2 results match your criteria: "CNR Institute of Macromolecular Studies (ISMAC)[Affiliation]"
In silico screening of Rac1 ligand specificity.
Annu Int Conf IEEE Eng Med Biol Soc
May 2009
CNR Institute of Macromolecular Studies (ISMAC), Section of Genoa, Via De Marini 6, 16149, Italy.
Microtubule (MT) destabilization promotes the formation of actin stress fibers and enhances the contractility of cells. The actin cytoskeleton is bound to each junction and controls the integrity of each through actin remodeling and these junctions can be disassembled or assembled to either increase or decrease cellular permeability. Mediators, such as thrombin, stimulate their respective receptor on endothelial cells to initiate signaling that increases cytosolic Ca2+ and activates myosin light chain kinase (MLCK), as well as monomeric GTPases RhoA, Rac1, and Cdc42.
View Article and Find Full Text PDFAgeWa: an integrated approach for antisense experiment design.
IEEE Trans Nanobioscience
December 2002
CNR Institute of Macromolecular Studies (ISMAC), via de Marini 6, 16149 Genova, Italy.
Article Synopsis
- The Human Genome Project has significantly advanced our understanding of disease molecular mechanisms, aiding in drug design through the identification and interaction analysis of relevant genes.
- New gene expression analysis methods, like microarray technology, enable the evaluation of multiple genes simultaneously but require further validation using in vitro or in vivo models to confirm gene functions.
- The paper introduces Automatic Gene Walk (AgeWa), a novel tool combining neural filtering and database mining, to enhance the selection of targets for antisense oligonucleotide (ASO) experiments, addressing the lack of standardized procedures in target selection.