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Long-term oral bisphosphonate use in relation to fracture risk in postmenopausal women with breast cancer: findings from the Women's Health Initiative.

Menopause

November 2016

1University of Washington School of Public Health, Seattle, WA 2Division of Epidemiology and Department of Family and Preventive Medicine, University of California San Diego, San Diego, CA 3Fred Hutchinson Cancer Research Center, Seattle, WA 4Group Health Research Institute, Group Health Cooperative, Seattle, WA 5University of Washington School of Pharmacy, Seattle, WA 6Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center, Torrance, CA 7The North American Menopause Society, Cleveland, OH 8David Geffen School of Medicine at University of California, Los Angeles, CA 9University of Tennessee Health Science Center, Memphis, TN.

Objective: The aim of the study was to examine the association of long-term oral bisphosphonate use, compared with short-term use, with fracture risk among postmenopausal women with breast cancer.

Methods: We studied 887 postmenopausal women who were enrolled to the Women's Health Initiative from 1993 to 1998, diagnosed with breast cancer after enrollment, and reported current oral bisphosphonate use of 2 years or more on a medication inventory administered in 2008 to 2009. The outcome of any clinical fracture was ascertained by self-report on an annual study form; a subset of fractures was confirmed with medical records.

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