Allele frequency of genetic variations related to the gene-drug pair in a group of Iranian population.

Objectives: The efficacy and safety of drug treatments vary widely due to genetic variations. Pharmacogenomics investigates the impact of genetic variations on patient drug response. This research investigates the frequency of genetic variations in the Iranian population, comparing them with global data to provide insights into the pharmacogenomic approach in the Iranian population.

Contribution of bone turnover markers (BTMs) and vitamin D to bone health in Iranian elderly women.

Purpose: While only a few postmenopausal women exhibit biochemical signs of hypovitaminosis D, it has been shown that vitamin D insufficiency has detrimental effects on the overall skeleton mineralization, bone turnover rate, and may be a significant risk factor for osteoporosis and fracture. We evaluated the concurrent effect of Vitamin D levels and biochemical markers of bone turnover on bone health of postmenopausal women.

Methods: The present study was conducted within the framework of the Bushehr Elderly Health (BEH) program, a population-based prospective cohort study being conducted in Bushehr, a southern province of Iran.

Survival Analysis of Glioblastoma: A Scientometric Perspective.

Background: Glioblastoma is the most aggressive primary brain tumor and the outlook for patients is usually pessimistic. Numerous ongoing studies have focused on enhancing the survival rate of glioblastoma patients. This study aims to analyze the research trends surrounding glioblastoma survival and facilitate studying recent topics to provide insight into the perspective, research fields, and international collaborations.

Ceratonia siliqua L. pod Effects on Viability Gene Expression of Endometrial Mesenchymal Stromal/Stem Cells Isolated from Women with Endometriosis-Associated Infertility.

Background: This study aims to investigate the effects of carob (Ceratonia siliqua L.) pod extract (CPE) on the viability of human endometrial mesenchymal stromal/stem cells (EnMSCs) and its impact on mRNA and protein expressions of DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B), histone deacetylase 1 (HDAC1), matrix metalloproteinase-2 (MMP2), and cyclooxygenase-2 (COX-2) in endometriotic patients.

Materials And Methods: In this experimental study, EnMSCs were derived from endometrium of patients with ovarian endometrioma (OMA-EnMSCs group) and deep infiltrative endometriosis (DIE) samples of 10 endometriosisassociated infertility (EAI) women (E-EnMSCs group) and compared to EnMSCs derived from the endometrium of an endometriosis-free, normal woman as the control group (C-EnMSCs).

Copper-cobalt peroxide nanoparticles: a biomimetic cascade reaction for enhanced Fenton-like therapy at physiologically relevant pH.

Traditional Fenton-like reactions, commonly employed in chemodynamic therapy (CDT) for cancer treatment, face limitations due to the mildly acidic tumor microenvironment (TME) and scarce HO availability. Aiming to overcome these hurdles, we report herein the preparation of copper-cobalt peroxide (CCp) nanoparticles, a novel catalyst that enables a pH-activated, self-supplying HO-mediated cascade reaction. In the slightly acidic TME (pH 6.

Sclerostin as a Genetic Determinant of Trabecular Bone Score in Postmenopausal Women: The Bushehr Elderly Health (BEH) Program.

Background: Sclerostin, a protein encoded by the gene, is an important genetic risk factor for osteoporosis in postmenopausal women. This study was conducted on the Iranian postmenopausal women, to investigate the association between this gene and the Trabecular Bone Score (TBS) as a novel index used for assessing osteoporosis.

Methods: The present study, conducted in 2024, was performed on 1071 women aged 60 years and older who participated in the Bushehr Elderly Health (BEH) program.

Trans-radial vs. trans-femoral approaches in diagnostic cerebral angiography: A comprehensive systematic review and meta-analysis of practicality and cost-effectiveness.

Background: Selecting most appropriate approach between the transfemoral access (TFA) and transradial access (TRA) for diagnostic cerebral angiography is a subject of debate.

Objective: To compare the safety and efficacy of TFA and TRA for diagnostic cerebral angiography.

Methods: We performed a systematic search through four databases to find relevant clinical studies.

A perspective on the methodological challenges in the emerging field of antifouling paint particles.

Antifouling paint particles are anthropogenic particles primarily originating from marine coatings. Recent investigations have shed light on their toxicity at concentrations found in the environment. However, several significant challenges still impede accurate antifouling paint particle quantification.

The History of Rare Bleeding Disorders.

Deficiencies in coagulation factors I (FI), FII, FV, combined FV and FVIII (CF5F8) and vitamin K-dependent coagulation factors FVII, FX, FXI, and FXIII have been referred to as rare bleeding disorders (RBDs), rare coagulation factor deficiencies (RCFDs), or recessively inherited coagulation disorders. Fibrinogen was most likely the first member of this group to be identified, with reports of its discovery spanning from 1859 to 1966. If not, then the first coagulation factor to be identified was prothrombin in 1894, and the last coagulation factor to be found was FX in 1956, about 60 years later.

