Self-assembly processes of 2D Au(I)-S(CH)COOH lamellae.

Solving the assembled structure of Au(I)-thiolate linear coordination polymers has been a challenging task as they generally lack good crystallinity. This has prevented the elucidation of their assembly processes at the molecular level. In this paper, selected area electron diffraction (SAED) patterns of two-dimensional (2D) Au(I)-S(CH)COOH (Au(I)-MPA) lamellae are obtained by applying cryogenic transmission electron microscopy.

Robust undulatory locomotion through neuromechanical adjustments in a dissipative medium.

Dissipative environments are ubiquitous in nature, from microscopic swimmers in low-Reynolds-number fluids to macroscopic animals in frictional media. In this study, we consider a mathematical model of a slender elastic locomotor with an internal rhythmic neural pattern generator to examine various undulatory locomotion such as swimming and crawling behaviours. By using local mechanical load as mechanosensory feedback, we have found that undulatory locomotion robustly emerges in different rheological media.

Geographic differences in the phenology of gonadal development and moult, but not of egg laying, are genetically based in a small songbird.

To forecast how fast populations can adapt to climate change, it is essential to determine the evolutionary potential of different life-cycle stages under selection. In birds, timing of gonadal development and moult are primarily regulated by photoperiod, while laying date is highly phenotypically plastic to temperature. We tested whether geographic variation in phenology of these life-cycle events between populations of great tits () has a genetic basis, indicating that contemporary genetic adaptation is possible.

The promise of community-driven preprints in ecology and evolution.

Publishing preprints is quickly becoming commonplace in ecology and evolutionary biology. Preprints can facilitate the rapid sharing of scientific knowledge establishing precedence and enabling feedback from the research community before peer review. Yet, significant barriers to preprint use exist, including language barriers, a lack of understanding about the benefits of preprints and a lack of diversity in the types of research outputs accepted (e.

Social learning preserves both useful and useless theories by canalizing learners' exploration.

In many domains, learning from others is crucial for leveraging cumulative cultural knowledge, which encapsulates the efforts of successive generations of innovators. However, anecdotal and experimental evidence suggests that reliance on social information can reduce the exploration of the problem space. Here, we experimentally investigate the extent to which cultural transmission fosters the persistence of arbitrary solutions in a context where participants are incentivized to improve a physical system across multiple trials.

Transition Metal-Free Direct Electrochemical Carboxylation of Organic Halides Using a Sacrificial Magnesium Anode: Straightforward Synthesis of Carboxylic Acids.

The direct electrochemical carboxylation of aryl, benzyl and alkyl halides by CO is described using a magnesium anode and a nickel foam cathode in an undivided cell. The process employs a sacrificial anode and does not require the additional use of a transition metal catalyst or demanding conditions, as the reactions are carried out under galvanostatic mode, at -10 °C and with commercial DMF. Under these operationally simple conditions, an important range of carboxylic acids are affordable.

Unveiling the Etiopathogenic Role of Epstein-Barr Virus in Periodontitis.

Periodontitis, a prevalent and costly oral disease, remains incompletely understood in its etiopathogenesis. The conventional model attributes it to pathogenic bacteria, but emerging evidence suggests dysbiosis involving bacteria, herpesviruses, and an exaggerated host immune response. Among herpesviruses, Epstein-Barr virus (EBV) closely links to severe periodontitis, yet the mechanisms underlying EBV-related pathogenesis remain elusive.

Rapid, Accurate and Reproducible Prediction of the Glass Transition Temperature Using Ensemble-Based Molecular Dynamics Simulation.

For the computational design of new polymeric materials, accurate methods for determining the glass transition temperature () are required. We apply an ensemble approach in molecular dynamics (MD) and examine its predictions of and their associated uncertainty. We separate the uncertainty into the aleatoric contributions arising from dynamical chaos and that due to the computational scenarios chosen to compute .

SALL4 as a Useful Marker for the Distinction of Various Gestational Trophoblastic Disease Subtypes: Choriocarcinoma From Other Trophoblastic Lesions and Early Complete Hydatidiform Mole From Partial Mole and NonMolar Villi.

The distinction between choriocarcinoma and residual trophoblastic cell proliferation from a complete hydatidiform mole/invasive mole (CHM/IM) without villi is challenging on curettage materials. We investigated whether SALL4 immunostaining could help differentiate various gestational trophoblastic diseases. Placental site nodules (PSN; n=10), atypical PSN (APSN; n=8), placental site trophoblastic tumors (PSTT; n=9), epithelioid trophoblastic tumors (ETT; n=5), gestational choriocarcinomas (n=31), partial hydatidiform moles (PHM; n=13), CHM/IM (n=47), and nonmolar products of conception (POC) (n=26) were included.

Which dietary shifts to improve nutritional quality while reducing diet cost in the French West Indies?

Background: The French West Indies are facing increasing rates of obesity and diet-related chronic diseases. Food prices are more than 30% higher compared with mainland France, while a large part of the population is socioeconomically disadvantaged. The affordability of a healthy diet is a key issue.

