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Role of Cardiovascular Risk Factors on the Association Between Physical Activity and Brain Integrity Markers in Older Adults.
Neurology
May 2022
From PhIND, "Physiopathology and Imaging of Neurological Disorders" (F.F., J.G., C.P., A.G.-C., F.M., B.L., A.C., A.Q., E.F.-D., D.V., G.C., G.P.), Institut Blood and Brain at Caen-Normandie, Normandie Univ, UNICAEN, INSERM, U1237, Cyceron, Caen; Clinical and Research Memory Center of Lyon (A.G.-C.), Lyon Institute For Elderly, Charpennes Hospital, Hospices Civils de Lyon; Claude Bernard University Lyon 1 (A.G.-C.); Department of General Practice (E.F.-D.), Normandie Univ, UNIROUEN, Rouen; Rouen University Hospital, CIC-CRB 1404 (E.F.-D.); PSL Université, EPHE (V.d.L.S.), Normandie Univ, UNICAEN, INSERM, U1077, CHU de Caen, GIP Cyceron, NIMH; and Département de Recherche Clinique (D.V.), CHU Caen-Normandie, Caen, France.
Background And Objectives: Physical activity has been associated with a decreased risk for dementia, but the mechanisms underlying this association remain to be determined. Our objective was to assess whether cardiovascular risk factors mediate the association between physical activity and brain integrity markers in older adults.
Methods: At baseline, participants from the Age-Well study completed a physical activity questionnaire and underwent cardiovascular risk factors collection (systolic blood pressure, body mass index [BMI], current smoker status, and high-density lipoprotein cholesterol, total cholesterol, and insulin levels) and multimodal neuroimaging (structural MRI, diffusion MRI, FDG-PET, and florbetapir PET).