1,895,663 results match your criteria: "CA; University of California Agriculture and Natural Resources[Affiliation]"
J Med Cases
January 2025
Department of Surgery, Arrowhead Regional Medical Center, Colton, CA, USA.
Anomalous pulmonary vein drainage is a rare but clinically relevant variant of the cardiovascular anatomy. We present a case report of a 22-year-old male who was incidentally found to have anomalous pulmonary vein drainage into the innominate vein. The patient had a known history of seizures and was brought to the emergency department following a simple tonic-clonic seizure.
View Article and Find Full Text PDFResearch (Wash D C)
January 2025
Department of Cardiology of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Protein phosphatase 2A (PP2A) is one of the most abundant serine/threonine phosphatases and plays critical roles in regulating cell fate and function. We previously showed that PP2A regulates the differentiation of CD4 T cells and the development of thymocytes. Nevertheless, its role in CD8 T cells remains elusive.
View Article and Find Full Text PDFFront Oncol
December 2024
Department of Neurosurgery, The Second Hospital of Lanzhou University, Lanzhou, China.
Scalp arteriovenous fistula (sAVF) is a rare disease caused by a congenital defect or exogenous injury, but no standard treatment exists. In this article, we report a rare case of sAVF combined with type C sAVF and cirsoid aneurysm (CA), which was successfully treated by staging microsurgery. Individualized surgical incisions were designed based on the size and range of the sAVF, and then staging microsurgery was performed.
View Article and Find Full Text PDFFront Oncol
December 2024
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
fusion is one of the classes of emerging therapeutic targets of precision oncology and is observed in many solid tumor types. Our understanding of oncogenic mechanisms and therapy effects of molecular targets tends to reflect those occurring in overrepresented tumor types, posing a challenge in therapy planning of the same targets occurring in unusual tumor types. We present a case of a primary high-grade serous tubo-ovarian carcinoma with a novel fusion, an exceedingly rare combination of tumor type and fusion class, with an unusually short-lived response to futibatinib.
View Article and Find Full Text PDFGenes Dis
March 2025
College of Stomatology, Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China.
Orthodontic tooth movement (OTM) depends on periodontal ligament cells (PDLCs), which sense biomechanical stimuli and initiate alveolar bone remodeling. Light (optimal) forces accelerate OTM, whereas heavy forces decelerate it. However, the mechanisms by which PDLCs sense biomechanical stimuli and affect osteoclastic activities under different mechanical forces (MFs) remain unclear.
View Article and Find Full Text PDFGenes Dis
March 2025
Pediatric Orthopaedic Hospital, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710032, China.
Although the pathogenesis and mechanism of congenital skeletal dysplasia are better understood, progress in drug development and intervention research remains limited. Here we report that melatonin treatment elicits a mitigating effect on skeletal abnormalities caused by deficiency. In addition to our previous finding of endoplasmic reticulum stress upon deficiency, we found calcium (Ca) overload jointly contributed to -associated chondrodysplasias.
View Article and Find Full Text PDFOpen Life Sci
December 2024
Department of Ophthalmology, University Hospital of Udine, p.le S. Maria della Misericordia 15, 33100, Udine, Italy.
Retinal diseases, which can lead to significant vision loss, are complex conditions involving various cellular and molecular mechanisms. The interleukin-6 (IL-6) family, particularly Oncostatin M (OSM), has garnered attention for their roles in retinal inflammation, angiogenesis, and neuroprotection. This comprehensive review explores the dual nature of OSM and other IL-6 family members in retinal pathophysiology, highlighting their contribution to both degenerative and regenerative processes.
View Article and Find Full Text PDFiScience
December 2024
Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Strigolactones serve as germination signals for several root-parasitic plant species within the Orobanchaceae family. Yet, their role in the life cycle of the facultatively parasitic genus has remained elusive. Here, we demonstrate that strigolactones initiate the formation of haustorium-like structures in .
View Article and Find Full Text PDFiScience
December 2024
Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA 92617, USA.
Cephalopods, marine animals like squid, octopus, cuttlefish, or nautilus, have attracted the interest of the scientific community for many years due to their sophisticated neurophysiology, complex behavioral patterns, and stunning camouflage displays. It is thus not surprising that these animals have inspired a plethora of scientific advances in the fields of neuroscience, cell biology, and materials engineering. A part of this exciting research is reflected in the Special Issue "Cephalopods: Inspired science".
