2 results match your criteria: "CNR Institute of Neurogenetics and Neuropharmacology[Affiliation]"
Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid.
Eur J Endocrinol
August 2002
CNR Institute of Neurogenetics and Neuropharmacology, Cagliari, Monserrato, Italy.
Objective: Previous reports have shown that the Delta(9)-tetrahydrocannabinol (Delta(9)TCH), the major psychoactive cannabinoid components of marijuana, is able [corrected] to inhibit thyroid hormonal activity. The aim of this study was to characterize the CB1 functional expression in the rat thyroid by a multi-methods approach.
Methods And Results: RT-PCR was used to detect the mRNA expression of the CB1 cannabinoid receptor (17.
Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats.
Psychopharmacology (Berl)
January 2002
CNR Institute of Neurogenetics and Neuropharmacology, c/o Department of Neuroscience, University of Cagliari, S.S. 554, Km 4.5, I-09042, Monserrato (CA), Italy.
Rationale: Recent studies have shown that the cannabinoid CB1 receptor antagonist, SR 141716, is capable of reducing voluntary ethanol intake in rodents, suggesting the involvement of the CB1 receptor in the neural circuitry mediating the positive reinforcing properties of ethanol.
Objectives: The present study extended to the agonists the investigation on the pharmacological manipulation of ethanol intake by cannabinoid agents.
Methods: Selectively bred, Sardinian alcohol-preferring (sP) rats were offered ethanol and water under the two-bottle free choice procedure with unlimited access for 24 h/day.