Epidemiology and Management of Actinic Keratosis in France: A General Population Survey (REAKT).

The objective of this retrospective observational study was to estimate the prevalence of actinic keratosis (AK) in individuals aged ≥ 40 years in France, to describe the characteristics of affected patients, and to describe treatments. A representative panel of 20,000 households with ≥ 1 member aged ≥ 40 years were invited to participate. Participants who reported AK lesions diagnosed by a physician were eligible.

Immunonutrition to improve the quality of life of upper gastrointestinal cancer patients undergoing neoadjuvant treatment prior to surgery (NEOIMMUNE): double-blind randomized controlled multicenter clinical trial.

Background: Malnutrition is common with esophagogastric cancers and is associated with negative outcomes. We aimed to evaluate if immunonutrition during neoadjuvant treatment improves patient's health-related quality of life (HRQOL) and reduces postoperative morbidity and toxicities during neoadjuvant treatment.

Methods: A multicenter double-blind randomized controlled trial (RCT) was undertaken.

Exogenous dsRNA triggers sequence-specific RNAi and fungal stress responses to control Magnaporthe oryzae in Brachypodium distachyon.

In vertebrates and plants, dsRNA plays crucial roles as PAMP and as a mediator of RNAi. How higher fungi respond to dsRNA is not known. We demonstrate that Magnaporthe oryzae (Mo), a globally significant crop pathogen, internalizes dsRNA across a broad size range of 21 to about 3000 bp.

Investigation into the PSD characteristics of internally unstable soils susceptible to suffosion.

Internal instability of embankment soils under seepage can occur in two distinct ways: suffusion and suffosion. Suffusion involves the removal of fine particles from the matrix without causing significant disturbance to the soil skeleton, while suffosion is characterized by the movement of fine particles accompanied by skeleton collapse or deformation. In terms of dam safety, suffosion poses a greater threat than suffusion.

Mathematical model linking telomeres to senescence in Saccharomyces cerevisiae reveals cell lineage versus population dynamics.

Telomere shortening ultimately causes replicative senescence. However, identifying the mechanisms driving replicative senescence in cell populations is challenging due to the heterogeneity of telomere lengths and the asynchrony of senescence onset. Here, we present a mathematical model of telomere shortening and replicative senescence in Saccharomyces cerevisiae which is quantitatively calibrated and validated using data of telomerase-deficient single cells.

LDPC-cat codes for low-overhead quantum computing in 2D.

The main obstacle to large scale quantum computing are the errors present in every physical qubit realization. Correcting these errors requires a large number of additional qubits. Two main avenues to reduce this overhead are (i) low-density parity check (LDPC) codes requiring very few additional qubits to correct errors (ii) cat qubits where bit-flip errors are exponentially suppressed by design.

Overlooked tripartite microbial interactions influencing chemical cycling in the ocean.

Inter-microbial interactions fundamentally govern ocean ecology and biogeochemistry. Recently, Henshaw and colleagues revealed that important inter-bacterial associations in the ocean can be shaped by viral infections, whereby infected cyanobacteria release specific chemicals that attract heterotrophic bacteria, uncovering a new tripartite microbial interaction that influences carbon transfer in the surface ocean.

Quantitative and Visual Benefits of Data-Driven Motion Correction on Oncologic PET/CT: A Prospective Cross-sectional Study.

Rationale And Objective: Conventional positron emission tomography (PET) respiratory gating utilizes a fraction of acquired PET counts (i.e., optimal gate [OG]), whereas elastic motion correction with deblurring (EMCD) utilizes all PET counts to reconstruct motion-corrected images without increasing image noise.

DIEP flap reconstruction for sacrectomy defects: Two case reports.

Introduction: Vertical rectus abdominis myocutaneous (VRAM) flap is the most common option for large sacral defect reconstruction but is known to have donor-site abdominal morbidity compared to deep inferior epigastric perforator (DIEP) flaps.

Report: Fifty-seven and 63 year-old men were admitted for large sacral soft tissue defects after tumour excisions. They both underwent an inferiorly based pedicled vertical DIEP flap passed transabdominally with successful postoperative outcomes and not any abdominal wall complication.

Platelet extracellular vesicles-loaded hydrogel bandages for personalized wound care.

Autologous or allogeneic platelet-derived extracellular vesicles (pEVs) show potential in enhancing tissue recovery and healing chronic wounds. pEVs promote neovascularization and cell migration while reducing inflammation, oxidative stress, and scarring. However, their efficacy in clinical settings is challenged by their susceptibility to washout by wound exudate.

Effects of isolation methods on physicochemical properties of defatted starch from the acorn (Quercus brantii).

This study explores the innovative combined effects of alkaline isolation with ultrasound pretreatment on the physicochemical properties of acorn (Quercus brantii) starch. The optimal pH for maximizing the yield of alkaline-isolated acorn starch (AAS) was determined, followed by comparison with alkaline-isolated defatted acorn starch (ADAS), ultrasound-pretreated acorn starch (UAS), and ultrasound-pretreated defatted acorn starch (UDAS). The results demonstrated substantial improvements in yield and purity, with the highest yield (68.

Unveiling an innovative sustainable blue resource-ecofriendly extraction technique towards a circular economy: Optimization of natural deep eutectic solvent and ultrasonication synergistic pathways for type-I collagen refined recovery from discarded fish scales.

A vast sum of fish waste is being annually discarded by marine fishing industries imposing serious environmental pollution concerns. However, these aquatic discarded matters are captivating sources of collagen, a fibrous protein with eminent social and economic relevance. Collagen is conventionally recovered using outdated complex processes requiring many reagents, multiple steps, and extended periods.