View Article and Find Full Text PDFiScience
December 2024
Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Different neuron types develop characteristic axonal and dendritic arborizations that determine their inputs, outputs, and functions. Expression of fate-determinant transcription factors is essential for specification of their distinct identities. However, the mechanisms downstream of fate-determinant factors coordinating different aspects of neuron identity are not understood.
View Article and Find Full Text PDFiScience
December 2024
Florida Institute of Technology, Department of Psychology, 150 W. University Dr., Melbourne, FL 32905, USA.
Episodic memory is accounted for with two processes: "familiarity" when generally recognizing an item and "recollection" when retrieving the full contextual details bound with the item. We tested a combination of item recognition confidence and source memory, focusing upon three conditions: "item-only hits with source unknown" ('item familiarity'), "low-confidence hits with correct source memory" ('context familiarity'), and "high-confidence hits with correct source memory" ('recollection'). Behaviorally, context familiarity was slower than the others during item recognition, but faster during source memory.
View Article and Find Full Text PDFTherap Adv Gastroenterol
January 2025
F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, West Hollywood 90048, CA, USAKarsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Background: Despite its significant health burden, there is a lack of national-level temporal patterns in gastrointestinal bleeding (GIB) mortality.
Objectives: To comprehensively decipher the annual and monthly trend of GIB-related mortality in the United States.
Design: Cross-sectional study.
RSC Adv
January 2025
Dept. of Chemical Engineering, McGill University 3610 Rue Universite Montreal QC H3A 0C5 Canada
Compositions of ethylene glycol dicyclopentenyl ether methacrylate (EGDEMA), a vegetable oil based alkyl methacrylate (C13MA), and furfuryl methacrylate (FMA) were terpolymerized for dual-crosslinked networks with tailored mechanical and thermal properties. Specifically, initiators for continuous activator regeneration (ICAR) atom transfer radical polymerization (ATRP) afforded materials with tailored glass transition temperature ( ) and incorporation of furan and norbornene functionalities within a single chain. The terpolymer with high furan and norbornene functionality (Ter2: = 0.
View Article and Find Full Text PDFThe potential application of materials referred to as perovskite hydrides in hydrogen storage - a crucial element of renewable energy systems - has sparked a great deal of interest. We use density functional theory (DFT) to investigate the structural, formation energy, hydrogen storage, electronics, thermoelectric and elastic properties of NaXH (X = Be, Mg, Ca, and Sr) hydrides. The band gap is calculated using WC-GGA and WC-GGA+mBJ potentials.
View Article and Find Full Text PDFRSC Adv
January 2025
School of Petrochemical Engineering, Shenyang University of Technology Liaoyang 111003 China
A sunflower seed shell matrix catalyst (SMS-750) was prepared from sunflower seed shell waste by pretreatment and pyrolytic carbonization. A series of characterization analyses showed that the prepared catalyst was rich in Ca, Mg, K, and other mineral elements and mainly existed in the form of metal oxides. SMS-750 was used to catalyze the glycolysis of waste PET, and the main factors affecting the BHET yield were screened out by a one-way experimental design, and then the BHET yield was used as the response value, and the response surface method was used to design and analyze the effects of the respective variables and their interactions on the degradation of PET according to the principle of Box-Behnken central combinatorial design.
View Article and Find Full Text PDFCureus
January 2025
Department of Surgery, Wrightington, Wigan and Leigh NHS Foundation Trust, Wigan, GBR.
Background Ectopic pregnancy (EP) is a significant cause of maternal morbidity and mortality. Accurate and timely diagnosis is crucial, particularly in women of reproductive age presenting with acute abdominal pain. This audit aimed to assess the completeness and accuracy of gynecological history documentation, including pregnancy status, in female patients admitted for emergency surgery due to abdominal pain.
View Article and Find Full Text PDFEur Urol Open Sci
January 2025
Department of Urology, University of California-San Diego School of Medicine, La Jolla, CA, USA.
Background And Objective: Our aim was to determine the clinical characteristics, temporal trends, and survival outcomes for sarcomatoid-dedifferentiated renal cell carcinoma (sRCC), as sRCC has historically had poor prognosis and a contemporary cohort has not been well characterized in a population-based study.
Methods: Data for 302 630 RCC cases from 2010 to 2019 were extracted from the National Cancer Data Base, of which 4.1% (12 329) were sRCC.
Turk J Biol
October 2024
Neuropyschopharmacology Application and Research Center, Üsküdar University, İstanbul, Turkiye.
