1 results match your criteria: "C.G.). judith.cosemans@maastrichtuniversity.nl.[Affiliation]"
Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity.
Arterioscler Thromb Vasc Biol
December 2015
From the Department of Biochemistry (T.G.M., M.A.H.F., R.M.W.K., M.T.J.v.d.B., F.S., P.E.J.v.d.M., J.M.E.M.C.) and Synapse BV (R.M.W.K.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; School of Physiology and Pharmacology (M.T.J.v.d.B.) and School of Clinical Sciences (J.L.J.), University of Bristol, Bristol, United Kingdom; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (L.D.G., L.M.); Department of Haematology, University of Cambridge, Cambridge, United Kingdom (C.B., C.G.); and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom (C.B., C.G.).
Objective: Platelets are increasingly implicated in processes beyond hemostasis and thrombosis, such as vascular remodeling. Members of the matrix metalloproteinase (MMP) family not only remodel the extracellular matrix but also modulate platelet function. Here, we made a systematic comparison of the roles of MMP family members in acute thrombus formation under flow conditions and assessed platelet-dependent collagenolytic activity over time.
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