8 results match your criteria: "Byramjee-Jeejeebhoy Medical College-Johns Hopkins University Clinical Research Site[Affiliation]"
Drug resistance and epidemiological success of modern Mycobacterium tuberculosis lineages in western India.
J Infect Dis
May 2024
Department of Biomedical Informatics, Harvard Medical School, Boston MA, USA.
Background: Transmission is contributing to the slow decline of tuberculosis (TB) incidence globally. Drivers of TB transmission in India, the country estimated to carry a quarter of the World's burden, are not well studied. We conducted a genomic epidemiology study to compare epidemiological success, host factors and drug resistance (DR) among the four major Mycobacterium tuberculosis (Mtb) lineages (L1-4) circulating in Pune, India.
View Article and Find Full Text PDFGlycated Hemoglobin Trajectories and Their Association With Treatment Outcomes Among Patients With Pulmonary TB in India: A Prospective Cohort Study.
Chest
February 2024
Department of Global Health, Boston University School of Public Health, Boston, MA. Electronic address:
Background: Transient hyperglycemia is seen commonly during TB treatment, yet its association with unfavorable treatment outcomes is unclear.
Research Question: Does an association exist between glycated hemoglobin (HbA1c) trajectories and TB treatment outcomes?
Study Design And Methods: Adults with pulmonary TB were evaluated prospectively for 18 months after the second HbA1c measurement. HbA1c trajectories during the initial 3 months of treatment were defined as follows: persistent euglycemia, HbA1c < 6.
Whole Genome Sequencing Assessing Impact of Diabetes Mellitus on Tuberculosis Mutations and Type of Recurrence in India.
Clin Infect Dis
September 2022
Hackensack Meridian Health, Center for Discovery and Innovation, Nutley, New Jersey, USA.
Article Synopsis
- This study investigates how diabetes mellitus (DM) affects the mutation rate and recurrence of Mycobacterium tuberculosis (Mtb) in TB patients in India by comparing isolates from those with and without DM.
- Out of 1,633 enrolled participants, 236 had confirmed TB treatment failure/recurrence, with whole genome sequencing performed on 76 Mtb isolate pairs to analyze mutations.
- Results indicate that TB patients with DM had significantly higher mutation rates during recurrence compared to those without DM, and one-fourth of the DM patients experienced exogenous reinfection.
Host lipidome and tuberculosis treatment failure.
Eur Respir J
January 2022
National Institute for Research in Tuberculosis, Chennai, India.
Introduction: Host lipids play important roles in tuberculosis (TB) pathogenesis. Whether host lipids at TB treatment initiation (baseline) affect subsequent treatment outcomes has not been well characterised. We used unbiased lipidomics to study the prospective association of host lipids with TB treatment failure.
View Article and Find Full Text PDFDiabetes Mellitus and Tuberculosis Treatment Outcomes in Pune, India.
Open Forum Infect Dis
April 2021
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Article Synopsis
- Diabetes mellitus (DM) increases the risk of tuberculosis (TB), and a study in India compared treatment outcomes between TB patients with and without DM over 18 months.
- Among 799 participants, those with DM had a similar overall rate of unfavorable treatment outcomes (20% for TB-DM vs 21% for TB-only), but had higher mortality rates.
- The study highlighted that early mortality was significantly higher for TB patients with DM, suggesting a need for interventions to improve outcomes for this group.
Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes.
Prostaglandins Other Lipid Mediat
April 2020
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Byramjee-Jeejeebhoy Medical College-Johns Hopkins University Clinical Research Site, Pune, India.
Article Synopsis
- * A study involving 40 individuals (20 with newly diagnosed DM and 20 without) analyzed serum samples to quantify pro-inflammatory and pro-resolving lipid mediators, identifying specific lipid families that are abundant in each group.
- * Findings revealed that individuals with TB-DM exhibited stronger connections between pro-inflammatory and pro-resolving lipid mediators than those with TB alone, suggesting a complex molecular balance at play in this comorbidity.
Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India.
Int J Tuberc Lung Dis
December 2017
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Setting: Pune, India.
Objectives: To estimate the prevalence and risk factors of pre-diabetes mellitus (DM) and DM, and its associations with the clinical presentation of tuberculosis (TB).
Design: Screening for DM was conducted among adults (age 18 years) with confirmed TB between December 2013 and January 2017.