24 results match your criteria: "CNR Istituto di Fisiologia Clinica[Affiliation]"
Comput Methods Programs Biomed
March 2023
Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy.
Background And Objectives: Gold nanorod-assisted photothermal therapy (GNR-PTT) is a cancer treatment whereby GNRs incorporated into the tumour act as photo-absorbers to elevate the thermal destruction effect. In the case of bladder, there are few possible routes to target the tumour with GNRs, namely peri/intra-tumoural injection and intravesical instillation of GNRs. These two approaches lead to different GNR distribution inside the tumour and can affect the treatment outcome.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
April 2021
BioLabs, Institute of Life Science, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56127, Pisa, Italy.
The plant association of Populus alba L. 'Villafranca', Brassica oleracea var. acephala sebellica (kale), and B.
View Article and Find Full Text PDFG Ital Cardiol (Rome)
September 2019
Dipartimento di Scienze Cardiache, Toraciche e Vascolari, Policlinico Universitario di Padova.
The radiation dose received by interventional cardiologists during their activity in the catheterization laboratory is a matter of concern in terms of possible deterministic and stochastic risk. At the same time, very often, the knowledge of the effect and consequences of radiation exposure in the interventional cardiology community is limited. This document endorsed by the Italian Society of Interventional Cardiology (SICI-GISE) provides recommendations for cardiologists' radiation protection.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
September 2019
Institute of Life Science, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, I-56127, Pisa, Italy.
Phthalates are micro-pollutants of great concern due to their negative effects on ecosystem functioning and human health. Thanks to its capability in uptake and accumulation of organic pollutants, Populus alba L. "Villafranca" clone could be a good candidate for reducing the impacts derived by the persistence of such compounds in the environment.
View Article and Find Full Text PDFTree Physiol
January 2018
BioLabs, Institute of Life Science, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, I-56127 Pisa, Italy.
Surfactants are widely used detergent ingredients and, thanks to their chemical properties, they are applied for remediation of sites polluted by heavy metals and organic contaminants, both in soil flushing and in phytoremediation. However, their direct effects on tree physiology especially in consociation with heavy metal pollution, as well as their possible absorption by plants, have not been appropriately investigated. In order to evaluate plant uptake/translocation of the surfactant sodium dodecyl sulfate (SDS) and the heavy metal zinc (Zn) in Populus alba L.
View Article and Find Full Text PDFG Ital Nefrol
December 2017
Consiglio Nazionale delle Ricerche (CNR) - Istituto di Fisiologia Clinica (IFC), Pisa e Dipartimento di Medicina, Università di Padova.
Fragility fractures occur in all stages of chronic kidney disease (CKD) due to low bone mineral density and poor bone quality (namely osteoporosis), as well as in CKD-mineral and bone disorders (CKD-MBD). As in postmenopausal women and older adults, the prompt identification of CKD subjects with a history of fragility fractures is crucial in order to implement strategies to reduce the risk of new fragility fractures and their consequences. The treatment of severe osteoporosis for patients with stages 1-3 CKD should not differ from patients without CKD, while clinical decisions and pharmacological treatments in subjects with stages 4-5/5D CKD differ greatly, being more tricky and challenging.
View Article and Find Full Text PDFG Ital Nefrol
December 2017
Bone Clinic, Dipartimento delle Cure Geriatriche, Ortogeriatria e Riabilitazione, Ospedale Galliera, Genova, Italia.
Fragility fractures (FF) are common in patients with chronic kidney disease (CKD), and they occur at a younger age and with a higher frequency than in the general population, producing significant morbidity, mortality and healthcare costs. The pathogenic mechanisms underlying FF in CKD patients have not been completely understood. Behind CKD-MBD, the uremic toxicity should play a role in their pathogenesis, by affecting bone quality (uremic osteoporosis).
