l-Quebrachitol Promotes the Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells: Involvement of the BMP-2/Runx2/MAPK/Wnt/β-Catenin Signaling Pathway.

Osteoporosis is widely recognized as a major health problem caused by an inappropriate rate of bone resorption compared to bone formation. Previously we showed that d-pinitol inhibits osteoclastogenesis but has no effect on osteoblastogenesis. However, the effect on osteoblast differentiation of its isomer, l-quebrachitol, has not yet been reported.

Workplace accommodations following work-related mild traumatic brain injury: what works?

Individuals who have experienced a work-related mild traumatic brain injury face a variety of challenges when returning to work. Research has demonstrated that the implementation of workplace accommodations can reduce the incidence of workplace disability. Few studies investigate work-related mild traumatic brain injury from injured workers' perspectives, and none examine workplace accommodations in detail.

Intravenous Iron in Patients Undergoing Maintenance Hemodialysis.

Background: Intravenous iron is a standard treatment for patients undergoing hemodialysis, but comparative data regarding clinically effective regimens are limited.

Methods: In a multicenter, open-label trial with blinded end-point evaluation, we randomly assigned adults undergoing maintenance hemodialysis to receive either high-dose iron sucrose, administered intravenously in a proactive fashion (400 mg monthly, unless the ferritin concentration was >700 μg per liter or the transferrin saturation was ≥40%), or low-dose iron sucrose, administered intravenously in a reactive fashion (0 to 400 mg monthly, with a ferritin concentration of <200 μg per liter or a transferrin saturation of <20% being a trigger for iron administration). The primary end point was the composite of nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure, or death, assessed in a time-to-first-event analysis.

The mechanism of synergistic effect between iron-carbon microelectrolysis and biodegradation for strengthening phenols removal in coal gasification wastewater treatment.

A novel iron-carbon microelectrolysis (ICME) inoculated with activated sludge (AS) process was specifically designed to look into the roles of microelectrolysis and biodegradation as well as their synergistic effect on phenols removal in coal gasification wastewater (CGW) treatment. The results indicated that the removal efficiency of COD, phenols and TOC in integrated ICME-AS process reached 87.36 ± 2.

Potential enhancement of direct interspecies electron transfer for anaerobic degradation of coal gasification wastewater using up-flow anaerobic sludge blanket (UASB) with nitrogen doped sewage sludge carbon assisted.

Waste sewage sludge was converted into the novel conductive material of nitrogen doped sewage sludge carbon (N-SC) to enhance anaerobic degradation of coal gasification wastewater (CGW). The results indicated that N-SC played a significant role in enhanced efficiencies, with chemical oxygen demand (COD) removal efficiency increased by 25.4%, methane production rate improved by 68.

Sex & gender considerations in concussion research.

The study of concussion, a common form of mild traumatic brain injury, has received increased notice over the last decade. Recently, more researchers have been addressing the historic paucity of attention over sex and gender influences on recovery outcomes after concussion. This development has led to exciting progress in our understanding of concussion incidence and outcomes.

Discrimination of typical cyclic compounds and selection of toxicity evaluation bioassays for coal gasification wastewater (CGW) based on toxicity mechanism of actions (MOAs).

This paper originally investigated toxicity discrimination of typical cyclic compounds and bioassays selection on toxicity evaluation for coal gasification wastewater (CGW) effluent with mechanism-oriented investigation. Initially, representative cyclic toxicants were selected and classified with quantitative structure-toxicity relationship (QSTR). Nitrogen heterocyclic compounds (NHCs) and polycyclic aromatic hydrocarbons (PAHs) were basically discriminated as nonpolar narcotics with significant correlation to hydrophobicity (p < 0.

Persulfate Reaction in a Hair-Bleaching Formula: Unveiling the Unconventional Reactivity of 1,13-Diamino-4,7,10-Trioxatridecane.

The stability and unconventional reactivity of 1,13-diamino-4,7,10-trioxatridecane in the presence of NH, HO, and (NH)SO are described. The ether-diamine is an ingredient marketed to hair salons and consumers for so-called "plex" services to compensate for hair damage during bleaching. The main reaction product identified is an unexpected azanyl ester derivative.

New insights into enhanced anaerobic degradation of coal gasification wastewater (CGW) with the assistance of graphene.

The up-flow anaerobic sludge blanket (UASB) system with graphene assisted was developed for coal gasification wastewater (CGW) treatment. Short-term results showed that optimal graphene addition (0.5 g/L) resulted in a more significant enhancement of methane production and chemical oxygen demand (COD) removal compared with that of the optimal activated carbon addition (10.

