CircIRAK3 Promotes Neutrophil Extracellular Trap Formation by Improving the Stability of ELANE mRNA in Sepsis.

Excessive formation of neutrophil extracellular traps (NETs) has been shown to exacerbate inflammatory injury and organ damage in patients with sepsis. Circular RNAs (circRNAs) abnormally expressed in immune cells of sepsis patients, and play an important role in the pathogenesis of dysregulated immune responses. However, the functions of circRNAs in NET formation during sepsis remain unknown.

First aid treatment and airway management for chemical burns combined with inhalation injury: A case report.

Chemical burns account for a small percentage of burn patients, and there are even fewer burn patients suffering from chemical burns combined with inhalation injury. As chemical substances corrode the airway, which leads to persistent necrotic shedding of the respiratory mucosa and scarring contracture as the airway heals, a proportion of patients develop airway stenosis, requiring more aggressive treatment or even surgery. A 38-year-old female chemical factory worker sustained an inhalation injury due to exposure to reactive substances (liquid and smoke) during production.

Corneal protein repair after amniotic membrane photo-tissue bonding versus amniotic membrane graft in the treatment of corneal ulcer (an experimental study).

Corneal alkali burns persist as a significant challenge in our field, often leading to a prolonged treatment course with various sight-threatening problems. This work, of utmost importance, aimed to apply the photo-tissue bonding technique (PTB) to weld the amniotic membrane (AM) to the corneal surface versus an amniotic membrane graft (AMG) and explore its safety in saving corneal protein against alkali burn.Methods Twenty-seven rabbits with an induced corneal ulcer using 1 mol/L NaOH solution.

3D extrusion bioprinting of microbial inks for biomedical applications.

In recent years, the field of 3D bioprinting has witnessed the intriguing development of a new type of bioink known as microbial inks. Bioinks, typically associated with mammalian cells, have been reimagined to involve microbes, enabling many new applications beyond tissue engineering and regenerative medicine. This review presents the latest advancements in microbial inks, including their definition, types, composition, salient characteristics, and biomedical applications.

[Burns].

In the Netherlands, an average of 92,000 patients with burn injuries are seen annually by a general practitioners. A burn injury is defined as skin damage caused by heat, radiation, electricity, and/or chemical agents. It is crucial to make an accurate assessment of the severity of the burn.

Chloride Interferences in Wet Chemical Oxidation Measurements: Plausible Mechanisms and Implications.

Wet chemical oxidation (WCO) methods measure total organic carbon (TOC) in aqueous solutions through the formation and detection of carbon dioxide (CO). Prior research documents chloride (Cl) interference during WCO. However, the mechanism that determines WCO interference is not established.

Chemical eye injury in remote and urgent care clinic settings.

Background: Chemical eye injuries are potentially sight-threatening injuries, representing 10-22% of all ocular trauma presentations. Prompt assessment and management of chemical eye injuries in general practice and urgent care clinic settings can prevent patients from losing vision.

Objective: This article presents a clinically useful guide for general practitioners to support the primary management of chemical-related eye injuries, particularly in rural and regional settings.

Alkali exposure: an evidence-based approach to diagnosis and treatment.

Alkali caustic exposures can occur in the workplace with industrial chemicals, or in the home with common household products. These exposures, whether accidental or intentional, create risk for death or acute injury, such as airway compromise and esophageal or gastric perforation, as well as long-term complications such as stricture formation. Swift diagnosis and grading of these injuries will guide management options and are essential to reduce morbidity and mortality in these patients.

Characterization and Potential Food Applications of Oat Flour and Husks from Differently Colored Genotypes as Novel Nutritional Sources of Bioactive Compounds.

Oats are gluten-free cereals rich in dietary fiber, -glucans, phenolic acids, flavonoids, carotenoids, vitamin E, and phytosterols. They have been used in traditional medicine for centuries to treat hyperacidity, acute pancreatitis, burns, and skin inflammation. This study assessed the nutritional and phenolic profile of oat flour (OF) and ground oat husks (OHs) from white, brown, and black hulled oat genotypes, as well as the antioxidant and antimicrobial activity of their extracts.

Role of radiation emergency medicine: historical view-a perspective on the past, present, and future.

The more science progresses, the more life and society change. Medicine also changes with the times and the culture. This is also true for radiation emergency medicine, which includes dose-assessment leading to diagnosis, treatment, medical follow-up and prognosis of persons who have developed acute injury or illness due to radioactive contamination or radiation exposure.

Autologous simple limbal stem cell transplantation with conjunctival autograft in chronic unilateral total LSCD with severe symblepharon due to severe alkali burn.

This report details the case of a middle-aged man with chronic unilateral total limbal stem cell deficiency with severe symblepharon in his left eye with upper lid mechanical ptosis, restricted ocular movements and visual acuity limited to counting fingers at 2 feet. 9 months prior to his first visit, he sustained an accidental unilateral alkali injury to the left eye. He underwent autologous simple limbal epithelial transplantation combined with conjunctival autograft in the left eye.

Increasing the utility of epidemiologic studies as key evidence in chemical risk assessment.

The Society of Toxicology 2024 meeting assembled risk assessors, epidemiologists, and toxicologists to discuss the utility of integrating epidemiologic data into the derivation of reference values. Advantages of the use of epidemiologic evidence include (i) human relevance; (ii) increased likelihood that exposure levels are relevant to risk assessment; and (iii) incorporation of uncertainties attributed to co-exposures or other population-based considerations. The workshop panelists discussed the challenges of incorporating epidemiologic evidence due to uncertain exposure measurements, confounding, heterogeneity, and inherent study design limitations.

Green synthesis of propolis mediated silver nanoparticles with antioxidant, antibacterial, anti-inflammatory properties and their burn wound healing efficacy in animal model.

