Involvement of muscarinic acetylcholine receptor-mediated cholinergic neurotransmission in TMS-EEG responses.

The combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) is emerging as a valuable tool for investigating brain functions in health and disease. However, the detailed neural mechanisms underlying TMS-EEG responses, including TMS-evoked EEG potentials (TEPs) and TMS-induced EEG oscillations (TIOs), remain largely unknown. Combining TMS-EEG with pharmacological interventions provides a unique opportunity to elucidate the roles of specific receptor-mediated neurotransmissions in these responses.

The Impact of Lexical-semantic Impairment on Spoken Verb Production in Individuals With Mild Cognitive Impairment.

Background: Although episodic memory is the primary concern in individuals with mild cognitive impairment (MCI), other cognitive functions may also be affected, including language. Language impairment in individuals with MCI has been attributed primarily to the breakdown of semantic representations, difficulties in accessing semantic information, and the weakening of executive functions. However, in most prior studies of word processing in individuals with MCI, researchers have used measures focused on noun production.

Rasch Analysis of the Chinese Version of the Nociception Coma Scale-Revised in Patients with Prolonged Disorders of Consciousness.

Objectives: The aim of this study was to analyze the Chinese version of the Nociception Coma Scale-Revised in patients with prolonged disorders of consciousness within the framework of Rasch modeling, including investigating the invariance of total scores across different etiologies of disorders of consciousness.

Design: Prospective psychometric study.

Participants: Patients with prolonged disorders of consciousness from the Rehabilitation and Neurology units in hospital.

Exploring SCN5A variants associated with atrial fibrillation in atrial cardiomyocytes derived from human induced pluripotent stem cells: A characterization study.

Background: Atrial fibrillation (AF) poses a major risk for heart failure, myocardial infarction, and stroke. Several studies have linked SCN5A variants to AF, but their precise mechanistic contribution remains unclear. Human induced pluripotent stem cells (hiPSCs) provide a promising platform for modeling AF-linked SCN5A variants and their functional alterations.

Canadian Workers' Well-Being During the Beginning of the COVID-19 Pandemic: A Latent Profile Analysis.

To explore workers' well-being during COVID-19, researchers have primarily utilized variable-centered approaches (e.g., regression) focusing on describing workers' general level of well-being.

Beneficial effects of miR-132/212 deficiency in the zQ175 mouse model of Huntington's disease.

Huntington's disease (HD) is a rare genetic neurodegenerative disorder caused by an expansion of CAG repeats in the Huntingtin (HTT) gene. One hypothesis suggests that the mutant HTT gene contributes to HD neuropathology through transcriptional dysregulation involving microRNAs (miRNAs). In particular, the miR-132/212 cluster is strongly diminished in the HD brain.

Dataset of images for visual and non-visual analysis of colour applications in architecture.

This paper describes three datasets which include 443 folders and approximately 4430 images. The images were obtained from the interior of a 1:50 scale model using a fisheye camera connected to a Raspberry Pi microcomputer. This dataset aims to analyze the photobiological effects (visual and non-visual) of the interplay between coloured surfaces and different types of lighting strategies.

Cognitive Motor Dissociation in Disorders of Consciousness.

Background: Patients with brain injury who are unresponsive to commands may perform cognitive tasks that are detected on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). This phenomenon, known as cognitive motor dissociation, has not been systematically studied in a large cohort of persons with disorders of consciousness.

Methods: In this prospective cohort study conducted at six international centers, we collected clinical, behavioral, and task-based fMRI and EEG data from a convenience sample of 353 adults with disorders of consciousness.

Feasibility and acceptability of a videoconference-based cognitive-behavioral intervention for caregivers of individuals living with mild cognitive impairment or early Alzheimer's disease.

Objective: The objective of the current pilot study was to investigate the feasibility and acceptability of a videoconference-based cognitive behavioral (CBT) intervention for caregivers of individuals living with mild cognitive impairment or early Alzheimer's disease. The intervention included psychoeducation on emotions, strategies for management of unhelpful emotions and thoughts, behavioral activation, breathing and relaxation, strategies for communication and information on external resources.

Methods: This study used a cross-sectional design with two groups of four caregivers who received an 8-week CBT-based intervention via videoconference.

