6,992 results match your criteria: "Burn Wound Infections"

Burns and chronic wounds present significant challenges in wound management due to risks of infection, excessive inflammation, and prolonged healing. Silver-based treatments have long been central to burn care, but limitations have prompted the exploration of nanocrystalline silver as an alternative, with its nanoscale properties offering distinct benefits. This paper reviews the structure, properties, mechanisms of action, and clinical applications of nanocrystalline silver in burn and general wound management, with particular emphasis on how wound healing processes inform the application of these dressings.

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Depression and anxiety, peripheral blood inflammatory factors, and stress levels on therapeutic outcomes in patients with chronic wounds.

World J Psychiatry

December 2024

Department of Burns and Plastic Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde 415000, Hunan Province, China.

Background: The incidence of chronic wounds is rising due to an aging population and lifestyle changes in our country. In addition, as the disease spectrum evolves, chronic wounds have become common clinical issues that seriously threaten health and impose significant social and economic burdens.

Aim: To investigate how depression, anxiety, peripheral blood inflammatory factors, and stress levels affect therapeutic outcomes in patients with chronic wounds.

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KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus.

Arthritis Res Ther

December 2024

Department of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.

Background: Neutropenia is more common in patients with systemic lupus erythematosus (SLE) and is a major cause of life-threatening infections. The increased apoptosis of neutrophils is likely to be an essential cause of neutropenia in SLE. However, the detailed mechanisms of increased neutrophil apoptosis in SLE remain unknown.

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Bacterial infections and antibiotic resistance represent significant global public health challenges, necessitating the development of innovative antibacterial agents with targeted delivery capabilities. Our study utilized macrophages' natural ability to recognize bacteria and the increased reactive oxygen species (ROS) at infection sites to develop a novel nanoparticle for targeted delivery and controlled release. We prepared bacteria-activated macrophage membranes triggered by Staphylococcus aureus (Sa-MMs), which showed significantly higher expression of Toll-like receptors (TLRs), compared to normal macrophage membranes (MMs).

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Infections are a leading complication in patients with burns. Effective antimicrobial treatment with regenerative tissue healing is required. Utilizing components derived from plant origin such as natural oils as a sustainable and eco-friendly approach for managing disease is highly required nowadays.

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Post-COVID-19 mucormycosis, particularly the rhino-orbital-cerebral form, can be life-threatening. This case highlights the importance of maintaining high clinical suspicion, especially in patients with recent COVID-19 history. Prompt diagnosis, aggressive surgical debridement, and antifungal therapy are crucial for successful management, even in patients without traditional risk factors.

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The most prevalent and harmful injuries are burns, which are still a major global health problem. Burn injuries can cause issues because they boost the inflammatory and metabolic response, which can cause organ malfunction and systemic failure. On the other hand, a burn wound infection creates an environment that is conducive to the growth of bacteria and might put the patient at risk for sepsis.

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Update burn surgery: overview of current multidisciplinary treatment concepts.

Innov Surg Sci

December 2024

Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany.

The treatment of severe burn injuries is an essential part of plastic-reconstructive surgery. Severe burned patients are treated in burn centers, which have highly specialized technical and personnel equipment. In addition to clear recommendations for prehospital management, intensive care therapy is usually required for extensive burn wounds.

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Wound healing represents a complex and evolutionarily conserved process across vertebrates, encompassing a series of life-rescuing events. The healing process runs in three main phases: inflammation, proliferation, and maturation/remodelling. While acute inflammation is indispensable for cleansing the wound, removing infection, and eliminating dead tissue characterised by the prevalence of neutrophils, the proliferation phase is characterised by transition into the inflammatory cell profile, shifting towards the prevalence of macrophages.

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Downregulated YTHDF2 expression in systemic lupus erythematosus is associated with inflammatory and neutrophil cytokine production.

Clin Rheumatol

December 2024

Department of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No.17, YongwaiZhengjie, Donghu District, Nanchang, 330006, Jiangxi, China.

Objectives: An increasing body of evidence suggests that N6-methyladenosine (m6A) plays a crucial role in the etiology of SLE. We focused on YTHDF2 expression in neutrophils and the relationship between YTHDF2 and the pathogenesis of SLE.

Methods: Sixty-one patients with SLE and 48 healthy controls (HC) were recruited, and their clinical characteristics were recorded.

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Article Synopsis
  • - Corneal haze results from abnormal healing processes following injuries or surgeries, causing vision impairment due to eye opacity and irregularities, often linked to myofibroblast formation triggered by inflammation.
  • - Major causes of corneal haze include surgical procedures like PRK and LASIK, as well as non-surgical factors such as trauma and infections, with research focusing on the TGFβ pathway and inflammation management methods.
  • - Losartan, usually used for treating high blood pressure, shows promise in ophthalmology for reducing corneal fibrosis after various injuries and surgeries, leading to this review of its effectiveness and potential future applications in treating corneal haze.
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Isotonic medium treatment limits burn wound microbial colonisation and improves tissue repair.

Wound Repair Regen

December 2024

Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.

Burn injuries undergo a complex healing process in which progressive spreading of epithelial damage can lead to secondary complications such as wound infection, which is a major driver of mortality among burn patients. We recently reported that burning larval zebrafish triggers dysregulated keratinocyte dynamics compared to mechanical injury. Here, we investigate keratinocyte behaviour following burn injury and the subsequent potential for microbial colonisation of burn wounds over time.