Developing an efficient and cost-effective wound-healing substance to treat wounds and regenerate skin is desperately needed in the current world. The present study evaluated in vivo wound healing and in vitro antioxidant, antibacterial, anti-inflammatory activities of propolis mediated silver nanoparticles. Extract of Bee propolis from northeast Punjab, Pakistan, has been prepared via maceration and subjected to chemical identification.

In search of herbistasis: COT-metsulfuron methyl displays rare herbistatic properties.

Weed management is an essential intervention for maintaining food security and protecting biodiversity but is heavily reliant on chemical control measures (, herbicides). Concerningly, only one herbicide has been developed with a new mode of action (MOA) since the 1980s. Therefore, alternative strategies for preventing weed growth need to be explored.

Ocular findings in dogs and cats following chemical injury by the Bronze Orange Bug (Musgraveia sulciventris).

Objective: To describe the ocular findings in dogs and cats after chemical injury by the Bronze Orange Bug (Musgraveia sulciventris), which is endemic to eastern Australia in Queensland and New South Wales.

Animals Studied: Medical records were reviewed for the keywords "stink bug" between February 2013 and January 2023. Signalment, clinical signs, month at presentation, and affected eye(s) were recorded.

Management of Eyelid Pathologies That Cause Corneal Lesions.

Corneal injuries, which make up 3% of emergency room visits, can vary from small scratches to exposure or trauma-related damage that might be fatal to vision. Mechanical trauma, diseases of the eyelids, neurotrophic abnormalities, and chemical burns are common causes. A thorough examination is necessary for an accurate diagnosis and treatment plan.

The Significance of Paying Attention to Medical Emergencies in Medical Diagnostic Laboratories in Iran.

Medical diagnostic laboratories as high-risk environments are often exposed to unpredictable situations such as patient fainting, blood pressure drops, chemical spills, and burns. These life-threatening events defined as medical emergencies and necessitate urgent actions. Hence, determining the most common medical emergencies in medical laboratories, so understanding and planning strategies to effective management seems to be crucial.

A carboxymethyl chitosan and dextran hydrogel with slow and rapid photothermal conversion for sequential promoting burn wound healing and inhibiting scar proliferation.

Facilitating swift burn wound healing while effectively preventing scar formation continues to be a considerable challenge in medical practice. In this study, an injectable carboxymethyl chitosan/oxidized dextran/polyvinylpyrrolidone/dopamine (COPD) hydrogel was designed for the effective sequentially promotion of burn wound healing and inhibition of scar formation. The COPD hydrogel precursor solution was injected into the burn wound via a double-barreled syringe and transformed into an adherent hydrogel within 25 s.

Oral switch vs continued intravenous antibiotic therapy in patients with bacteraemia and sepsis: a systematic review and meta-analysis.

Background: Bacteraemia and sepsis have traditionally required continued intravenous (IV) antibiotics.

Objectives: To evaluate if early transition to oral antibiotics is noninferior to continued IV antibiotic therapy in treating patients with bacteraemia and sepsis.

Data Sources: MEDLINE, Embase, Web of Science, the Cochrane library, and Wanfang databases from inception to July 13, 2024, along with clinical trial registries and Google.

High-Pressure Injection Injuries of the Hand: A Report of Three Cases Presenting With Acute Compartment Syndrome.

High-pressure injection injuries of the hand occur after contact with the nozzle of a high-pressure injecting system such as a paint gun or air compressor, usually on the non-dominant hand of industrial laborers. The severity and real extent of damage in high-pressure injection injuries are often hidden behind a small punctiform wound at initial presentation and are generally underestimated. High-pressure injected material spreads into the tendon sheath, along neurovascular bundles and fascial planes, resulting in neurovascular compromise and acute compartment syndrome.

Clinical Outcomes and Early Postoperative Complications in Boston Type I Keratoprosthesis Implantation: A Retrospective Study.

The purpose of this study is to evaluate clinical outcomes and early postoperative complications in patients undergoing Boston type I keratoprosthesis (BKPro) implantation, with a specific focus on the onset and nature of ocular surface disorders during the early postoperative period. This retrospective study included 77 eyes that underwent BKPro implantation between 2019 and March 2022. Patients were treated at the Saint Barbara Hospital, Trauma Centre, Sosnowiec, Poland, and District Railway Hospital, Katowice, Poland.

Arginine-Biofunctionalized Ternary Hydrogel Scaffolds of Carboxymethyl Cellulose-Chitosan-Polyvinyl Alcohol to Deliver Cell Therapy for Wound Healing.

Wound healing is important for skin after deep injuries or burns, which can lead to hospitalization, long-term morbidity, and mortality. In this field, tissue-engineered skin substitutes have therapy potential to assist in the treatment of acute and chronic skin wounds, where many requirements are still unmet. Hence, in this study, a novel type of biocompatible ternary polymer hybrid hydrogel scaffold was designed and produced through an entirely eco-friendly aqueous process composed of carboxymethyl cellulose, chitosan, and polyvinyl alcohol and chemically cross-linked by citric acid, forming three-dimensional (3D) matrices, which were biofunctionalized with L-arginine (L-Arg) to enhance cellular adhesion.

Trophic status analysis and nutrient source allocation in urban lakes of Dhaka, Bangladesh: a comprehensive approach to eutrophication monitoring.

Urban lakes are vital to ecosystems, providing essential services and recreational spaces in densely populated megacities. However, rapid urbanization and anthropogenic activities, particularly eutrophication driven by macronutrient accumulation, severely threaten these water bodies. This study underscores the critical need for continuous trophic state monitoring to sustain fish, wildlife, and plant ecosystems.