Biotoxicity assessment and toxicity mechanism on coal gasification wastewater (CGW): A comparative analysis of effluent from different treatment processes.

Even though coal gasification wastewater (CGW) treated by various biochemical treatment processes generally met the national discharge standard, its potential biotoxicity was still unknown. Therefore, in this study, bioassay with Tetrahymena thermophila (T. thermophila) was conducted to comprehensively evaluate the variation of biotoxicity in raw CGW and the treated effluent from lab-scale micro-electrolysis integrated with biological reactor (MEBR), single iron-carbon micro-electrolysis (ICME) and conventional activated sludge (CAS) processes.

Effects of environmental parameters on the chestnut gall wasp and its complex of indigenous parasitoids.

The chestnut gall wasp (CGW), Dryocosmus kuriphilus, an invasive pest native to China, has caused severe yield and economic losses to chestnut production in Europe since its arrival in 2002. In Southern Italy, the complex of indigenous parasitoids colonizing CGW was monitored between 2013 and 2015, with the aim of estimating the composition of the indigenous parasitoid complex, its ability to control CGW populations, and the interactions of both factors with several measured environmental parameters. We compared results among three differently managed field types.

Inhibitory effect of high phenol concentration in treating coal gasification wastewater in anaerobic biofilter.

In this paper, the inhibition of methanogens by phenol in coal gasification wastewater (CGW) was investigated by both anaerobic toxicity tests and a lab-scale anaerobic biofilter reactor (AF). The anaerobic toxicity tests indicated that keeping the phenol concentration in the influent under 280mg/L could maintain the methanogenic activity. In the AF treating CGW, the result showed that adding glucose solution as co-substrate could be beneficial for the quick start-up of the reactor.

Nasopharyngeal carriage of Streptococcus pneumoniae among HIV-infected and -uninfected children <5 years of age before introduction of pneumococcal conjugate vaccine in Mozambique.

Nasopharyngeal carriage is a precursor for pneumococcal disease and can be useful for evaluating pneumococcal conjugate vaccine (PCV) impact. We studied pre-PCV pneumococcal carriage among HIV-infected and -uninfected children in Mozambique. Between October 2012 and March 2013, we enrolled HIV-infected children age <5 years presenting for routine care at seven HIV clinics in 3 sites, including Maputo (urban-south), Nampula (urban-north), and Manhiça (rural-south).

Enhanced degradation of phenolic compounds in coal gasification wastewater by a novel integration of micro-electrolysis with biological reactor (MEBR) under the micro-oxygen condition.

The aim of this work was to study an integration of micro-electrolysis with biological reactor (MEBR) for strengthening removal of phenolic compounds in coal gasification wastewater (CGW). The results indicated MEBR achieved high efficiencies in removal of COD and phenolic compounds as well as improvement of biodegradability of CGW under the micro-oxygen condition. The integrated MEBR process was more favorable to improvement of the structural stability of activated sludge and biodiversity of specific functional microbial communities.

A qualitative exploration of work-related head injury: vulnerability at the intersection of workers' decision making and organizational values.

Background: Work-related head injury is a critical public health issue due to its rising prevalence; the association with profound disruption of workers' lives; and significant economic burdens in terms of medical costs and lost wages. Efforts to understand and prevent these types of injuries have largely been dominated by epidemiological research and safety science, which has focused on identifying risk at the level of the individual worker, population group, or organizational sector. Limited research has focused on the perspectives of the workers, a key stakeholder group for informing understanding of vulnerability to work-related head injury.

Stacking interactions involving non-Watson-Crick basepairs: dispersion corrected density functional theory studies.

The G:A basepair, stabilized by hydrogen bonding through the sugar edge of guanine and Hoogsteen edge of adenine in trans orientation (G:A S:HT), appears very frequently in the solved RNA structures and is very stable. We have carried out stacking energy analyses of two sequences, namely C:G W:WC::G:A S:HT and G:C W:WC::G:A S:HT (':' represents basepairing and '::' represents stacking interactions), formed by this non-Watson-Crick basepair, by DFT-D. We have scanned nearly the complete phase space by modeling structures of these sequences using different values of the basepair orientation parameters to determine the most stable conformations.

An International, Multicenter, Observational Study of Cerebral Oxygenation during Infant and Neonatal Anesthesia.

Background: General anesthesia during infancy is associated with neurocognitive abnormalities. Potential mechanisms include anesthetic neurotoxicity, surgical disease, and cerebral hypoxia-ischemia. This study aimed to determine the incidence of low cerebral oxygenation and associated factors during general anesthesia in infants.

Mode pair selection of circumferential guided waves for cumulative second-harmonic generation in a circular tube.

