable electrocatalysts is now well-established. However, it most often requires highly alkaline media, limiting dramatically the use of such electrodes at neutral pH. This is notably the case of Ni-based electrodes.

Understanding complex volcanic hydrosystems using a multi-tracer approach.

Climate change affects groundwater availability and residence times, necessitating a thorough understanding of aquifer characteristics to define sustainable yields, particularly in regions where water is heavily exploited. This study focuses on the Volvic volcanic aquifer (Chaîne des Puys, France), where groundwater recharge has decreased due to climate change, raising concerns about water use sustainability. To address these challenges, this work proposes a multi-tracer approach, based on hydrogeological monitoring, including the estimation of groundwater ages, major elements chemistry and water stable isotopes to better characterise this resource decrease and more peculiarly its origin and its impact on the environment that has never been addressed.

Investigating the quality of European silver eels by quantifying contaminants and parasite infestation in a French Mediterranean lagoon complex.

Coastal lagoons are diverse habitats with significant ecological gradients, which provide crucial ecosystem services but face threats from human activities such as invasive species and pollution. Among the species inhabiting the lagoons, the critically endangered European eel (Anguilla anguilla) is an emblematic species strongly impacted by contamination and parasitism. Several indicators were developed to assess the quality of eel at a large geographic scale.

Sleep quality in lung cancer and specifically non-small-cell lung cancer: a rapid review.

Purpose: Sleep quality contributes to the improvement of quality of life in cancer patients. However, sleep disturbances, of variable and heterogeneous etiologies, are common and frequently overlooked in lung cancer patients. The present study undertakes a rapid review of available peer-reviewed literature on sleep quality in lung cancer patients, specifically non-small-cell lung cancer patients.

Clinical significance criteria in the ICSD and DSM sleep disorder classifications: a content overlap analysis using the Jaccard index.

Study Objectives: Both the (ICSD) and the sleep-wake disorders section of the (DSM) emphasize the importance of clinical judgment in distinguishing the normal from the pathological in sleep medicine. The fourth edition of the DSM (DSM-IV, 1994) introduced the clinical significance criterion (CSC) to standardize this judgment and enhance diagnostic reliability.

Methods: This review conducts a theoretical and historical content analysis of CSC presence, frequency, and formulation in the diagnostic criteria of sleep disorders.

Functional carbohydrate-active enzymes acquired by horizontal gene transfer from plants in the whitefly Bemisia tabaci.

Carbohydrate-active enzymes (CAZymes) involved in the degradation of plant cell walls and/or the assimilation of plant carbohydrates for energy uptake are widely distributed in microorganisms. In contrast, they are less frequent in animals, although there are exceptions, including examples of CAZymes acquired by horizontal gene transfer (HGT) from bacteria or fungi in several of phytophagous arthropods and plant-parasitic nematodes. Although the whitefly Bemisia tabaci is a major agricultural pest, knowledge of HGT-acquired CAZymes in this phloem-feeding insect of the Hemiptera order (subfamily Aleyrodinae) is still lacking.

Patterns of Treatment and Real-World Outcomes of Patients With Non-small Cell Lung Cancer With EGFR Exon 20 Insertion Mutations Receiving Mobocertinib: The EXTRACT Study.

Background: Real-world data regarding patients with non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion (ex20ins) mutations receiving mobocertinib are limited. This study describes these patients' characteristics and outcomes.

Methods: A chart review was conducted across three countries (Canada, France, and Hong Kong), abstracting data from eligible patients (NCT05207423).

Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections.

Cyclophilin (Cyp) inhibitors are of clinical interest in respect to their antiviral activities in the context of many viral infections including chronic hepatitis B and C. Cyps are a group of enzymes with peptidyl-prolyl isomerase activity (PPIase), known to be required for replication of diverse viruses including hepatitis B and C viruses (HBV and HCV). Amongst the Cyp family, the molecular mechanisms underlying the antiviral effects of CypA have been investigated in detail, but potential roles of other Cyps are less well studied in the context of viral hepatitis.

Spatial Distribution of Genetic, Ploidy, and Morphological Variation of the Edaphic Steno-Endemic (Brassicaceae) from the Western Balkans.

Polyploidy is a powerful mechanism driving genetic, physiological, and phenotypic changes among cytotypes of the same species across both large and small geographic scales. These changes can significantly shape population structure and increase the evolutionary and adaptation potential of cytotypes. , an edaphic steno-endemic species with a narrow distribution in the Balkan Peninsula, serves as an intriguing case study.

A Guinea Pig Model of Pediatric Metabolic Dysfunction-Associated Steatohepatitis: Poor Vitamin C Status May Advance Disease.

Children and teenagers display a distinct metabolic dysfunction-associated steatohepatitis (MASH) phenotype, yet studies of childhood MASH are scarce and validated animal models lacking, limiting the development of treatments. Poor vitamin C (VitC) status may affect MASH progression and often co-occurs with high-fat diets and related metabolic imbalances. As a regulator of DNA methylation, poor VitC status may further contribute to MASH by regulating gene expression This study investigated guinea pigs-a species that, like humans, depends on vitC in the diet-as a model of pediatric MASH, examining the effects of poor VitC status on MASH hallmarks and global DNA methylation levels.

An Extensive Study of an Eco-Friendly Fireproofing Process of Lignocellulosic × Particles and Their Application in Flame-Retardant Panels.