Time-resolved momentum microscopy with fs-XUV photons at high repetition rates with flexible energy and time resolution.

Time-resolved momentum microscopy is an emerging technique based on photoelectron spectroscopy for characterizing ultrafast electron dynamics and the out-of-equilibrium electronic structure of materials in the entire Brillouin zone with high efficiency. In this article, we introduce a setup for time-resolved momentum microscopy based on an energy-filtered momentum microscope coupled to a custom-made high-harmonic generation photon source driven by a multi-100 kHz commercial Yb-ultrafast laser that delivers fs pulses in the extreme ultraviolet range. The laser setup includes a nonlinear pulse compression stage employing spectral broadening in a Herriott-type bulk-based multi-pass cell.

Pediatric eosinophilic fasciitis: similarities and differences with adult forms.

The purpose of this study was to identify pediatric eosinophilic fasciitis, which is an extremely rare condition, in order to describe their clinical, paraclinical, and therapeutic characteristics. We made a call for observations via societies for pediatric rheumatology in France and surrounding countries and collected clinical and paraclinical data of the cases fulfilling the diagnostic criteria. Eight patients under 18 years of age with confirmed eosinophilic fasciitis followed between April 2004 and July 2022 in France, Germany, Italy, and Spain were included.

fMRI data acquisition and analysis for task-free, anesthetized rats.

Templates for the acquisition of large datasets such as the Human Connectome Project guide the neuroimaging community to reproducible data acquisition and scientific rigor. By contrast, small animal neuroimaging often relies on laboratory-specific protocols, which limit cross-study comparisons. The establishment of broadly validated protocols may facilitate the acquisition of large datasets, which are essential for uncovering potentially small effects often seen in functional MRI (fMRI) studies.

The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow.

The default mode network (DMN) is implicated in many aspects of complex thought and behavior. Here, we leverage postmortem histology and in vivo neuroimaging to characterize the anatomy of the DMN to better understand its role in information processing and cortical communication. Our results show that the DMN is cytoarchitecturally heterogenous, containing cytoarchitectural types that are variably specialized for unimodal, heteromodal and memory-related processing.

Chromatin environment-dependent effects of DOT1L on gene expression in male germ cells.

The H3K79 methyltransferase DOT1L is essential for multiple aspects of mammalian development where it has been shown to regulate gene expression. Here, by producing and integrating epigenomic and spike-in RNA-seq data, we decipher the molecular role of DOT1L during mouse spermatogenesis and show that it has opposite effects on gene expression depending on chromatin environment. On one hand, DOT1L represses autosomal genes that are devoid of H3K79me2 at their bodies and located in H3K27me3-rich/H3K27ac-poor environments.

Radon on Mars and the Moon derived from Martian and lunar meteorites.

The radioactive gas radon-222, a fluid and aerosol tracer in Earth's lithosphere and atmosphere, can also reveal subtle rock physics processes in extraterrestrial environments, such as those involving water, but remains poorly constrained in planetary bodies due to the limited number of samples available. Here we measure the effective radium-226 concentration (EC) of six Martian and nine lunar meteorites to derive radon source terms for Martian and lunar rocks. EC values are 0.

A guide for active learning in synergistic drug discovery.

Synergistic drug combination screening is a promising strategy in drug discovery, but it involves navigating a costly and complex search space. While AI, particularly deep learning, has advanced synergy predictions, its effectiveness is limited by the low occurrence of synergistic drug pairs. Active learning, which integrates experimental testing into the learning process, has been proposed to address this challenge.

Neural circuits underlying context-dependent competition between defensive actions in Drosophila larvae.

To ensure their survival, animals must be able to respond adaptively to threats within their environment. However, the precise neural circuit mechanisms that underlie flexible defensive behaviors remain poorly understood. Using neuronal manipulations, machine learning-based behavioral detection, electron microscopy (EM) connectomics and calcium imaging in Drosophila larvae, we map second-order interneurons that are differentially involved in the competition between defensive actions in response to competing aversive cues.

Can a single coastal tide gauge help predict internal solitary wave activity offshore.

Internal solitary waves (ISWs) propagate in stratified waters, enhancing diapycnal mixing, sediment and mass transport on shelves. They have typical wavelengths of hundreds of meters and tens of minutes periods, requiring high resolution and high frequency measurements for their sampling. But such in-situ measurements are scarce and ISWs remain largely unpredictable.

High-rate quantum LDPC codes for long-range-connected neutral atom registers.

High-rate quantum error correcting (QEC) codes with moderate overheads in qubit number and control complexity are highly desirable for achieving fault-tolerant quantum computing. Recently, quantum error correction has experienced significant progress both in code development and experimental realizations, with neutral atom qubit architecture rapidly establishing itself as a leading platform in the field. Scalable quantum computing will require processing with QEC codes that have low qubit overhead and large error suppression, and while such codes do exist, they involve a degree of non-locality that has yet to be integrated into experimental platforms.