View Article and Find Full Text PDFJ Plant Physiol
November 2017
CNR-Istituto per la Protezione Sostenibile delle Piante, Area della Ricerca di Firenze, Via Madonna del Piano 10, 50019 Sesto Fiorentino, FI, Italy. Electronic address:
Combination of biotic and abiotic stress is a major challenge for crop and fruit production. Thus, identification of genes involved in cross-response to abiotic and biotic stress is of great importance for breeding superior genotypes. Lectins are glycan-binding proteins with a functions in the developmental processes as well as in the response to biotic and abiotic stress.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
November 2016
Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
This guideline summarizes the current view of the European Association of Nuclear Medicine Drug Development Committee. The purpose of this guideline is to guarantee a high standard of PET studies that are aimed at measuring target occupancy in the brain within the framework of development programs of drugs that act within the central nervous system (CNS drugs). This guideline is intended to present information specifically adapted to European practice.
View Article and Find Full Text PDFSci Total Environ
November 2016
Institute of Life Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, I-56127 Pisa, Italy.
Populus alba Villafranca clone was chosen for a proof of concept study to determine the potential uptake and accumulation of antibiotics by trees. Plants were grown hydroponically and irrigated with a recirculating Hoagland's nutrient solution (control) and Hoagland's nutrient solution fortified with erythromycin at 0.01, 0.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
April 2016
Institute of Life Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, I-56127, Pisa, Italy.
This is the first study reporting the presence of endogenous caffeine, theobromine, and theophylline in all organs of poplar plants. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was used in order to evaluate the uptake, translocation, and metabolism of caffeine-(trimethyl-(13)C) in Populus alba L. Villafranca clone grown in hydroponic conditions.
View Article and Find Full Text PDFBioorg Med Chem Lett
June 2015
CNR Istituto di Fisiologia Clinica, Via Moruzzi, 1, 56124 Pisa, Italy.
In the present work, we report the synthesis of new aryliodonium salts used as precursors of single-stage nucleophilic (18)F radiofluorination. The corresponding unlabelled fluorinated derivatives showed to be CB2 cannabinoid receptor specific ligands, with Ki values in the low nanomolar range and high CB2/CB1 selectivity. The radiolabelled compound [(18)F]CB91, was successfully formulated for in vivo administration, and its preliminary biodistribution was assessed with microPET/CT.
View Article and Find Full Text PDFMicrorna
June 2016
CNR Istituto di Fisiologia Clinica, Via Moruzzi, 1 - 56124 Pisa, Italy.
MiRNAs are gene (post-transcriptional) regulators that bind the 3'UTR of target genes. Single-nucleotide polymorphisms (SNPs) located within a miRNA binding site can impact miRNAdependent gene regulation by weakening or reinforcing the microRNA:mRNA bond. We present a general in silico approach enabling researchers to "predict" which of the several SNPs of 3'UTR of H2AFX gene can mainly affect its regulation.
View Article and Find Full Text PDFBMC Med Genet
April 2013
CNR Istituto di Fisiologia Clinica, Via Moruzzi 1, Pisa 56124, Italy.
Background: The purpose of our study was to investigate the potential contribution of germline mutations in NOTCH1, GATA5 and TGFBR1 and TGFBR2 genes in a cohort of Italian patients with familial Bicuspid Aortic Valve (BAV).
Methods: All the coding exons including adjacent intronic as well as 5' and 3' untranslated (UTR) sequences of NOTCH1, GATA5, TGFBR1 and TGFBR2 genes were screened by direct gene sequencing in 11 index patients (8 males; age = 42 ± 19 years) with familial BAV defined as two or more affected members.
Results: Two novel mutations, a missense and a nonsense mutation (Exon 5, p.
Pediatr Cardiol
February 2013
Unità di Ricerca Genetica, G Pasquinucci Hospital, CNR Istituto di Fisiologia Clinica, Via Aurelia Sud-Montepepe, 54100 Massa, Italy.
