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Combination of metformin and luteolin synergistically protects carbon tetrachloride-induced hepatotoxicity: Mechanism involves antioxidant, anti-inflammatory, antiapoptotic, and Nrf2/HO-1 signaling pathway.
Biofactors
July 2019
Department of Internal Medicine, CAS Cancer Hospital, Hefei, China.
Article Synopsis
- Liver diseases can be serious due to the liver's essential functions, with carbon tetrachloride (CCl4) frequently used to model liver damage in research.
- Metformin (Met) and luteolin (Lut) demonstrate protective effects against liver injuries caused by CCl4, with their combination showing enhanced benefits compared to their individual use.
- Both drugs lead to reduced inflammatory responses and apoptosis in liver cells, bolstering antioxidant enzyme activity and increasing the expression of protective proteins like NRF2 and HO-1.