The appropriate mode pairs of primary and double-frequency circumferential guided waves (CGWs) have been investigated and selected for generation of the cumulative second harmonics, which are applicable for quantitative assessment of damage/degradation in a circular tube. The selection criteria follow the requirements: the higher efficiency of cumulative second-harmonic generation (SHG) of primary CGW propagation, and the larger response sensitivity of cumulative SHG to material damage/degradation [characterized by variation in the third-order elastic (TOE) constants]. The acoustic nonlinearity parameter β of CGW propagation and the change rate of normalized β versus the TOE constants of tube material are, respectively, used to describe the efficiency of SHG and its response sensitivity to damage/degradation.

Enhanced nitrogen removal from coal gasification wastewater by simultaneous nitrification and denitrification (SND) in an oxygen-limited aeration sequencing batch biofilm reactor.

Simultaneous nitrification and denitrification (SND) for treating coal gasification wastewater (CGW) was achieved successfully in a lab-scale sequencing batch biofilm reactor (SBBR) by oxygen-limited aeration. SND efficiency increased gradually with the concentration of dissolved oxygen (DO) decreased from 4.5mg/L to 0.

Inhibition of ammonia on anaerobic digestion of synthetic coal gasification wastewater and recovery using struvite precipitation.

Coal gasification wastewater (CGW) contains very high concentrations of phenols and ammonia. However, the potential impact of ammonia on the anaerobic digestion of phenols remained unclear. Firstly, the methanogens and phenols degraders had a good tolerance up to 1gL of total ammonia nitrogen (TAN), but the substrate utilization rate for phenol, and specific methanogenic activity of sludge were decreased by 89% and 67% at 5g TAN L, and 94% and 100% at 10g TAN L, respectively.

Degradation of landfill leachate compounds by persulfate for groundwater remediation.

In this study, batch and column experiments were conducted to evaluate the feasibility of using persulfate oxidation to treat groundwater contaminated by landfill leachate (CGW). In batch experiments, persulfate was compared with HO, and permanganate for oxidation of organic compounds in CGW. It was also compared with the potential of biodegradation for contaminant removal from CGW.

Post-Traumatic Sleep-Wake Disorders.

All living organisms that face a traumatic life event are susceptible to sleep-wake disturbances. Stress, which can result in trauma, evokes a high level of physiological arousal associated with sympathetic nervous system activation, during both sleep and wakefulness. Heredity, sex hormones, early losses, developmental factors and intra- and interpersonal conflicts, contribute to the level of baseline physiological arousal, producing either subclinical, clinical or complex clinical traits, acutely and at any time after exposure to a traumatic event.

Association of Implementation of Practice Standards for Electrocardiographic Monitoring With Nurses' Knowledge, Quality of Care, and Patient Outcomes: Findings From the Practical Use of the Latest Standards of Electrocardiography (PULSE) Trial.

Background: Although continuous electrocardiographic (ECG) monitoring is ubiquitous in hospitals, monitoring practices are inconsistent. We evaluated implementation of American Heart Association practice standards for ECG monitoring on nurses' knowledge, quality of care, and patient outcomes.

Methods And Results: The PULSE (Practical Use of the Latest Standards of Electrocardiography) Trial was a 6-year multisite randomized clinical trial with crossover that took place in 65 cardiac units in 17 hospitals.

A cannabigerol-rich Cannabis sativa extract, devoid of [INCREMENT]9-tetrahydrocannabinol, elicits hyperphagia in rats.

Nonpsychoactive phytocannabinoids (pCBs) from Cannabis sativa may represent novel therapeutic options for cachexia because of their pleiotropic pharmacological activities, including appetite stimulation. We have recently shown that purified cannabigerol (CBG) is a novel appetite stimulant in rats. As standardized extracts from Cannabis chemotypes dominant in one pCB [botanical drug substances (BDSs)] often show greater efficacy and/or potency than purified pCBs, we investigated the effects of a CBG-rich BDS, devoid of psychoactive [INCREMENT]-tetrahydrocannabinol, on feeding behaviour.

Polyphenolic enriched extract of Cassia glauca Lamk, improves streptozotocin-induced type-1 diabetes linked with partial insulin resistance in rats.

Ethnopharmacological Relevance: Traditionally Cassia glauca (CG) has been used to treat diabetes.

Aim Of The Study: The study was undertaken to evaluate anti-diabetic and antioxidant activity of polyphenolic enriched extract of CG in standardized streptozotocin (STZ)-induced diabetic rats.

Materials And Methods: The effect of ethanol (CGE) and water (CGW) extracts of CG (200 and 400mg/kg) treatment were evaluated in STZ (50mg/kg, iv) induced diabetic rats.