The GSTP1 gene, highly expressed early in fetal life, is the most abundant phase 2 xenobiotic metabolism enzyme in a human placenta. Fetal inherited GSTP1 Ile105Val polymorphism may modify the metabolism and excretion of xenobiotics from fetal tissue and increase the risk of congenital heart disease (CHD). This study aimed to analyze the joint effects of GSTP1 genetic polymorphism (Ile105Val) and maternal environmental exposure on CHD risk.
View Article and Find Full Text PDFAims: High-risk single nucleotide polymorphisms (SNPs) have been recently identified as risk factors for ischemic heart disease in large epidemiological and genome-wide association studies. However, their influence on prognosis remains uncertain. The aim of the study was to investigate the impact of previously identified SNPs and their joint effects in a genetic score (GS) on Major Adverse Cardiac Events (MACEs).
View Article and Find Full Text PDFMinerva Endocrinol
June 2004
Laboratorio di Biochimica Cardiovascolare, CNR Istituto di Fisiologia Clinica, Pisa, Italy.
Background: The evaluation of big-endothelin (ET)-1 plasmatic concentrations may serve as another noninvasive marker in patients with cardiovascular diseases, based on the assumption that it may reflect endothelin overproduction more accurately than circulating ET-1. For this reason the analytical performance of an immunoenzimatic assay for plasma Big-ET-1, with or without a preliminary step of extraction, was evaluated.
Methods And Results: Sensitivity for direct assay was 0.
Cell Mol Biol (Noisy-le-grand)
March 2001
CNR Istituto di Fisiologia Clinica, Pisa, Italy.
3H-ouabain is useful to evaluate the tissue localization of Na,K-ATPase. In this work we determined the distribution of 3H-ouabain in rabbit tissue by digital radioautography. Using this method, we were able to obtain a comparison of various organs in a relatively short time (6.
View Article and Find Full Text PDFNa+/K+ATPase is a transport membrane protein which contains the functional receptor for digitalis compounds. In this work we compare the inhibition curves of Na+/K+ATPase measured by the inhibition of 86Rb uptake in human red blood cells by cardiac glycosides and by an endogenous digitalis like factor (EDLF) extracted from human newborn cord blood. The curves of Na+/K+TPase inhibition show a monophasic shape for ouabain, strophantidin, digitoxin, proscillaridin and EDLF whereas a biphasic shape for ouabagenin, digoxin, digoxigenin and digitoxigenin.
View Article and Find Full Text PDFJ Endocrinol Invest
December 1999
CNR Istituto di Fisiologia Clinica, Pisa, Italy.
We report an original application of quantitative reverse transcription-polymerase chain reaction (Q.RT-PCR) for the evaluation of atrial natriuretic factor (ANF), brain natriuretic peptide (BNP) and beta-actin mRNA in small atrial samples (10-15 mg). A fixed amount of total RNA was simultaneously reverse transcribed and amplified with dilutions of a competitor RNA fragment used as a control.
View Article and Find Full Text PDFA sizeable proportion (20-30%) of patients undergoing coronary arteriography for a chest pain syndrome are found to have angiographically normal coronary arteries. Some of these subjects (10-15%) have ischemic-like electrocardiographic changes during stress and no evidence of spasm of the epicardial coronary arteries (syndrome X). The vast majority of these patients are middle aged females.
View Article and Find Full Text PDFAm Rev Respir Dis
September 1989
CNR Istituto di Fisiologia Clinica, Università di Pisa, Italy.
Am Rev Respir Dis
December 1988
CNR Istituto di Fisiologia Clinica, Pisa, Italy.
N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine (HIPDM), a synthetic basic compound with high affinity for lung tissue of various animal species, was labeled with 123I and injected into normal smokers (n = 9) and into asymptomatic smokers (n = 9). Time/activity curves were recorded for 90 min by gamma camera. HIPDM lung clearance was described by two exponential components.
View Article and Find Full Text PDF