Critical dynamics in spontaneous EEG predict anesthetic-induced loss of consciousness and perturbational complexity.

Consciousness has been proposed to be supported by electrophysiological patterns poised at criticality, a dynamical regime which exhibits adaptive computational properties, maximally complex patterns and divergent sensitivity to perturbation. Here, we investigate dynamical properties of the resting-state electroencephalogram (EEG) of healthy subjects undergoing general anesthesia with propofol, xenon or ketamine. Importantly, all participants were unresponsive under anesthesia, while consciousness was retained only during ketamine anesthesia (in the form of vivid dreams), enabling an experimental dissociation between unresponsiveness and unconsciousness.

High-throughput low-cost digital lickometer system for the assessment of licking behaviours in mice.

Background: Proper hydration is essential for maintaining health and supports various biological processes, including temperature regulation, immune function, nutrient delivery, and organ function. Visual assessment has traditionally been used to quantify liquid intake, although technological advances in optical and electrical sensors now offer higher accuracy and larger potential for automatic operation with millisecond precision and individual lick resolution.

New Method: We describe an inexpensive electronic sensor board to monitor mouse licking behavior.

Imagery dataset of interior and exterior northern architectural spaces for photobiological lighting analyses.

This paper details an imagery dataset of interior and exterior ambiances to assess and represent photobiological outcomes of the built environment in northern territories. The images were obtained using a Raspberry Pi Camera Module (RPiCM) mounted in a holder that fixes the camera in place. This holder allows to rotate the camera by 30° and take 12 high dynamic range (HDR) images which are then combined to create a panoramic image.

Normative Data for the Famous People Fluency Test in the Adult French-Quebec Population and Validation Study in Mild Cognitive Impairment and Alzheimer's Disease.

Objective: The production of words in verbal fluency tests relies heavily on executive functions and linguistic abilities. New tests such as the famous people fluency test can also be useful in clinical practice and research. This test, in which participants are asked to name so many famous people, has the potential to distinguish healthy individuals from participants with neurological disorders such as mild cognitive impairment or Alzheimer's disease.

Psychotic Disorders and exosomes: An overview of current evidence and future directions.

Due to its reliance on heterogeneous symptomatology, the accurate diagnosis of psychotic disorders remains a challenging task in clinical practice. Precise and early diagnosis of psychotic disorders facilitates early intervention, which has been shown to have substantial benefits for long-term outcomes. Still, the lack of specific biomarkers is an important limitation in early diagnosis and intervention.

Musical Expertise Influences the Processing of Short and Long Auditory Time Intervals: An Electroencephalography Study.

Musical expertise has been proven to be beneficial for time perception abilities, with musicians outperforming nonmusicians in several explicit timing tasks. However, it is unclear how musical expertise impacts implicit time perception. Twenty nonmusicians and 15 expert musicians participated in an EEG recording during a passive auditory oddball paradigm with 0.

Broader Issues in Test Translation and Validation: A Commentary Inspired by Macina et al. (2023).

Macina et al. (2023) recently reported mixed results on the German translation of the Self and Interpersonal Functioning Scale (SIFS). By focusing on suboptimal indices of structural validity, they recommended choosing other available instruments over the SIFS in future research on personality impairment.

Lateral frontoparietal effective connectivity differentiates and predicts state of consciousness in a cohort of patients with traumatic disorders of consciousness.

Neuroimaging studies have suggested an important role for the default mode network (DMN) in disorders of consciousness (DoC). However, the extent to which DMN connectivity can discriminate DoC states-unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS)-is less evident. Particularly, it is unclear whether effective DMN connectivity, as measured indirectly with dynamic causal modelling (DCM) of resting EEG can disentangle UWS from healthy controls and from patients considered conscious (MCS+).

Swallowing Assessment in Post-Comatose Patients: A Feasibility Study on the SWADOC Tool.

After a severe brain injury and a coma, patients may develop disorders of consciousness (DoC), frequently accompanied by severe dysphagia. The evaluation and therapy of swallowing are therefore essential aspects of their management. Objectives: This study aims to evaluate the SWallowing Assessment in Disorders of Consciousness (SWADOC) tool in the assessment of swallowing in post-comatose patients.