Posterior extent of left anterior temporal lobectomy and picture naming decline.

Objective: Recent voxel-based lesion symptom mapping (VLSM) studies have identified a critical region for picture naming, located 3.4 to 6.1 cm from the temporal pole.

One hundred thirty-four germ line PU.1 variants and the agammaglobulinemic patients carrying them.

Leukopoiesis is lethally arrested in mice lacking the master transcriptional regulator PU.1. Depending on the animal model, subtotal PU.

Impact of under-assisted ventilation on diaphragm function and structure in a porcine model.

Background: Long-term controlled mechanical ventilation (CMV) in intensive care unit (ICU) induces ventilatory-induced-diaphragm-dysfunction (VIDD). The transition from CMV to assisted mechanical ventilation is a challenge that requires clinicians to balance over-assistance and under-assistance. While the effects of over-assistance on the diaphragm are well known, we aimed to assess the impact of under-assistance on diaphragm function and structure in piglet model with pre-existing VIDD (after long-term CMV) or without VIDD (short-term CMV).

Ecological interactions amplify cumulative effects in marine ecosystems.

Biodiversity encompasses not only species diversity but also the complex interactions that drive ecological dynamics and ecosystem functioning. Still, these critical interactions remain overwhelmingly overlooked in environmental management. In this study, we introduce an ecosystem-based approach that assesses the cumulative effects of climate change and human activities on species in the St.

Cryo-EM structure and regulation of human NAD kinase.

Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is a crucial reducing cofactor for reductive biosynthesis and protection from oxidative stress. To fulfill their heightened anabolic and reductive power demands, cancer cells must boost their NADPH production. Progrowth and mitogenic protein kinases promote the activity of cytosolic NAD kinase (NADK), which produces NADP, a limiting NADPH precursor.

Hydration of 3-Methyl-1,2,3-butanetricarboxylic Acid Evidenced by Matrix-Isolation Infrared Spectroscopy.

The hydration mechanism of 3-methyl-1,2,3-butanetricarboxylic acid (MBTCA), a relevant marker of secondary organic aerosol formation from the atmospheric oxidation of α-pinene, has been investigated using the matrix-isolation infrared spectroscopy technique. The experimental results were supported by theoretical calculations. Monomers of MBTCA and heterocomplexes MBTCA-(HO) were identified.

Semiconducting Overoxidized Polypyrrole Nano-Particles for Photocatalytic Water Splitting.

Capturing sunlight to fuel the water splitting reaction (WSR) into O and H is the leitmotif of the research around artificial photosynthesis. Organic semiconductors have now joined the quorum of materials currently dominated by inorganic oxides, where for both families of compounds the bandgaps and energies can be adjusted synthetically to perform the Water Splitting Reaction. However, elaborated and tedious synthetic pathways are necessary to optimize the photophysical properties of organic semiconductors.

Visible-Light Photo-Iniferter Polymerization of Molecularly Imprinted Polymers for Direct Integration with Nanotransducers.

Molecularly Imprinted Polymers (MIPs) have gained prominence as synthetic receptors, combining simplicity of synthesis with robust molecular recognition akin to antibodies and enzymes. One of their main application areas is chemical sensing. However, direct integration of MIPs with nanostructured transducers, crucial for enhancing sensing capabilities and broadening MIPs sensing applications, remains limited.

A Non-Equilibrium Species Distribution Model Reveals Unprecedented Depth of Time Lag Responses to Past Environmental Change Trajectories.

Previous studies have demonstrated legacy effects of current species distributions to past environmental conditions, but the temporal extent of such time lag dynamics remains unknown. Here, we have developed a non-equilibrium Species Distribution Modelling (SDM) approach quantifying the temporal extent that must be taken into account to capture 95% of the effect that a given time series of past environmental conditions has on the current distribution of a species. We applied this approach on the distribution of 92 European forest birds in response to past trajectories of change in forest cover and climate.

Reactions of Tertiary Aliphatic Cations with Silylated Alkynes: Substitution, Cyclization and Unexpected C-H Activation Products.

Capozzi's groundbreaking work in 1982 introduced a fascinating reaction involving highly reactive tertiary aliphatic cations and silylated alkynes. This reaction provided an innovative solution to the challenge of coupling a fully substituted tertiary aliphatic fragment with an alkyne moiety. Building upon Capozzi's pioneering efforts, we started an extensive exploration of reaction conditions to expand the initial scope of this reaction.

Effects of protection on large-bodied reef fishes in the western Indian Ocean.

Predatory and large-bodied coral reef fishes have fundamental roles in the functioning and biodiversity of coral reef ecosystems, but their populations are declining, largely due to overexploitation in fisheries. These fishes include sharks, groupers, Humphead wrasse (Cheilinus undulatus), and Green Humphead parrotfish (Bolbometopon muricatum). In the western Indian Ocean, this situation is exacerbated by limited population data on these fishes, including from conventional visual census methods, which limit the surface area surveyed.

Inherited non-syndromic polydactyly in a Berber and Arabian-Berber horse family.

Background: Supernumerary digits, or polydactyly, have been described in various species including humans, wild and domestic animals. In horses, it represents the most common congenital limb malformation, which has only been described in isolated cases or nuclear families. Molecular aetiology has not been reported.

Ultrasensitive Chemiresistive Gas Sensors Based on Dual-Mesoporous Zinc Stannate Composites for Room Temperature Rice Quality Monitoring.