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Advances in preparation of acellular human dermis for tissue banking and transplantation.

Cell Tissue Bank

December 2024

NHS Blood and Transplant, Tissue Services R&D, 14 Estuary Banks, Speke, Liverpool, L24 8RB, UK.

Article Synopsis
  • Non-healing wounds lead to significant costs for the NHS, totaling over £5.6 billion annually, prompting the use of skin allografts for better infection protection.
  • A study aimed to validate a new decellularisation method using Benzonase, a single enzyme, to remove DNA from donor skin, which could simplify the process compared to the current dual-enzyme approach.
  • Results showed that both Benzonase and the existing method effectively removed DNA without significant differences in their performance, demonstrating Benzonase's non-toxicity and potential as a cost-effective alternative in wound treatment.
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Bacterial infections and severe bleeding continue to pose significant challenges in wound repair. There is an urgent need for innovative, nature-inspired hydrogel dressings with antibacterial and hemostatic properties. A Ge-β-CD-CS-OREC conjugate hydrogel was developed by grafting β-CD and CS-OREC nanocomposites into a Ge matrix using EDC/NHS crosslinking, as confirmed by FT-IR and EDX analyses.

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Novosorb BTM- history, production and application in challenging wounds.

Front Bioeng Biotechnol

November 2024

Department of Plastic and Reconstructive Surgery, Austin Health, Heidelberg, VIC, Australia.

Article Synopsis
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Article Synopsis
  • Acute skin injuries compromise the skin barrier, increasing the risk of infections; Histatin 1 (Hst1) aids in wound healing by promoting cell adhesion and migration.
  • However, Hst1 is rapidly degraded in wound exudates, whereas Cyclized hst1 (Cyclic-hst1) is more stable and resistant to protease degradation.
  • Synthesized through a click reaction, Cyclic-hst1 demonstrated superior wound healing properties at significantly lower concentrations than Hst1, showing enhanced anti-inflammatory and tissue regeneration effects, making it a promising treatment for acute skin wounds.
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Chest trauma is a common injury in civilian and military polytrauma patients and is a leading cause of death and chronic disabilities. Evolving surgical techniques and advancements in chest wall reconstruction have improved clinical outcomes, reduced operative complications, and decreased mortality. In this case report, a 23-year-old male U.

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High-Pressure Injection Injuries of the Hand: A Report of Three Cases Presenting With Acute Compartment Syndrome.

Cureus

October 2024

Department of Plastic and Reconstructive Surgery and Burns Unit, Coimbra Local Health Unit, Coimbra, PRT.

High-pressure injection injuries of the hand occur after contact with the nozzle of a high-pressure injecting system such as a paint gun or air compressor, usually on the non-dominant hand of industrial laborers. The severity and real extent of damage in high-pressure injection injuries are often hidden behind a small punctiform wound at initial presentation and are generally underestimated. High-pressure injected material spreads into the tendon sheath, along neurovascular bundles and fascial planes, resulting in neurovascular compromise and acute compartment syndrome.

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A three-way junction probe triggered CRISPR/Cas14a1 enhanced EXPonential amplification reaction for sensitive detection.

Anal Methods

December 2024

Xiang'an Hospital of Xiamen University, No. 2000, East Xiang'an Road, Xiang'an District, Xiamen City, Fujian Province, 361100, China.

(, PA) is a rod-shaped Gram-negative opportunistic bacterium capable of causing nosocomial infections during nursing, such as burn wound infections and meningitis. However, sensitive and rapid PA detection remains a huge challenge. Herein, a new fluorescent biosensor was developed for the sensitive detection of PA using a three-way junction (TWJ) probe for specific identification and CRISPR/Cas14a1 for enhanced exponential amplification.

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Article Synopsis
  • The increasing issue of multidrug resistance (MDR) in pathogenic bacteria like Staphylococcus aureus has prompted the search for new treatment methods, including FDA-drug repurposing.
  • Ambroxol was tested against clinical MDR S. aureus isolates and showed effective antibacterial activity, with concentrations needed to inhibit growth between 0.75 to 1.5 mg/mL, and also disrupted biofilm formation in about 42% of the isolates.
  • In vivo studies demonstrated ambroxol's ability to enhance skin tissue healing in S. aureus infected burn injuries by reducing bacterial presence and inflammation, with further investigations suggesting its action may involve binding to several targets in the bacterium.
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Periodontal disease is a multifactorial, bacterially induced inflammatory disorder characterized by progressive destruction of periodontal tissues. Additionally, diabetes mellitus exacerbates periodontitis, resulting in expedited resorption of periodontal bone. However, methods such as mechanical debridement, anti-inflammatory medications, and surgical approaches often fail to eradicate local infections and inflammation, complicating the reconstruction of periodontal tissue structures.

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Article Synopsis
  • Autologous fat grafting has been a popular method in plastic surgery since the 1980s due to its advantages like cost-effectiveness and low risk of complications.
  • A study conducted at a Karachi hospital compared outcomes of patients with chronic non-healing wounds who received fat grafting followed by split-thickness skin grafts (STSGs) versus those who only received STSGs.
  • Results showed that patients receiving the combined treatment had a significantly higher rate of wound healing (66.7%) compared to those with STSGs alone (30%), indicating that fat grafting enhances healing outcomes.
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