Correspondence. Reply to the article "Cornelis S, Mufty S, Peters S. Isolated distal radioulnar joint septic arthritis, the intact triangular fibrocartilaginous complex serving as an anatomical barrier. Hand Surg Rehabil, January 2025.

Cornelis et al. reported an isolated DRUJ infection treated with open surgery to prevent spread to the radiocarpal joint. We suggest that arthroscopy, proven effective in other joint infections and technically feasible for the DRUJ without damaging the TFCC,could have been a less invasive and effective alternative.

Case report: Study of a bulky melanoma mimicking sarcoma.

Introduction: Large melanomas, while relatively uncommon, present significant diagnostic challenges due to their size and potential to mimic other malignancies, leading to delays in appropriate treatment. Initial misdiagnosis is a substantial concern, impacting patient outcomes. This case highlights the importance of immunohistochemistry in cancer diagnosis, and of appropriate therapeutic management, which here included excision surgery of the tumor mass.

An unexpected guest: First report of Tintelnotia destructans as an agent of maxillary fungus ball.

Fungal rhinosinusal infections comprise several nosological entities, including sinus fungus ball. Diagnosis of sinus fungus ball relies on patient interrogation and clinical and paraclinical findings. Mold species commonly involved include Aspergillus, as well as dematiaceous fungi.

Hepatoblastoma in a patient with neurofibromatosis type 1: A case report.

Background: Neurofibromatosis type 1 (NF1) is one of the most common genodermatoses. It can affect every organ and is associated with an increased risk of benign and malignant tumors. Most common tumoral locations involve nervous system and soft tissues but a large variety of tumors have been described.

Enhanced mechanical properties and in vitro bioactivity of silicon nitride ceramics with SiO, YO, and AlO as sintering aids.

Silicon nitride (Si₃N₄) ceramics exhibit excellent mechanical properties and biocompatibility, making them highly suitable for biomedical applications, particularly in implants. In this study, the mechanical properties and bioactivity of Si₃N₄ ceramics with varying amounts of Y₂O₃-Al₂O₃-SiO₂ sintering aids were investigated. Increasing the sintering additive content from 4 wt% to 8 wt% substantially improved the bulk density of the ceramics, leading to notable enhancements in mechanical properties.

Electrochemical pH modulator coupled with Ni-based electrode for glucose sensing.

The non-enzymatic electrochemical detection of glucose by direct oxidation using electrodes modified with suitable electrocatalysts is now well-established. However, it most often requires highly alkaline media, limiting dramatically the use of such electrodes at neutral pH. This is notably the case of Ni-based electrodes.

Understanding complex volcanic hydrosystems using a multi-tracer approach.

Climate change affects groundwater availability and residence times, necessitating a thorough understanding of aquifer characteristics to define sustainable yields, particularly in regions where water is heavily exploited. This study focuses on the Volvic volcanic aquifer (Chaîne des Puys, France), where groundwater recharge has decreased due to climate change, raising concerns about water use sustainability. To address these challenges, this work proposes a multi-tracer approach, based on hydrogeological monitoring, including the estimation of groundwater ages, major elements chemistry and water stable isotopes to better characterise this resource decrease and more peculiarly its origin and its impact on the environment that has never been addressed.

Investigating the quality of European silver eels by quantifying contaminants and parasite infestation in a French Mediterranean lagoon complex.

Coastal lagoons are diverse habitats with significant ecological gradients, which provide crucial ecosystem services but face threats from human activities such as invasive species and pollution. Among the species inhabiting the lagoons, the critically endangered European eel (Anguilla anguilla) is an emblematic species strongly impacted by contamination and parasitism. Several indicators were developed to assess the quality of eel at a large geographic scale.

Sleep quality in lung cancer and specifically non-small-cell lung cancer: a rapid review.

Purpose: Sleep quality contributes to the improvement of quality of life in cancer patients. However, sleep disturbances, of variable and heterogeneous etiologies, are common and frequently overlooked in lung cancer patients. The present study undertakes a rapid review of available peer-reviewed literature on sleep quality in lung cancer patients, specifically non-small-cell lung cancer patients.

Clinical significance criteria in the ICSD and DSM sleep disorder classifications: a content overlap analysis using the Jaccard index.

Study Objectives: Both the (ICSD) and the sleep-wake disorders section of the (DSM) emphasize the importance of clinical judgment in distinguishing the normal from the pathological in sleep medicine. The fourth edition of the DSM (DSM-IV, 1994) introduced the clinical significance criterion (CSC) to standardize this judgment and enhance diagnostic reliability.

Methods: This review conducts a theoretical and historical content analysis of CSC presence, frequency, and formulation in the diagnostic criteria of sleep disorders.

Functional carbohydrate-active enzymes acquired by horizontal gene transfer from plants in the whitefly Bemisia tabaci.

Carbohydrate-active enzymes (CAZymes) involved in the degradation of plant cell walls and/or the assimilation of plant carbohydrates for energy uptake are widely distributed in microorganisms. In contrast, they are less frequent in animals, although there are exceptions, including examples of CAZymes acquired by horizontal gene transfer (HGT) from bacteria or fungi in several of phytophagous arthropods and plant-parasitic nematodes. Although the whitefly Bemisia tabaci is a major agricultural pest, knowledge of HGT-acquired CAZymes in this phloem-feeding insect of the Hemiptera order (subfamily Aleyrodinae) is still lacking.