Distribution, environmental risks, and conservation challenges of chemical pollutants in Persian Gulf marine protected areas.

This study investigates the occurrence and distribution of chemical pollutants, including total petroleum hydrocarbons (TPHs), organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), anionic surfactants, and total organic carbon (TOC), in the Marine Protected Areas (MPAs) waters in the northern Persian Gulf. Water samples were collected from five MPAs during the winter and summer of 2022. The study identified significant seasonal variations, with higher pollutant levels recorded in winter compared to summer.

Identification of meat adulteration in minced meat samples labeled as beef and mutton in Tehran stores using duplex PCR.

Food fraud and profiteering are becoming increasingly common in the meat industry. Therefore, it is essential to identify such practices to prevent consumer deception and maintain food safety. This study aimed to determine the contents of minced meat samples labeled as beef and mutton in retail stores across Tehran province, Iran, to identify instances of meat adulteration.

Estimation of hydrogen solubility in aqueous solutions using machine learning techniques for hydrogen storage in deep saline aquifers.

The porous underground structures have recently attracted researchers' attention for hydrogen gas storage due to their high storage capacity. One of the challenges in storing hydrogen gas in aqueous solutions is estimating its solubility in water. In this study, after collecting experimental data from previous research and eliminating four outliers, nine machine learning methods were developed to estimate the solubility of hydrogen in water.

Cardiometabolic risk factor clusters in older adults using latent class analysis on the Bushehr elderly health program.

Metabolic syndrome (MetS), comprising obesity, insulin resistance, hypertension, and dyslipidemia, increases the risk of type II diabetes mellitus and cardiovascular disease. This study aimed to identify the prevalence and determinants of specific clusters of the MetS components and tobacco consumption among older adults in Iran. The current study was conducted in the second stage of the Bushehr Elderly Health (BEH) program in southern Iran-a population-based cohort including 2424 subjects aged ≥ 60 years.

Exploring the Potential Value of [ 68 Ga]Ga-FAPI-46 PET/CT for Molecular Assessment of Fibroblast Activation in Interstitial Lung Disease : A Single-Center Pilot Study.

Background: The aim of the study was to evaluate the association of high-resolution computed tomography (HRCT) findings with pulmonary fibrotic activity in the corresponding regions using [ 68 Ga]Ga-fibroblast activation fibroblast inhibitor (FAPI) PET/CT in patients with interstitial lung disease (ILD). Additionally, the potential of [ 68 Ga]Ga-FAPI-46 PET/CT for evaluating the active fibrosis process and 99m Tc-MIBI scintigraphy for assessing the inflammatory process in ILD patients was also assessed.

Methods: In this pilot study, 20 ILD patients underwent [ 68 Ga]Ga-FAPI-46 PET/CT and 99m Tc-MIBI SPECT/CT.

Treatments for Olfactory Dysfunction in COVID-19: A Systematic Review.

 Olfactory dysfunction (OD) has emerged as a notable symptom among coronavirus disease 2019 (COVID-19) patients, with its prevalence varying among different populations. Recognizing the need to provide therapeutic solutions for these individuals, the present study seeks to comprehensively review the current evidence on potential underlying mechanisms and treatment modalities to manage OD in COVID-19 patients.  To review the recent evidence on treatments for OD in COVID-19.

Predictors of the willingness to receive the third dose of COVID-19 vaccine based on the Health Belief Model: A cross-sectional study in South Khorasan province.

Coronavirus disease 2019 (COVID-19) infections have re-emerged in several countries due to reduced levels of antibodies provided by vaccines or the rapid emergence of viral variants, such as Alpha, Beta, Gamma, and Delta. A considerable supplementary intervention is recommended, including an additional dose of vaccination. The present study aimed to assess the predictors of the willingness to receive the third dose of the COVID-19 vaccine based on the Health Belief Model (HBM) constructs among people referring to health centers in South Khorasan province.

A Systematic Review of Telehealth Applications in Endocrinology.

Introduction: The prevalence of telehealth has witnessed a significant increase in various medical domains, especially in endocrinology. Telehealth brings about considerable advantages for both patients and health care professionals. However, despite these positive aspects, the growing prominence of telehealth is accompanied by certain challenges.

The Effects of Coffee/Caffeine in Patients with Multiple Sclerosis; A Systematic Review.

Background: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Caffeine, as the most widely consumed psychoactive substance, has been suggested to have potential effects on the clinical course and disability levels of MS patients. This study aimed to review the current evidence on the effects of coffee/caffeine in patients with MS.