4 results match your criteria: "CEITEC Masaryk University Brno Czech Republic.[Affiliation]"
Lipid bi-layered particles known as membrane vesicles (MVs), produced by Gram-positive bacteria are a communication tool throughout the entire bacterial growth. However, the MVs characteristics may vary across all stages of maternal culture growth, leading to inconsistencies in MVs research. This, in turn, hinders their employment as nanocarriers, vaccines and other medical applications.
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- Meiosis is a specialized cell division process that reduces chromosome number and is crucial for the formation of gametes in plants like Arabidopsis, where it transitions to gametophyte development through translation inhibition mechanisms involving TDM1 and SMG7.
- Mutants lacking these mechanisms experience abnormal nuclear divisions due to the inability to downregulate cyclin-dependent kinases, resulting in the failure to form tetrads.
- A suppressor screen identified mutation in CDKD;3, which alleviates these meiotic defects by preventing aberrant divisions and promoting the formation of functional microspores, indicating its complex role in cell cycle regulation beyond just activating CDKA;1.
Altered copy number of certain highly repetitive regions of the genome, such as satellite DNA within heterochromatin and ribosomal RNA loci (rDNA), is hypothesized to help safeguard the genome against damage derived from external stressors. We quantified copy number of the 18S rDNA and a pericentromeric satellite DNA (Msat-160) in bank voles () inhabiting the Chernobyl Exclusion Zone (CEZ), an area that is contaminated by radionuclides and where organisms are exposed to elevated levels of ionizing radiation. We found a significant increase in 18S rDNA and Msat-160 content in the genomes of bank voles from contaminated locations within the CEZ compared with animals from uncontaminated locations.
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- Mapping-by-sequencing is a fast way to find variations in genomes, but requires advanced bioinformatics skills and infrastructure, limiting its use.
- A new tool called artMAP has been developed to identify ethyl methanesulfonate (EMS) mutations in the Arabidopsis genome, designed to be user-friendly.
- artMAP uses a Docker container to integrate existing tools and can run on regular laptops, allowing users to visualize mutation data easily with interactive graphs.