Self-assembled latanoprost loaded soluplus nanomicelles as an ophthalmic drug delivery system for the management of glaucoma.

Glaucoma, a leading cause of blindness due to elevated intraocular pressure (IOP), is managed with medications like latanoprost (LAT), a prostaglandin analogue, to enhance aqueous outflow. Despite the challenge posed by eye anatomy and tear dynamics, effective ocular bioavailability via topical administration remains elusive. This study aims to optimize self-assembled nanomicelles incorporating LAT, an anti-glaucoma drug, belonging to BCS Class II (low solubility and high permeability) via a two-level, two-factor full factorial design, the nanomicelles were formulated via direct dissolution method and validated using design of expert.

Novel efficacy of pregnane and flavonoid glycosides from in in vivo nociceptive and inflammatory paradigms and their target prediction by cheminformatics approach.

Inflammation is associated with multiple life-threatening conditions. is an edible plant and traditionally used for managing various diseases. Three novel molecules, namely desmiflavaside-C (), nizwaside (), and desmiflanoside () were isolated from , and their structures were confirmed by mass spectrometry and through reported literature.

6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression.

Neuropathy is a disturbance of function or a pathological change in nerves causing poor health and quality of life. A proportion of chronic pain patients in the community suffer persistent neuropathic pain symptoms because current drug therapies may be suboptimal so there is a need for new therapeutic modalities. This study investigated the neuroprotective flavonoid, 6-methoxyflavone (6MF), as a potential therapeutic agent and gabapentin as the standard comparator, against neuropathic models.

A fungal based synthesis method for copper nanoparticles with the determination of anticancer, antidiabetic and antibacterial activities.

Background: Biological procedures for the synthesis of copper nanoparticles (CuNPs) are eco-friendly, cost-effective, and easily scalable as compared to chemical and physical methods.

Methods: In the present study, a simple fungus based synthesis method was used for copper nanoparticles. After morphological and molecular characterization of fungal strains, Aspergillus niger strain STA9 was used for CuNPs synthesis.

Muriolide, a novel antioxidant lactone from .

Muriolide (), a new aromatic lactone, has been isolated from the ethyl acetate fraction of . The compound was structurally characterized with the help of UV, IR, mass, 1D- and 2D-NMR data. It was tested for antioxidant and lipoxygenase inhibitory potential.

Biodegradation of Poly(3-hydroxybutyrate) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by Newly Isolated Penicillium oxalicum SS2 in Soil Microcosms and Partial Characterization of Extracellular Depolymerase.

A fungus, designated as strain SS2 able to degrade aliphatic polyesters, poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), was isolated from soil. Strain SS2 was identified through rDNA gene sequencing and showed maximum closeness to Penicillium oxalicum. The newly isolated P.

Evolution of efficacious pangenotypic hepatitis C virus therapies.

Hepatitis C compromises the quality of life of more than 350 million individuals worldwide. Over the last decade, therapeutic regimens for treating hepatitis C virus (HCV) infections have undergone rapid advancements. Initially, structure-based drug design was used to develop molecules that inhibit viral enzymes.

ISCB-Student Council Narratives: Strategical development of the ISCB-Regional Student Groups in 2016.

Regional Student Groups are groups established and managed by the ISCB-Student Council in different regions of the world. The article highlights some of the initiatives and management lessons from our 'top-performing' Spotlight Regional Student Groups (RSGs), RSG-Argentina and RSG-UK, for the current year (2016). In addition, it details some of the operational hurdles faced by RSGs and possible solutions.