Background/aim: In an aging model established using male Wistar albino rats via the administration of D-galactose (D-gal), the aim of this study was to examine the effects of chelidonic acid (CA) on cognitive function and the levels of glutathione (GSH), malondialdehyde (MDA), total antioxidant status (TAS), and brain-derived neurotrophic factor (BDNF).
Materials And Methods: Thirty-two, three-month-old Wistar albino male rats (n = 8) were divided into four groups, as the control (C) group, CA group (2 mg/kg of CA via oral gavage), D-gal group (150 mg/kg of D-gal, subcutaneously), and D-gal + CA group (150 mg/kg of D-gal and 2 mg/kg of CA). Following overnight fasting, the 10-week trial was concluded with intramuscular injections of anesthetic drugs xylazine (8-10 mg/kg) and ketamine (80-100 mg/kg), and subsequently, the collection of cardiac blood.
Addict Behav Rep
June 2025
Institute of Behavioral Science, University of Colorado Boulder, 1440 15th St., Boulder, CO 80309, USA.
This study examines whether adolescent nicotine and cannabis vaping types (i.e., nicotine-only, cannabis-only, and dual use) differ across sociodemographic and school characteristics (e.
View Article and Find Full Text PDFiScience
January 2025
Centre for Cancer Cell & Molecular Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Pleural mesothelioma is a highly chemotherapy-resistant cancer. Approximately 50% of mesotheliomas do not express argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme in arginine biosynthesis, making arginine depletion with pegylated arginine deiminase (ADI-PEG20) an attractive therapeutic strategy. We investigated whether combinatory treatment composed of ADI-PEG20 and polyamine inhibitors constitutes a promising novel therapeutic strategy to overcome ADI-PEG20 resistance in mesothelioma patients.
View Article and Find Full Text PDFiScience
January 2025
Program in Public Health, College of Health Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Freshwater snails are obligate intermediate hosts for the transmission of schistosomiasis, one of the world's most devastating parasitic diseases. To decipher the mechanisms underlying snail resistance to schistosomes, recombinant inbred lines (RILs) were developed from two well-defined homozygous lines (iM line and iBS90) of the snail . Whole-genome sequencing (WGS) was used to scan the genomes of 46 individual RIL snails, representing 46 RILs, half of which were resistant or susceptible to .
View Article and Find Full Text PDFiScience
January 2025
Sana Biotechnology Inc., 1 Tower Place, South San Francisco, CA, USA.
Hypoimmune (HIP) allogeneic cell therapeutics hold the promise to allow off-the-shelf treatments for a broad patient population. Our HIP approach includes the depletion of major histocompatibility complex (MHC) class I and II molecules and the overexpression of Cd47. Here, we report the engineering of HIP mice that stably exhibit the HIP phenotype in all cell types.
View Article and Find Full Text PDFToxicol Rep
June 2025
Grupo Malaria, Universidad de Antioquia, Colombia.
Unlabelled: Hemozoin (HZ) is a waste product of hemoglobin digestion by and has been implicated in several pathological processes, including inflammation, oxidative stress, endothelial dysfunction, and immune dysregulation. Studying the effects of HZ on the human placenta is essential to understanding the impact of malaria infection during pregnancy. The present study explored the impact of HZ produced by and β-hematin, referred to here as natural HZ (nHZ) and synthetic HZ (sHZ), respectively, on human placental explants exposed .
View Article and Find Full Text PDFFront Neurol
December 2024
School of Physical Education and Sports Science, South China Normal University, Guangzhou, Guangdong, China.
Background: This study aims to evaluate the optimal rehabilitation regimen for lower limb dysfunction in stroke patients by analyzing the effects of proprioceptive training (PT) in combination with different rehabilitation interventions.
Methods: Randomized controlled trials (RCTs) published up to April 23, 2024, were searched from PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, VIP, and SinoMed. The quality of the included studies was assessed using the Cochrane Risk of Bias tool (ROB 2.
Open Forum Infect Dis
January 2025
Vaccines, Pfizer Inc, Collegeville, Pennsylvania, USA.
Background: Serotype-specific urinary antigen detection (UAD) assay results can be used to estimate the serotype contribution among adults with pneumococcal community-acquired pneumonia (CAP) and to guide recommendations regarding higher-valency pneumococcal conjugate vaccines (PCVs).
Methods: Adults aged ≥18 years hospitalized with radiographic evidence of CAP were prospectively enrolled in 4 US cities from November 2019 to December 2020, overlapping the coronavirus disease 2019 (COVID-19) pandemic. Data were collected by patient interview and medical chart review.