4 results match your criteria: "C-11 Hydroxylase Deficiency"
Steroids excreted in urine by neonates with 21-hydroxylase deficiency. 3. Characterization, using GC-MS and GC-MS/MS, of androstanes and androstenes.
Steroids
November 2012
Department of Clinical Biochemistry, King's College Hospital, Denmark Hill, London SE5 9RS, UK.
Article Synopsis
Fusarium Tri4 encodes a key multifunctional cytochrome P450 monooxygenase for four consecutive oxygenation steps in trichothecene biosynthesis.
Biochem Biophys Res Commun
February 2007
Plant and Microbial Metabolic Engineering Research Unit, Discovery Research Institute (DRI), RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Article Synopsis
- Fusarium Tri4 is a gene that codes for an enzyme (CYP) involved in creating trichothecenes by modifying an intermediate compound called trichodiene (TDN).
- Researchers engineered yeast (Saccharomyces cerevisiae) to produce TDN and discovered several chemical intermediates during the process, which led to the identification of further compounds at different pH levels.
- The study confirmed that FgTri4 has multiple functions, enabling additional chemical changes (epoxidation and hydroxylation) to produce isotrichotriol (4), demonstrating its essential role in trichothecene biosynthesis.
Changes of several adrenal delta 4-steroids measured by HPLC-UV spectrometry in neonatal patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Horm Res
September 1990
Department of Pediatrics, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
We have developed an easy and rapid method of reverse-phase high-performance liquid chromatography (HPLC)-UV spectrometry for measuring adrenal delta 4-steroids. Three female neonates with adrenal 21-hydroxylase deficiency (2 salt-losers and 1 simple virilizer), two of whom were recalled by neonatal mass-screening for congenital adrenal hyperplasia (CAH), were diagnosed using this method. Changes of several adrenal steroids were examined in these patients before and after treatment with hydrocortisone.
View Article and Find Full Text PDFAdrenal tumors accidently detected by CT scan are increasingly seen in patients without clinical signs of adrenal diseases. We studied whether enhanced adrenal stimulation is of importance in the development of adrenal tumors. For this purpose 22 patients with adrenogenital syndrome (AGS) were studied by CT scan.
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