Increasing the flame retardancy of lignocellulosic materials such as × can effectively enable their wide use. This study examines the fireproofing process of Miscanthus particles using an eco-friendly process by grafting phytic acid and urea in aqueous solution. Miscanthus particles underwent a steam explosion step before being grafted.

Minimizing Delay and Power Consumption at the Edge.

Edge computing systems must offer low latency at low cost and low power consumption for sensors and other applications, including the IoT, smart vehicles, smart homes, and 6G. Thus, substantial research has been conducted to identify optimum task allocation schemes in this context using non-linear optimization, machine learning, and market-based algorithms. Prior work has mainly focused on two methodologies: (i) formulating non-linear optimizations that lead to NP-hard problems, which are processed via heuristics, and (ii) using AI-based formulations, such as reinforcement learning, that are then tested with simulations.

A Review of CNN Applications in Smart Agriculture Using Multimodal Data.

This review explores the applications of Convolutional Neural Networks (CNNs) in smart agriculture, highlighting recent advancements across various applications including weed detection, disease detection, crop classification, water management, and yield prediction. Based on a comprehensive analysis of more than 115 recent studies, coupled with a bibliometric study of the broader literature, this paper contextualizes the use of CNNs within Agriculture 5.0, where technological integration optimizes agricultural efficiency.

Anion-Directed Assembly of a Bimetallic Pd/Ag Nanocluster: Synthesis, Characterization, and HER Activity.

Palladium-doped silver nanoclusters (NCs) have been highlighted for their unique physicochemical properties and potential applications in catalysis, optics, and electronics. Anion-directed synthesis offers a powerful route to control the morphology and properties of these NCs. Herein, we report a novel Pd-doped Ag NC, [Pd(H)Ag(S){SP(OPr)}] (), synthesized through the inclusion of sulfide and hydride anions.

Synthesis of an Azido-Substituted 8-Membered Ring Laddersiloxane and Its Application in Catalysis.

A first -type tricyclic 8-8-8 (three fused-8-membered ring) laddersiloxane functionalized with four azido groups was successfully synthesized through efficient and highly selective hydrosilylation and nucleophilic substitution, achieving an excellent overall yield. The starting material, a tetravinyl-substituted 8-8-8 laddersiloxane, was prepared via a straightforward and scalable method. The obtained azido-functionalized ladder compound, fully characterized, constitutes a versatile building block for hybrid materials.

Furan-Indole-Chromenone-Based Organic Photocatalyst for α-Arylation of Enol Acetate and Free Radical Polymerization Under LED Irradiation.

In this study we report on the efficiency of a furane-indole-chromenone-based organic derivative () as a photocatalyst in the α-arylation of enol acetate upon LED irradiation at 405 nm, and as a photoinitiator/photocatalyst in the free radical polymerization of an acrylate group in the presence of -(4--butylphenyl)iodonium hexafluorophosphate (Iod) as an additive, or in the presence of both Iod and ethyl-4-(dimethyl amino) benzoate (EDB) under LED irradiation at 365 nm. The photochemical properties of this new light-sensitive compound are described, and the wide redox window (3.27 eV) and the high excited-state potentials / (+2.

A Bis-Glycosylamine Strategy for the Synthesis of Dimeric Iminosugars Based on a DAB-1 Scaffold.

A straightforward synthetic route towards DAB-1 scaffolded dimeric iminosugars is described here, starting from readily available bis-glycosylamines. The method allows the integration of a variety of linkages (aryl, alkyl, polyethyleneglycol chains) between both iminosugars through the choice of the bis-amine used in the first step. Moreover, an additional substituent (allyl, ethynyl) may be inserted into the structure via nucleophilic addition of an organometallic reagent to the starting bis-glycosylamine.

The Role of Atmospheric Composition in Defining the Habitable Zone Limits and Supporting Growth.

Studying exoplanet atmospheres is essential for assessing their potential to host liquid water and their capacity to support life (their habitability). Each atmosphere uniquely influences the likelihood of surface liquid water, defining the habitable zone (HZ)-the region around a star where liquid water can exist. However, being within the HZ does not guarantee habitability, as life requires more than just liquid water.

Development of Tailored Porous Ti6Al4V Materials by Extrusion 3D Printing.

Nowadays, metallic bone replacement is in high demand due to different issues, like sicknesses and accidents. Thus, bone implants are fabricated with tailored properties and microstructure for long-term use in the human body. To improve such implants, 3D printing is the most promising technique.

A Manufacturing Technique for Binary Clathrate Hydrates for Cold and Very Cold Neutron Production.

Intense sources of very cold neutrons (VCNs) would be beneficial for various neutron scattering techniques and low-energy particle physics experiments. Binary clathrate hydrates hosting deuterated tetrahydrofuran (THF-d) and dioxygen show promise as potential moderators for such sources due to a rich spectrum of localized low-energy excitations of the encaged guest molecules. In this article, we present a reliable manufacturing technique for such hydrates.

Terbium-Labeled Gold Nanoparticles as Nanoscale Brachytherapy Agents Against Breast Cancer.

Due to their intriguing emission profile, Terbium-161 (Tb) radiopharmaceuticals seem to bring significant advancement in theranostic applications to cancer treatment. The combination of Tb with nanoscale brachytherapy as an approach for cancer treatment is particularly advantageous and promising. Herein, we propose the application of a hybrid nanosystem comprising gold decorated (Au@TADOTAGA) iron oxide nanoflowers as a form of injectable nanobrachytherapy for the local treatment of breast cancer.