The integration of dual-mesoporous structures, the construction of heterojunctions, and the incorporation of highly concentrated oxygen vacancies are pivotal for advancing metal oxide-based gas sensors. Nonetheless, achieving an optimal design that simultaneously combines mesoporous structures, precise heterojunction modulation, and controlled oxygen vacancies through a one-step process remains challenging. This study proposes an innovative method for fabricating zinc stannate semiconductors featuring dual-mesoporous structures and tunable oxygen vacancies via a direct solution precursor plasma spray technique.

Pollen-Derived Fatty Acids and Amino Acids Mediate Variance in Pollinator Visitation.

Pollinators help maintain functional landscapes and are sensitive to floral nutritional quality. Both proteins and lipids influence pollinator foraging, but the role of individual biochemical components in pollen remains unclear. We conducted an experiment comprising common garden plots of six plant species (Asteraceae, Rosaceae, Onagraceae, Boraginaceae, and Plantaginaceae).

A multivariable prediction model for invasive pulmonary aspergillosis in immunocompromised patients with acute respiratory failure (IPA-GRRR-OH score).

Purpose: Invasive pulmonary aspergillosis (IPA) is a life-threatening opportunistic infection in immunocompromised patients. The diagnosis is often made late, with mortality reaching 90% when mechanical ventilation is needed. We sought to develop and validate a risk prediction model for the diagnosis of IPA.

External validation of a CT score for predicting ischaemia in adhesive small-bowel obstruction.

Objectives: To assess the diagnostic accuracy, in a validation cohort, of a score based on three CT items, which has shown good performance for predicting ischaemia complicating acute adhesive small-bowel obstruction (SBO).

Methods: This retrospective single-centre study of diagnostic accuracy included consecutive patients admitted for acute adhesive SBO in 2015-2022, who were treated conservatively or underwent surgery within 24 h after CT. The gold standard for ischaemia was an intraoperative diagnosis for operated patients, while the absence of ischaemia was confirmed either by its absence during surgery or by clinical follow-up in patients who did not undergo surgery.

Role of Heterogeneous Reactions in the Atmospheric Oxidizing Capacity in Island Environments.

The source of nitrous acid (HONO) and its importance in island or marine environments are poorly understood. Herein, based on comprehensive field measurements at a hilltop on Corsica Island, we find an inverse diel variation of HONO with higher concentrations during daytime. Night-time HONO budget analysis indicates significant HONO formation during air mass transport along the hillside.

Molecular study of the status of Angiostrongylus cantonensis in rats in Haiti.

Angiostrongylus cantonensis, commonly known as the rat lungworm, causes Eosinophilic meningitis in humans. Our study aimed to investigate the prevalence and distribution of this parasite in rats in Haiti. Rats were trapped at 8 sites, 7 in Artibonite (rural region) and one in an urban area of Port-au-Prince.

Interactions among Zinc, Iron, and Paraquat in the Physiological and Toxicological Responses of the Egyptian Cotton Leafworm .

Agricultural pollutants co-interact and affect the vital functions, stress tolerance, resistance, immunity, and survival of insect pests. These metal-herbicide interactions have inevitable but remarkable effects on insects, which remain poorly understood. Here, we examined the effects of the interactions among zinc (Zn), iron (Fe), and paraquat (PQ) at a sublethal dose on the physiological response of the Egyptian cotton leafworm .

Does Clostridium Perfringens Epsilon Toxin Mimic an Auto-Antigen Involved in Multiple Sclerosis?

Multiple sclerosis (MS) is a chronic immune-mediated neurological disorder, characterized by progressive demyelination and neuronal cell loss in the central nervous system. Many possible causes of MS have been proposed, including genetic factors, environmental triggers, and infectious agents. Recently, epsilon toxin (ETX) has been incriminated in MS, based initially on the isolation of the bacteria from a MS patient, combined with an immunoreactivity to ETX.

Chitosan and Its Nanoparticles: A Multifaceted Approach to Antibacterial Applications.

Chitosan, a multifaceted amino polysaccharide biopolymer derived from chitin, has extensive antibacterial efficacy against diverse pathogenic microorganisms, including both Gram-negative and Gram-positive bacteria, in addition to fungi. Over the course of the last several decades, chitosan nanoparticles (NPs), which are polymeric and bio-based, have garnered a great deal of interest as efficient antibacterial agents. This is mostly due to the fact that they are used in a wide variety of applications, including medical treatments, food, chemicals, and agricultural products.

Evaluation of Nanomagnetite-Biochar Composite for BTA Removal.

In this study, the removal of benzotriazole (BTA), a pervasive aquatic contaminant widely used for its anti-corrosion, UV-stabilizing, and antioxidant properties, by nanomagnetite, biochar, and nanomagnetite-biochar composite is investigated. Nanomagnetite and nanomagnetite-biochar composite were synthesized under anoxic conditions and tested for BTA removal efficiency at neutral pH under both oxic and anoxic conditions at different time scales. Within the short time scale (up to 8 h), the removal of BTA by nanomagnetite-biochar composite was shown to be due to BTA deprotonation by the nanomagnetite surface.

Various Sizes and Shapes of Mixed-Anion Fe(NHtrz)(BF)(SiF)@SiO Nanohybrid Particles Undergoing Spin Crossover Just Above Room Temperature.

Spin crossover (SCO) iron (II) coordination compounds in the form of nanohybrid SCO@SiO particles were prepared using a reverse micelles technique based on the TritonX-100/cyclohexane/water ternary system. Tetraethyl orthosilicate (TEOS) acts as precursor of both the SiF counter-anion and SiO to obtain Fe(NHtrz)(BF)(SiF)@SiO nanoparticles with different sizes and morphologies while modifying the TEOS concentration and reaction time. The adjustable mixed-anion strategy leads to a range of quite scarce abrupt spin crossover behaviors with hysteresis just above room temperature (ca.